|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
ISO |
KRN 7000 results in increased expression of CXCL10 protein |
CTD |
PMID:15867097 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
KRN 7000 results in increased expression of IL12B protein |
CTD |
PMID:15867097 |
|
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport |
ISO |
ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine |
CTD |
PMID:21436125 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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|
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of ABCB1 |
CTD |
PMID:11573427 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein N-acetylsphingosine results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:12640124 PMID:16215670 PMID:21821001 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bad |
BCL2-associated agonist of cell death |
decreases phosphorylation multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of BAD protein N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein] |
CTD |
PMID:24420784 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of BAX mRNA |
CTD |
PMID:24420784 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein |
CTD |
PMID:9295281 PMID:16215670 PMID:24420784 |
|
NCBI chr13:22,689,783...22,853,920
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|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions increases degradation |
ISO |
LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] |
CTD |
PMID:21821001 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein N-acetylsphingosine results in increased activity of CASP3 protein |
CTD |
PMID:10919278 PMID:16215670 PMID:21259059 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:12640124 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions decreases localization |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] |
CTD |
PMID:15319326 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity |
ISO |
N-acetylsphingosine results in increased activity of CFTR protein |
CTD |
PMID:15474513 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Clk1 |
CDC-like kinase 1 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of CLK1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
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G |
Ctsd |
cathepsin D |
increases secretion |
EXP |
N-acetylsphingosine results in increased secretion of CTSD protein |
CTD |
PMID:15040013 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Dapk1 |
death associated protein kinase 1 |
increases activity |
ISO EXP |
N-acetylsphingosine results in increased activity of DAPK1 protein |
CTD |
PMID:17087515 |
|
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
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G |
Dffb |
DNA fragmentation factor subunit beta |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of DFFB protein |
CTD |
PMID:15040013 |
|
NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dnm1l |
dynamin 1-like |
increases expression |
EXP |
N-acetylsphingosine results in increased expression of DNM1L protein |
CTD |
PMID:18006463 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] |
CTD |
PMID:11082532 |
|
NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions increases expression |
ISO |
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] N-acetylsphingosine results in increased expression of F3 protein |
CTD |
PMID:27556861 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression |
EXP |
N-acetylsphingosine results in increased expression of FIS1 protein |
CTD |
PMID:18006463 |
|
NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
decreases phosphorylation |
ISO |
N-acetylsphingosine results in decreased phosphorylation of GSK3A protein |
CTD |
PMID:21821001 |
|
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation decreases expression multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of GSK3B protein N-acetylsphingosine results in decreased expression of GSK3B protein modified form GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein] |
CTD |
PMID:21821001 PMID:24420784 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions decreases expression |
EXP |
N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein] N-acetylsphingosine results in decreased expression of GSTA2 protein |
CTD |
PMID:15155840 PMID:15319326 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
decreases expression |
EXP |
N-acetylsphingosine results in decreased expression of GSTA3 protein |
CTD |
PMID:15155840 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
decreases expression |
EXP |
N-acetylsphingosine results in decreased expression of GSTA5 protein |
CTD |
PMID:15155840 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Hmox1 |
heme oxygenase 1 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of HMOX1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hnf1a |
HNF1 homeobox A |
multiple interactions decreases ubiquitination |
EXP |
N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein N-acetylsphingosine results in decreased ubiquitination of HNF1A protein |
CTD |
PMID:15155840 |
|
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G |
Hrk |
harakiri, BCL2 interacting protein |
increases expression multiple interactions |
ISO |
N-acetylsphingosine results in increased expression of HRK mRNA N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] |
CTD |
PMID:24420784 |
|
NCBI chr12:38,387,484...38,409,652
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|
G |
Id2 |
inhibitor of DNA binding 2 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of ID2 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Il16 |
interleukin 16 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of IL16 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] |
CTD |
PMID:27556861 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA] |
CTD |
PMID:15313899 PMID:15741222 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Klf6 |
Kruppel-like factor 6 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of KLF6 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G |
Lgals3 |
galectin 3 |
multiple interactions increases expression decreases response to substance |
ISO |
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] LGALS3 results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:21821001 |
|
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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|
G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
multiple interactions |
ISO |
N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] |
CTD |
PMID:18270325 |
|
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of MAPK1 protein |
CTD |
PMID:10700234 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of MAPK3 protein |
CTD |
PMID:10700234 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] |
CTD |
PMID:18270325 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions increases degradation |
ISO |
LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] |
CTD |
PMID:21821001 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein |
CTD |
PMID:18206046 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mfn2 |
mitofusin 2 |
decreases response to substance |
EXP |
MFN2 protein results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:18006463 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mir15b |
microRNA 15b |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR15B mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
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G |
Mir20a |
microRNA 20a |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR20A mRNA |
CTD |
PMID:20145152 |
|
NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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G |
Mir25 |
microRNA 25 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR25 mRNA |
CTD |
PMID:20145152 |
|
NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015
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|
G |
Mir93 |
microRNA 93 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR93 mRNA |
CTD |
PMID:20145152 |
|
NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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G |
Mirlet7b |
microRNA let-7b |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7B mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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G |
Mirlet7d |
microRNA let-7d |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7D mRNA |
CTD |
PMID:20145152 |
|
NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
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G |
Mirlet7i |
microRNA let-7i |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7I mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases localization |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] |
CTD |
PMID:15319326 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] |
CTD |
PMID:12381813 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
|
|
G |
Nrp1 |
neuropilin 1 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] |
CTD |
PMID:15741222 |
|
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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|
G |
Nrp2 |
neuropilin 2 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] |
CTD |
PMID:15741222 |
|
NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
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|
G |
Odc1 |
ornithine decarboxylase 1 |
decreases activity |
ISO |
N-acetylsphingosine results in decreased activity of ODC1 protein |
CTD |
PMID:17521618 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases activity |
ISO |
N-acetylsphingosine results in increased activity of PARP1 protein |
CTD |
PMID:24420784 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pink1 |
PTEN induced kinase 1 |
decreases response to substance |
ISO |
PINK1 protein results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:24792327 |
|
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
|
|
G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
[N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein |
CTD |
PMID:11107162 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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|
G |
Plcg1 |
phospholipase C, gamma 1 |
multiple interactions increases degradation |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] |
CTD |
PMID:16215670 |
|
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
|
|
G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of RAF1 protein |
CTD |
PMID:10700234 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
|
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects activity |
ISO |
N-acetylsphingosine affects the activity of RELA protein |
CTD |
PMID:12853972 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
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G |
Rhob |
ras homolog family member B |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of RHOB mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
|
|
G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
[N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein |
CTD |
PMID:11107162 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO EXP |
N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein] |
CTD |
PMID:9535218 PMID:10428046 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sts |
steroid sulfatase |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] |
CTD |
PMID:16178010 |
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NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G |
Tfe3 |
transcription factor binding to IGHM enhancer 3 |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein |
CTD |
PMID:29945972 |
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NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571
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G |
Tgif1 |
TGFB-induced factor homeobox 1 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of TGIF1 mRNA |
CTD |
PMID:18270325 |
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NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein] N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein |
CTD |
PMID:9535218 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txn1 |
thioredoxin 1 |
decreases activity multiple interactions |
ISO |
N-acetylsphingosine results in decreased activity of TXN protein TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein] |
CTD |
PMID:18270325 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Txnip |
thioredoxin interacting protein |
increases expression multiple interactions |
ISO |
N-acetylsphingosine results in increased expression of TXNIP protein N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] |
CTD |
PMID:18270325 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein |
CTD |
PMID:15313899 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
dihydroceramide analog results in increased expression of ATF4 protein |
CTD |
PMID:32397857 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
dihydroceramide metabolite results in increased cleavage of CASP3 protein |
CTD |
PMID:17586710 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
increases cleavage |
ISO |
dihydroceramide metabolite results in increased cleavage of CASP6 protein |
CTD |
PMID:17586710 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
dihydroceramide metabolite results in increased cleavage of CASP9 protein |
CTD |
PMID:17586710 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Degs1 |
delta(4)-desaturase, sphingolipid 1 |
multiple interactions |
ISO |
[N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in decreased activity of DEGS1 protein] which results in decreased reduction of dihydroceramide |
CTD |
PMID:27635674 |
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NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
dihydroceramide analog results in increased expression of and results in increased lipidation of MAP1LC3B protein |
CTD |
PMID:32397857 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
ISO |
dihydroceramide analog results in increased expression of TRIB3 protein |
CTD |
PMID:32397857 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Asah2 |
N-acylsphingosine amidohydrolase 2 |
multiple interactions |
ISO |
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:15946935 |
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NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
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G |
Atf4 |
activating transcription factor 4 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ATF4 mRNA ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ATF6 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Cs |
citrate synthase |
decreases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in decreased expression of CS mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases abundance |
ISO |
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:27556861 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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G |
Itpr2 |
inositol 1,4,5-trisphosphate receptor, type 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ITPR2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
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G |
Lipc |
lipase C, hepatic type |
multiple interactions |
ISO |
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine |
CTD |
PMID:24777581 |
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NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
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G |
Lipg |
lipase G, endothelial type |
multiple interactions |
ISO |
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine |
CTD |
PMID:24777581 |
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NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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G |
Mfn2 |
mitofusin 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of MFN2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Pacs2 |
phosphofurin acidic cluster sorting protein 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of PACS2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583
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G |
Pc |
pyruvate carboxylase |
multiple interactions |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] |
CTD |
PMID:28223344 |
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NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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G |
Tnf |
tumor necrosis factor |
increases abundance multiple interactions |
ISO |
TNF protein results in increased abundance of N-palmitoylsphingosine ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:15946935 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vdac1 |
voltage-dependent anion channel 1 |
multiple interactions |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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