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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acrivastine
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Accession:CHEBI:83168 term browser browse the term
Definition:A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urticaria, and rhinitis.
Synonyms:exact_synonym: (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid
 related_synonym: (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid;   BW 825C;   BW A825C;   Formula=C22H24N2O2;   InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+;   InChIKey=PWACSDKDOHSSQD-IUTFFREVSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1cccc(\\C=C\\C(O)=O)n1;   acrivastina;   acrivastinum
 xref: CAS:87848-99-5;   Drug_Central:82;   KEGG:D02760
 xref_mesh: MESH:C043648
 xref: PMID:1355745;   PMID:1715267;   PMID:18968530;   PMID:1970907;   PMID:22936420;   PMID:23047471;   PMID:24813276;   PMID:2569998;   PMID:2569999;   PMID:2570000;   PMID:2570001;   PMID:2570003;   PMID:2574054;   PMID:2859204;   PMID:2901993;   PMID:2906886;   PMID:6149965;   PMID:7860231;   PMID:8630717;   Reaxys:6739893;   Wikipedia:Acrivastine


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acrivastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO acrivastine results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        pharmacological role 19101
          antagonist 17168
            histamine antagonist 4888
              H1-receptor antagonist 4140
                acrivastine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    main group molecular entity 19853
                      s-block molecular entity 19684
                        hydrogen molecular entity 19673
                          hydrides 19150
                            inorganic hydride 18129
                              pnictogen hydride 18118
                                nitrogen hydride 18024
                                  azane 17823
                                    ammonia 17822
                                      organic amino compound 17822
                                        tertiary amino compound 10136
                                          N-alkylpyrrolidine 1214
                                            acrivastine 1
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