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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:83168 term browser browse the term
Definition:A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urticaria, and rhinitis.
Synonyms:exact_synonym: (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid
 related_synonym: (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid;   BW 825C;   BW A825C;   Formula=C22H24N2O2;   InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+;   InChIKey=PWACSDKDOHSSQD-IUTFFREVSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1cccc(\\C=C\\C(O)=O)n1;   acrivastina;   acrivastinum
 xref: CAS:87848-99-5;   Drug_Central:82;   KEGG:D02760
 xref_mesh: MESH:C043648
 xref: PMID:1355745;   PMID:1715267;   PMID:18968530;   PMID:1970907;   PMID:22936420;   PMID:23047471;   PMID:24813276;   PMID:2569998;   PMID:2569999;   PMID:2570000;   PMID:2570001;   PMID:2570003;   PMID:2574054;   PMID:2859204;   PMID:2901993;   PMID:2906886;   PMID:6149965;   PMID:7860231;   PMID:8630717;   Reaxys:6739893;   Wikipedia:Acrivastine

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acrivastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO acrivastine results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        pharmacological role 18832
          antagonist 16319
            histamine antagonist 4620
              H1-receptor antagonist 4117
                acrivastine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            inorganic hydride 17688
                              pnictogen hydride 17668
                                nitrogen hydride 17540
                                  azane 17273
                                    ammonia 17272
                                      organic amino compound 17272
                                        tertiary amino compound 8695
                                          N-alkylpyrrolidine 1183
                                            acrivastine 1
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