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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:83168 term browser browse the term
Definition:A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urticaria, and rhinitis.
Synonyms:exact_synonym: (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid
 related_synonym: (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid;   BW 825C;   BW A825C;   Formula=C22H24N2O2;   InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+;   InChIKey=PWACSDKDOHSSQD-IUTFFREVSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1cccc(\\C=C\\C(O)=O)n1;   acrivastina;   acrivastinum
 xref: CAS:87848-99-5;   Drug_Central:82;   KEGG:D02760
 xref_mesh: MESH:C043648
 xref: PMID:1355745;   PMID:1715267;   PMID:18968530;   PMID:1970907;   PMID:22936420;   PMID:23047471;   PMID:24813276;   PMID:2569998;   PMID:2569999;   PMID:2570000;   PMID:2570001;   PMID:2570003;   PMID:2574054;   PMID:2859204;   PMID:2901993;   PMID:2906886;   PMID:6149965;   PMID:7860231;   PMID:8630717;   Reaxys:6739893;   Wikipedia:Acrivastine

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acrivastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO acrivastine results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          antagonist 16197
            histamine antagonist 4603
              H1-receptor antagonist 4099
                acrivastine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          N-alkylpyrrolidine 1133
                                            acrivastine 1
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