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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Daphnia tenebrosa metabolite
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Accession:CHEBI:83146 term browser browse the term
Definition:A Daphnia metabolite produced by the species Daphnia tenebrosa.
Synonyms:related_synonym: Daphnia tenebrosa metabolites


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(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid results in decreased expression of ALOX5 protein CTD PMID:17056761 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21724996 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of CXCL2 protein] CTD PMID:21724996 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 protein] CTD PMID:21724996 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:21724996 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:21724996 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:21724996 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21724996 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA] CTD PMID:21724996 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21724996 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of NFKBIA mRNA] CTD PMID:21724996 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid binds to and affects the activity of PPARG protein CTD PMID:17056761 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21724996 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased activity of RELA protein] CTD PMID:21724996 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid results in decreased secretion of TNF protein
CTD PMID:17056761 PMID:21724996 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:21724996 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein affects expression ISO docosapentaenoic acid affects the expression of CRP protein CTD PMID:22113248 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Pla2g6 phospholipase A2 group VI multiple interactions EXP docosapentaenoic acid inhibits the reaction [Ethanol results in decreased expression of PLA2G6 protein] CTD PMID:25029343 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP docosapentaenoic acid results in decreased expression of PTGS2 protein
docosapentaenoic acid inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]
CTD PMID:22476691 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO docosapentaenoic acid binds to RXRA protein CTD PMID:16258897 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance ISO FECH protein affects the abundance of 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine CTD PMID:29906468 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
leptomycin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO leptomycin B inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] CTD PMID:10497241 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of AKT1 protein]
leptomycin B results in increased phosphorylation of AKT1 protein
CTD PMID:28942004 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA CTD PMID:20803015 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor multiple interactions ISO leptomycin B inhibits the reaction [SB 216763 results in decreased localization of AR protein] CTD PMID:21980429 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects localization
multiple interactions
ISO leptomycin B affects the localization of BACH1 protein
leptomycin B inhibits the reaction [Cadmium Chloride affects the localization of BACH1 protein]; leptomycin B inhibits the reaction [Cadmium results in decreased activity of BACH1 protein]
CTD PMID:14504288 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in increased expression of BAX protein] CTD PMID:14592536 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2 protein] CTD PMID:14592536 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2L1 protein] CTD PMID:14592536 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects localization ISO leptomycin B affects the localization of BIRC2 protein CTD PMID:15265700 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects localization ISO leptomycin B affects the localization of BIRC3 protein CTD PMID:15265700 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO [epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 protein; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; leptomycin B promotes the reaction [gefitinib results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein]
leptomycin B results in decreased expression of BIRC5 mRNA; leptomycin B results in decreased expression of BIRC5 protein
CTD PMID:20803015 PMID:25922640 PMID:28942004 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA
leptomycin B results in decreased expression of BRCA1 mRNA
CTD PMID:20803015 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO leptomycin B results in increased expression of BTG2 mRNA CTD PMID:20803015 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Casp1 caspase 1 multiple interactions ISO leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased activity of CASP1 protein] CTD PMID:23430110 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion
multiple interactions
ISO leptomycin B results in increased secretion of CCL2 protein
polydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein]
CTD PMID:21967610 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO leptomycin B results in decreased expression of CCNB2 mRNA CTD PMID:20803015 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO leptomycin B inhibits the reaction [kahweol results in increased degradation of CCND1 protein] CTD PMID:27424123 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO leptomycin B results in decreased expression of CCNE2 mRNA CTD PMID:20803015 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO leptomycin B results in decreased expression of CDC25A mRNA CTD PMID:20803015 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO leptomycin B results in decreased expression of CDC25C mRNA CTD PMID:20803015 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO leptomycin B results in decreased expression of CDK1 mRNA CTD PMID:20803015 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A protein; leptomycin B inhibits the reaction [gefitinib results in decreased expression of CDKN1A protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein]
leptomycin B results in increased expression of CDKN1A mRNA; leptomycin B results in increased expression of CDKN1A protein
CTD PMID:20803015 PMID:25922640 PMID:28942004 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO leptomycin B results in decreased expression of CHEK1 mRNA CTD PMID:20803015 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA CTD PMID:20803015 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion
multiple interactions
ISO leptomycin B results in decreased secretion of CXCL10 protein
acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]; Quercetin promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21967610 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions
ISO leptomycin B results in increased expression of CYP3A4 mRNA
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CYP3A4 mRNA
CTD PMID:25922640 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA
leptomycin B results in decreased expression of DNMT1 mRNA
CTD PMID:20803015 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO leptomycin B results in decreased expression of E2F1 mRNA CTD PMID:20803015 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO leptomycin B results in increased expression of E2F3 mRNA CTD PMID:20803015 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO leptomycin B results in increased expression of EI24 mRNA CTD PMID:20803015 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO leptomycin B inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] CTD PMID:15899841 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO leptomycin B results in decreased localization of and results in increased phosphorylation of FGF1 protein CTD PMID:15574884 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Foxo1 forkhead box O1 affects localization ISO leptomycin B affects the localization of FOXO1 protein CTD PMID:26026911 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO leptomycin B results in increased expression of GADD45A mRNA CTD PMID:20803015 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO leptomycin B results in increased expression of GPX1 mRNA
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of GPX1 mRNA
CTD PMID:25922640 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO leptomycin B promotes the reaction [Bortezomib results in increased expression of H2AX protein modified form] CTD PMID:16778179 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hax1 HCLS1 associated protein X-1 affects localization ISO leptomycin B affects the localization of HAX1 protein CTD PMID:23164465 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA CTD PMID:20803015 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions ISO leptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein] CTD PMID:23523789 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased expression of IL1B protein] CTD PMID:23430110 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA CTD PMID:20803015 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO leptomycin B results in increased phosphorylation of MAPK1 protein
leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK1 protein]
CTD PMID:28942004 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK3 protein]
leptomycin B results in increased phosphorylation of MAPK3 protein
CTD PMID:28942004 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO leptomycin B results in increased expression of MDM2 mRNA CTD PMID:20803015 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA CTD PMID:20803015 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions EXP leptomycin B promotes the reaction [Potassium Chloride affects the localization of MYH4 protein] CTD PMID:29293066 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA CTD PMID:20803015 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:25341891 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] CTD PMID:14592536 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO leptomycin B inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein] CTD PMID:23283970 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nup62 nucleoporin 62 multiple interactions EXP leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein] CTD PMID:25341891 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO leptomycin B results in increased expression of PIDD1 mRNA CTD PMID:20803015 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO leptomycin B inhibits the reaction [Lipopolysaccharides results in increased localization of PML protein] CTD PMID:23430110 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO leptomycin B results in decreased expression of PRC1 mRNA CTD PMID:20803015 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA CTD PMID:20803015 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression ISO leptomycin B results in decreased expression of PTTG1 mRNA CTD PMID:20803015 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Ranbp1 RAN binding protein 1 affects localization
multiple interactions
EXP leptomycin B affects the localization of RANBP1 protein
leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]
CTD PMID:10421839 PMID:25341891 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO leptomycin B affects the localization of RELA protein CTD PMID:25704882 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases activity ISO leptomycin B results in decreased activity of RPS6KB2 protein CTD PMID:12087098 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] CTD PMID:14592536 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sesn1 sestrin 1 increases expression ISO leptomycin B results in increased expression of SESN1 mRNA CTD PMID:20803015 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]] CTD PMID:26354774 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] CTD PMID:26354774 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO [leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein CTD PMID:26354774 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO leptomycin B results in increased expression of SOD2 mRNA
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of SOD2 mRNA
CTD PMID:25922640 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat4 signal transducer and activator of transcription 4 affects localization ISO leptomycin B affects the localization of STAT4 protein CTD PMID:15004198 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stk4 serine/threonine kinase 4 multiple interactions ISO leptomycin B promotes the reaction [Bortezomib results in increased activity of STK4 protein] CTD PMID:16778179 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] CTD PMID:26354774 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 increases expression
multiple interactions
ISO leptomycin B results in increased expression of TNFRSF10D mRNA
[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of TNFRSF10D mRNA
CTD PMID:20803015 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
increases expression
affects expression
decreases degradation
ISO
EXP
3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [leptomycin B results in increased expression of TP53 protein]; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of TNFRSF10D mRNA; [sodium arsenite co-treated with leptomycin B] results in increased phosphorylation of TP53 protein; leptomycin B affects the localization of and results in decreased degradation of TP53 protein; leptomycin B inhibits the reaction [Cycloheximide results in increased degradation of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite affects the localization of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite results in increased degradation of TP53 protein mutant form]; leptomycin B inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; PCB 180 promotes the reaction [leptomycin B results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [leptomycin B results in decreased degradation of TP53 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein]
TP53 gene mutant form results in increased susceptibility to leptomycin B
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]
leptomycin B affects the expression of TP53 protein
CTD PMID:11751435 PMID:15459018 PMID:15625077 PMID:16467109 PMID:19010883 PMID:19751709 PMID:20803015 PMID:21454520 PMID:24792400 PMID:31645432 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA
leptomycin B results in decreased expression of TP63 mRNA
CTD PMID:20803015 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Txndc5 thioredoxin domain containing 5 increases expression
multiple interactions
ISO leptomycin B results in increased expression of TXNDC5 mRNA
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [leptomycin B results in increased expression of TXNDC5 mRNA]
CTD PMID:24515801 NCBI chr17:26,925,828...26,953,981
Ensembl chr17:26,925,828...26,953,970
JBrowse link
G Wtip WT1 interacting protein decreases localization ISO leptomycin B results in decreased localization of WTIP protein CTD PMID:14736876 NCBI chr 1:89,966,496...89,999,892 JBrowse link
G Xpo1 exportin 1 decreases activity
multiple interactions
ISO leptomycin B results in decreased activity of XPO1 protein
[leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein
CTD PMID:26354774 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Xpo4 exportin 4 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] CTD PMID:26354774 NCBI chr15:37,835,580...37,926,715
Ensembl chr15:37,835,580...37,926,715
JBrowse link
tetracosanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 increases expression ISO lignoceric acid results in increased expression of EDN1 protein CTD PMID:16895544 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link

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  CHEBI ontology 19853
    role 19804
      biological role 19804
        biochemical role 19339
          metabolite 19319
            eukaryotic metabolite 18976
              animal metabolite 18776
                crustacean metabolite 15897
                  Daphnia metabolite 15897
                    Daphnia tenebrosa metabolite 91
                      (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid + 4
                      all-cis-docosa-4,7,10,13,16,19-hexaenoic acid + 17
                      cetoleic acid + 0
                      tetracosanoic acid + 76
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