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ONTOLOGY REPORT - ANNOTATIONS


Term:Z-Val-Phe-H
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Accession:CHEBI:82818 term browser browse the term
Definition:A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpain I and II, and is also a gamma-secretase inhibitor.
Synonyms:exact_synonym: benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}butan-2-yl]carbamate
 related_synonym: Cbz-Val-Phe-H;   Formula=C22H26N2O4;   InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1;   InChIKey=NGBKFLTYGSREKK-PMACEKPBSA-N;   L-benzyloxycarbonyl-L-valyl-L-phenylalaninal;   MDL 28,170;   MDL 28170;   N-benzyloxycarbonylvalylphenylalaninal;   N-benzyloxycarbonylvalylphenylalanine aldehyde;   SMILES=CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O;   Z-Val-Phe-al;   calpain inhibitor III;   carbobenzoxyvalylphenylalanine aldehyde
 xref: CAS:88191-84-8 "ChemIDplus";   LINCS:LSM-2958
 xref_mesh: MESH:C058076
 xref: PMID:12001809 "Europe PMC";   PMID:15282090 "Europe PMC";   PMID:15777753 "Europe PMC";   PMID:16817871 "Europe PMC";   PMID:16842979 "Europe PMC";   PMID:17600513 "Europe PMC";   PMID:20657463 "Europe PMC";   PMID:20874056 "Europe PMC";   PMID:22253611 "Europe PMC";   PMID:22356295 "Europe PMC";   Reaxys:6824325 "Reaxys"


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Z-Val-Phe-H term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:6480464
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Sptan1 spectrin, alpha, non-erythrocytic 1 JBrowse link 3 8,534,437 8,599,259 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        inhibitor 18059
          apoptosis inhibitor 6554
            Z-Val-Phe-H 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                peptide 9297
                                                  oligopeptide 1070
                                                    dipeptide 255
                                                      Z-Val-Phe-H 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.