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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prodigiosin
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Accession:CHEBI:82758 term browser browse the term
Definition:A member of the class of tripyrroles that is a red-coloured pigment with antibiotic properties produced by Serratia marcescens.
Synonyms:exact_synonym: 4-methoxy-5-[(Z)-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-1H,1'H-2,2'-bipyrrole
 related_synonym: 4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)-2,2'-bipyrrole;   Formula=C20H25N3O;   InChI=1S/C20H25N3O/c1-4-5-6-8-15-11-16(22-14(15)2)12-19-20(24-3)13-18(23-19)17-9-7-10-21-17/h7,9-13,21,23H,4-6,8H2,1-3H3/b16-12-;   InChIKey=SZXDNGVQRDTJSD-VBKFSLOCSA-N;   SMILES=CCCCCC1=C\\C(=C\\c2[nH]c(cc2OC)-c2ccc[nH]2)N=C1C
 xref: CAS:82-89-3
 xref_mesh: MESH:D011353
 xref: MetaCyc:CPD-16992;   PMID:15853884;   PMID:24247721;   PMID:24372158;   PMID:24440841;   PMID:24587717;   PMID:24619531;   PMID:24781979;   PMID:24817724;   PMID:25063175;   PMID:25199250;   PMID:25201292;   Reaxys:4526727;   Wikipedia:Prodigiosin


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prodigiosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Prodigiosin results in increased expression of ABCC1 mRNA CTD PMID:15746575 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
decreases response to substance		 ISO Prodigiosin results in decreased expression of BIRC5 mRNA; Prodigiosin results in decreased expression of BIRC5 protein
Prodigiosin inhibits the reaction [Paclitaxel results in increased expression of BIRC5 protein]
BIRC5 results in decreased susceptibility to Prodigiosin		 CTD PMID:19133282 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions		 ISO Prodigiosin results in increased cleavage of CASP3 protein
Prodigiosin results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [Prodigiosin results in increased activity of CASP3 protein]		 CTD PMID:15746575 PMID:31077745 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage
increases activity		 ISO Prodigiosin results in increased cleavage of CASP8 protein
Prodigiosin results in increased activity of CASP8 protein		 CTD PMID:15746575 PMID:31077745 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity		 ISO Prodigiosin results in increased cleavage of CASP9 protein
Prodigiosin results in increased activity of CASP9 protein		 CTD PMID:15746575 PMID:19133282 PMID:31077745 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein] CTD PMID:21925195 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of JUN protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:31077745 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:31077745 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:31077745 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Prodigiosin results in decreased phosphorylation of MAPK8 protein CTD PMID:31077745 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation ISO Prodigiosin results in decreased phosphorylation of MAPK9 protein CTD PMID:31077745 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased degradation of NFKBIA protein] CTD PMID:21925195 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein] CTD PMID:21925195 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Prodigiosin results in increased cleavage of PARP1 protein CTD PMID:15746575 PMID:19133282 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression
decreases response to substance		 ISO pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]; SB 203580 inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]
Prodigiosin results in decreased expression of RAD51 mRNA; Prodigiosin results in decreased expression of RAD51 protein
RAD51 protein results in decreased susceptibility to Prodigiosin		 CTD PMID:22579953 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of RELA protein] CTD PMID:21925195 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO Prodigiosin results in increased expression of SQSTM1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of SQSTM1 protein]		 CTD PMID:31077745 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        antimicrobial agent 17941
          prodigiosin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic molecule 19651
                              organic cyclic compound 19457
                                organic heterocyclic compound 18816
                                  organonitrogen heterocyclic compound 18025
                                    polypyrrole 680
                                      tripyrrole 17
                                        prodigiosin 17
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