|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
increases phosphorylation multiple interactions decreases phosphorylation decreases expression
|
ISO EXP
|
plumbagin results in increased phosphorylation of AKT1 protein plumbagin inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] plumbagin results in decreased phosphorylation of AKT1 protein plumbagin results in decreased expression of AKT1 mRNA
|
CTD |
PMID:20028456 PMID:32691977 PMID:36336213 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Bad
|
BCL2-associated agonist of cell death
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in increased expression of BAD protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression
|
EXP
|
plumbagin results in decreased expression of BCL2 protein
|
CTD |
PMID:34302802 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
decreases expression
|
ISO
|
[Plumbagin alone or cotreated with IL-6] decreases expression of BCL2L1 mRNA in liver
|
RGD |
PMID:25815436 |
RGD:126925996 |
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
|
|
G
|
Casp3
|
caspase 3
|
increases activity multiple interactions
|
ISO EXP
|
plumbagin results in increased activity of CASP3 protein NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]; plumbagin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
|
CTD |
PMID:20028456 PMID:20576514 PMID:32691977 PMID:34302802 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
increases activity multiple interactions
|
ISO
|
plumbagin results in increased activity of CASP8 protein Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]
|
CTD |
PMID:20576514 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions increases activity decreases expression increases expression
|
ISO EXP
|
Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP9 protein] plumbagin results in decreased expression of CASP9 protein plumbagin results in increased expression of CASP9 mRNA
|
CTD |
PMID:20576514 PMID:34302802 PMID:36336213 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in increased expression of CCL2 protein]
|
CTD |
PMID:32691977 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
|
|
G
|
Ccnd1
|
cyclin D1
|
decreases expression
|
ISO
|
[Plumbagin alone or cotreated with IL-6] decreases expression of CCND1 mRNA in liver
|
RGD |
PMID:25815436 |
RGD:126925996 |
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression
|
ISO
|
plumbagin results in increased expression of CDKN1A mRNA
|
CTD |
PMID:36336213 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
|
|
G
|
Ctrl
|
chymotrypsin-like
|
multiple interactions decreases activity
|
ISO
|
Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein]
|
CTD |
PMID:31276663 |
|
NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979
|
|
G
|
Cyp19a1
|
cytochrome P450, family 19, subfamily a, polypeptide 1
|
decreases expression
|
EXP
|
plumbagin results in decreased expression of CYP19A1 mRNA
|
CTD |
PMID:34302802 |
|
NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression multiple interactions
|
ISO
|
plumbagin results in increased expression of DDIT3 protein Acetylcysteine inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]
|
CTD |
PMID:31276663 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
|
|
G
|
Dhodh
|
dihydroorotate dehydrogenase
|
decreases activity
|
ISO EXP
|
plumbagin results in decreased activity of DHODH protein
|
CTD |
PMID:10658902 |
|
NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496
|
|
G
|
E2f1
|
E2F transcription factor 1
|
decreases expression
|
ISO
|
plumbagin results in decreased expression of E2F1 mRNA
|
CTD |
PMID:36336213 |
|
NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563
|
|
G
|
Fabp3
|
fatty acid binding protein 3
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881
|
|
G
|
Fas
|
Fas cell surface death receptor
|
increases expression
|
ISO
|
plumbagin results in increased expression of FAS mRNA; plumbagin results in increased expression of FAS protein
|
CTD |
PMID:20576514 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
|
|
G
|
Fshr
|
follicle stimulating hormone receptor
|
decreases expression
|
EXP
|
plumbagin results in decreased expression of FSHR mRNA
|
CTD |
PMID:34302802 |
|
NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288
|
|
G
|
G6pc1
|
glucose-6-phosphatase catalytic subunit 1
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein]
|
CTD |
PMID:22960630 |
|
NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
increases expression
|
ISO
|
plumbagin results in increased expression of GCLM mRNA
|
CTD |
PMID:20028456 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
|
|
G
|
Gstp1
|
glutathione S-transferase pi 1
|
increases expression
|
ISO
|
plumbagin results in increased expression of GSTP1 mRNA
|
CTD |
PMID:20028456 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
|
|
G
|
Hk1
|
hexokinase 1
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Streptozocin results in decreased activity of HK1 protein]
|
CTD |
PMID:22960630 |
|
NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions increases expression
|
ISO EXP
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein] plumbagin results in increased expression of HMOX1 mRNA; plumbagin results in increased expression of HMOX1 protein plumbagin promotes the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
|
CTD |
PMID:20028456 PMID:32691977 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
increases expression multiple interactions
|
ISO
|
plumbagin results in increased expression of HSPA5 protein Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]
|
CTD |
PMID:31276663 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO EXP
|
plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] plumbagin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]
|
CTD |
PMID:23942037 PMID:32691977 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
|
CTD |
PMID:22960630 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
increases phosphorylation
|
ISO
|
plumbagin results in increased phosphorylation of MAPK1 protein
|
CTD |
PMID:20028456 PMID:20576514 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
increases phosphorylation
|
ISO
|
plumbagin results in increased phosphorylation of MAPK3 protein
|
CTD |
PMID:20028456 PMID:20576514 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions decreases expression
|
ISO
|
plumbagin results in decreased expression of and results in decreased activity of MMP2 protein plumbagin results in decreased expression of MMP2 mRNA
|
CTD |
PMID:36336213 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
decreases expression
|
ISO
|
[Plumbagin alone and cotreated with IL-6] decreases expression of MMP9 in liver plumbagin results in decreased expression of MMP9 mRNA
|
CTD RGD |
PMID:36336213 PMID:25815436 |
RGD:126925996 |
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions affects response to substance affects localization
|
ISO EXP
|
NFE2L2 mRNA affects the reaction [plumbagin results in decreased susceptibility to tert-Butylhydroperoxide]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA] NFE2L2 mRNA affects the susceptibility to plumbagin NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]] plumbagin affects the localization of NFE2L2 protein
|
CTD |
PMID:20028456 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nppb
|
natriuretic peptide B
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
increases expression multiple interactions
|
ISO
|
plumbagin results in increased expression of NQO1 mRNA; plumbagin results in increased expression of NQO1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of NQO1 protein]; wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein]
|
CTD |
PMID:20028456 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
decreases expression
|
ISO
|
plumbagin results in decreased expression of PARP1 mRNA; plumbagin results in decreased expression of PARP1 protein
|
CTD |
PMID:36336213 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
|
|
G
|
Per2
|
period circadian regulator 2
|
decreases response to substance
|
ISO
|
PER2 protein mutant form results in decreased susceptibility to plumbagin
|
CTD |
PMID:25628599 |
|
NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993
|
|
G
|
Pgr
|
progesterone receptor
|
decreases expression
|
EXP
|
plumbagin results in decreased expression of PGR mRNA
|
CTD |
PMID:34302802 |
|
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
|
|
G
|
Pten
|
phosphatase and tensin homolog
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
|
|
G
|
Ptpn2
|
protein tyrosine phosphatase, non-receptor type 2
|
multiple interactions
|
ISO
|
plumbagin binds to and results in decreased activity of PTPN2 protein
|
CTD |
PMID:31248982 |
|
NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481
|
|
G
|
Pygb
|
glycogen phosphorylase B
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in increased expression of PYGB protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 3:160,072,141...160,118,930
Ensembl chr 3:160,072,115...160,123,961
|
|
G
|
Slc2a4
|
solute carrier family 2 member 4
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
|
CTD |
PMID:22960630 |
|
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
|
|
G
|
Sqstm1
|
sequestosome 1
|
increases expression
|
ISO
|
plumbagin results in increased expression of SQSTM1 protein
|
CTD |
PMID:31276663 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
|
|
G
|
Tesk1
|
testis associated actin remodelling kinase 1
|
decreases expression
|
EXP
|
plumbagin results in decreased expression of TESK1 mRNA
|
CTD |
PMID:34302802 |
|
NCBI chr 5:62,487,763...62,493,492
Ensembl chr 5:62,487,763...62,493,492
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
|
|
G
|
Timp2
|
TIMP metallopeptidase inhibitor 2
|
increases expression
|
ISO
|
plumbagin results in increased expression of TIMP2 mRNA
|
CTD |
PMID:36336213 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214
|
|
G
|
Tnni3
|
troponin I3, cardiac type
|
multiple interactions
|
EXP
|
plumbagin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein]
|
CTD |
PMID:32691977 |
|
NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253
|
|
G
|
Tp53
|
tumor protein p53
|
increases expression
|
EXP
|
plumbagin results in increased expression of TP53 protein
|
CTD |
PMID:34302802 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
G
|
Txnrd1
|
thioredoxin reductase 1
|
increases expression
|
ISO
|
plumbagin results in increased expression of TXNRD1 mRNA
|
CTD |
PMID:20028456 |
|
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
increases glucuronidation
|
ISO
|
UGT1A1 protein results in increased glucuronidation of plumbagin
|
CTD |
PMID:14557274 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Ugt1a9
|
UDP glucuronosyltransferase family 1 member A9
|
increases glucuronidation
|
ISO
|
UGT1A9 protein results in increased glucuronidation of plumbagin
|
CTD |
PMID:14557274 |
|
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
|
|
G
|
Uhrf1
|
ubiquitin-like with PHD and ring finger domains 1
|
decreases expression
|
ISO
|
plumbagin results in decreased expression of UHRF1 mRNA; plumbagin results in decreased expression of UHRF1 protein
|
CTD |
PMID:36336213 |
|
NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,222,063...1,241,792
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
decreases expression
|
ISO
|
Plumbagin decreases expression of VEGFA mRNA in liver
|
RGD |
PMID:25815436 |
RGD:126925996 |
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
|
|