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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:idelalisib
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Accession:CHEBI:82701 term browser browse the term
Definition:A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.
Synonyms:exact_synonym: 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one
 related_synonym: 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one;   CAL-101;   Formula=C22H18FN7O;   GS-1101;   InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1;   InChIKey=IFSDAJWBUCMOAH-HNNXBMFYSA-N;   SMILES=CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1;   ZYDELIG
 xref: CAS:870281-82-6;   Drug_Central:4878;   LINCS:LSM-1205
 xref_mesh: MESH:C552946
 xref: PMID:24376763;   PMID:24450857;   PMID:24450858;   PMID:24463402;   PMID:24615776;   PMID:24615777;   PMID:24615778;   PMID:24619588;   PMID:24659719;   PMID:24795031;   PMID:25093123;   PMID:25187123;   PMID:25274697;   Reaxys:12464214;   Wikipedia:Idelalisib


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idelalisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; [idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein] CTD PMID:23676220 PMID:31445927 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein]; [FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein CTD PMID:31445927 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein]; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein CTD PMID:31445927 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein]; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein CTD PMID:31445927 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein]; [FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein CTD PMID:31445927 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein CTD PMID:23676220 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein] CTD PMID:31445927 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; [FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein CTD PMID:31445927 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO idelalisib decreases expression of Cxcl1 protein in liver and spleen RGD PMID:27999013 RGD:40890273 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Fas Fas cell surface death receptor affects response to substance
multiple interactions
ISO idelalisib affects the susceptibility to FAS protein
FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]
CTD PMID:31445927 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein; [FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein; [idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein] CTD PMID:31445927 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
affects expression
increases expression
ISO [Galactosamine co-treated with Lipopolysaccharides] promotes the reaction [idelalisib results in increased expression of ALT protein]; FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]
idelalisib affects the expression of GPT protein
CTD PMID:31445927 PMID:31501888 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Ifng interferon gamma decreases expression ISO idelalisib decreases expression of Ifng protein in liver, spleen and lymph node RGD PMID:27999013 RGD:40890273 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 decreases expression ISO idelalisib decreases expression of Il10 protein in liver, lymph node and spleen RGD PMID:27999013 RGD:40890273 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il4 interleukin 4 decreases expression ISO idelalisib decreases expression of Il4 protein in lymph node RGD PMID:27999013 RGD:40890273 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression ISO idelalisib decreases expression of Il6 protein in liver and spleen RGD PMID:27999013 RGD:40890273 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mir122 microRNA 122 affects expression ISO idelalisib affects the expression of MIR122 mRNA CTD PMID:31501888 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein CTD PMID:23676220 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 increases expression ISO idelalisib results in increased expression of PIK3IP1 mRNA CTD PMID:23676220 NCBI chr14:83,559,397...83,572,481
Ensembl chr14:83,560,541...83,572,473
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein] CTD PMID:31445927 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions
ISO idelalisib results in increased susceptibility to TNF protein
2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]; [TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein
CTD PMID:31445927 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          apoptosis inducer 11024
            idelalisib 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  organic heteropolycyclic compound 17977
                                    organic heterobicyclic compound 16784
                                      imidazopyrimidine 5592
                                        purines 5590
                                          idelalisib 21
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