Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:olodaterol
go back to main search page
Accession:CHEBI:82700 term browser browse the term
Definition:A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.
Synonyms:exact_synonym: 6-hydroxy-8-[(1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl]-2H-1,4-benzoxazin-3(4H)-one
 related_synonym: BI 1744;   Formula=C21H26N2O5;   InChI=1S/C21H26N2O5/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26)/t18-/m0/s1;   InChIKey=COUYJEVMBVSIHV-SFHVURJKSA-N;   SMILES=COc1ccc(CC(C)(C)NC[C@H](O)c2cc(O)cc3NC(=O)COc23)cc1
 xref: CAS:868049-49-4;   Drug_Central:4814;   KEGG:D10145
 xref_mesh: MESH:C549647
 xref: PMID:20096576;   PMID:20371707;   PMID:21839850;   PMID:24158691;   PMID:24247039;   PMID:24269928;   PMID:24307202;   PMID:24966672;   PMID:25045258;   PMID:25114521;   PMID:25187881;   Reaxys:12431799;   Wikipedia:Olodaterol
 cyclic_relationship: is_conjugate_base_of CHEBI:83312


show annotations for term's descendants           Sort by:
 
olodaterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions
affects expression
increases expression
ISO Cycloheximide inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]; EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]; olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 PMID:24705868 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression
ISO 2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; N(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; olodaterol inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]; olodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]; olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 PMID:22796455 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO olodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            bronchodilator agent 3730
              olodaterol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        secondary amino compound 6583
                                          olodaterol 3
paths to the root