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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:olodaterol
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Accession:CHEBI:82700 term browser browse the term
Definition:A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.
Synonyms:exact_synonym: 6-hydroxy-8-[(1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl]-2H-1,4-benzoxazin-3(4H)-one
 related_synonym: BI 1744;   Formula=C21H26N2O5;   InChI=1S/C21H26N2O5/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26)/t18-/m0/s1;   InChIKey=COUYJEVMBVSIHV-SFHVURJKSA-N;   SMILES=COc1ccc(CC(C)(C)NC[C@H](O)c2cc(O)cc3NC(=O)COc23)cc1
 xref: CAS:868049-49-4;   Drug_Central:4814;   KEGG:D10145
 xref_mesh: MESH:C549647
 xref: PMID:20096576;   PMID:20371707;   PMID:21839850;   PMID:24158691;   PMID:24247039;   PMID:24269928;   PMID:24307202;   PMID:24966672;   PMID:25045258;   PMID:25114521;   PMID:25187881;   Reaxys:12431799;   Wikipedia:Olodaterol
 cyclic_relationship: is_conjugate_base_of CHEBI:83312


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olodaterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions
affects expression
increases expression		 ISO Cycloheximide inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]; EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]; olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 PMID:24705868 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression		 ISO 2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; N(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; olodaterol inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]; olodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]; olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 PMID:22796455 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO olodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            bronchodilator agent 3820
              olodaterol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            inorganic hydride 18191
                              pnictogen hydride 18181
                                nitrogen hydride 18092
                                  azane 17895
                                    ammonia 17894
                                      organic amino compound 17894
                                        secondary amino compound 6958
                                          olodaterol 3
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