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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7-oxolithocholic acid
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Accession:CHEBI:82679 term browser browse the term
Definition:A bile acid that is lithocholic acid carrying an additional oxo substituent at position 7.
Synonyms:exact_synonym: (3alpha,5beta)-3-hydroxy-7-oxocholan-24-oic acid
 related_synonym: 3-alpha-Hydroxy-7-oxo-5-beta-cholan-24-oic acid;   3alpha-Hydroxy-7-oxo-5beta-cholanic acid;   3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid;   7-Ketolithocholic acid;   7-oxo-3alpha-hydroxycholan-24-oic acid;   Formula=C24H38O4;   InChI=1S/C24H38O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-19,22,25H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,22+,23+,24-/m1/s1;   InChIKey=DXOCDBGWDZAYRQ-AURDAFMXSA-N;   Nutriacholic acid;   SMILES=C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CC[C@@H](O)C[C@H]1CC3=O
 xref: CAS:4651-67-6;   HMDB:HMDB0000467;   LIPID_MAPS_instance:LMST04010150
 xref_mesh: MESH:C023020
 xref: PMID:13525374;   PMID:21453287;   PMID:23933573;   PMID:2401860;   PMID:2811609;   PMID:2912152;   PMID:3480039;   PMID:3943698;   PMID:3943699;   PMID:4016150;   PMID:4063074;   PMID:4090568;   PMID:520764;   PMID:6631218;   PMID:7084613;   PMID:7380227;   PMID:7435569;   Reaxys:3222783
 cyclic_relationship: is_conjugate_acid_of CHEBI:78605



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7-oxolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases reduction
multiple interactions
ISO HSD11B1 protein results in increased reduction of 7-ketolithocholic acid
[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid; [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid
CTD PMID:21453287 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      application 19465
        pharmaceutical 19355
          drug 19355
            protective agent 17978
              geroprotector 17133
                lithocholic acid 265
                  7-oxolithocholic acid 1
                    7-oxotaurolithocholic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic molecule 19506
                              organic cyclic compound 19324
                                organic polycyclic compound 17120
                                  steroid 14334
                                    steroid fundamental parent 14097
                                      cholane 987
                                        cholanoid 987
                                          cholanic acids 972
                                            cholanic acid 974
                                              5beta-cholanic acid 972
                                                hydroxy-5beta-cholanic acid 974
                                                  bile acid 974
                                                    lithocholic acid 265
                                                      7-oxolithocholic acid 1
                                                        7-oxotaurolithocholic acid 0
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