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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
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Accession:CHEBI:82665 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
Synonyms:related_synonym: ATP:cyclin phosphotransferase inhibitor;   ATP:cyclin phosphotransferase inhibitors;   Bur1 Cdk inhibitor;   Bur1 Cdk inhibitors;   Bur1 inhibitor;   Bur1 inhibitors;   CDK inhibitor;   CDK inhibitors;   Cak1 inhibitor;   Cak1 inhibitors;   Cak1p inhibitor;   Cak1p inhibitors;   Cdc28p inhibitor;   Cdc28p inhibitors;   Cdk-activating protein kinase inhibitors;   Cdk1 inhibitor;   Cdk1 inhibitors;   Cdk19 inhibitor;   Cdk19 inhibitors;   Cdk2 inhibitor;   Cdk2 inhibitors;   Cdk3 inhibitor;   Cdk3 inhibitors;   Cdk4 inhibitor;   Cdk4 inhibitors;   Cdk5 inhibitor;   Cdk5 inhibitors;   Cdk6 inhibitor;   Cdk6 inhibitors;   Cdk7 inhibitor;   Cdk7 inhibitors;   Cdk8 inhibitor;   Cdk8 inhibitors;   Cdk9 inhibitor;   Cdk9 inhibitors;   D-type cyclin kinase inhibitor;   D-type cyclin kinase inhibitors;   EC 2.7.11.22 (cyclin-dependent kinase) inhibitors;   EC 2.7.11.22 inhibitor;   EC 2.7.11.22 inhibitors;   PCTAIRE-1 inhibitor;   PCTAIRE-1 inhibitors;   STK25 inhibitor;   STK25 inhibitors;   cdc2 inhibitor;   cdc2 inhibitors;   cdc2 kinase inhibitor;   cdc2 kinase inhibitors;   cdk-activating kinase inhibitor;   cdk-activating kinase inhibitors;   cyclin A-activated cdc2 inhibitor;   cyclin A-activated cdc2 inhibitors;   cyclin A-activated cdk2 inhibitor;   cyclin A-activated cdk2 inhibitors;   cyclin D-cdk6 kinase inhibitor;   cyclin D-cdk6 kinase inhibitors;   cyclin D-dependent kinase inhibitor;   cyclin D-dependent kinase inhibitors;   cyclin E kinase inhibitor;   cyclin E kinase inhibitors;   cyclin-A associated kinase inhibitor;   cyclin-A associated kinase inhibitors;   cyclin-dependent kinase 6 inhibitor;   cyclin-dependent kinase 6 inhibitors;   cyclin-dependent kinase inhibitor;   cyclin-dependent kinase inhibitors;   cyclin-dependent kinase-2 inhibitor;   cyclin-dependent kinase-2 inhibitors;   cyclin-dependent kinase-4 inhibitor;   cyclin-dependent kinase-4 inhibitors;   cyclin-dependent protein kinase activating kinase inhibitor;   cyclin-dependent protein kinase activating kinase inhibitors;   cyk inhibitor;   cyk inhibitors;   ndk inhibitor;   ndk inhibitors;   neuronal cdc2-like kinase inhibitor;   neuronal cdc2-like kinase inhibitors


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adapalene term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:6480464
G Crabp2 cellular retinoic acid binding protein 2 JBrowse link 2 187,322,416 187,326,794 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:6480464
alsterpaullone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
alvocidib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6480464
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bag1 BAG cochaperone 1 JBrowse link 5 57,254,421 57,267,002 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Btg2 BTG anti-proliferation factor 2 JBrowse link 13 50,913,185 50,916,944 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cbr3 carbonyl reductase 3 JBrowse link 11 33,909,417 33,917,674 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:6480464
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hmga1 high mobility group AT-hook 1 JBrowse link 20 7,132,501 7,140,155 RGD:6480464
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:6480464
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6480464
G Isg15 ISG15 ubiquitin-like modifier JBrowse link 5 173,624,862 173,629,124 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:6480464
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:6480464
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mx2 MX dynamin like GTPase 2 JBrowse link 11 38,035,306 38,066,185 RGD:6480464
G Nelfa negative elongation factor complex member A JBrowse link 14 82,093,837 82,117,913 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Perp PERP, TP53 apoptosis effector JBrowse link 1 14,224,392 14,236,838 RGD:6480464
G Polr2a RNA polymerase II subunit A JBrowse link 10 56,339,277 56,364,888 RGD:6480464
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:6480464
G Pygl glycogen phosphorylase L JBrowse link 6 92,597,759 92,643,734 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rbl1 RB transcriptional corepressor like 1 JBrowse link 3 153,263,692 153,321,351 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Supt5h SPT5 homolog, DSIF elongation factor subunit JBrowse link 1 85,437,780 85,466,854 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464
bohemine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
indirubin-3'-monoxime term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 JBrowse link 8 77,640,234 77,719,488 RGD:6480464
G Aqp9 aquaporin 9 JBrowse link 8 77,559,621 77,599,781 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Cd80 Cd80 molecule JBrowse link 11 64,815,201 64,855,293 RGD:6480464
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:6480464
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link 6 99,433,575 99,436,288 RGD:6480464
G Hspa9 heat shock protein family A (Hsp70) member 9 JBrowse link 18 27,731,072 27,749,235 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Ido1 indoleamine 2,3-dioxygenase 1 JBrowse link 16 72,216,326 72,228,098 RGD:6480464
G Ido2 indoleamine 2,3-dioxygenase 2 JBrowse link 16 72,232,852 72,291,227 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il27 interleukin 27 JBrowse link 1 198,003,615 198,010,112 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6480464
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rad23a RAD23 homolog A, nucleotide excision repair protein JBrowse link 19 25,949,488 25,956,677 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6480464
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ung uracil-DNA glycosylase JBrowse link 12 48,246,593 48,255,547 RGD:6480464
olomoucine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tpi1 triosephosphate isomerase 1 JBrowse link 4 157,328,375 157,331,905 RGD:6480464
palbociclib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Anln anillin, actin binding protein JBrowse link 8 23,336,455 23,397,122 RGD:6480464
G Asf1b anti-silencing function 1B histone chaperone JBrowse link 19 25,077,918 25,092,491 RGD:6480464
G Aurka aurora kinase A JBrowse link 3 170,364,177 170,380,278 RGD:6480464
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:6480464
G Bard1 BRCA1 associated RING domain 1 JBrowse link 9 78,297,723 78,368,777 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Bora bora, aurora kinase A activator JBrowse link 15 83,442,217 83,463,737 RGD:6480464
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase JBrowse link 3 120,373,604 120,404,910 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Ccnb2 cyclin B2 JBrowse link 8 76,847,972 76,861,165 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6480464
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6480464
G Ccnf cyclin F JBrowse link 10 13,594,687 13,619,935 RGD:6480464
G Cdc20 cell division cycle 20 JBrowse link 5 137,260,728 137,264,931 RGD:6480464
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:6480464
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:6480464
G Cdc37 cell division cycle 37 JBrowse link 8 22,160,922 22,173,797 RGD:6480464
G Cdc45 cell division cycle 45 JBrowse link 11 86,328,785 86,354,099 RGD:6480464
G Cdca3 cell division cycle associated 3 JBrowse link 4 157,347,876 157,351,889 RGD:6480464
G Cdca5 cell division cycle associated 5 JBrowse link 1 221,448,661 221,462,235 RGD:6480464
G Cdca8 cell division cycle associated 8 JBrowse link 5 142,911,310 142,933,536 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Cdk7 cyclin-dependent kinase 7 JBrowse link 2 30,710,642 30,735,522 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:6480464
G Cdkn2c cyclin-dependent kinase inhibitor 2C JBrowse link 5 129,347,731 129,352,886 RGD:6480464
G Cdkn3 cyclin-dependent kinase inhibitor 3 JBrowse link 15 23,553,171 23,564,538 RGD:6480464
G Cdt1 chromatin licensing and DNA replication factor 1 JBrowse link 19 55,381,565 55,386,511 RGD:6480464
G Cenpa centromere protein A JBrowse link 6 27,072,259 27,080,863 RGD:6480464
G Cenpe centromere protein E JBrowse link 2 240,395,974 240,454,785 RGD:6480464
G Cenpf centromere protein F JBrowse link 13 108,132,499 108,178,609 RGD:6480464
G Cenpm centromere protein M JBrowse link 7 123,464,615 123,476,336 RGD:6480464
G Cep55 centrosomal protein 55 JBrowse link 1 256,745,251 256,760,794 RGD:6480464
G Ckap2l cytoskeleton associated protein 2-like JBrowse link 3 121,796,221 121,822,352 RGD:6480464
G Cpa4 carboxypeptidase A4 JBrowse link 4 57,883,849 57,907,826 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Dennd6b DENN domain containing 6B JBrowse link 7 130,162,728 130,178,282 RGD:6480464
G Depdc1b DEP domain containing 1B JBrowse link 2 39,980,796 40,069,982 RGD:6480464
G Dlgap5 DLG associated protein 5 JBrowse link 15 24,167,484 24,199,417 RGD:6480464
G Donson downstream neighbor of SON JBrowse link 11 31,834,608 31,847,751 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G E2f2 E2F transcription factor 2 JBrowse link 5 154,516,611 154,540,228 RGD:6480464
G Eln elastin JBrowse link 12 24,978,478 25,021,864 RGD:6480464
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:6480464
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fam111a family with sequence similarity 111, member A JBrowse link 1 229,003,778 229,019,532 RGD:6480464
G Fam83d family with sequence similarity 83, member D JBrowse link 3 155,269,344 155,288,612 RGD:6480464
G Fanci FA complementation group I JBrowse link 1 141,116,565 141,172,997 RGD:6480464
G Fbxo5 F-box protein 5 JBrowse link 1 42,461,277 42,467,646 RGD:6480464
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:6480464
G Flt3 Fms related receptor tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:6480464
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:6480464
G Gins2 GINS complex subunit 2 JBrowse link 19 54,151,048 54,163,701 RGD:6480464
G Gmnn geminin, DNA replication inhibitor JBrowse link 17 42,302,523 42,310,783 RGD:6480464
G Gpsm2 G-protein signaling modulator 2 JBrowse link 2 211,480,120 211,528,096 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hjurp Holliday junction recognition protein JBrowse link 9 95,347,739 95,362,228 RGD:6480464
G Hmgb2 high mobility group box 2 JBrowse link 16 36,077,615 36,080,191 RGD:6480464
G Hmmr hyaluronan-mediated motility receptor JBrowse link 10 25,861,490 25,890,639 RGD:6480464
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Il20rb interleukin 20 receptor subunit beta JBrowse link 8 108,745,906 108,778,561 RGD:6480464
G Incenp inner centromere protein JBrowse link 1 225,923,448 225,953,384 RGD:6480464
G Kif11 kinesin family member 11 JBrowse link 1 256,035,866 256,088,299 RGD:6480464
G Kif14 kinesin family member 14 JBrowse link 13 53,350,073 53,421,992 RGD:6480464
G Kif15 kinesin family member 15 JBrowse link 8 132,033,117 132,103,528 RGD:6480464
G Kif20a kinesin family member 20A JBrowse link 18 27,424,328 27,432,814 RGD:6480464
G Kif23 kinesin family member 23 JBrowse link 8 66,866,043 66,893,241 RGD:6480464
G Kif2c kinesin family member 2C JBrowse link 5 136,027,923 136,053,268 RGD:6480464
G Kif4a kinesin family member 4A JBrowse link X 70,461,700 70,561,084 RGD:6480464
G Kifc1 kinesin family member C1 JBrowse link 20 5,509,059 5,526,175 RGD:6480464
G Knstrn kinetochore-localized astrin/SPAG5 binding protein JBrowse link 3 110,618,256 110,638,024 RGD:6480464
G Kpna2 karyopherin subunit alpha 2 JBrowse link 10 95,200,029 95,212,111 RGD:6480464
G Lama3 laminin subunit alpha 3 JBrowse link 18 3,704,866 3,941,215 RGD:6480464
G Lamb3 laminin subunit beta 3 JBrowse link 13 112,031,614 112,073,187 RGD:6480464
G Lamc2 laminin subunit gamma 2 JBrowse link 13 70,566,643 70,632,126 RGD:6480464
G Lmnb1 lamin B1 JBrowse link 18 51,785,111 51,822,264 RGD:6480464
G Mcm10 minichromosome maintenance 10 replication initiation factor JBrowse link 17 77,224,218 77,245,486 RGD:6480464
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 12 19,306,615 19,313,877 RGD:6480464
G Mef2d myocyte enhancer factor 2D JBrowse link 2 187,511,775 187,541,285 RGD:6480464
G Melk maternal embryonic leucine zipper kinase JBrowse link 5 59,783,835 59,844,356 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mxd4 Max dimerization protein 4 JBrowse link 14 81,819,415 81,833,456 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Ncapd2 non-SMC condensin I complex, subunit D2 JBrowse link 4 157,682,855 157,705,903 RGD:6480464
G Ncapg non-SMC condensin I complex, subunit G JBrowse link 14 69,898,268 69,927,885 RGD:6480464
G Ncapg2 non-SMC condensin II complex, subunit G2 JBrowse link 6 144,291,313 144,362,454 RGD:6480464
G Ndc80 NDC80 kinetochore complex component JBrowse link 9 119,837,857 119,871,435 RGD:6480464
G Nek2 NIMA-related kinase 2 JBrowse link 13 110,511,546 110,524,750 RGD:6480464
G Nusap1 nucleolar and spindle associated protein 1 JBrowse link 3 111,422,267 111,452,600 RGD:6480464
G Oip5 Opa interacting protein 5 JBrowse link 3 111,413,662 111,422,320 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pbk PDZ binding kinase JBrowse link 15 42,489,253 42,500,377 RGD:6480464
G Pclaf PCNA clamp associated factor JBrowse link 8 71,514,281 71,526,182 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6480464
G Phf19 PHD finger protein 19 JBrowse link 3 13,957,136 13,978,283 RGD:6480464
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:6480464
G Pimreg PICALM interacting mitotic regulator JBrowse link 10 58,613,588 58,618,524 RGD:6480464
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:6480464
G Pola2 DNA polymerase alpha 2, accessory subunit JBrowse link 1 221,297,417 221,321,601 RGD:6480464
G Pole2 DNA polymerase epsilon 2, accessory subunit JBrowse link 6 91,494,348 91,532,355 RGD:6480464
G Porcn porcupine O-acyltransferase JBrowse link X 15,035,569 15,048,440 RGD:6480464
G Prc1 protein regulator of cytokinesis 1 JBrowse link 1 142,087,181 142,108,746 RGD:6480464
G Prim1 DNA primase subunit 1 JBrowse link 7 2,435,524 2,451,169 RGD:6480464
G Prr11 proline rich 11 JBrowse link 10 74,393,683 74,436,073 RGD:6480464
G Prss23 serine protease 23 JBrowse link 1 153,732,528 153,742,111 RGD:6480464
G Psrc1 proline and serine rich coiled-coil 1 JBrowse link 2 211,176,437 211,181,078 RGD:6480464
G Pttg1 PTTG1 regulator of sister chromatid separation, securin JBrowse link 10 29,014,332 29,026,088 RGD:6480464
G Racgap1 Rac GTPase-activating protein 1 JBrowse link 7 141,277,303 141,308,849 RGD:6480464
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rbl1 RB transcriptional corepressor like 1 JBrowse link 3 153,263,692 153,321,351 RGD:6480464
G Rbl2 RB transcriptional corepressor like 2 JBrowse link 19 17,300,088 17,346,865 RGD:6480464
G Rdh5 retinol dehydrogenase 5 JBrowse link 7 3,335,681 3,342,573 RGD:6480464
G Rfc5 replication factor C subunit 5 JBrowse link 12 44,931,494 44,941,051 RGD:6480464
G Rps29 ribosomal protein S29 JBrowse link 6 91,455,333 91,456,709 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Rrm1 ribonucleotide reductase catalytic subunit M1 JBrowse link 1 167,538,387 167,562,688 RGD:6480464
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link 6 43,884,627 43,890,818 RGD:6480464
G Sapcd2 suppressor APC domain containing 2 JBrowse link 3 2,590,355 2,597,283 RGD:6480464
G Senp3 SUMO specific peptidase 3 JBrowse link 10 56,277,609 56,286,867 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Shox2 short stature homeobox 2 JBrowse link 2 164,118,175 164,126,783 RGD:6480464
G Slc16a4 solute carrier family 16, member 4 JBrowse link 2 210,045,122 210,161,017 RGD:6480464
G Smc4 structural maintenance of chromosomes 4 JBrowse link 2 165,600,934 165,629,415 RGD:6480464
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:6480464
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6480464
G Spc24 SPC24 component of NDC80 kinetochore complex JBrowse link 8 22,780,639 22,785,908 RGD:6480464
G Spc25 SPC25 component of NDC80 kinetochore complex JBrowse link 3 55,438,534 55,451,961 RGD:6480464
G Stil STIL, centriolar assembly protein JBrowse link 5 133,819,302 133,851,362 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tk1 thymidine kinase 1 JBrowse link 10 106,817,556 106,828,888 RGD:6480464
G Tmpo thymopoietin JBrowse link 7 31,847,412 31,872,416 RGD:6480464
G Tmprss2 transmembrane serine protease 2 JBrowse link 11 38,063,914 38,103,406 RGD:6480464
G Top1 DNA topoisomerase I JBrowse link 3 156,635,688 156,717,686 RGD:6480464
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tpx2 TPX2, microtubule nucleation factor JBrowse link 3 148,327,965 148,370,187 RGD:6480464
G Troap trophinin associated protein JBrowse link 7 140,758,576 140,766,423 RGD:6480464
G Ttc14 tetratricopeptide repeat domain 14 JBrowse link 2 120,266,883 120,277,505 RGD:6480464
G Ttk Ttk protein kinase JBrowse link 8 91,368,065 91,405,995 RGD:6480464
G Tubb4b tubulin, beta 4B class IVb JBrowse link 3 2,441,585 2,444,369 RGD:6480464
G Tubb5 tubulin, beta 5 class I JBrowse link 20 3,422,448 3,426,420 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Ube2c ubiquitin-conjugating enzyme E2C JBrowse link 3 161,236,971 161,239,371 RGD:6480464
G Ube2t ubiquitin-conjugating enzyme E2T JBrowse link 13 51,790,877 51,801,379 RGD:6480464
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 JBrowse link 9 10,738,211 10,758,403 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Zeb1 zinc finger E-box binding homeobox 1 JBrowse link 17 54,656,627 54,714,920 RGD:6480464
G Zwint ZW10 interacting kinetochore protein JBrowse link 20 17,075,781 17,091,715 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        inhibitor 18156
          enzyme inhibitor 18079
            EC 2.* (transferase) inhibitor 13511
              EC 2.7.* (P-containing group transferase) inhibitor 13176
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8108
                  EC 2.7.11.22 (cyclin-dependent kinase) inhibitor 262
                    (R)-DRF053 + 0
                    (R)-DRF053 hydrochloride hydrate 0
                    2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                    4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide 0
                    4-(2,6-difluorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide 0
                    AMG-925 0
                    CCT251545 0
                    DH334 0
                    DH334(1+) + 0
                    LDC4297 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-1-(N,N-dimethylglycyl)piperidine-4-carboxamide 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)piperidine-4-carboxamide 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)tetrahydro-2H-pyran-4-carboxamide 0
                    N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                    PHA-533533 0
                    THZ531 0
                    adapalene 6
                    alsterpaullone 6
                    alvocidib 67
                    alvocidib hydrochloride 0
                    bohemine 1
                    indirubin-3'-monoxime 47
                    olomoucine 6
                    palbociclib 169
                    paullone + 6
                    seliciclib 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        inhibitor 18156
          enzyme inhibitor 18079
            EC 2.* (transferase) inhibitor 13511
              EC 2.7.* (P-containing group transferase) inhibitor 13176
                protein kinase inhibitor 12656
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8108
                    EC 2.7.11.22 (cyclin-dependent kinase) inhibitor 262
                      (R)-DRF053 + 0
                      (R)-DRF053 hydrochloride hydrate 0
                      2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                      4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide 0
                      4-(2,6-difluorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide 0
                      AMG-925 0
                      CCT251545 0
                      DH334 0
                      DH334(1+) + 0
                      LDC4297 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-1-(N,N-dimethylglycyl)piperidine-4-carboxamide 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)piperidine-4-carboxamide 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)tetrahydro-2H-pyran-4-carboxamide 0
                      N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                      PHA-533533 0
                      THZ531 0
                      adapalene 6
                      alsterpaullone 6
                      alvocidib 67
                      alvocidib hydrochloride 0
                      bohemine 1
                      indirubin-3'-monoxime 47
                      olomoucine 6
                      palbociclib 169
                      paullone + 6
                      seliciclib 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.