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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
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Accession:CHEBI:82665 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
Synonyms:related_synonym: ATP:cyclin phosphotransferase inhibitor;   ATP:cyclin phosphotransferase inhibitors;   Bur1 Cdk inhibitor;   Bur1 Cdk inhibitors;   Bur1 inhibitor;   Bur1 inhibitors;   CDK inhibitor;   CDK inhibitors;   Cak1 inhibitor;   Cak1 inhibitors;   Cak1p inhibitor;   Cak1p inhibitors;   Cdc28p inhibitor;   Cdc28p inhibitors;   Cdk-activating protein kinase inhibitors;   Cdk1 inhibitor;   Cdk1 inhibitors;   Cdk19 inhibitor;   Cdk19 inhibitors;   Cdk2 inhibitor;   Cdk2 inhibitors;   Cdk3 inhibitor;   Cdk3 inhibitors;   Cdk4 inhibitor;   Cdk4 inhibitors;   Cdk5 inhibitor;   Cdk5 inhibitors;   Cdk6 inhibitor;   Cdk6 inhibitors;   Cdk7 inhibitor;   Cdk7 inhibitors;   Cdk8 inhibitor;   Cdk8 inhibitors;   Cdk9 inhibitor;   Cdk9 inhibitors;   D-type cyclin kinase inhibitor;   D-type cyclin kinase inhibitors;   EC 2.7.11.22 (cyclin-dependent kinase) inhibitors;   EC 2.7.11.22 inhibitor;   EC 2.7.11.22 inhibitors;   PCTAIRE-1 inhibitor;   PCTAIRE-1 inhibitors;   STK25 inhibitor;   STK25 inhibitors;   cdc2 inhibitor;   cdc2 inhibitors;   cdc2 kinase inhibitor;   cdc2 kinase inhibitors;   cdk-activating kinase inhibitor;   cdk-activating kinase inhibitors;   cyclin A-activated cdc2 inhibitor;   cyclin A-activated cdc2 inhibitors;   cyclin A-activated cdk2 inhibitor;   cyclin A-activated cdk2 inhibitors;   cyclin D-cdk6 kinase inhibitor;   cyclin D-cdk6 kinase inhibitors;   cyclin D-dependent kinase inhibitor;   cyclin D-dependent kinase inhibitors;   cyclin E kinase inhibitor;   cyclin E kinase inhibitors;   cyclin-A associated kinase inhibitor;   cyclin-A associated kinase inhibitors;   cyclin-dependent kinase 6 inhibitor;   cyclin-dependent kinase 6 inhibitors;   cyclin-dependent kinase inhibitor;   cyclin-dependent kinase inhibitors;   cyclin-dependent kinase-2 inhibitor;   cyclin-dependent kinase-2 inhibitors;   cyclin-dependent kinase-4 inhibitor;   cyclin-dependent kinase-4 inhibitors;   cyclin-dependent protein kinase activating kinase inhibitor;   cyclin-dependent protein kinase activating kinase inhibitors;   cyk inhibitor;   cyk inhibitors;   ndk inhibitor;   ndk inhibitors;   neuronal cdc2-like kinase inhibitor;   neuronal cdc2-like kinase inhibitors


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adapalene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule increases expression ISO Adapalene results in increased expression of CD1D protein CTD PMID:17518990 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO Adapalene results in increased expression of CRABP2 mRNA CTD PMID:8396608 PMID:9990415 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Il10 interleukin 10 decreases expression ISO Adapalene results in decreased expression of IL10 protein CTD PMID:17518990 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Rarg retinoic acid receptor, gamma affects response to substance ISO RARG protein affects the susceptibility to Adapalene CTD PMID:9990413 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Adapalene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Adapalene results in decreased expression of TLR2 protein CTD PMID:17518990 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
alsterpaullone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases activity ISO alsterpaullone analog results in increased activity of AR protein CTD PMID:21111724 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Casp3 caspase 3 multiple interactions EXP alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein] CTD PMID:20300959 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO alsterpaullone results in decreased activity of CDK2 protein CTD PMID:12534346 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO alsterpaullone results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO alsterpaullone results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Tp53 tumor protein p53 affects localization
multiple interactions
ISO alsterpaullone affects the localization of TP53 protein
alsterpaullone results in decreased degradation of and results in increased expression of TP53 protein
CTD PMID:16055726 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
alvocidib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein; [alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein; [alvocidib co-treated with Bortezomib] results in decreased expression of ABL1 protein CTD PMID:15039284 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization ISO alvocidib results in increased localization of AIFM1 protein CTD PMID:12734434 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alvocidib co-treated with Bortezomib] results in decreased expression of AKT1 protein modified form CTD PMID:15039284 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Imatinib Mesylate co-treated with alvocidib] results in decreased expression of BAD protein CTD PMID:12231544 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bag1 BAG cochaperone 1 decreases expression ISO alvocidib results in decreased expression of BAG1 mRNA; alvocidib results in decreased expression of BAG1 protein; alvocidib results in decreased expression of BAG1 protein alternative form CTD PMID:10887097 PMID:15972445 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases cleavage
increases expression
multiple interactions
ISO alvocidib affects the localization of BAX protein
alvocidib results in increased cleavage of BAX protein
alvocidib results in increased expression of BAX protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of BAX protein; [alvocidib co-treated with gemcitabine] results in increased expression of BAX protein; [alvocidib co-treated with TNFSF10 protein] results in increased localization of BAX protein; Epothilones promotes the reaction [alvocidib affects the localization of BAX protein]
CTD PMID:12517783 PMID:12589031 PMID:12734434 PMID:15634644 PMID:15770523 PMID:16951203 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
decreases response to substance
multiple interactions
increases expression
ISO alvocidib results in decreased expression of BCL2 mRNA; alvocidib results in decreased expression of BCL2 protein
BCL2 protein mutant form results in decreased susceptibility to alvocidib; BCL2 protein results in decreased susceptibility to alvocidib
[alvocidib co-treated with gemcitabine] results in decreased expression of BCL2 protein; BCL2 protein mutant form inhibits the reaction [alvocidib affects the localization of CYCS protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP3 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP9 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of BID protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of PARP1 protein]; BCL2 protein results in decreased susceptibility to [alvocidib co-treated with Epothilones]
alvocidib results in increased expression of BCL2
CTD PMID:10887097 PMID:10995888 PMID:12170773 PMID:12517783 PMID:12589031 PMID:12734434 PMID:15770523 PMID:15972445 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO [alvocidib co-treated with Bortezomib] results in decreased expression of BCL2L1 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of BCL2L1 protein; Epothilones promotes the reaction [alvocidib results in decreased expression of BCL2L1 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of BCL2L1 protein]
alvocidib results in decreased expression of BCL2L1; alvocidib results in decreased expression of BCL2L1 mRNA; alvocidib results in decreased expression of BCL2L1 protein
CTD PMID:12517783 PMID:15039284 PMID:15634644 PMID:16820931 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of BID protein; [alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of BID protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of BID protein]; Boc-D-FMK inhibits the reaction [alvocidib results in increased cleavage of BID protein] CTD PMID:11464216 PMID:12170773 PMID:12231544 PMID:15634644 PMID:16951203 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple interactions
ISO alvocidib results in decreased expression of BIRC3 mRNA; alvocidib results in decreased expression of BIRC3 protein
Epothilones promotes the reaction [alvocidib results in decreased expression of BIRC3 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of BIRC3 protein]
CTD PMID:12517783 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO [alvocidib co-treated with 7-hydroxystaurosporine] results in decreased expression of BIRC5 protein; [alvocidib co-treated with PBOX-6] results in decreased expression of BIRC5 protein; alvocidib inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of BIRC5 protein]; alvocidib results in decreased phosphorylation of and results in decreased expression of BIRC5 protein
alvocidib results in decreased expression of BIRC5; alvocidib results in decreased expression of BIRC5 mRNA; alvocidib results in decreased expression of BIRC5 protein
CTD PMID:12517783 PMID:12517802 PMID:16012789 PMID:16820931 PMID:20206141 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO alvocidib results in increased expression of BTG2 mRNA CTD PMID:21382384 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Casp3 caspase 3 affects cleavage
multiple interactions
increases cleavage
increases activity
ISO
EXP
alvocidib affects the cleavage of CASP3 protein
alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]
alvocidib results in increased cleavage of CASP3 protein
alvocidib results in increased activity of CASP3 protein
[alvocidib co-treated with 7-hydroxystaurosporine] results in increased activity of CASP3 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP3 protein; [alvocidib co-treated with gemcitabine] results in increased cleavage of CASP3 protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP3 protein; [irinotecan co-treated with alvocidib] results in increased activity of CASP3 protein; alvocidib affects the cleavage of and results in increased activity of CASP3 protein; alvocidib promotes the reaction [Paclitaxel results in increased activity of CASP3 protein]; alvocidib promotes the reaction [romidepsin results in increased activity of CASP3 protein]; alvocidib results in increased cleavage of and results in increased activity of CASP3 protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP3 protein]; Boc-D-FMK inhibits the reaction [alvocidib results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:9808574 PMID:10430095 PMID:10896673 PMID:11482875 PMID:11751522 PMID:12170773 PMID:12231544 PMID:12517783 PMID:12589031 PMID:12941380 PMID:14555534 PMID:15014036 PMID:15634644 PMID:15770523 PMID:16012789 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP8 protein; [alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP8 protein
alvocidib results in increased cleavage of CASP8 protein
CTD PMID:10896673 PMID:12231544 PMID:12589031 PMID:15634644 PMID:16012789 PMID:16951203 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 affects cleavage
increases activity
multiple interactions
ISO alvocidib affects the cleavage of CASP9 protein
alvocidib results in increased activity of CASP9 protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP9 protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP9 protein]
CTD PMID:10896673 PMID:12170773 PMID:15634644 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr3 carbonyl reductase 3 decreases expression ISO alvocidib results in decreased expression of CBR3 mRNA CTD PMID:21382384 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO alvocidib results in decreased expression of and results in decreased activity of CCNA2 protein CTD PMID:16731754 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO [alvocidib co-treated with PBOX-6] results in decreased expression of CCNB1 protein; alvocidib inhibits the reaction [Paclitaxel results in increased expression of CCNB1 protein]; alvocidib results in decreased expression of and results in decreased activity of CCNB1 protein
alvocidib results in decreased expression of CCNB1 protein
CTD PMID:10430095 PMID:12517783 PMID:15014036 PMID:16731754 PMID:20206141 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
decreases activity
ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of CCND1 protein
alvocidib results in decreased expression of CCND1 protein
alvocidib results in decreased activity of CCND1 protein
CTD PMID:9802881 PMID:9829756 PMID:10441105 PMID:12517783 PMID:12589031 PMID:12734434 PMID:15634644 PMID:16905211 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO alvocidib results in decreased expression of CCNE1 protein CTD PMID:15014036 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
decreases activity
ISO [alvocidib co-treated with PBOX-6] results in decreased activity of CDK1 protein
alvocidib results in decreased expression of CDK1 protein modified form
alvocidib results in decreased activity of CDK1 protein
CTD PMID:9427698 PMID:9802881 PMID:12517783 PMID:16905211 PMID:20206141 PMID:24102143 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
decreases activity
multiple interactions
ISO alvocidib results in decreased expression of CDK2 protein modified form
alvocidib results in decreased activity of CDK2 protein
alvocidib binds to and results in decreased activity of CDK2 protein; alvocidib inhibits the reaction [Paclitaxel results in increased activity of CDK2 protein]
CTD PMID:9802881 PMID:10430095 PMID:12517783 PMID:16905211 PMID:24102143 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases activity
multiple interactions
decreases expression
ISO alvocidib results in decreased activity of CDK4 protein
alvocidib binds to and results in decreased activity of CDK4 protein
alvocidib results in decreased expression of CDK4 protein
CTD PMID:12517783 PMID:12734434 PMID:24102143 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions EXP alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein] CTD PMID:12941380 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk9 cyclin-dependent kinase 9 multiple interactions ISO alvocidib binds to and results in decreased activity of CDK9 protein CTD PMID:24102143 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
increases cleavage
increases expression
affects expression
ISO [alvocidib co-treated with gemcitabine] results in increased expression of CDKN1A protein; alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A promoter]; alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]]
alvocidib results in decreased expression of CDKN1A protein
alvocidib results in increased cleavage of CDKN1A protein
alvocidib results in increased expression of CDKN1A protein
alvocidib affects the expression of CDKN1A protein
CTD PMID:10537362 PMID:12734434 PMID:15014036 PMID:15180955 PMID:15770523 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases cleavage
increases expression
ISO alvocidib results in increased cleavage of CDKN1B protein
[alvocidib results in increased expression of TP53 protein] which results in increased expression of CDKN1B protein; alvocidib results in increased expression of CDKN1B protein
CTD PMID:10537362 PMID:12589031 PMID:15180955 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator affects expression
multiple interactions
decreases expression
ISO alvocidib affects the expression of CFLAR mRNA
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alvocidib results in decreased expression of CFLAR protein]
alvocidib results in decreased expression of CFLAR; alvocidib results in decreased expression of CFLAR protein
CTD PMID:16820931 PMID:16951203 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions ISO [alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein CTD PMID:15039284 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO alvocidib affects the localization of CYCS protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of CYCS protein; BCL2 protein mutant form inhibits the reaction [alvocidib affects the localization of CYCS protein]
CTD PMID:12170773 PMID:12517783 PMID:15634644 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions
ISO alvocidib affects the localization of DIABLO protein
[alvocidib co-treated with Bortezomib] results in increased secretion of DIABLO protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of DIABLO protein; [Imatinib Mesylate co-treated with alvocidib] results in increased secretion of DIABLO protein
CTD PMID:12231544 PMID:12517783 PMID:15039284 PMID:15634644 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G E2f1 E2F transcription factor 1 increases expression
increases response to substance
decreases expression
ISO alvocidib results in increased expression of E2F1 protein
E2F1 results in increased susceptibility to alvocidib
alvocidib results in decreased expression of E2F1 mRNA
CTD PMID:12533675 PMID:21239698 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G H2ax H2A.X variant histone affects expression ISO alvocidib affects the expression of H2AX protein CTD PMID:15078984 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO alvocidib results in decreased expression of HMGA1 mRNA CTD PMID:21239698 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Htra2 HtrA serine peptidase 2 affects localization ISO alvocidib affects the localization of HTRA2 protein CTD PMID:12517783 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein results in increased expression of ISG15 mRNA] CTD PMID:23589332 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein results in increased expression of ISG15 mRNA] CTD PMID:23589332 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Imatinib Mesylate co-treated with alvocidib] results in increased activity of JUN protein CTD PMID:12231544 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
decreases phosphorylation
ISO alvocidib results in decreased expression of KIT mRNA; alvocidib results in decreased expression of KIT promoter
alvocidib results in decreased phosphorylation of KIT protein
CTD PMID:16740725 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein CTD PMID:15039284 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein] CTD PMID:15039284 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO alvocidib inhibits the reaction [Bortezomib results in increased expression of MAPK1 protein modified form]; alvocidib results in decreased activity of and results in decreased phosphorylation of MAPK1 protein CTD PMID:15014036 PMID:15039284 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:15634644 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO alvocidib inhibits the reaction [Bortezomib results in increased expression of MAPK3 protein modified form]; alvocidib results in decreased activity of and results in decreased phosphorylation of MAPK3 protein CTD PMID:15014036 PMID:15039284 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased phosphorylation of and results in increased activity of MAPK8 protein; alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:15039284 PMID:15634644 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression
decreases response to substance
decreases expression
multiple interactions
ISO alvocidib affects the expression of MCL1 mRNA; alvocidib affects the expression of MCL1 protein
MCL1 results in decreased susceptibility to alvocidib
alvocidib results in decreased expression of MCL1 mRNA; alvocidib results in decreased expression of MCL1 protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of MCL1 protein; [Imatinib Mesylate co-treated with alvocidib] results in decreased expression of MCL1 protein; Epothilones promotes the reaction [alvocidib results in decreased expression of MCL1 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of MCL1 protein]
CTD PMID:10887097 PMID:12231544 PMID:12429644 PMID:12517783 PMID:12533675 PMID:15634644 PMID:15972445 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO alvocidib results in decreased expression of MDM2 mRNA; alvocidib results in decreased expression of MDM2 protein CTD PMID:12589031 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mx1 MX dynamin like GTPase 1 multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr11:37,891,150...37,916,775
Ensembl chr11:37,891,156...37,914,983
JBrowse link
G Nelfa negative elongation factor complex member A multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr14:82,093,837...82,117,913
Ensembl chr14:82,093,837...82,117,906
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO alvocidib results in increased expression of NFKBIA protein modified form
alvocidib promotes the reaction [Bortezomib results in increased expression of NFKBIA protein modified form]; Bortezomib promotes the reaction [alvocidib results in increased expression of NFKBIA protein modified form]
CTD PMID:15039284 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO alvocidib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of PARP1 protein; [alvocidib co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of PARP1 protein; [alvocidib co-treated with gemcitabine] results in increased cleavage of PARP1 protein; alvocidib promotes the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of PARP1 protein] CTD PMID:10430095 PMID:12170773 PMID:12517783 PMID:15039284 PMID:15634644 PMID:15770523 PMID:15972445 PMID:16012789 PMID:20663931 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions EXP alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein] CTD PMID:12941380 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pcna proliferating cell nuclear antigen decreases activity ISO alvocidib results in decreased activity of PCNA protein CTD PMID:10441105 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO alvocidib results in increased expression of PERP mRNA CTD PMID:21382384 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Polr2a RNA polymerase II subunit A decreases expression
decreases phosphorylation
multiple interactions
ISO alvocidib results in decreased expression of POLR2A mRNA
alvocidib results in decreased phosphorylation of POLR2A protein
Bortezomib promotes the reaction [alvocidib results in decreased phosphorylation of POLR2A protein]
alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]
CTD PMID:15039284 PMID:21239698 PMID:23589332 PMID:24102143 NCBI chr10:56,339,277...56,364,888
Ensembl chr10:56,339,284...56,365,084
JBrowse link
G Pygb glycogen phosphorylase B affects binding ISO PYGB protein binds to alvocidib CTD PMID:11368340 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Pygl glycogen phosphorylase L affects binding ISO PYGL protein binds to alvocidib CTD PMID:11368340 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases activity
decreases response to substance
multiple interactions
decreases phosphorylation
decreases expression
ISO alvocidib results in decreased activity of RB1 protein modified form
RB1 results in decreased susceptibility to alvocidib
[docetaxel co-treated with alvocidib] results in decreased phosphorylation of and results in decreased expression of RB1 protein
alvocidib results in decreased phosphorylation of RB1 protein
alvocidib results in decreased expression of RB1 protein; alvocidib results in decreased expression of RB1 protein modified form
CTD PMID:9829756 PMID:10441105 PMID:15180955 PMID:15297405 PMID:16905211 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO alvocidib results in decreased expression of RBL1 protein CTD PMID:9829756 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
ISO [alvocidib co-treated with Bortezomib] results in decreased phosphorylation of and results in decreased activity of STAT3 protein
alvocidib results in decreased expression of STAT3 mRNA
CTD PMID:15039284 PMID:21239698 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Supt5h SPT5 homolog, DSIF elongation factor subunit multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr 1:85,437,780...85,466,854
Ensembl chr 1:85,437,780...85,466,854
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO alvocidib analog results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alvocidib inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21204955 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO alvocidib results in increased expression of TNFRSF10A CTD PMID:16820931 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
increases expression
ISO [alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [alvocidib co-treated with TNFSF10 protein] results in increased localization of BAX protein
alvocidib results in increased susceptibility to TNFSF10
alvocidib results in increased expression of TNFSF10
CTD PMID:16820931 PMID:16951203 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 decreases expression
multiple interactions
increases expression
ISO alvocidib results in decreased expression of TP53 protein
[docetaxel co-treated with alvocidib] results in increased expression of TP53 protein
[alvocidib results in increased expression of TP53 protein] which results in increased expression of CDKN1B protein; alvocidib results in increased expression of TP53 protein
CTD PMID:9808574 PMID:10537362 PMID:12589031 PMID:15180955 PMID:15297405 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO alvocidib results in decreased expression of VEGFA mRNA CTD PMID:21239698 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions
ISO alvocidib results in decreased expression of XIAP mRNA; alvocidib results in decreased expression of XIAP protein
[irinotecan co-treated with alvocidib] results in increased cleavage of XIAP protein; Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP protein]
CTD PMID:10887097 PMID:11751522 PMID:12517783 PMID:15385934 PMID:15972445 PMID:16951203 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
bohemine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk2 cyclin dependent kinase 2 decreases activity ISO bohemine results in decreased activity of CDK2 protein CTD PMID:15026556 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
indirubin-3'-monoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta affects expression ISO indirubin-3'-monoxime affects the expression of ACTB protein CTD PMID:18958680 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
ISO AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]
indirubin-3'-monoxime binds to and results in increased activity of AHR protein
indirubin-3'-monoxime binds to AHR protein
CTD PMID:15001395 PMID:21948866 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression
ISO Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of ALDH1A1 protein] CTD PMID:21948866 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO indirubin-3'-monoxime results in decreased expression of ALDH1A2 protein CTD PMID:21948866 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] CTD PMID:18344322 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Ar androgen receptor increases activity ISO indirubin-3'-monoxime analog results in increased activity of AR protein; indirubin-3'-monoxime results in increased activity of AR protein CTD PMID:21111724 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO indirubin-3'-monoxime results in decreased expression of BAX mRNA CTD PMID:18958680 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BCL2L1 mRNA CTD PMID:18958680 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CASP8 mRNA CTD PMID:18958680 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CAT mRNA CTD PMID:18958680 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL4 mRNA CTD PMID:18958680 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cd40 CD40 molecule multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD40 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]
indirubin-3'-monoxime results in decreased expression of CD40 protein
CTD PMID:21948866 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd80 Cd80 molecule increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of CD80 protein
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased expression of CD80 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]
CTD PMID:21948866 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD86 protein; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] CTD PMID:21948866 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO indirubin-3'-monoxime results in decreased activity of CDK2 protein CTD PMID:12534346 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CDKN1A mRNA CTD PMID:18958680 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 protein
indirubin-3'-monoxime results in increased expression of CYP1A1 mRNA
indirubin-3'-monoxime results in increased expression of CYP1A1 protein
CTD PMID:15001395 PMID:18958680 PMID:21948866 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO indirubin-3'-monoxime results in decreased expression of EPHX2 mRNA CTD PMID:18958680 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO indirubin-3'-monoxime results in decreased expression of GPX1 mRNA CTD PMID:18958680 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO indirubin-3'-monoxime results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO indirubin-3'-monoxime results in increased expression of GSR mRNA CTD PMID:18958680 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HMOX1 mRNA CTD PMID:18958680 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA2 mRNA CTD PMID:18958680 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions
increases expression
ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA9 mRNA
indirubin-3'-monoxime results in increased expression of HSPA9 mRNA
CTD PMID:18958680 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of ICAM1 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
indirubin-3'-monoxime results in decreased expression of ICAM1 protein
CTD PMID:21948866 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of IDO1 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO1 protein]
CTD PMID:21948866 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of IDO2 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO2 protein]
CTD PMID:21948866 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Ifng interferon gamma decreases secretion ISO indirubin-3'-monoxime results in decreased secretion of IFNG protein CTD PMID:21948866 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases secretion
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased secretion of IL10 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
indirubin-3'-monoxime results in decreased secretion of IL10 protein
CTD PMID:21948866 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL1B protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:21948866 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases secretion ISO indirubin-3'-monoxime results in increased secretion of IL2 protein CTD PMID:21948866 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il27 interleukin 27 decreases expression
multiple interactions
ISO indirubin-3'-monoxime results in decreased expression of IL27 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of IL27 protein]
CTD PMID:21948866 NCBI chr 1:198,003,615...198,010,112
Ensembl chr 1:198,003,683...198,008,893
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of IL6 protein; [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL6 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21948866 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgax integrin subunit alpha X multiple interactions
decreases expression
ISO AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAX protein] CTD PMID:21948866 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO indirubin-3'-monoxime results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA6 mRNA CTD PMID:18958680 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MT2A mRNA CTD PMID:18958680 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of NFKBIA mRNA CTD PMID:18958680 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein CTD PMID:18958680 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO indirubin-3'-monoxime results in decreased expression of RAD23A mRNA CTD PMID:18958680 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased activity of RELA protein
indirubin-3'-monoxime results in decreased activity of RELA protein
CTD PMID:21948866 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA CTD PMID:18958680 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases activity ISO indirubin-3'-monoxime results in decreased activity of SGK1 protein CTD PMID:12534346 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOD2 mRNA CTD PMID:18958680 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of TGFB2 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB2 protein]
CTD PMID:21948866 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of TGFB3 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB3 protein]
CTD PMID:21948866 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of TNF protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21948866 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ung uracil-DNA glycosylase increases expression ISO indirubin-3'-monoxime results in increased expression of UNG mRNA CTD PMID:18958680 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
olomoucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
ISO
EXP
olomoucine results in decreased activity of CDK2 protein
olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein]
CTD PMID:12387751 PMID:15026556 PMID:20149834 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO olomoucine results in increased expression of RB1 mRNA; olomoucine results in increased expression of RB1 protein CTD PMID:14653808 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO olomoucine results in increased expression of SP1 mRNA; olomoucine results in increased expression of SP1 protein CTD PMID:14653808 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpi1 triosephosphate isomerase 1 multiple interactions ISO olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein] CTD PMID:20149834 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
Ensembl chr 9:157,328,379...157,331,905
JBrowse link
palbociclib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO palbociclib results in increased expression of ABCA1 mRNA CTD PMID:22869556 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein] CTD PMID:23676220 PMID:24986516 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Anln anillin, actin binding protein decreases expression ISO palbociclib results in decreased expression of ANLN mRNA CTD PMID:22869556 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
JBrowse link
G Apoe apolipoprotein E increases expression ISO palbociclib results in increased expression of APOE mRNA CTD PMID:28620137 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO palbociclib results in decreased expression of ASF1B mRNA CTD PMID:22869556 NCBI chr19:25,077,918...25,092,491
Ensembl chr19:25,077,918...25,092,491
JBrowse link
G Aurka aurora kinase A decreases expression ISO palbociclib results in decreased expression of AURKA mRNA CTD PMID:22869556 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Aurkb aurora kinase B decreases expression ISO palbociclib results in decreased expression of AURKB mRNA CTD PMID:22869556 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO palbociclib results in decreased expression of BARD1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO palbociclib results in decreased expression of BIRC5 mRNA CTD PMID:22869556 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO palbociclib results in decreased expression of BORA mRNA CTD PMID:22869556 NCBI chr15:83,442,217...83,463,737
Ensembl chr15:83,442,144...83,463,717
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of BUB1 mRNA CTD PMID:22869556 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases cleavage
ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
palbociclib results in increased cleavage of CASP3 protein
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein
palbociclib results in decreased cleavage of CASP3 protein
CTD PMID:22302033 PMID:22751436 PMID:23676220 PMID:24098593 PMID:27099147 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP7 protein]
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein
CTD PMID:22302033 PMID:24098593 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO palbociclib results in increased expression of CCN1 mRNA CTD PMID:22869556 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions
ISO palbociclib results in decreased expression of CCNA2 mRNA; palbociclib results in decreased expression of CCNA2 protein
E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]
CTD PMID:20100483 PMID:20473330 PMID:21367843 PMID:21593195 PMID:22751436 PMID:22869556 PMID:23708653 PMID:24606660 PMID:26318986 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO palbociclib results in decreased expression of CCNB1 mRNA CTD PMID:22869556 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO palbociclib results in decreased expression of CCNB2 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 decreases response to substance
multiple interactions
increases expression
ISO CCND1 gene results in decreased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND1 protein
[BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; Doxorubicin inhibits the reaction [palbociclib results in increased expression of CCND1 protein]; palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]
CTD PMID:20473330 PMID:21278246 PMID:22094256 PMID:22751436 PMID:22869556 PMID:23708653 PMID:24098593 PMID:24986516 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib CTD PMID:24098593 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]
[CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND3 protein
CTD PMID:20473330 PMID:22094256 PMID:24098593 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases response to substance
decreases expression
increases expression
ISO CCNE1 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased expression of CCNE1 protein
palbociclib results in increased expression of CCNE1 protein
CTD PMID:17537993 PMID:21278246 PMID:21880723 PMID:23708653 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO palbociclib analog results in decreased expression of CCNE2 mRNA; palbociclib results in decreased expression of CCNE2 mRNA CTD PMID:15542782 PMID:22869556 PMID:26318986 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnf cyclin F decreases expression ISO palbociclib results in decreased expression of CCNF mRNA CTD PMID:22869556 PMID:24606660 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO palbociclib results in decreased expression of CDC20 mRNA CTD PMID:22869556 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO palbociclib results in decreased expression of CDC25A mRNA CTD PMID:22869556 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO palbociclib results in decreased expression of CDC25C mRNA CTD PMID:22869556 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein] CTD PMID:29091774 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO palbociclib results in decreased expression of CDC45 mRNA CTD PMID:22869556 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression ISO palbociclib results in decreased expression of CDCA3 mRNA CTD PMID:22869556 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO palbociclib results in decreased expression of CDCA5 mRNA CTD PMID:22869556 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO palbociclib results in decreased expression of CDCA8 mRNA CTD PMID:22869556 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdh1 cadherin 1 affects localization
multiple interactions
ISO palbociclib affects the localization of CDH1 protein
CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]
CTD PMID:22094256 PMID:22869556 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDH2 protein] CTD PMID:22869556 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO palbociclib analog results in decreased expression of CDK1 mRNA; palbociclib results in decreased expression of CDK1 mRNA CTD PMID:15542782 PMID:22869556 PMID:24606660 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
decreases phosphorylation
decreases expression
ISO palbociclib results in decreased activity of CDK2 protein
palbociclib results in increased phosphorylation of and results in increased expression of CDK2 protein
palbociclib results in decreased phosphorylation of CDK2 protein
palbociclib results in decreased expression of CDK2 protein
CTD PMID:17537993 PMID:20100483 PMID:20473330 PMID:21880723 PMID:22869556 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases response to substance
decreases activity
multiple interactions
increases expression
increases response to substance
ISO CDK4 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased activity of CDK4 protein
[CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CDK4 protein
palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]
CDK4 protein results in increased susceptibility to palbociclib
CTD PMID:20473330 PMID:22094256 PMID:22711607 PMID:22761470 PMID:22869556 PMID:23708653 PMID:24098593 PMID:24795392 PMID:29091774 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein]
palbociclib results in increased expression of CDK6 protein
[CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib
CTD PMID:20473330 PMID:22094256 PMID:22869556 PMID:23138228 PMID:24098593 PMID:29091774 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression ISO palbociclib results in increased expression of CDK7 mRNA CTD PMID:24606660 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO palbociclib results in increased expression of CDKN1A protein CTD PMID:20473330 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
decreases expression
ISO palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]
palbociclib results in increased expression of CDKN1B mRNA; palbociclib results in increased expression of CDKN1B protein
palbociclib results in decreased expression of CDKN1B protein
CTD PMID:17537993 PMID:20473330 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects response to substance
increases response to substance
multiple interactions
decreases response to substance
ISO CDKN2A gene modified form affects the susceptibility to palbociclib; CDKN2A gene mutant form affects the susceptibility to palbociclib; CDKN2A protein affects the susceptibility to palbociclib
CDKN2A gene mutant form results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
CDKN2A protein results in decreased susceptibility to palbociclib
[CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib
CTD PMID:20534551 PMID:21278246 PMID:22711607 PMID:24098593 PMID:24495407 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression
multiple interactions
decreases response to substance
ISO palbociclib results in increased expression of CDKN2B protein
2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDKN2B protein]
CDKN2B protein results in decreased susceptibility to palbociclib
CTD PMID:22711607 PMID:22869556 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions ISO [CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib CTD PMID:20534551 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO palbociclib results in decreased expression of CDKN3 mRNA CTD PMID:22869556 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO palbociclib results in decreased expression of CDT1 mRNA CTD PMID:22869556 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cenpa centromere protein A decreases expression ISO palbociclib results in decreased expression of CENPA mRNA CTD PMID:22869556 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
JBrowse link
G Cenpe centromere protein E decreases expression ISO palbociclib results in decreased expression of CENPE mRNA CTD PMID:22869556 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Cenpf centromere protein F decreases expression ISO palbociclib results in decreased expression of CENPF mRNA CTD PMID:22869556 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Cenpm centromere protein M decreases expression ISO palbociclib results in decreased expression of CENPM mRNA CTD PMID:22869556 NCBI chr 7:123,464,615...123,476,336
Ensembl chr 7:123,464,490...123,476,238
JBrowse link
G Cep55 centrosomal protein 55 decreases expression ISO palbociclib results in decreased expression of CEP55 mRNA CTD PMID:22869556 NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796
JBrowse link
G Ckap2l cytoskeleton associated protein 2-like decreases expression ISO palbociclib results in decreased expression of CKAP2L mRNA CTD PMID:22869556 NCBI chr 3:121,796,221...121,822,352
Ensembl chr 3:121,796,238...121,822,436
JBrowse link
G Cpa4 carboxypeptidase A4 increases expression ISO palbociclib results in increased expression of CPA4 mRNA CTD PMID:22869556 NCBI chr 4:57,883,849...57,907,826
Ensembl chr 4:57,883,849...57,907,826
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CTNNB1 protein] CTD PMID:22869556 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dennd6b DENN domain containing 6B increases expression ISO palbociclib results in increased expression of DENND6B mRNA CTD PMID:22869556 NCBI chr 7:130,162,728...130,178,282
Ensembl chr 7:130,164,675...130,176,696
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO palbociclib results in decreased expression of DEPDC1B mRNA CTD PMID:22869556 NCBI chr 2:39,980,796...40,069,982
Ensembl chr 2:40,000,313...40,069,975
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO palbociclib results in decreased expression of DLGAP5 mRNA CTD PMID:22869556 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Donson DNA replication fork stabilization factor DONSON decreases expression ISO palbociclib results in decreased expression of DONSON mRNA CTD PMID:22869556 NCBI chr11:31,834,608...31,847,751
Ensembl chr11:31,837,839...31,847,490
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]] CTD PMID:22751436 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions
decreases expression
ISO E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased expression of RNR2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
palbociclib results in decreased expression of E2F2 mRNA
CTD PMID:20100483 PMID:20473330 PMID:22869556 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G Eln elastin increases expression ISO palbociclib results in increased expression of ELN protein CTD PMID:21880723 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Exo1 exonuclease 1 decreases expression ISO palbociclib results in decreased expression of EXO1 mRNA CTD PMID:22869556 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression ISO palbociclib results in decreased expression of EZH2 mRNA; palbociclib results in decreased expression of EZH2 protein CTD PMID:20948315 PMID:22869556 PMID:24736461 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO palbociclib results in increased expression of F3 mRNA CTD PMID:22869556 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fam111a FAM111 trypsin like peptidase A decreases expression ISO palbociclib results in decreased expression of FAM111A mRNA CTD PMID:22869556 NCBI chr 1:229,003,778...229,019,532
Ensembl chr 1:229,003,961...229,019,527
JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO palbociclib results in decreased expression of FAM83D mRNA CTD PMID:22869556 NCBI chr 3:155,269,344...155,288,612
Ensembl chr 3:155,269,347...155,288,533
JBrowse link
G Fance FA complementation group E decreases expression ISO palbociclib results in decreased expression of FANCE mRNA CTD PMID:28620137 NCBI chr20:7,888,927...7,906,142
Ensembl chr20:7,895,083...7,906,142
JBrowse link
G Fanci FA complementation group I decreases expression ISO palbociclib results in decreased expression of FANCI mRNA CTD PMID:22869556 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483
JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO palbociclib results in decreased expression of FBXO5 mRNA CTD PMID:22869556 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO palbociclib results in decreased expression of FEN1 mRNA CTD PMID:22869556 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression
affects response to substance
decreases phosphorylation
multiple interactions
ISO palbociclib results in decreased expression of FLT3 mRNA; palbociclib results in decreased expression of FLT3 protein
FLT3 protein affects the susceptibility to palbociclib
palbociclib results in decreased phosphorylation of FLT3 protein
[FLT3 protein affects the susceptibility to palbociclib] which results in decreased expression of FLT3 protein
CTD PMID:27099147 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of FOXM1 protein]; CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]; palbociclib results in decreased expression of and results in decreased activity of FOXM1 protein
palbociclib results in decreased expression of FOXM1 mRNA
CTD PMID:22094256 PMID:22869556 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Gins2 GINS complex subunit 2 decreases expression ISO palbociclib results in decreased expression of GINS2 mRNA CTD PMID:22869556 NCBI chr19:54,151,048...54,163,701
Ensembl chr19:54,151,048...54,163,608
JBrowse link
G Gls glutaminase increases expression ISO palbociclib results in increased expression of GLS mRNA CTD PMID:28620137 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gmnn geminin, DNA replication inhibitor decreases expression ISO palbociclib results in decreased expression of GMNN mRNA CTD PMID:22869556 NCBI chr17:42,302,523...42,310,783
Ensembl chr17:42,302,540...42,310,783
JBrowse link
G Gpsm2 G-protein signaling modulator 2 decreases expression ISO palbociclib results in decreased expression of GPSM2 mRNA CTD PMID:22869556 NCBI chr 2:211,480,120...211,528,096
Ensembl chr 2:211,480,400...211,527,919
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO palbociclib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G H2ax H2A.X variant histone multiple interactions
decreases phosphorylation
ISO Doxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein] CTD PMID:22302033 PMID:22751436 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO palbociclib results in decreased expression of H4C3 mRNA CTD PMID:22869556 NCBI chr 4:170,144,871...170,145,311
Ensembl chr 4:170,144,951...170,145,262
JBrowse link
G Hjurp Holliday junction recognition protein decreases expression ISO palbociclib results in decreased expression of HJURP mRNA CTD PMID:22869556 NCBI chr 9:95,347,739...95,362,228
Ensembl chr 9:95,349,086...95,362,014
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO palbociclib results in decreased expression of HMGB2 mRNA CTD PMID:22869556 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO palbociclib results in decreased expression of HMMR mRNA CTD PMID:22869556 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein CTD PMID:24986516 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression ISO palbociclib results in increased expression of IL20RB mRNA CTD PMID:22869556 NCBI chr 8:108,745,906...108,778,561
Ensembl chr 8:108,747,204...108,777,717
JBrowse link
G Incenp inner centromere protein decreases expression ISO palbociclib results in decreased expression of INCENP mRNA CTD PMID:22869556 NCBI chr 1:225,923,448...225,953,384
Ensembl chr 1:225,925,773...225,952,516
JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO palbociclib results in decreased expression of KIF11 mRNA CTD PMID:22869556 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Kif14 kinesin family member 14 decreases expression ISO palbociclib results in decreased expression of KIF14 mRNA CTD PMID:22869556 NCBI chr13:53,350,073...53,421,992
Ensembl chr13:53,351,717...53,420,111
JBrowse link
G Kif15 kinesin family member 15 decreases expression ISO palbociclib results in decreased expression of KIF15 mRNA CTD PMID:22869556 NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO palbociclib results in decreased expression of KIF20A mRNA CTD PMID:22869556 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO palbociclib results in decreased expression of KIF23 mRNA CTD PMID:22869556 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Kif2c kinesin family member 2C decreases expression ISO palbociclib results in decreased expression of KIF2C mRNA CTD PMID:22869556 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Kif4a kinesin family member 4A decreases expression ISO palbociclib results in decreased expression of KIF4A mRNA CTD PMID:22869556 NCBI chr  X:70,461,700...70,561,084
Ensembl chr  X:70,461,718...70,561,189
JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO palbociclib results in decreased expression of KIFC1 mRNA CTD PMID:22869556 NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175
JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein decreases expression ISO palbociclib results in decreased expression of KNSTRN mRNA CTD PMID:22869556 NCBI chr 3:110,618,256...110,638,024
Ensembl chr 3:110,618,298...110,638,046
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO palbociclib results in decreased expression of KPNA2 mRNA CTD PMID:22869556 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO palbociclib results in increased expression of LAMA3 mRNA CTD PMID:22869556 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO palbociclib results in increased expression of LAMB3 mRNA CTD PMID:22869556 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO palbociclib results in increased expression of LAMC2 mRNA CTD PMID:22869556 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO palbociclib results in decreased expression of LMNB1 mRNA CTD PMID:22869556 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO palbociclib results in decreased expression of MCM10 mRNA CTD PMID:22869556 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 multiple interactions
decreases expression
ISO RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]
palbociclib results in decreased expression of MCM7 mRNA; palbociclib results in decreased expression of MCM7 protein
CTD PMID:20473330 PMID:22869556 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein] CTD PMID:22094256 NCBI chr 2:187,511,775...187,541,285
Ensembl chr 2:187,512,164...187,538,026
JBrowse link
G Melk maternal embryonic leucine zipper kinase decreases expression ISO palbociclib results in decreased expression of MELK mRNA CTD PMID:22869556 NCBI chr 5:59,783,835...59,844,356
Ensembl chr 5:59,783,890...59,844,356
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
ISO Doxorubicin promotes the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein] CTD PMID:15542782 PMID:22170262 PMID:22383795 PMID:22751436 PMID:23708653 PMID:26318986 PMID:28620137 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mxd4 Max dimerization protein 4 increases expression ISO palbociclib results in increased expression of MXD4 mRNA CTD PMID:22869556 NCBI chr14:81,819,415...81,833,456
Ensembl chr14:81,819,415...81,833,456
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO palbociclib results in decreased expression of MYC protein CTD PMID:27099147 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 decreases expression ISO palbociclib results in decreased expression of NCAPD2 mRNA CTD PMID:22869556 NCBI chr 4:157,682,855...157,705,903
Ensembl chr 4:157,683,077...157,704,596
JBrowse link
G Ncapg non-SMC condensin I complex, subunit G decreases expression ISO palbociclib results in decreased expression of NCAPG mRNA CTD PMID:22869556 NCBI chr14:69,898,268...69,927,885
Ensembl chr14:69,899,128...69,927,938
JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 decreases expression ISO palbociclib results in decreased expression of NCAPG2 mRNA CTD PMID:22869556 NCBI chr 6:144,291,313...144,362,454
Ensembl chr 6:144,291,974...144,363,947
JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression ISO palbociclib results in decreased expression of NDC80 mRNA CTD PMID:22869556 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO palbociclib results in decreased expression of NEK2 mRNA CTD PMID:22869556 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO palbociclib results in decreased expression of NUSAP1 mRNA CTD PMID:22869556 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Oip5 Opa interacting protein 5 decreases expression ISO palbociclib results in decreased expression of OIP5 mRNA CTD PMID:22869556 NCBI chr 3:111,413,662...111,422,320
Ensembl chr 3:111,416,536...111,422,203
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]] CTD PMID:22751436 PMID:23676220 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pbk PDZ binding kinase decreases expression ISO palbociclib results in decreased expression of PBK mRNA CTD PMID:22869556 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Pclaf PCNA clamp associated factor decreases expression ISO palbociclib results in decreased expression of PCLAF mRNA CTD PMID:22869556 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO palbociclib results in decreased expression of PCNA mRNA; palbociclib results in decreased expression of PCNA protein CTD PMID:20473330 PMID:22869556 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]] CTD PMID:21880723 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Phf19 PHD finger protein 19 decreases expression ISO palbociclib results in decreased expression of PHF19 mRNA CTD PMID:22869556 NCBI chr 3:13,957,136...13,978,283
Ensembl chr 3:13,957,136...13,978,224
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of PIM1 mRNA CTD PMID:27099147 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Pimreg PICALM interacting mitotic regulator decreases expression ISO palbociclib results in decreased expression of PIMREG mRNA CTD PMID:22869556 NCBI chr10:58,613,588...58,618,524
Ensembl chr10:58,613,674...58,618,514
JBrowse link
G Plk1 polo-like kinase 1 decreases expression
multiple interactions
ISO palbociclib results in decreased expression of PLK1 mRNA
palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]
CTD PMID:20100483 PMID:22869556 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLA2 mRNA CTD PMID:22869556 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLE2 mRNA CTD PMID:22869556 NCBI chr 6:91,494,348...91,532,355
Ensembl chr 6:91,494,393...91,518,996
JBrowse link
G Porcn porcupine O-acyltransferase increases expression ISO palbociclib results in increased expression of PORCN mRNA CTD PMID:22869556 NCBI chr  X:15,035,569...15,048,440
Ensembl chr  X:15,035,569...15,048,440
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO palbociclib results in decreased expression of PRC1 mRNA CTD PMID:22869556 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO palbociclib results in decreased expression of PRIM1 mRNA CTD PMID:22869556 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Prr11 proline rich 11 decreases expression ISO palbociclib results in decreased expression of PRR11 mRNA CTD PMID:22869556 NCBI chr10:74,393,683...74,436,073
Ensembl chr10:74,393,699...74,413,745
JBrowse link
G Prss23 serine protease 23 increases expression ISO palbociclib results in increased expression of PRSS23 mRNA CTD PMID:22869556 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO palbociclib results in decreased expression of PSRC1 mRNA CTD PMID:22869556 NCBI chr 2:211,176,437...211,181,078
Ensembl chr 2:211,176,556...211,181,123
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression ISO palbociclib results in decreased expression of PTTG1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO palbociclib results in decreased expression of RACGAP1 mRNA CTD PMID:22869556 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO palbociclib results in decreased expression of RAD51AP1 mRNA CTD PMID:22869556 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Ranbp1 RAN binding protein 1 decreases expression ISO palbociclib results in decreased expression of RANBP1 mRNA CTD PMID:28620137 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation
decreases expression
increases response to substance
multiple interactions
affects response to substance
decreases response to substance
affects reaction
increases phosphorylation
decreases phosphorylation
ISO palbociclib affects the phosphorylation of RB1 protein
palbociclib results in decreased expression of RB1 mRNA; palbociclib results in decreased expression of RB1 protein
RB1 protein results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to palbociclib
BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RB1 protein]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RB1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
RB1 gene mutant form results in decreased susceptibility to palbociclib; RB1 mutant form results in decreased susceptibility to palbociclib
RB1 protein affects the reaction palbociclib
palbociclib results in increased phosphorylation of RB1 protein
CTD PMID:15542782 PMID:16690963 PMID:17537993 PMID:19435910 PMID:19874578 PMID:20100483 PMID:20354191 PMID:20473330 PMID:20534551 PMID:21217777 PMID:21278246 PMID:21367843 PMID:21593195 PMID:21880723 PMID:22094256 PMID:22170262 PMID:22383795 PMID:22751436 PMID:22761470 PMID:22869556 PMID:23138228 PMID:23676220 PMID:23708653 PMID:24098593 PMID:24495407 PMID:24736461 PMID:24986516 PMID:25221644 PMID:26174628 PMID:26318986 PMID:26873845 PMID:28620137 PMID:30684532 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of RBL1 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]; palbociclib promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RBL1 protein]; palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RBL1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]
palbociclib results in decreased expression of RBL1 mRNA; palbociclib results in decreased expression of RBL1 protein
CTD PMID:20100483 PMID:20473330 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases phosphorylation
ISO palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib results in decreased phosphorylation of and results in increased expression of RBL2 protein; palbociclib results in increased expression of and results in increased stability of RBL2 protein
palbociclib results in decreased phosphorylation of RBL2 protein
CTD PMID:20100483 PMID:20473330 PMID:22094256 PMID:26174628 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Rdh5 retinol dehydrogenase 5 increases expression ISO palbociclib results in increased expression of RDH5 mRNA CTD PMID:22869556 NCBI chr 7:3,335,681...3,342,573
Ensembl chr 7:3,335,742...3,342,491
JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO palbociclib results in decreased expression of RFC5 mRNA CTD PMID:22869556 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324
JBrowse link
G Rps29 ribosomal protein S29 increases expression ISO palbociclib results in increased expression of RPS29 mRNA CTD PMID:22869556 NCBI chr 6:91,455,333...91,456,709
Ensembl chr 6:91,455,333...91,456,696
Ensembl chr 3:91,455,333...91,456,696
Ensembl chr 7:91,455,333...91,456,696
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:24986516 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression ISO palbociclib results in decreased expression of RRM1 mRNA CTD PMID:22869556 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO palbociclib results in decreased expression of RRM2 mRNA CTD PMID:22869556 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Sapcd2 suppressor APC domain containing 2 decreases expression ISO palbociclib results in decreased expression of SAPCD2 mRNA CTD PMID:22869556 NCBI chr 3:2,590,355...2,597,283
Ensembl chr 3:2,591,331...2,596,583
JBrowse link
G Senp3 SUMO specific peptidase 3 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein] CTD PMID:22094256 NCBI chr10:56,277,609...56,286,867
Ensembl chr10:56,277,615...56,286,391
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO palbociclib results in increased expression of SERPINE1 mRNA CTD PMID:22869556 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Shox2 short stature homeobox 2 multiple interactions ISO palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein] CTD PMID:22094256 NCBI chr 2:164,118,175...164,126,783
Ensembl chr 2:164,118,191...164,126,783
JBrowse link
G Slc16a4 solute carrier family 16, member 4 increases expression ISO palbociclib results in increased expression of SLC16A4 mRNA CTD PMID:22869556 NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO palbociclib results in decreased expression of SMC4 mRNA CTD PMID:22869556 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of SNAI2 protein] CTD PMID:22869556 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein] CTD PMID:21880723 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression ISO palbociclib results in increased expression of SPARC mRNA CTD PMID:28620137 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Spc24 SPC24 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC24 mRNA CTD PMID:22869556 NCBI chr 8:22,780,639...22,785,908
Ensembl chr 8:22,780,725...22,785,671
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC25 mRNA CTD PMID:22869556 NCBI chr 3:55,438,534...55,451,961
Ensembl chr 3:55,438,536...55,451,798
JBrowse link
G Stil STIL, centriolar assembly protein decreases expression ISO palbociclib results in decreased expression of STIL mRNA CTD PMID:22869556 NCBI chr 5:133,819,302...133,851,362
Ensembl chr 5:133,819,726...133,851,416
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO palbociclib results in decreased expression of STMN1 mRNA CTD PMID:22869556 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO palbociclib results in decreased expression of TACC3 mRNA CTD PMID:28620137 NCBI chr14:82,336,283...82,350,069
Ensembl chr14:82,336,324...82,347,679
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases activity ISO palbociclib results in increased activity of TGFB1 protein CTD PMID:22869556 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO palbociclib analog results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 protein CTD PMID:15542782 PMID:22170262 PMID:22869556 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tmpo thymopoietin decreases expression ISO palbociclib results in decreased expression of TMPO mRNA CTD PMID:22869556 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO palbociclib promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] CTD PMID:23708653 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO palbociclib results in decreased expression of TOP1 mRNA CTD PMID:24549232 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO palbociclib analog results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A protein
palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]
CTD PMID:15542782 PMID:20948315 PMID:22751436 PMID:22869556 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 decreases response to substance ISO TP53 protein mutant form results in decreased susceptibility to palbociclib CTD PMID:21278246 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO palbociclib results in decreased expression of TPX2 mRNA CTD PMID:22869556 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187
JBrowse link
G Troap trophinin associated protein decreases expression ISO palbociclib results in decreased expression of TROAP mRNA CTD PMID:22869556 NCBI chr 7:140,758,576...140,766,423
Ensembl chr 7:140,758,615...140,766,423
JBrowse link
G Ttc14 tetratricopeptide repeat domain 14 increases expression ISO palbociclib results in increased expression of TTC14 mRNA CTD PMID:22869556 NCBI chr 2:120,266,883...120,277,505
Ensembl chr 2:120,266,933...120,276,616
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO palbociclib results in decreased expression of TTK mRNA CTD PMID:22869556 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression ISO palbociclib results in decreased expression of TUBB4B mRNA CTD PMID:22869556 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO palbociclib results in decreased expression of TUBB mRNA CTD PMID:22869556 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO palbociclib results in decreased expression of TYMS mRNA; palbociclib results in decreased expression of TYMS protein CTD PMID:20948315 PMID:22869556 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO palbociclib results in decreased expression of UBE2C mRNA CTD PMID:22869556 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T decreases expression ISO palbociclib results in decreased expression of UBE2T mRNA CTD PMID:22869556 NCBI chr13:51,790,877...51,801,379
Ensembl chr13:51,795,867...51,801,163
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO palbociclib results in decreased expression of UHRF1 mRNA CTD PMID:22869556 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vim vimentin increases expression ISO palbociclib results in increased expression of VIM protein CTD PMID:22869556 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein] CTD PMID:22094256 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO palbociclib results in decreased expression of ZWINT mRNA CTD PMID:22869556 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19775
    role 19722
      biological role 19722
        inhibitor 18469
          enzyme inhibitor 18261
            EC 2.* (transferase) inhibitor 13903
              EC 2.7.* (P-containing group transferase) inhibitor 13540
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8194
                  EC 2.7.11.22 (cyclin-dependent kinase) inhibitor 271
                    (R)-DRF053 + 0
                    (R)-DRF053 hydrochloride hydrate 0
                    2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                    4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide 0
                    4-(2,6-difluorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide 0
                    AMG-925 0
                    CCT251545 0
                    DH334 0
                    DH334(1+) + 0
                    LDC4297 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-1-(N,N-dimethylglycyl)piperidine-4-carboxamide 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)piperidine-4-carboxamide 0
                    N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)tetrahydro-2H-pyran-4-carboxamide 0
                    N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                    PHA-533533 0
                    SGC-CLK-1 0
                    THZ531 0
                    adapalene 6
                    alsterpaullone 6
                    alvocidib 69
                    alvocidib hydrochloride 0
                    bohemine 1
                    indirubin-3'-monoxime 48
                    olomoucine 6
                    palbociclib 176
                    paullone + 6
                    rohitukine 0
                    seliciclib 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19775
    role 19722
      biological role 19722
        inhibitor 18469
          enzyme inhibitor 18261
            EC 2.* (transferase) inhibitor 13903
              EC 2.7.* (P-containing group transferase) inhibitor 13540
                protein kinase inhibitor 13068
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8194
                    EC 2.7.11.22 (cyclin-dependent kinase) inhibitor 271
                      (R)-DRF053 + 0
                      (R)-DRF053 hydrochloride hydrate 0
                      2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                      4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide 0
                      4-(2,6-difluorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide 0
                      AMG-925 0
                      CCT251545 0
                      DH334 0
                      DH334(1+) + 0
                      LDC4297 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-1-(N,N-dimethylglycyl)piperidine-4-carboxamide 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)piperidine-4-carboxamide 0
                      N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)tetrahydro-2H-pyran-4-carboxamide 0
                      N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                      PHA-533533 0
                      SGC-CLK-1 0
                      THZ531 0
                      adapalene 6
                      alsterpaullone 6
                      alvocidib 69
                      alvocidib hydrochloride 0
                      bohemine 1
                      indirubin-3'-monoxime 48
                      olomoucine 6
                      palbociclib 176
                      paullone + 6
                      rohitukine 0
                      seliciclib 0
paths to the root