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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elemental iron
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Accession:CHEBI:82663 term browser browse the term
Definition:An elemental molecular entity in which all of the atoms have atomic number 26.


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ferbam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO ferbam results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
ferric ammonium citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 increases activity
decreases activity		 ISO ferric ammonium citrate results in increased activity of ACO1 protein
ferric ammonium citrate results in decreased activity of ACO1 protein		 CTD PMID:11054110 PMID:18073202 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Aco2 aconitase 2 multiple interactions
increases activity		 ISO ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
ferric ammonium citrate results in increased activity of ACO2 protein		 CTD PMID:16625280 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant increases expression
multiple interactions		 EXP ferric ammonium citrate results in increased expression of ACP5 protein
Silybin inhibits the reaction [ferric ammonium citrate results in increased expression of ACP5 protein]		 CTD PMID:36087815 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] CTD PMID:32283200 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of ALB protein] CTD PMID:24862973 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein; Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein] CTD PMID:36087815 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Anxa3 annexin A3 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein] CTD PMID:19515424 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein] CTD PMID:19515424 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of BECN1 protein; [Hydrogen Peroxide co-treated with [ferric ammonium citrate results in increased abundance of Iron]] results in increased expression of BECN1 protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]] CTD PMID:34826546 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO ferric ammonium citrate results in increased cleavage of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]		 CTD PMID:17191120 PMID:26318285 PMID:27481217 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein] CTD PMID:12807743 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO ferric ammonium citrate results in decreased expression of COL1A1 mRNA CTD PMID:19735707 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Cyclosporine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; ferric ammonium citrate results in decreased phosphorylation of and affects the localization of DNM1L protein; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:26318285 PMID:27481217 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:32283200 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein] CTD PMID:19515424 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions		 ISO ferric ammonium citrate results in increased expression of F3 mRNA
Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]		 CTD PMID:25858758 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO ferric ammonium citrate promotes the reaction [Palmitic Acid results in increased expression of FTH1 protein] CTD PMID:32283200 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression		 ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA
ferric ammonium citrate results in increased expression of FTL1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]		 CTD PMID:12393473 PMID:19913091 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GAPDH protein] CTD PMID:19515424 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein] CTD PMID:19515424 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression		 ISO Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]; ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 ferric ammonium citrate results in increased expression of HMOX1 protein
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein]		 CTD PMID:12393473 PMID:16439612 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPA1A protein] CTD PMID:19515424 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPD1 protein] CTD PMID:19515424 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL1B protein] CTD PMID:24862973 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; ferric ammonium citrate inhibits the reaction [Ozone results in increased secretion of IL6 protein] CTD PMID:24862973 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]] CTD PMID:32283200 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] CTD PMID:32283200 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ireb2 iron responsive element binding protein 2 decreases expression
decreases activity		 EXP
ISO		 ferric ammonium citrate results in decreased expression of IREB2 protein
ferric ammonium citrate results in decreased activity of IREB2 protein		 CTD PMID:11054110 PMID:17469137 PMID:18073202 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein] CTD PMID:17350462 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Hydrogen Peroxide inhibits the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein] CTD PMID:34826546 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein
ferric ammonium citrate results in increased phosphorylation of MAPK1 protein		 CTD PMID:17191120 PMID:25858758 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO ferric ammonium citrate results in increased phosphorylation of MAPK14 protein CTD PMID:17191120 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein
ferric ammonium citrate results in increased phosphorylation of MAPK3 protein		 CTD PMID:17191120 PMID:25858758 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mrps9 mitochondrial ribosomal protein S9 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of MRPS9 protein] CTD PMID:19515424 NCBI chr 9:45,113,554...45,172,375
Ensembl chr 9:45,113,554...45,172,375 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein] CTD PMID:32283200 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA] CTD PMID:9826428 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Oga O-GlcNAcase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of OGA protein] CTD PMID:24862973 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein] CTD PMID:19515424 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein] CTD PMID:34826546 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein] CTD PMID:19515424 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PGK1 protein] CTD PMID:19515424 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Ppia peptidylprolyl isomerase A multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PPIA protein] CTD PMID:19515424 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA] CTD PMID:24862973 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of RACK1 protein] CTD PMID:19515424 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
decreases expression		 ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of RUNX2 protein] CTD PMID:36087815 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]
Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SIRT1 protein]		 CTD PMID:34826546 PMID:36087815 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A1 mRNA CTD PMID:11054110 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A2 mRNA CTD PMID:11054110 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression
multiple interactions		 EXP
ISO		 ferric ammonium citrate results in increased expression of SLC40A1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]		 CTD PMID:19913091 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of SOD1 mRNA] CTD PMID:24862973 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression		 ISO
EXP		 Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SOD2 protein] CTD PMID:36087815 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tf transferrin multiple interactions ISO ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron] CTD PMID:11335103 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfr2 transferrin receptor 2 decreases expression ISO ferric ammonium citrate results in decreased expression of TFR2 protein CTD PMID:25633564 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591 		JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions		 ISO ferric ammonium citrate results in decreased expression of TFRC mRNA; ferric ammonium citrate results in decreased expression of TFRC protein
[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA		 CTD PMID:11054110 PMID:12393473 PMID:16760464 PMID:18073202 PMID:25633564 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of TNF protein] CTD PMID:24862973 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpd52l1 TPD52 like 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of TPD52L1 protein] CTD PMID:19515424 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of VDAC2 protein] CTD PMID:19515424 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of XBP1 protein] CTD PMID:32283200 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
iron(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Iron] CTD PMID:16679408 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects metabolic processing ISO ABCG2 protein affects the metabolism of Iron CTD PMID:17194590 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 multiple interactions EXP Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron] CTD PMID:16908409 NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [teferrol results in increased abundance of Iron] which results in decreased activity of ACHE protein CTD PMID:35307918 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Aco1 aconitase 1 affects metabolic processing
multiple interactions		 ISO
EXP		 ACO1 protein affects the metabolism of Iron
[Deferoxamine results in decreased abundance of Iron] which results in increased activity of ACO1 protein
Iron inhibits the reaction [nickel chloride results in increased activity of ACO1 protein]; Iron inhibits the reaction [Nickel results in increased activity of ACO1 protein]		 CTD PMID:15893546 PMID:16039939 PMID:16877034 PMID:17194590 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Aco2 aconitase 2 multiple interactions
increases activity		 EXP [[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron; ACO2 protein affects the reaction [Paraquat results in increased abundance of Iron]; Iron deficiency promotes the reaction [Clofibrate results in increased expression of ACO2 protein]; Iron inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Iron results in increased activity of ACO2 protein		 CTD PMID:9675333 PMID:11969379 PMID:16162655 PMID:21517855 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP Iron deficiency results in decreased expression of ACSF2 mRNA CTD PMID:16629162 NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Iron deficiency results in decreased expression of ACSL1 mRNA CTD PMID:19821111 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression EXP Iron deficiency results in decreased expression of ACSL3 mRNA CTD PMID:19821111 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 decreases expression ISO Iron deficiency results in decreased expression of ADGRG1 mRNA CTD PMID:20368581 NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108 		JBrowse link
G Ahsp alpha hemoglobin stabilizing protein multiple interactions ISO AHSP protein binds to and affects the folding of and affects the stability of [HBA1 protein binds to Iron] CTD PMID:16901899 NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:182,880,076...182,885,506 		JBrowse link
G Akap13 A-kinase anchoring protein 13 decreases expression EXP Iron deficiency results in decreased expression of AKAP13 mRNA CTD PMID:16629162 NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:17172471 PMID:32828744 PMID:33580994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression ISO Iron results in increased expression of ALAS2 mRNA CTD PMID:16424395 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [[Iron co-treated with Bicarbonates] results in increased abundance of Malondialdehyde]; ALB protein inhibits the reaction [[Iron co-treated with Phosphates] results in increased abundance of Malondialdehyde] CTD PMID:16027354 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Iron deficiency results in decreased expression of ALDOC mRNA CTD PMID:20368581 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Ankrd22 ankyrin repeat domain 22 increases expression ISO Iron deficiency results in increased expression of ANKRD22 mRNA CTD PMID:20368581 NCBI chr 1:231,639,035...231,670,537
Ensembl chr 1:231,639,314...231,670,381 		JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression EXP
ISO		 Iron deficiency results in increased expression of ANKRD37 mRNA CTD PMID:16629162 PMID:23776592 NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963 		JBrowse link
G Anxa1 annexin A1 decreases expression EXP Iron deficiency results in decreased expression of ANXA1 mRNA CTD PMID:19821111 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa2 annexin A2 increases expression ISO Iron deficiency results in increased expression of ANXA2 mRNA CTD PMID:20368581 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Ap1s3 adaptor related protein complex 1 subunit sigma 3 decreases expression ISO Iron deficiency results in decreased expression of AP1S3 mRNA CTD PMID:20368581 NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798 		JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in decreased expression of AP2A1 mRNA CTD PMID:24619124 NCBI chr 1:95,384,306...95,414,170
Ensembl chr 1:95,384,309...95,414,147 		JBrowse link
G Apoe apolipoprotein E increases response to substance ISO APOE gene polymorphism results in increased susceptibility to Iron CTD PMID:15993987 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Apoh apolipoprotein H decreases expression EXP Iron deficiency results in decreased expression of APOH mRNA CTD PMID:19821111 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G App amyloid beta precursor protein increases expression
increases uptake		 ISO Iron results in increased expression of APP mRNA
Iron results in increased uptake of APP protein		 CTD PMID:15993987 PMID:16308480 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp4 aquaporin 4 increases expression
multiple interactions		 EXP
ISO		 Iron deficiency results in increased expression of AQP4 mRNA
[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 mRNA; [ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein; SB 203580 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; U 0126 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; Vitamin E inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]		 CTD PMID:16629162 PMID:30914277 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Arid3b AT-rich interaction domain 3B increases expression ISO Iron deficiency results in increased expression of ARID3B mRNA CTD PMID:20368581 NCBI chr 8:58,193,268...58,240,901
Ensembl chr 8:58,193,418...58,238,318 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter] CTD PMID:10777486 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Iron deficiency results in increased expression of ARRDC3 mRNA CTD PMID:20368581 NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978 		JBrowse link
G Atm ATM serine/threonine kinase affects response to substance
multiple interactions
affects abundance		 ISO ATM protein affects the susceptibility to Iron
Iron results in increased phosphorylation of and results in increased activity of ATM protein
ATM protein affects the abundance of Iron		 CTD PMID:15336622 PMID:16959548 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp7a ATPase copper transporting alpha affects metabolic processing
increases expression
multiple interactions
affects transport
decreases oxidation
increases response to substance		 ISO
EXP		 ATP7A protein mutant form affects the metabolism of Iron
Iron deficiency results in increased expression of ATP7A; Iron deficiency results in increased expression of ATP7A mRNA; Iron deficiency results in increased expression of ATP7A protein
[Iron deficiency results in increased expression of ATP7A] which results in increased abundance of Copper
ATP7A mutant form affects the transport of Iron
ATP7A gene mutant form results in decreased oxidation of Iron
ATP7A gene mutant form results in increased susceptibility to Iron deficiency
[ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Copper; [ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Iron; ATP7A gene mutant form promotes the reaction [Iron deficiency results in increased expression of MT1 mRNA]; Iron deficiency inhibits the reaction [ATP7A gene mutant form results in decreased oxidation of Iron]		 CTD PMID:16629162 PMID:21852364 PMID:23174565 PMID:23776592 PMID:23814049 More... NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta increases abundance EXP ATP7B gene mutant form results in increased abundance of Iron CTD PMID:15911138 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G B2m beta-2 microglobulin multiple interactions
affects metabolic processing		 ISO [HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron
B2M protein affects the metabolism of Iron		 CTD PMID:16841247 PMID:17194590 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein] CTD PMID:30626086 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; [Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:30626086 PMID:33285147 PMID:33393188 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor multiple interactions ISO [Arsenic co-treated with Iron] results in increased expression of BCL10 mRNA CTD PMID:31739468 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein; [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein] CTD PMID:19620254 PMID:33285147 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein] CTD PMID:19620254 PMID:27916511 PMID:30626086 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Iron deficiency results in increased expression of BCL3 mRNA CTD PMID:20368581 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of BECN1 protein; [Hydrogen Peroxide co-treated with [ferric ammonium citrate results in increased abundance of Iron]] results in increased expression of BECN1 protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]] CTD PMID:34826546 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases abundance
increases expression
decreases abundance
decreases expression		 ISO
EXP		 BMP6 gene mutant form results in increased abundance of Iron
Iron results in increased expression of BMP6 mRNA
BMP6 protein results in decreased abundance of Iron
Iron deficiency results in decreased expression of BMP6 mRNA		 CTD PMID:19252486 PMID:19252488 PMID:20164366 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Iron deficiency results in increased expression of BNIP3 mRNA CTD PMID:23776592 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Calr calreticulin increases expression ISO Iron results in increased expression of CALR mRNA; Iron results in increased expression of CALR protein CTD PMID:11500943 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta multiple interactions ISO [Arsenic co-treated with Iron] results in increased expression of CAMK2D mRNA CTD PMID:31739468 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein]; Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CASP3 protein
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]		 CTD PMID:19620254 PMID:27916511 PMID:30626086 PMID:31678598 PMID:32828744 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO
EXP		 Iron deficiency inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]; Iron promotes the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]; Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron promotes the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Iron promotes the reaction [mezerein results in decreased activity of CAT protein]; Iron promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
Iron results in decreased activity of CAT protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein; [teferrol results in increased abundance of Iron] which results in increased activity of CAT protein; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CAT protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein]; leonurine inhibits the reaction [Iron results in decreased activity of CAT protein]		 CTD PMID:12065085 PMID:12067571 PMID:12504893 PMID:17176674 PMID:22534743 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 affects localization EXP Iron affects the localization of CAV1 protein CTD PMID:17172471 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO
EXP		 Iron deficiency results in increased expression of CCL2 mRNA
[Iron co-treated with Diethylnitrosamine] results in increased expression of CCL2 mRNA; Iron promotes the reaction [[Copper co-treated with Diethylnitrosamine] results in increased expression of CCL2 mRNA]		 CTD PMID:20302851 PMID:20368581 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CCL3 mRNA CTD PMID:22198552 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Iron deficiency results in increased expression of CCL5 mRNA CTD PMID:20368581 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [Arsenic co-treated with Iron] results in decreased expression of CCNA2 mRNA CTD PMID:31739468 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO
EXP		 Iron results in increased expression of CCND1
Iron deficiency results in increased expression of CCND1 mRNA; Iron results in increased expression of CCND1; Iron results in increased expression of CCND1 mRNA; Iron results in increased expression of CCND1 protein		 CTD PMID:16629162 PMID:16890145 PMID:22649188 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Iron deficiency results in increased expression of CCNG2 mRNA CTD PMID:20368581 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO Iron deficiency results in increased expression of CCPG1 mRNA CTD PMID:20368581 NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430 		JBrowse link
G Ccsap centriole, cilia and spindle-associated protein increases expression ISO Iron deficiency results in increased expression of CCSAP mRNA CTD PMID:20368581 NCBI chr19:51,824,954...51,843,469
Ensembl chr19:51,826,994...51,842,753 		JBrowse link
G Cd109 CD109 molecule increases expression ISO Iron deficiency results in increased expression of CD109 mRNA CTD PMID:20368581 NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194 		JBrowse link
G Cd14 CD14 molecule multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Iron deficiency results in increased expression of CD14 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Iron deficiency results in increased expression of CD14 protein]; Vitamin D promotes the reaction [Iron deficiency results in increased expression of CD14 protein] CTD PMID:20368581 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd1d1 CD1d1 molecule decreases expression EXP Iron deficiency results in decreased expression of CD1D1 mRNA CTD PMID:19821111 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd300a Cd300a molecule increases expression ISO Iron deficiency results in increased expression of CD300A mRNA CTD PMID:20368581 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Cd36 CD36 molecule decreases expression EXP Iron deficiency results in decreased expression of CD36 mRNA CTD PMID:16629162 PMID:19821111 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd70 Cd70 molecule increases expression ISO Iron deficiency results in increased expression of CD70 mRNA CTD PMID:20368581 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO Iron deficiency results in decreased expression of CD74 mRNA CTD PMID:20368581 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase decreases expression EXP Iron deficiency results in decreased expression of CDIPT mRNA CTD PMID:19821111 NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CDKN1A mRNA CTD PMID:22198552 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression EXP Iron deficiency results in decreased expression of CDKN1C mRNA CTD PMID:16629162 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D increases expression ISO Iron deficiency results in increased expression of CDKN2D mRNA CTD PMID:20368581 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Cdo1 cysteine dioxygenase type 1 multiple interactions EXP Iron binds to and results in increased activity of CDO1 protein CTD PMID:16611640 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296 		JBrowse link
G Cdrt4 CMT1A duplicated region transcript 4 increases expression ISO Iron deficiency results in increased expression of CDRT4 mRNA CTD PMID:20368581 NCBI chr10:47,625,470...47,657,493
Ensembl chr10:47,625,470...47,657,493 		JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 decreases expression EXP Iron deficiency results in decreased expression of CDS1 mRNA CTD PMID:19821111 NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681 		JBrowse link
G Cel carboxyl ester lipase increases expression EXP Iron deficiency results in increased expression of CEL mRNA CTD PMID:19821111 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of CHEK2 mRNA CTD PMID:22198552 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chi3l1 chitinase 3 like 1 decreases expression ISO Iron deficiency results in decreased expression of CHI3L1 mRNA CTD PMID:20368581 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in decreased expression of CHRND mRNA CTD PMID:24619124 NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP
ISO		 deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Iron results in increased activity of [CHUK protein binds to IKBKB protein]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]		 CTD PMID:17172471 PMID:33285147 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cldn2 claudin 2 increases expression EXP Iron deficiency results in increased expression of CLDN2 mRNA CTD PMID:16629162 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Clps colipase increases expression EXP Iron deficiency results in increased expression of CLPS mRNA CTD PMID:19821111 NCBI chr20:6,620,529...6,622,709
Ensembl chr20:6,620,529...6,622,689 		JBrowse link
G Cnn3 calponin 3 increases expression EXP Iron deficiency results in increased expression of CNN3 mRNA CTD PMID:16629162 NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Iron promotes the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA] CTD PMID:11306436 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cp ceruloplasmin affects binding
multiple interactions
increases expression
increases abundance
increases activity
increases oxidation
decreases export		 ISO
EXP		 CP protein binds to [TF protein binds to Iron]
[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]
Iron deficiency results in increased expression of CP protein; Iron deficiency results in increased expression of CP protein modified form
CP gene mutant form results in increased abundance of Iron
Iron deficiency results in increased activity of CP promoter
[CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in increased expression of CP protein]
[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein; ARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter]
CP gene mutant form results in decreased export of Iron		 CTD PMID:10777486 PMID:12572680 PMID:16988052 PMID:19061943 PMID:20655381 More... NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CSF2 mRNA CTD PMID:22198552 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cstf2t cleavage stimulation factor subunit 2, tau variant decreases expression ISO Iron deficiency results in decreased expression of CSTF2T mRNA CTD PMID:20368581 NCBI chr 1:228,952,617...228,956,183
Ensembl chr 1:228,952,504...228,955,873 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 decreases expression EXP Iron deficiency results in decreased expression of CTNNBIP1 mRNA CTD PMID:19821111 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CXCL1 protein CTD PMID:22198552 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CXCL2 protein CTD PMID:22198552 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cybrd1 cytochrome b reductase 1 decreases expression
increases expression		 ISO
EXP		 Iron results in decreased expression of CYBRD1 protein
Iron deficiency results in increased expression of CYBRD1 mRNA
Iron results in increased expression of CYBRD1 protein		 CTD PMID:16629162 PMID:18815723 PMID:19821111 PMID:21540277 PMID:23776592 More... NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 decreases expression EXP Iron deficiency results in decreased expression of CYP2B15 mRNA CTD PMID:16629162 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492 		JBrowse link
G Cytip cytohesin 1 interacting protein increases expression ISO Iron deficiency results in increased expression of CYTIP mRNA CTD PMID:20368581 NCBI chr 3:42,698,058...42,774,955
Ensembl chr 3:42,698,768...42,725,993 		JBrowse link
G Dapl1 death associated protein-like 1 decreases expression EXP Iron deficiency results in decreased expression of DAPL1 mRNA CTD PMID:16629162 NCBI chr 3:43,960,993...43,980,940
Ensembl chr 3:43,960,810...43,980,940 		JBrowse link
G Daxx death-domain associated protein increases expression ISO Iron results in increased expression of DAXX mRNA CTD PMID:16308480 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO
EXP		 Iron deficiency results in increased expression of DDIT3 mRNA
[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of DDIT3 mRNA		 CTD PMID:20368581 PMID:22198552 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Defa5 defensin alpha 5 increases expression EXP Iron deficiency results in increased expression of DEFA6 mRNA CTD PMID:16629162 NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836 		JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression EXP Iron deficiency results in increased expression of DGKA mRNA CTD PMID:19821111 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression EXP Iron deficiency results in increased expression of DLC1 mRNA CTD PMID:16629162 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439 		JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Iron deficiency results in increased expression of DOCK10 mRNA CTD PMID:20368581 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [manganese chloride co-treated with Iron deficiency] results in decreased expression of DRD1 protein CTD PMID:22479410 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP [manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein CTD PMID:22479410 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of E2F1 mRNA CTD PMID:22198552 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Iron deficiency results in increased expression of E2F8 mRNA CTD PMID:20368581 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein; Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein] CTD PMID:20302851 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase increases expression EXP Iron deficiency results in increased expression of EEF2K mRNA CTD PMID:16629162 NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Arsenic co-treated with Iron] results in decreased expression of EGFR mRNA CTD PMID:31739468 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 affects binding ISO Iron binds to EGLN1 protein CTD PMID:16649251 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Iron deficiency results in increased expression of EGLN3 mRNA CTD PMID:16629162 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions		 EXP Iron deficiency results in increased expression of EGR1 mRNA
[Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of EGR1 mRNA		 CTD PMID:16629162 PMID:24619124 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elane elastase, neutrophil expressed decreases expression ISO Iron deficiency results in decreased expression of ELANE mRNA CTD PMID:20368581 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Iron deficiency results in increased expression of EMP1 mRNA CTD PMID:20368581 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904 		JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions
increases expression		 ISO
EXP		 Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein]; Iron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]
Iron deficiency results in increased expression of EPAS1 protein		 CTD PMID:17973296 PMID:23814049 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Epo erythropoietin affects response to substance ISO Iron affects the susceptibility to EPO protein CTD PMID:24806658 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Exoc6 exocyst complex component 6 affects metabolic processing ISO EXOC6 protein affects the metabolism of Iron CTD PMID:17194590 NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015 		JBrowse link
G F13a1 coagulation factor XIII A1 chain decreases expression ISO Iron deficiency results in decreased expression of F13A1 mRNA CTD PMID:20368581 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F2 coagulation factor II, thrombin decreases activity ISO Iron results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression EXP Iron deficiency results in increased expression of FABP2 mRNA CTD PMID:19821111 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089 		JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression EXP Iron deficiency results in increased expression of FABP6 mRNA CTD PMID:19821111 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282 		JBrowse link
G Fam117b family with sequence similarity 117, member B increases expression EXP Iron deficiency results in increased expression of FAM117B mRNA CTD PMID:16629162 NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:61,340,249...61,408,483 		JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase decreases expression ISO Iron deficiency results in decreased expression of FAM20C mRNA CTD PMID:20368581 NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543 		JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in decreased expression of FBXW5 mRNA CTD PMID:24619124 NCBI chr 3:8,322,543...8,327,092
Ensembl chr 3:8,322,543...8,327,092 		JBrowse link
G Fech ferrochelatase multiple interactions ISO [Aminolevulinic Acid results in decreased activity of FECH protein] which results in increased abundance of Iron; [Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron; [Porphobilinogen results in decreased activity of FECH protein] which results in increased abundance of Iron; heme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]
[pyridoxal isonicotinoyl hydrazone results in decreased abundance of Iron] which results in decreased expression of FECH protein		 CTD PMID:15078340 PMID:30517741 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO Iron binds to and inhibits the reaction [NEIL1 protein binds to FEN1 protein] CTD PMID:20622253 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Flot1 flotillin 1 increases expression ISO Iron deficiency results in increased expression of FLOT1 mRNA CTD PMID:20368581 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Fn3k fructosamine 3 kinase multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of FN3K mRNA CTD PMID:24619124 NCBI chr10:106,700,670...106,715,903
Ensembl chr10:106,700,670...106,715,895 		JBrowse link
G Fntb farnesyltransferase, CAAX box, beta increases expression EXP Iron deficiency results in increased expression of FNTB mRNA CTD PMID:16629162 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein; [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of FOS mRNA; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:24619124 PMID:32828744 PMID:33580994 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fth1 ferritin heavy chain 1 affects abundance
increases expression
multiple interactions
affects binding
decreases expression
affects metabolic processing		 ISO
EXP		 FTH1 protein affects the abundance of Iron
Iron results in increased expression of FTH1 mRNA
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTH1 mRNA; Iron deficiency promotes the reaction [Vitamin A deficiency results in decreased expression of FTH1 protein]
Iron binds to FTH1 protein
[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; FTH1 protein inhibits the reaction [Iron results in increased abundance of Reactive Oxygen Species]
[[NBD peptide, mouse results in decreased expression of FTH1 mRNA] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]
Iron results in decreased expression of FTH1 mRNA
FTH1 protein affects the metabolism of Iron		 CTD PMID:15893546 PMID:16424395 PMID:16448386 PMID:16988052 PMID:17070541 More... NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
decreases expression
affects binding
decreases uptake		 ISO
EXP		 2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; 2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA; Deferoxamine inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; Deferoxamine inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Paraquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Razoxane inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Vitamin K 3 promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]
Iron results in increased expression of FTL1 mRNA
Iron results in decreased expression of FTL1 mRNA
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA; [Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA; Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA]
[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA; [Iron co-treated with Ethanol] results in increased expression of FTL1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of FTL1 mRNA]; Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of FTL1 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of FTL1 mRNA]
FTL protein mutant form results in decreased uptake of Iron		 CTD PMID:12393473 PMID:12644586 PMID:15893546 PMID:16424395 PMID:16822677 More... NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Ftmt ferritin mitochondrial multiple interactions
affects localization
affects binding		 ISO 2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; 2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; [diallyl trisulfide results in decreased expression of FTMT protein] which results in increased abundance of Iron; Deferoxamine inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; Deferoxamine inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Paraquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Razoxane inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Vitamin K 3 promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]
FTMT protein affects the localization of Iron		 CTD PMID:12644586 PMID:16757684 PMID:21616139 NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123 		JBrowse link
G Fxn frataxin increases abundance
affects metabolic processing
affects binding
increases metabolic processing		 ISO FXN gene mutant form results in increased abundance of Iron
FXN protein affects the metabolism of Iron
Iron binds to FXN protein
FXN protein results in increased metabolism of Iron		 CTD PMID:16120311 PMID:16911956 PMID:17101455 PMID:17194590 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Iron deficiency results in decreased expression of G6PC1 mRNA CTD PMID:16629162 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions
decreases expression		 EXP [Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 mRNA; [Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 protein
Iron deficiency results in decreased expression of GABBR2 mRNA; Iron deficiency results in decreased expression of GABBR2 protein		 CTD PMID:18771689 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
decreases expression
increases expression		 EXP [Iron deficiency co-treated with manganese chloride] results in increased expression of GABRA1 protein
Iron deficiency results in decreased expression of GABRA1 mRNA
Iron deficiency results in increased expression of GABRA1 protein		 CTD PMID:18771689 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gar1 GAR1 ribonucleoprotein increases expression EXP Iron deficiency results in increased expression of GAR1 mRNA CTD PMID:16629162 NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524 		JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of GAS1 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of GAS1 mRNA CTD PMID:12393473 NCBI chr17:4,482,168...4,485,153 JBrowse link
G Gas7 growth arrest specific 7 increases expression ISO Iron deficiency results in increased expression of GAS7 mRNA CTD PMID:20368581 NCBI chr10:52,152,718...52,383,283
Ensembl chr10:52,152,493...52,383,276 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression
increases activity		 ISO
EXP		 Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA]
Iron results in decreased expression of GCLC protein
leonurine inhibits the reaction [Iron results in decreased expression of GCLC protein]
Iron results in increased activity of GCLC protein		 CTD PMID:17189828 PMID:19073151 PMID:35247364 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
decreases expression		 ISO Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLM mRNA] CTD PMID:19073151 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gkn1 gastrokine 1 increases expression EXP Iron deficiency results in increased expression of GKN1 mRNA CTD PMID:16629162 NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389 		JBrowse link
G Gkn2 gastrokine 2 increases expression EXP Iron deficiency results in increased expression of GKN2 mRNA CTD PMID:16629162 NCBI chr 4:119,778,326...119,824,366
Ensembl chr 4:119,818,280...119,824,363 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO [Arsenic co-treated with Iron] results in decreased expression of GLI3 mRNA CTD PMID:31739468 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases activity		 EXP Capsaicin inhibits the reaction [Iron results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein] CTD PMID:16956363 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression EXP Iron deficiency results in increased expression of GPAM mRNA CTD PMID:16629162 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpr34 G protein-coupled receptor 34 increases expression ISO Iron deficiency results in increased expression of GPR34 mRNA CTD PMID:20368581 NCBI chr  X:9,104,829...9,113,796
Ensembl chr  X:9,104,565...9,148,601 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression EXP Iron deficiency results in increased expression of GPRC5A mRNA CTD PMID:16629162 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 EXP
ISO		 [Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein; Capsaicin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein]; leonurine inhibits the reaction [Iron results in increased activity of GPT protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein]
Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein]		 CTD PMID:16956363 PMID:27916511 PMID:32828744 PMID:33580994 PMID:35247364 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases response to substance		 EXP
ISO		 [Iron co-treated with Hydrogen Peroxide] results in decreased expression of and results in decreased activity of GPX1 protein
GPX1 protein results in decreased susceptibility to Iron		 CTD PMID:16721761 PMID:17280487 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Iron deficiency results in increased expression of GPX2 mRNA CTD PMID:16629162 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions		 EXP Iron results in decreased expression of GPX4 protein
leonurine inhibits the reaction [Iron results in decreased expression of GPX4 protein]		 CTD PMID:35247364 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron] CTD PMID:19620254 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases expression
decreases activity		 ISO
EXP		 [Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GSR protein; Iron deficiency inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein]; Iron promotes the reaction [Benzoyl Peroxide results in decreased activity of GSR protein]; Iron promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
Iron results in decreased expression of GSR protein
Iron results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein; leonurine inhibits the reaction [Iron results in decreased expression of GSR protein]		 CTD PMID:12067571 PMID:12504893 PMID:17176674 PMID:33393188 PMID:35247364 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase multiple interactions
decreases expression		 ISO Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GSS mRNA] CTD PMID:19073151 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
decreases expression
increases expression		 EXP
ISO		 [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in decreased expression of GSTA2 mRNA
Iron results in decreased expression of GSTA1 protein
Iron results in increased expression of GSTA1 mRNA; Iron results in increased expression of GSTA1 protein		 CTD PMID:11755321 PMID:20302851 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP Iron results in increased expression of and results in increased activity of GSTA4 protein CTD PMID:7878679 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTA5 mRNA CTD PMID:20302851 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression
increases expression		 ISO Iron results in decreased expression of GSTM1 protein
Iron results in increased expression of GSTM1 mRNA; Iron results in increased expression of GSTM1 protein		 CTD PMID:11755321 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions EXP [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTM3 mRNA CTD PMID:20302851 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G H3f4 H3.4 histone, cluster member multiple interactions
increases methylation		 ISO [[Iron co-treated with Ketoglutaric Acids] results in increased activity of KDM3A protein] which results in decreased methylation of H3-4 protein
Iron results in increased methylation of H3-4 protein		 CTD PMID:16603237 PMID:21385672 NCBI chr10:43,740,702...43,741,262 JBrowse link
G Hamp hepcidin antimicrobial peptide decreases secretion
increases expression
affects expression
decreases expression
affects metabolic processing
multiple interactions		 ISO
EXP		 HAMP protein results in decreased secretion of Iron
Iron results in increased expression of HAMP protein
Iron affects the expression of HAMP mRNA
Iron deficiency results in decreased expression of HAMP mRNA
HAMP protein affects the metabolism of Iron
[Acetaminophen results in decreased expression of HAMP mRNA] which results in increased abundance of Iron; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of HAMP mRNA; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of HAMP mRNA]
Iron results in increased expression of HAMP mRNA
[IL6 protein results in increased expression of HAMP protein] which results in decreased secretion of Iron; Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]		 CTD PMID:11113132 PMID:16460831 PMID:16574947 PMID:16648237 PMID:17116712 More... NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO AHSP protein binds to and affects the folding of and affects the stability of [HBA1 protein binds to Iron] CTD PMID:16901899 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hbb hemoglobin subunit beta multiple interactions
affects abundance		 ISO [HBB-B1 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HBB-B1 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA
HBB-B1 protein affects the abundance of Iron		 CTD PMID:17018382 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hbb-b2 hemoglobin, beta adult minor chain multiple interactions
affects abundance		 ISO [HBB-B2 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA
HBB-B2 protein affects the abundance of Iron		 CTD PMID:17018382 NCBI chr 1:158,243,696...158,245,076
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions ISO Iron binds to and results in increased activity of HDAC8 protein CTD PMID:16681389 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Heph hephaestin affects metabolic processing
multiple interactions		 ISO
EXP		 HEPH protein affects the metabolism of Iron
[Zinc results in decreased expression of HEPH protein] which results in decreased uptake of Iron		 CTD PMID:16614402 PMID:17194590 NCBI chr  X:61,151,131...61,402,980
Ensembl chr  X:61,296,345...61,402,980 		JBrowse link
G Hfe homeostatic iron regulator increases uptake
affects metabolic processing
affects abundance
multiple interactions
decreases uptake
affects response to substance
increases abundance		 ISO HFE gene mutant form results in increased uptake of Iron
HFE protein affects the metabolism of Iron
HFE protein affects the abundance of Iron
[HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron
HFE protein results in decreased uptake of Iron
[HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron; [HFE protein binds to TFR2 protein] which affects the susceptibility to Iron; HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron]; TNF gene SNP promotes the reaction [HFE protein mutant form results in increased uptake of Iron]
HFE protein affects the susceptibility to Iron
HFE gene mutant form results in increased abundance of Iron; HFE gene polymorphism results in increased abundance of Iron
HFE gene polymorphism affects the abundance of Iron; HFE protein affects the abundance of Iron		 CTD PMID:10085150 PMID:12393473 PMID:16793930 PMID:16823846 PMID:16841247 More... NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases response to substance
decreases metabolic processing		 ISO
EXP		 [Deferoxamine results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA; [Quercetin results in decreased abundance of Iron] which results in increased expression of HIF1A protein; Iron inhibits the reaction [galangin results in increased expression of HIF1A protein]; Iron inhibits the reaction [manganese chloride results in increased expression of HIF1A protein]; Iron inhibits the reaction [Nickel results in increased stability of HIF1A protein]; Iron inhibits the reaction [Quercetin results in increased expression of and affects the localization of HIF1A protein]; Iron inhibits the reaction [Quercetin results in increased expression of HIF1A protein]
Iron deficiency results in decreased expression of HIF1A mRNA
HIF1A protein results in increased susceptibility to Iron
HIF1A gene mutant form results in decreased metabolism of Iron		 CTD PMID:12393473 PMID:16629162 PMID:16787915 PMID:16877034 PMID:17364964 More... NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hjv hemojuvelin BMP co-receptor affects metabolic processing ISO HJV protein affects the metabolism of Iron CTD PMID:17194590 NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Iron deficiency results in decreased expression of HMGCS2 mRNA CTD PMID:16629162 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
increases metabolic processing		 ISO
EXP		 [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HMOX1 mRNA; [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Iron; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; [Particulate Matter results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Iron promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]
Iron deficiency results in increased expression of HMOX1 mRNA; Iron results in increased expression of HMOX1 protein
[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of HMOX1 mRNA; [Iron co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein; Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein]; leonurine promotes the reaction [Iron results in increased expression of HMOX1 protein]
HMOX1 protein results in increased metabolism of Iron		 CTD PMID:12393473 PMID:15602829 PMID:16439612 PMID:16629162 PMID:19136476 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase increases expression ISO Iron deficiency results in increased expression of HPGDS mRNA CTD PMID:20368581 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
affects localization		 EXP HRAS protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]
Iron affects the localization of HRAS protein		 CTD PMID:17172471 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsbp1l1 heat shock factor binding protein 1-like 1 decreases expression ISO Iron deficiency results in decreased expression of HSBP1L1 mRNA CTD PMID:20368581 NCBI chr18:73,682,286...73,690,061
Ensembl chr18:73,682,286...73,688,045 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPA1A mRNA CTD PMID:22198552 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPA1L mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPA8 mRNA CTD PMID:22198552 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPA9 mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPB1 mRNA CTD PMID:22198552 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions EXP
ISO		 [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPH1 mRNA
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPH1 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA		 CTD PMID:12393473 PMID:22198552 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Htt huntingtin decreases uptake ISO HTT protein mutant form results in decreased uptake of Iron CTD PMID:20547568 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12633744 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Iron deficiency results in decreased expression of IDI1 mRNA CTD PMID:19821111 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Iron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein]; Iron affects the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ift172 intraflagellar transport 172 increases expression EXP Iron deficiency results in increased expression of SLB mRNA CTD PMID:16629162 NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP IGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Iron] CTD PMID:15745444 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression
multiple interactions		 EXP
ISO		 Iron deficiency results in increased expression of IGFBP3 mRNA
[Arsenic co-treated with Iron] results in decreased expression of IGFBP3 mRNA		 CTD PMID:16629162 PMID:31739468 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Iron results in increased activity of [CHUK protein binds to IKBKB protein]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Iron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Iron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Iron affects the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in increased expression of IL1A mRNA; [Iron co-treated with Diethylnitrosamine] results in increased expression of IL1A mRNA CTD PMID:20302851 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP
ISO		 [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of IL1B mRNA; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of IL1B protein; leonurine inhibits the reaction [Iron results in increased expression of IL1B protein]; lipopolysaccharide A promotes the reaction [Iron results in increased secretion of IL1B protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein]
[Particulate Matter results in increased abundance of Iron] which results in increased secretion of IL1B protein		 CTD PMID:16958088 PMID:22198552 PMID:32007923 PMID:32828744 PMID:35247364 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 EXP
ISO		 [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of IL6 mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of IL6 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of IL6 mRNA; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
Iron results in increased secretion of IL6 protein
[IL6 protein results in increased expression of HAMP protein] which results in decreased secretion of Iron		 CTD PMID:16460831 PMID:20302851 PMID:22198552 PMID:26416317 PMID:32828744 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 multiple interactions ISO [Arsenic co-treated with Iron] results in increased expression of IP6K2 mRNA CTD PMID:31739468 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166 		JBrowse link
G Iqcd IQ motif containing D increases expression ISO Iron deficiency results in increased expression of IQCD mRNA CTD PMID:20368581 NCBI chr12:35,955,522...35,972,420 JBrowse link
G Ireb2 iron responsive element binding protein 2 affects metabolic processing
multiple interactions
increases activity		 ISO
EXP		 IREB2 protein affects the metabolism of Iron
Clofibrate inhibits the reaction [Iron deficiency results in increased activity of IREB2 protein]		 CTD PMID:11969379 PMID:17194590 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression ISO Iron deficiency results in decreased expression of IRF8 mRNA CTD PMID:20368581 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Itga6 integrin subunit alpha 6 increases expression EXP Iron deficiency results in increased expression of ITGA6 mRNA CTD PMID:16629162 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 ISO Iron deficiency results in increased expression of ITGAM mRNA; Iron deficiency results in increased expression of ITGAM protein
Vitamin D promotes the reaction [Iron deficiency results in increased expression of ITGAM protein]		 CTD PMID:20368581 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 increases expression ISO Iron deficiency results in increased expression of ITGB2 mRNA CTD PMID:20368581 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Itln1 intelectin 1 multiple interactions ISO ITLN1 protein binds to and results in increased uptake of Iron CTD PMID:16936804 NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227 		JBrowse link
G Jazf1 JAZF zinc finger 1 increases expression ISO Iron deficiency results in increased expression of JAZF1 mRNA CTD PMID:20368581 NCBI chr 4:81,879,501...82,183,237
Ensembl chr 4:81,881,061...82,183,100 		JBrowse link
G Jchain joining chain of multimeric IgA and IgM increases expression EXP Iron deficiency results in increased expression of JCHAIN mRNA CTD PMID:16629162 NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO [Arsenic co-treated with Iron] results in increased expression of JUN mRNA; [Deferoxamine results in decreased abundance of Iron] which results in increased expression of JUN mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of JUN mRNA
Iron deficiency results in increased expression of JUN mRNA		 CTD PMID:12393473 PMID:20368581 PMID:31739468 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 increases expression EXP Iron deficiency results in increased expression of KCNE3 mRNA CTD PMID:16629162 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020 		JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions ISO [[Iron co-treated with Ketoglutaric Acids] results in increased activity of KDM3A protein] which results in decreased methylation of H3-4 protein CTD PMID:16603237 NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Iron deficiency results in decreased expression of KIT mRNA CTD PMID:20368581 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Klhdc7b kelch domain containing 7B increases expression ISO Iron deficiency results in increased expression of KLHDC7B mRNA CTD PMID:20368581 NCBI chr 7:120,452,081...120,455,737
Ensembl chr 7:120,453,932...120,455,737 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Iron deficiency results in increased expression of LAMC2 mRNA CTD PMID:16629162 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Lamp5 lysosomal-associated membrane protein family, member 5 decreases expression ISO Iron deficiency results in decreased expression of LAMP5 mRNA CTD PMID:20368581 NCBI chr 3:123,372,462...123,384,973
Ensembl chr 3:123,372,462...123,384,952 		JBrowse link
G Lcn2 lipocalin 2 increases expression
affects metabolic processing		 ISO Iron results in increased expression of LCN2 mRNA; Iron results in increased expression of LCN2 protein
LCN2 protein affects the metabolism of Iron		 CTD PMID:17194590 PMID:17350462 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lig3 DNA ligase 3 decreases activity ISO Iron results in decreased activity of LIG3 protein CTD PMID:20622253 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in increased expression of LOX mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 decreases expression EXP Iron deficiency results in decreased expression of LPAR1 mRNA CTD PMID:19821111 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Lrrc25 leucine rich repeat containing 25 increases expression ISO Iron deficiency results in increased expression of LRRC25 mRNA CTD PMID:20368581 NCBI chr16:18,806,888...18,813,723
Ensembl chr16:18,806,890...18,813,671 		JBrowse link
G Lta lymphotoxin alpha multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of LTA mRNA CTD PMID:22198552 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Ly75 lymphocyte antigen 75 decreases expression ISO Iron deficiency results in decreased expression of LY75 mRNA CTD PMID:20368581 NCBI chr 3:44,764,702...44,852,219
Ensembl chr 3:44,765,122...44,852,374 		JBrowse link
G Lypla1 lysophospholipase 1 decreases expression EXP Iron deficiency results in decreased expression of LYPLA1 mRNA CTD PMID:19821111 NCBI chr 5:14,679,605...14,708,774
Ensembl chr 5:14,679,606...14,708,746 		JBrowse link
G Maoa monoamine oxidase A decreases expression EXP Iron deficiency results in decreased expression of MAOA mRNA CTD PMID:16629162 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Hydrogen Peroxide inhibits the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Iron affects the reaction [Deferoxamine results in increased expression of MAP1LC3B protein]; Iron affects the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of MAP1LC3B protein]; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein] CTD PMID:25301941 PMID:34826546 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions
increases phosphorylation		 EXP Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein]; Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein] CTD PMID:17172471 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 multiple interactions EXP MAP3K14 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [Iron results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions
increases activity
affects localization		 EXP Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein]; Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [Iron results in increased secretion of TNF protein]
Iron affects the localization of MAP3K7 protein		 CTD PMID:17172471 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]; Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK1 protein]
[ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein
Iron results in increased phosphorylation of MAPK1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; [teferrol results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein; [Vanadium co-treated with Iron] results in increased phosphorylation of MAPK1 protein; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11306436 PMID:16728372 PMID:17172471 PMID:23100159 PMID:30914277 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; [Aluminum co-treated with Iron] results in increased phosphorylation of MAPK3 protein; [teferrol results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein; [Vanadium co-treated with Iron] results in increased phosphorylation of MAPK3 protein; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]
[ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein
[Iron co-treated with Arsenic] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11306436 PMID:16728372 PMID:17172471 PMID:23100159 PMID:30914277 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [teferrol results in increased abundance of Iron] which results in increased phosphorylation of MAPK8 protein CTD PMID:35307918 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression EXP Iron deficiency results in increased expression of MARCKS mRNA CTD PMID:16629162 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mcemp1 mast cell-expressed membrane protein 1 increases expression ISO Iron deficiency results in increased expression of MCEMP1 mRNA CTD PMID:20368581 NCBI chr12:1,721,781...1,727,350
Ensembl chr12:1,718,730...1,725,986 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 multiple interactions
increases expression		 ISO [Ethanol co-treated with Iron] results in increased expression of MCOLN1 mRNA; [Ethanol co-treated with Iron] results in increased expression of MCOLN1 protein; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of MCOLN1 mRNA]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of MCOLN1 protein]; Quercetin inhibits the reaction [Iron results in increased expression of MCOLN1 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of MCOLN1 protein]
Iron results in increased expression of MCOLN1 mRNA; Iron results in increased expression of MCOLN1 protein		 CTD PMID:24569067 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO Iron deficiency results in increased expression of MCTP1 mRNA CTD PMID:20368581 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Iron deficiency results in increased expression of ME1 mRNA CTD PMID:20368581 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA CTD PMID:22198552 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Miox myo-inositol oxygenase affects binding ISO [MIOX protein binds to Iron] which binds to Inositol CTD PMID:17012379 NCBI chr 7:120,405,031...120,407,529
Ensembl chr 7:120,405,031...120,407,537 		JBrowse link
G Mir196b microRNA 196b multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Iron] which results in increased expression of MIR196B mRNA CTD PMID:27506416 NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein] CTD PMID:19136476 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions		 EXP Iron results in increased activity of MPO protein
[Hexachlorocyclohexane co-treated with Iron] results in increased activity of MPO protein		 CTD PMID:11141352 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Ms4a6a membrane spanning 4-domains A6A decreases expression ISO Iron deficiency results in decreased expression of MS4A6A mRNA CTD PMID:20368581 NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758 		JBrowse link
G Ms4a7 membrane spanning 4-domains A7 increases expression EXP Iron deficiency results in increased expression of MS4A7 mRNA CTD PMID:16629162 NCBI chr 1:207,969,117...207,984,743
Ensembl chr 1:207,968,761...207,983,260 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression		 EXP [Zinc co-treated with Iron] results in increased expression of and affects the localization of MT1A protein; Iron results in increased expression of and affects the localization of MT1A protein
Iron deficiency results in increased expression of MT1A; Iron deficiency results in increased expression of MT1A mRNA		 CTD PMID:16629162 PMID:17241390 PMID:21852364 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A multiple interactions
affects abundance
increases expression		 ISO
EXP		 [Deferoxamine results in decreased abundance of Iron] which results in increased expression of MT2A mRNA; [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA
MT2A gene SNP affects the abundance of Iron
Iron deficiency results in increased expression of MT2 mRNA
[Zinc co-treated with Iron] results in increased expression of and affects the localization of MT2A protein; Iron results in increased expression of and affects the localization of MT2A protein
Iron deficiency results in increased expression of MT2A mRNA		 CTD PMID:12393473 PMID:16629162 PMID:17241390 PMID:21328412 PMID:24089420 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP Iron deficiency results in increased expression of MVD mRNA CTD PMID:19821111 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of MYC mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of MYC mRNA CTD PMID:12393473 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone binds to Iron] which results in increased expression of NDRG1 protein; NDRG1 protein results in decreased susceptibility to [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone binds to Iron] CTD PMID:24532803 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 affects expression ISO Iron affects the expression of NDUFS1 protein CTD PMID:11313346 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression EXP Iron deficiency results in increased expression of NEDD9 mRNA CTD PMID:16629162 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO Curcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]; Iron binds to and affects the folding of and results in decreased activity of NEIL1 protein; Iron binds to and inhibits the reaction [NEIL1 protein binds to FEN1 protein]; Iron binds to and inhibits the reaction [NEIL1 protein binds to POLB protein] CTD PMID:20622253 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258 		JBrowse link
G Neil2 nei-like DNA glycosylase 2 multiple interactions ISO Iron binds to and results in decreased activity of NEIL2 protein CTD PMID:20622253 NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases activity		 ISO
EXP		 NFE2L2 protein promotes the reaction [SLC40A1 protein results in increased export of Iron]
Iron affects the localization of NFE2L2 protein
[Particulate Matter results in increased abundance of Iron] which affects the localization of NFE2L2 protein; [Particulate Matter results in increased abundance of Iron] which results in increased expression of NFE2L2 mRNA
[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in increased expression of NFE2L2 mRNA; leonurine promotes the reaction [Iron affects the localization of NFE2L2 protein]
Iron results in increased activity of NFE2L2 promoter		 CTD PMID:20302851 PMID:21303654 PMID:21643505 PMID:26419736 PMID:35247364 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfib nuclear factor I/B multiple interactions ISO [Arsenic co-treated with Iron] results in decreased expression of NFIB mRNA CTD PMID:31739468 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Iron deficiency results in increased expression of NFIL3 mRNA CTD PMID:20368581 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of NFKBIA protein]; [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in decreased expression of NFKBIA mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of NFKBIA mRNA; HRAS protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of NFKBIA protein]; U 0126 inhibits the reaction [Iron results in increased phosphorylation of NFKBIA protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]		 CTD PMID:17172471 PMID:20302851 PMID:33285147 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngb neuroglobin decreases uptake ISO NGB protein results in decreased uptake of Iron CTD PMID:19154338 NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830 		JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 increases expression ISO Iron deficiency results in increased expression of NLRC4 mRNA CTD PMID:20368581 NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248 		JBrowse link
G Nmt2 N-myristoyltransferase 2 multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of NMT2 mRNA CTD PMID:24619124 NCBI chr17:74,917,833...74,964,788
Ensembl chr17:74,917,833...74,961,080 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 [Aluminum co-treated with Iron] results in increased expression of NOS2 protein; [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of NOS2 mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of NOS2 mRNA; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of NOS2 mRNA; [teferrol results in increased abundance of Iron] which results in increased expression of NOS2 mRNA
Iron inhibits the reaction [Asbestos, Crocidolite results in increased expression of NOS2 mRNA]; Iron inhibits the reaction [Asbestos, Crocidolite results in increased expression of NOS2 protein]		 CTD PMID:11461780 PMID:16728372 PMID:20302851 PMID:22198552 PMID:35307918 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 decreases abundance ISO NPC1 gene mutant form results in decreased abundance of Iron CTD PMID:24901380 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction
multiple interactions
increases expression		 ISO
EXP		 NQO1 protein results in increased reduction of Iron
leonurine promotes the reaction [Iron results in increased expression of NQO1 protein]
[Particulate Matter results in increased abundance of Iron] which results in increased expression of NQO1 mRNA		 CTD PMID:17178108 PMID:26419736 PMID:35247364 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ocln occludin multiple interactions EXP Iron inhibits the reaction [Lead results in decreased expression of OCLN mRNA]; Iron inhibits the reaction [Lead results in decreased expression of OCLN protein] CTD PMID:17234227 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity		 ISO Iron affects the reaction [3-chloroperbenzoic acid results in increased activity of ODC1 protein]; Iron deficiency inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]; Iron promotes the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]; Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron promotes the reaction [Hydrogen Peroxide results in increased activity of ODC1 protein]; Iron promotes the reaction [mezerein results in increased activity of ODC1 protein]; Iron promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
Iron results in increased activity of ODC1 protein		 CTD PMID:7653998 PMID:12065085 PMID:12067571 PMID:12504893 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Opn3 opsin 3 decreases expression ISO Iron deficiency results in decreased expression of OPN3 mRNA CTD PMID:20368581 NCBI chr13:87,589,333...87,619,847
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Osbpl11 oxysterol binding protein-like 11 increases expression ISO Iron deficiency results in increased expression of OSBPL11 mRNA CTD PMID:20368581 NCBI chr11:67,533,669...67,616,795
Ensembl chr11:67,533,672...67,596,444 		JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO Iron deficiency results in increased expression of P2RX7 mRNA CTD PMID:20368581 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 increases expression EXP Iron deficiency results in increased expression of P4HA1 mRNA CTD PMID:16629162 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G P4htm prolyl 4-hydroxylase, transmembrane multiple interactions ISO Iron inhibits the reaction [manganese chloride results in decreased activity of P4HTM protein] CTD PMID:19263519 NCBI chr 8:109,274,629...109,292,802
Ensembl chr 8:109,274,626...109,292,473 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein; [Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form; [ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form]; Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein] CTD PMID:30626086 PMID:31678598 PMID:34826546 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcgf5 polycomb group ring finger 5 increases expression ISO Iron deficiency results in increased expression of PCGF5 mRNA CTD PMID:20368581 NCBI chr 1:234,063,854...234,180,022
Ensembl chr 1:234,063,892...234,175,315 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP Iron deficiency results in decreased expression of PCK1 mRNA CTD PMID:16629162 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions		 EXP Iron deficiency results in increased expression of PCNA mRNA
[taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein		 CTD PMID:16629162 PMID:32828744 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression EXP Iron deficiency results in decreased expression of PCTP mRNA CTD PMID:19821111 NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP Iron promotes the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA] CTD PMID:11306436 PMID:12475806 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP Iron deficiency results in increased expression of PDK4 mRNA CTD PMID:16629162 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions ISO [cobaltous chloride results in decreased abundance of Iron] which results in increased expression of PFKFB4 mRNA; [Deferoxamine results in decreased abundance of Iron] which results in increased expression of PFKFB4 mRNA CTD PMID:16025159 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634 		JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 decreases expression EXP Iron deficiency results in decreased expression of PHOSPHO1 mRNA CTD PMID:16629162 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342 		JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta increases expression EXP Iron deficiency results in increased expression of PIK3C2B mRNA CTD PMID:16629162 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein; [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein] CTD PMID:32828744 PMID:33580994 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [Iron results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO Iron deficiency results in increased expression of PIM1 mRNA CTD PMID:20368581 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta increases expression ISO Iron deficiency results in increased expression of PIP5K1B mRNA CTD PMID:20368581 NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672 		JBrowse link
G Pla2g1b phospholipase A2 group IB increases expression EXP Iron deficiency results in increased expression of PLA2G1B mRNA CTD PMID:19821111 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases expression EXP Iron deficiency results in decreased expression of PLA2G4A mRNA CTD PMID:19821111 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plaa phospholipase A2, activating protein decreases expression EXP Iron deficiency results in decreased expression of PLAA mRNA CTD PMID:19821111 NCBI chr 5:109,428,600...109,460,373
Ensembl chr 5:109,428,265...109,460,282 		JBrowse link
G Pld4 phospholipase D family, member 4 decreases expression ISO Iron deficiency results in decreased expression of PLD4 mRNA CTD PMID:20368581 NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376 		JBrowse link
G Plpp1 phospholipid phosphatase 1 increases expression ISO Iron deficiency results in increased expression of PLPP1 mRNA CTD PMID:20368581 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268 		JBrowse link
G Plscr1 phospholipid scramblase 1 decreases expression EXP Iron deficiency results in decreased expression of PLSCR1 mRNA CTD PMID:19821111 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression
multiple interactions		 ISO
EXP		 Iron deficiency results in increased expression of PMP22 mRNA
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of PMP22 mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of PMP22 mRNA		 CTD PMID:12393473 PMID:16629162 PMID:20368581 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Pmvk phosphomevalonate kinase increases expression EXP Iron deficiency results in increased expression of PMVK mRNA CTD PMID:19821111 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364 		JBrowse link
G Pnlip pancreatic lipase increases expression EXP Iron deficiency results in increased expression of PNLIP mRNA CTD PMID:19821111 NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654 		JBrowse link
G Pnliprp1 pancreatic lipase-related protein 1 increases expression EXP Iron deficiency results in increased expression of PNLIPRP1 mRNA CTD PMID:19821111 NCBI chr 1:257,867,885...257,883,514
Ensembl chr 1:257,867,885...257,883,514 		JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 decreases expression EXP Iron deficiency results in decreased expression of PNLIPRP2 mRNA CTD PMID:16629162 NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434 		JBrowse link
G Poglut2 protein O-glucosyltransferase 2 increases expression ISO Iron deficiency results in increased expression of POGLUT2 mRNA CTD PMID:20368581 NCBI chr 9:46,256,388...46,268,714
Ensembl chr 9:46,256,390...46,268,532 		JBrowse link
G Polb DNA polymerase beta multiple interactions ISO Iron binds to and inhibits the reaction [NEIL1 protein binds to POLB protein] CTD PMID:20622253 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Polr3e RNA polymerase III subunit E multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of POLR3E mRNA CTD PMID:24619124 NCBI chr 1:175,466,091...175,494,679
Ensembl chr 1:175,466,127...175,494,667 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP		 [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein; [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein; Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] CTD PMID:16052486 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [[Iron co-treated with POR protein] results in increased metabolism of Paraquat] which results in increased abundance of Hydroxyl Radical; [Iron co-treated with POR protein] results in increased metabolism of Diquat; [Iron co-treated with POR protein] results in increased metabolism of Paraquat CTD PMID:21215309 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Iron deficiency results in increased expression of PPARG mRNA CTD PMID:20368581 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B increases expression ISO Iron deficiency results in increased expression of PPP1R16B mRNA CTD PMID:20368581 NCBI chr 3:147,323,652...147,419,658
Ensembl chr 3:147,324,126...147,418,937 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B increases expression EXP Iron deficiency results in increased expression of PPP1R1B mRNA CTD PMID:16629162 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 decreases expression ISO Iron deficiency results in decreased expression of PRG3 mRNA CTD PMID:20368581 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases expression EXP Iron deficiency results in decreased expression of PRKAA1 mRNA CTD PMID:19821111 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prnp prion protein multiple interactions
decreases abundance		 ISO [Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]; Iron, Dietary inhibits the reaction [PRNP gene mutant form results in decreased abundance of Iron] CTD PMID:16595185 PMID:23478311 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Prtn3 proteinase 3 decreases expression ISO Iron deficiency results in decreased expression of PRTN3 mRNA CTD PMID:20368581 NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of PTGS2 protein; leonurine inhibits the reaction [Iron results in increased expression of PTGS2 protein]
[Arsenic co-treated with Iron] results in increased expression of PTGS2 mRNA		 CTD PMID:20302851 PMID:31739468 PMID:35247364 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions ISO [Arsenic co-treated with Iron] results in increased expression of PTHLH mRNA CTD PMID:31739468 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Ptx3 pentraxin 3 increases expression ISO Iron deficiency results in increased expression of PTX3 mRNA CTD PMID:20368581 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Pxdn peroxidasin multiple interactions ISO [Arsenic co-treated with Iron] results in decreased expression of PXDN mRNA CTD PMID:31739468 NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345 		JBrowse link
G Rab30 RAB30, member RAS oncogene family decreases expression EXP Iron deficiency results in decreased expression of RAB30 mRNA CTD PMID:16629162 NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181 		JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions EXP Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron] CTD PMID:16908409 NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186 		JBrowse link
G Rbp7 retinol binding protein 7 increases expression EXP Iron deficiency results in increased expression of RBP7 mRNA CTD PMID:16629162 NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO
EXP		 [Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; U 0126 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]
Iron affects the localization of RELA protein
[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; leonurine inhibits the reaction [Iron affects the localization of RELA protein]		 CTD PMID:33285147 PMID:33580994 PMID:35247364 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Iron deficiency results in increased expression of RELB mRNA CTD PMID:20368581 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Retn resistin increases expression ISO Iron deficiency results in increased expression of RETN mRNA CTD PMID:20368581 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Iron deficiency results in increased expression of RGS1 mRNA CTD PMID:20368581 NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Iron deficiency results in increased expression of RGS2 mRNA CTD PMID:20368581 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rho rhodopsin multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773 		JBrowse link
G Rhob ras homolog family member B increases expression EXP Iron deficiency results in increased expression of RHOB mRNA CTD PMID:16629162 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Rnase4 ribonuclease A family member 4 increases expression ISO Iron deficiency results in increased expression of RNASE4 mRNA CTD PMID:20368581 NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117 		JBrowse link
G Ropn1l rhophilin associated tail protein 1-like decreases expression ISO Iron deficiency results in decreased expression of ROPN1L mRNA CTD PMID:20368581 NCBI chr 2:82,442,645...82,453,332
Ensembl chr 2:82,441,891...82,453,485 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403 		JBrowse link
G Rpl37 ribosomal protein L37 decreases expression ISO Iron results in decreased expression of RPL37 mRNA CTD PMID:27329587 NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:54,215,469...54,217,442 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions ISO [Iron co-treated with Oxygen] binds to RRM2 protein CTD PMID:16829694 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G RT1-Bb RT1 class II, locus Bb increases expression EXP Iron deficiency results in increased expression of RT1-BB mRNA CTD PMID:16629162 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression EXP Iron deficiency results in increased expression of RT1-DB1 mRNA CTD PMID:16629162 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression EXP Iron deficiency results in decreased expression of S100A9 mRNA CTD PMID:16629162 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression
decreases expression		 EXP Iron deficiency results in increased expression of SCD2 mRNA
Iron deficiency results in decreased expression of SCD2 mRNA		 CTD PMID:16629162 PMID:19821111 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232 		JBrowse link
G Scp2 sterol carrier protein 2 decreases expression EXP Iron deficiency results in decreased expression of SCP2 mRNA CTD PMID:19821111 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287 		JBrowse link
G Sele selectin E multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:12633744 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO Iron deficiency results in increased expression of SERPINB8 mRNA CTD PMID:20368581 NCBI chr13:23,626,936...23,650,277
Ensembl chr13:23,626,945...23,650,835 		JBrowse link
G Sesn3 sestrin 3 decreases expression ISO Iron deficiency results in decreased expression of SESN3 mRNA CTD PMID:20368581 NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein] CTD PMID:34826546 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Ska1 spindle and kinetochore associated complex subunit 1 increases expression ISO Iron deficiency results in increased expression of SKA1 mRNA CTD PMID:20368581 NCBI chr18:67,794,722...67,805,037
Ensembl chr18:67,794,725...67,805,037 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 multiple interactions ISO [CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA CTD PMID:16988052 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
increases uptake
affects abundance
increases expression
increases transport
decreases uptake
affects metabolic processing
decreases expression
decreases transport		 ISO
EXP		 [Deferoxamine results in decreased abundance of Iron] which results in increased expression of SLC11A2 mRNA; [HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein]; cupric chloride inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein]; Dronabinol inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]; ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]; prolinedithiocarbamate inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]
SLC11A2 gene SNP affects the abundance of Iron
Iron deficiency results in increased expression of SLC11A2 mRNA; Iron deficiency results in increased expression of SLC11A2 protein; Iron results in increased expression of SLC11A2 mRNA; Iron results in increased expression of SLC11A2 protein
[Doxorubicin results in increased expression of SLC11A2 protein] which results in increased uptake of Iron; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of manganese chloride]; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]; Manganese promotes the reaction [SLC11A2 protein results in increased transport of Iron]; Metals promotes the reaction [SLC11A2 protein results in increased transport of Iron]; Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]; SLC11A2 protein affects the reaction [Manganese results in increased transport of Iron]
Iron deficiency results in increased expression of SLC11A2 mRNA; Iron results in increased expression of SLC11A2 mRNA; Iron results in increased expression of SLC11A2 protein
SLC11A2 gene mutant form results in decreased uptake of Iron; SLC11A2 protein mutant form results in decreased uptake of Iron
SLC11A2 protein affects the metabolism of Iron
Iron results in decreased expression of SLC11A2 protein
SLC11A2 gene mutant form results in decreased transport of Iron
SLC11A2 protein alternative form results in increased uptake of Iron; SLC11A2 protein results in increased uptake of Iron
[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA; [Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein; [SLC11A2 protein mutant form results in decreased phosphorylation of SLC11A2 protein] which results in decreased uptake of Iron; [Staurosporine results in decreased phosphorylation of SLC11A2 protein] which results in decreased uptake of Iron; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC11A2 protein]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein]; Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 protein]		 CTD PMID:11439223 PMID:12220667 PMID:12388109 PMID:12393473 PMID:15157939 More... NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression EXP Iron deficiency results in increased expression of SLC12A2 mRNA CTD PMID:16629162 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression EXP Iron deficiency results in increased expression of SLC23A2 mRNA CTD PMID:16629162 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
G Slc26a11 solute carrier family 26 member 11 increases expression ISO Iron deficiency results in increased expression of SLC26A11 mRNA CTD PMID:20368581 NCBI chr10:104,613,498...104,635,873
Ensembl chr10:104,613,564...104,635,970 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 decreases expression ISO
EXP		 Iron deficiency results in decreased expression of SLC2A5 mRNA CTD PMID:16629162 PMID:20368581 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106 		JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP Iron deficiency results in decreased expression of SLC34A2 mRNA CTD PMID:16629162 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 multiple interactions
increases import
increases expression
increases uptake		 ISO 4,7-diphenylphenanthroline sulfonate inhibits the reaction [SLC39A14 protein results in increased uptake of Iron]; [Ethanol co-treated with Iron] results in increased expression of SLC39A14 mRNA; [Ethanol co-treated with Iron] results in increased expression of SLC39A14 protein; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC39A14 mRNA]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC39A14 protein]; Quercetin inhibits the reaction [Iron results in increased expression of SLC39A14 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of SLC39A14 protein]
SLC39A14 protein results in increased import of Iron
Iron results in increased expression of SLC39A14 mRNA; Iron results in increased expression of SLC39A14 protein		 CTD PMID:16950869 PMID:22898811 PMID:24569067 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524 		JBrowse link
G Slc39a8 solute carrier family 39 member 8 increases import
multiple interactions		 ISO
EXP		 SLC39A8 protein results in increased import of Iron
Cobalt inhibits the reaction [SLC39A8 protein results in increased import of Iron]; Iron inhibits the reaction [SLC39A8 protein results in increased import of Zinc]; Iron results in increased expression of and affects the localization of SLC39A8 protein; Manganese inhibits the reaction [SLC39A8 protein results in increased import of Iron]; Zinc inhibits the reaction [SLC39A8 protein results in increased import of Iron]
Protons affects the reaction [SLC39A8 protein results in increased import of Iron]		 CTD PMID:22898811 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions
increases expression
increases export
decreases export
affects metabolic processing		 ISO
EXP		 Iron results in decreased expression of SLC40A1 protein
[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein; Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]; Iron inhibits the reaction [SLC40A1 protein results in increased export of Manganese]
Iron deficiency results in increased expression of SLC40A1 mRNA; Iron results in increased expression of SLC40A1 mRNA
SLC40A1 protein mutant form results in increased export of Iron; SLC40A1 protein results in increased export of Iron
SLC40A1 protein mutant form results in decreased export of Iron
[HBB-B1 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 mRNA]; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 protein]; NFE2L2 protein promotes the reaction [SLC40A1 protein results in increased export of Iron]; SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron]
SLC40A1 protein affects the metabolism of Iron		 CTD PMID:16457665 PMID:16565419 PMID:16648237 PMID:17018382 PMID:17194590 More... NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 multiple interactions
increases expression
decreases expression		 EXP [Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 mRNA; [Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 protein; [Iron deficiency co-treated with manganese chloride] results in increased expression of SLC6A1 mRNA
Iron deficiency results in increased expression of SLC6A1 mRNA
Iron deficiency results in decreased expression of SLC6A1 protein		 CTD PMID:18771689 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions EXP [manganese chloride co-treated with Iron deficiency] results in decreased expression of SLC6A3 protein CTD PMID:22479410 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Iron deficiency results in decreased expression of SLPI mRNA CTD PMID:20368581 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Smim3 small integral membrane protein 3 increases expression EXP Iron deficiency results in increased expression of SMIM3 mRNA CTD PMID:16629162 NCBI chr18:53,930,019...53,982,339
Ensembl chr18:53,930,020...53,957,416 		JBrowse link
G Snapc1 small nuclear RNA activating complex, polypeptide 1 increases expression EXP Iron deficiency results in increased expression of SNAPC1 mRNA CTD PMID:16629162 NCBI chr 6:92,684,785...92,710,772
Ensembl chr 6:92,684,752...92,707,746 		JBrowse link
G Snca synuclein alpha multiple interactions
affects localization
increases response to substance		 ISO Cytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]; SNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Iron]
EUK-189 results in decreased susceptibility to [Iron co-treated with Paraquat co-treated with SNCA gene mutant form]
Iron affects the localization of SNCA protein		 CTD PMID:12401952 PMID:14535945 PMID:21039522 PMID:27324791 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects abundance		 ISO
EXP		 SOD1 protein inhibits the reaction [Asbestos, Crocidolite results in increased uptake of Iron]
[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD1 protein]
SOD1 protein affects the abundance of Iron
[Corn Oil co-treated with Iron] results in decreased activity of SOD1 protein; Iron promotes the reaction [Corn Oil results in decreased activity of SOD1 protein]		 CTD PMID:16272461 PMID:17194920 PMID:19482077 PMID:22534743 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 affects abundance
multiple interactions		 ISO
EXP		 SOD2 protein polymorphism affects the abundance of Iron
[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD2 protein]
Deferoxamine inhibits the reaction [SOD2 protein affects the reaction [Ethanol results in increased abundance of Iron]]; SOD2 protein affects the reaction [Ethanol results in increased abundance of Iron]
Iron results in decreased expression of and results in decreased activity of SOD2 protein		 CTD PMID:18760346 PMID:19063909 PMID:22534743 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sord sorbitol dehydrogenase affects abundance EXP SORD protein affects the abundance of Iron CTD PMID:18549825 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Sort1 sortilin 1 increases expression ISO Iron deficiency results in increased expression of SORT1 mRNA CTD PMID:20368581 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression EXP Iron deficiency results in increased expression of SOX9 mRNA CTD PMID:16629162 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp6 Sp6 transcription factor increases expression EXP Iron deficiency results in increased expression of SP6 mRNA CTD PMID:16629162 NCBI chr10:82,005,518...82,009,699
Ensembl chr10:82,005,294...82,011,013 		JBrowse link
G Spr sepiapterin reductase increases expression EXP Iron deficiency results in increased expression of SPR mRNA CTD PMID:16629162 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Arsenic co-treated with Iron] results in increased expression of SQSTM1 mRNA; [Iron co-treated with Deferoxamine] results in increased expression of SQSTM1 protein; Iron affects the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of SQSTM1 protein] CTD PMID:25301941 PMID:31739468 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:23100159 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Ssr1 signal sequence receptor subunit 1 multiple interactions ISO [Arsenic co-treated with Iron] results in decreased expression of SSR1 mRNA CTD PMID:31739468 NCBI chr17:26,833,720...26,861,821
Ensembl chr17:26,833,741...26,861,821 		JBrowse link
G Steap2 STEAP2 metalloreductase increases reduction
increases uptake		 ISO STEAP2 protein results in increased reduction of Iron
STEAP2 protein results in increased uptake of Iron		 CTD PMID:16609065 NCBI chr 4:28,347,769...28,368,177
Ensembl chr 4:28,348,362...28,375,791 		JBrowse link
G Steap3 STEAP3 metalloreductase affects metabolic processing
increases reduction
increases uptake		 ISO STEAP3 protein affects the metabolism of Iron
STEAP3 protein results in increased reduction of Iron
STEAP3 protein results in increased uptake of Iron		 CTD PMID:16609065 PMID:17194590 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Steap4 STEAP4 metalloreductase increases uptake
increases reduction		 ISO STEAP4 protein results in increased uptake of Iron
STEAP4 protein results in increased reduction of Iron		 CTD PMID:16609065 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO STK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]] CTD PMID:19620254 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Sulf2 sulfatase 2 increases expression ISO Iron deficiency results in increased expression of SULF2 mRNA CTD PMID:20368581 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 decreases expression ISO Iron deficiency results in decreased expression of TASL mRNA CTD PMID:20368581 NCBI chr  X:50,403,962...50,423,141
Ensembl chr  X:50,361,248...50,423,269 		JBrowse link
G Tert telomerase reverse transcriptase increases activity EXP Iron results in increased activity of TERT protein CTD PMID:17189828 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tes testin LIM domain protein increases expression ISO Iron deficiency results in increased expression of TES mRNA CTD PMID:20368581 NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829 		JBrowse link
G Tf transferrin multiple interactions
affects metabolic processing
affects binding
increases expression
increases uptake		 ISO
EXP		 [Aluminum binds to TF protein] which results in decreased uptake of Iron; [Iron binds to TF protein] which results in decreased uptake of Iron; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Iron; ammonium ferric sulfate promotes the reaction [TF protein results in increased uptake of Iron]; cobaltous chloride inhibits the reaction [TF protein results in increased uptake of Iron]; cuprous chloride inhibits the reaction [TF protein results in increased uptake of Iron]; ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron]; ferric chloride promotes the reaction [TF protein results in increased uptake of Iron]; ferrous sulfate promotes the reaction [TF protein results in increased uptake of Iron]; gallium nitrate promotes the reaction [TF protein results in increased uptake of Iron]; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and affects the transport of Iron; zinc chloride inhibits the reaction [TF protein results in increased uptake of Iron]
TRF protein affects the metabolism of Iron
Iron deficiency results in increased expression of TF protein
[Iron deficiency co-treated with Manganese] results in increased expression of TF protein; [Melatonin results in increased expression of TF protein] which affects the abundance of Iron; [S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron; Copper deficiency results in decreased expression of [Iron binds to TF protein]
[Iron binds to TF protein] which binds to TFRC protein; [TF protein binds to Iron] which binds to TFRC protein; CP protein binds to [TF protein binds to Iron]; Iron binds to TF protein; TF protein binds to Iron		 CTD PMID:2039817 PMID:2308257 PMID:8782865 PMID:11193083 PMID:11335103 More... NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tff1 trefoil factor 1 increases expression EXP Iron deficiency results in increased expression of TFF1 mRNA CTD PMID:16629162 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tfr2 transferrin receptor 2 multiple interactions
decreases expression
affects metabolic processing
increases uptake
affects response to substance		 ISO
EXP		 [HFE protein binds to TFR2 protein] which affects the susceptibility to Iron
Iron deficiency results in decreased expression of TFR2 protein
TFR2 protein affects the metabolism of Iron
TFR2 protein mutant form results in increased uptake of Iron
TFR2 protein affects the susceptibility to Iron
[HBB-B1 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of TFR2 protein]		 CTD PMID:16893896 PMID:16935854 PMID:17018382 PMID:17194590 PMID:17241880 More... NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591 		JBrowse link
G Tfrc transferrin receptor multiple interactions
increases expression
decreases expression
increases uptake
affects expression
affects metabolic processing
affects binding		 ISO
EXP		 [Deferoxamine results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [Fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron; [GGTI 298 results in decreased expression of TFRC protein] which results in decreased uptake of Iron; [Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein; [TFRC protein results in increased uptake of Iron] which results in increased abundance of Lipid Peroxides; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein]; HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron]
Iron deficiency results in increased expression of TFRC mRNA; Iron results in increased expression of TFRC mRNA
Iron results in decreased expression of TFRC mRNA
Iron deficiency results in increased expression of TFRC mRNA; Iron deficiency results in increased expression of TFRC protein
[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC protein; Clofibrate inhibits the reaction [Iron deficiency results in increased expression of TFRC mRNA]
Iron affects the expression of TFRC mRNA; Iron affects the expression of TFRC protein
TFRC protein affects the metabolism of Iron
[CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA; [Iron co-treated with Ethanol] results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC protein; Iron inhibits the reaction [Diethylnitrosamine results in increased expression of TFRC protein]; Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of TFRC mRNA]
Iron results in increased expression of TFRC protein
[Iron binds to TF protein] which binds to TFRC protein; [TF protein binds to Iron] which binds to TFRC protein		 CTD PMID:10085150 PMID:11068183 PMID:11969379 PMID:12393473 PMID:16428268 More... NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Iron promotes the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA] CTD PMID:11306436 PMID:12475806 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO [Arsenic co-treated with Iron] results in increased expression of TGFBR1 mRNA CTD PMID:31739468 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression EXP Iron deficiency results in increased expression of TGIF1 mRNA CTD PMID:16629162 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Tmem154 transmembrane protein 154 increases expression ISO Iron deficiency results in increased expression of TMEM154 mRNA CTD PMID:20368581 NCBI chr 2:170,015,247...170,054,903
Ensembl chr 2:170,015,184...170,052,481 		JBrowse link
G Tmem252 transmembrane protein 252 increases expression EXP Iron deficiency results in increased expression of TMEM252 mRNA CTD PMID:16629162 NCBI chr 1:222,316,982...222,321,946
Ensembl chr 1:222,316,795...222,321,943 		JBrowse link
G Tmem45b transmembrane protein 45b decreases expression EXP Iron deficiency results in decreased expression of TMEM45B mRNA CTD PMID:16629162 NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453 		JBrowse link
G Tmem86a transmembrane protein 86A increases expression EXP Iron deficiency results in increased expression of TMEM86A mRNA CTD PMID:16629162 NCBI chr 1:97,595,910...97,600,260
Ensembl chr 1:97,595,842...97,600,260 		JBrowse link
G Tmprss6 transmembrane serine protease 6 affects abundance ISO TMPRSS6 gene SNP affects the abundance of Iron CTD PMID:19820698 PMID:19820699 NCBI chr 7:109,991,008...110,021,626
Ensembl chr 7:109,985,931...110,021,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases uptake
increases expression
increases secretion
decreases abundance		 ISO
EXP		 [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; TNF gene SNP promotes the reaction [HFE protein mutant form results in increased uptake of Iron]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]
TNF protein results in increased uptake of Iron
Iron results in increased expression of TNF mRNA; Iron results in increased expression of TNF protein
Iron results in increased secretion of TNF protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased secretion of TNF protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of TNF protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]; leonurine inhibits the reaction [Iron results in increased expression of TNF protein]; lipopolysaccharide A promotes the reaction [Iron results in increased secretion of TNF protein]; MAP3K14 protein affects the reaction [Iron results in increased secretion of TNF protein]; MAP3K7 protein affects the reaction [Iron results in increased secretion of TNF protein]; PIK3R1 protein affects the reaction [Iron results in increased secretion of TNF protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]; TNF protein affects the transport of and results in decreased abundance of Iron; U 0126 inhibits the reaction [Iron results in increased secretion of TNF protein]
TNF protein results in decreased abundance of Iron		 CTD PMID:10865941 PMID:12633744 PMID:16566752 PMID:16793930 PMID:16890145 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Iron deficiency results in increased expression of TNFSF10 mRNA CTD PMID:20368581 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tppp3 tubulin polymerization-promoting protein family member 3 increases expression EXP Iron deficiency results in increased expression of TPPP3 mRNA CTD PMID:16629162 NCBI chr19:33,345,897...33,349,610
Ensembl chr19:33,345,898...33,349,577 		JBrowse link
G Treml2 triggering receptor expressed on myeloid cells-like 2 increases expression ISO Iron deficiency results in increased expression of TREML2 mRNA CTD PMID:20368581 NCBI chr 9:12,694,453...12,705,379
Ensembl chr 9:12,694,697...12,705,324 		JBrowse link
G Trim27 tripartite motif-containing 27 increases expression EXP Iron deficiency results in increased expression of TRIM27 mRNA CTD PMID:16629162 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases uptake ISO TRPC6 protein results in increased uptake of Iron CTD PMID:14640978 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Tshz1 teashirt zinc finger homeobox 1 increases expression EXP Iron deficiency results in increased expression of TSHZ1 mRNA CTD PMID:16629162 NCBI chr18:77,376,399...77,452,815
Ensembl chr18:77,377,394...77,453,509 		JBrowse link
G Tshz3 teashirt zinc finger homeobox 3 increases expression ISO Iron deficiency results in increased expression of TSHZ3 mRNA CTD PMID:20368581 NCBI chr 1:89,386,732...89,460,719
Ensembl chr 1:89,381,858...89,460,874 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO [3-aminopyridine-2-carboxaldehyde thiosemicarbazone binds to Iron] which results in increased oxidation of TXN2 protein CTD PMID:21195754 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNIP mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNIP protein CTD PMID:33393188 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of TXNRD1 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNRD1 protein CTD PMID:33393188 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 decreases expression ISO Iron deficiency results in decreased expression of UBE2E1 mRNA CTD PMID:20368581 NCBI chr15:7,439,751...7,493,410
Ensembl chr15:7,439,759...7,493,400 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of UGT1A6 mRNA CTD PMID:22198552 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases expression EXP Iron deficiency results in decreased expression of UGT2B17 mRNA CTD PMID:16629162 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 decreases expression EXP Iron deficiency results in decreased expression of UGT2B15 mRNA CTD PMID:16629162 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Urod uroporphyrinogen decarboxylase decreases activity
multiple interactions		 ISO
EXP		 Iron results in decreased activity of UROD protein
Iron inhibits the reaction [Ethinyl Estradiol results in increased activity of UROD protein]		 CTD PMID:3945969 PMID:12030801 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:12633744 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor increases expression ISO Iron deficiency results in increased expression of VDR mRNA CTD PMID:20368581 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vsig10l V-set and immunoglobulin domain containing 10 like decreases expression EXP Iron deficiency results in decreased expression of VSIG10L mRNA CTD PMID:16629162 NCBI chr 1:93,871,487...93,880,157
Ensembl chr 1:93,851,774...93,879,566 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Iron deficiency results in increased expression of WIPI1 mRNA CTD PMID:20368581 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
G Zfp503 zinc finger protein 503 increases expression EXP Iron deficiency results in increased expression of ZFP503 mRNA CTD PMID:16629162 NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848 		JBrowse link
iron(2+) sulfate (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO ferrous sulfate results in increased expression of ABCF1 mRNA CTD PMID:19428942 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433 		JBrowse link
G Aco1 aconitase 1 multiple interactions ISO [nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein] CTD PMID:16039939 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of ACTA2 protein CTD PMID:7593635 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO ferrous sulfate results in decreased expression of BAD mRNA CTD PMID:33554279 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP ferrous sulfate results in increased expression of BAX protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of BAX protein]		 CTD PMID:28583816 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions		 EXP
ISO		 ferrous sulfate results in decreased expression of BCL2 protein
ferrous sulfate results in increased expression of BCL2 mRNA
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in decreased expression of BCL2 protein]		 CTD PMID:28583816 PMID:33554279 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO ferrous sulfate results in increased expression of BCL2A1 mRNA CTD PMID:21540303 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases activity
multiple interactions		 EXP
ISO		 ferrous sulfate results in increased cleavage of CASP3 protein
ferrous sulfate results in decreased activity of CASP3 protein
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased cleavage of CASP3 protein]		 CTD PMID:17879260 PMID:28583816 PMID:33554279 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA] CTD PMID:17879260 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased degradation of Hyaluronic Acid]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein] CTD PMID:23692848 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 affects localization EXP ferrous sulfate affects the localization of CAV1 protein CTD PMID:17172471 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO ferrous sulfate results in decreased expression of CCL17 mRNA CTD PMID:19428942 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO ferrous sulfate results in decreased expression of CCL19 mRNA CTD PMID:19428942 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO ferrous sulfate results in increased expression of CCL20 mRNA CTD PMID:19428942 PMID:21540303 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO ferrous sulfate results in decreased expression of CCL21 mRNA CTD PMID:19428942 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO ferrous sulfate results in decreased expression of CCL24 mRNA CTD PMID:19428942 NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 decreases expression ISO ferrous sulfate results in decreased expression of CCL15 mRNA CTD PMID:19428942 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO ferrous sulfate results in decreased expression of CCR6 mRNA CTD PMID:19428942 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO ferrous sulfate results in decreased expression of CCR7 mRNA CTD PMID:19428942 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO ferrous sulfate results in decreased expression of CCR8 mRNA CTD PMID:19428942 NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein] CTD PMID:23692848 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ferrous sulfate results in increased expression of CDKN1A mRNA CTD PMID:21540303 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO ferrous sulfate results in increased expression of CEBPB mRNA CTD PMID:19428942 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Crp C-reactive protein decreases expression ISO ferrous sulfate results in decreased expression of CRP mRNA; ferrous sulfate results in decreased expression of CRP protein CTD PMID:17119383 PMID:19428942 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO ferrous sulfate results in increased expression of CSF2 mRNA CTD PMID:21540303 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO ferrous sulfate results in increased expression of CXCL10 mRNA CTD PMID:19428942 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO ferrous sulfate results in increased expression of CXCL11 mRNA CTD PMID:19428942 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO ferrous sulfate results in decreased expression of CXCL13 mRNA CTD PMID:19428942 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO ferrous sulfate results in decreased expression of CXCL14 mRNA CTD PMID:19428942 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP ferrous sulfate results in increased expression of CXCL2 mRNA CTD PMID:11708899 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO ferrous sulfate results in decreased expression of CXCR2 mRNA CTD PMID:19428942 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; ferrous sulfate inhibits the reaction [picolinic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] CTD PMID:10799651 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 decreases response to substance ISO DNAJB1 protein results in decreased susceptibility to ferrous sulfate CTD PMID:11359866 NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases activity ISO ferrous sulfate results in increased activity of EGLN1 protein CTD PMID:16649251 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO ferrous sulfate results in decreased expression of EGR1 mRNA CTD PMID:21540303 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein] CTD PMID:17973296 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; ferrous sulfate inhibits the reaction [Quercetin results in decreased expression of and results in increased ubiquitination of ERBB2 protein] CTD PMID:18655187 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G F10 coagulation factor X decreases activity ISO ferrous sulfate results in decreased activity of F10 protein CTD PMID:6421970 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin decreases activity ISO ferrous sulfate results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression		 ISO
EXP		 [nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]
ferrous sulfate results in increased expression of FTL1 protein		 CTD PMID:16039939 PMID:28993186 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression		 ISO ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]
ferrous sulfate results in decreased expression of GCLC protein		 CTD PMID:27424009 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases response to substance ISO GDNF protein results in decreased susceptibility to ferrous sulfate CTD PMID:17935603 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions		 EXP ferrous sulfate results in increased expression of GPX1 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein]		 CTD PMID:28583816 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP ferrous sulfate results in increased phosphorylation of GSK3B protein CTD PMID:19608791 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 EXP ferrous sulfate results in increased expression of H2AX protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein]		 CTD PMID:28583816 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferrous sulfate inhibits the reaction [Chromium results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Cobalt results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Nickel results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] CTD PMID:16386771 PMID:17973296 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of HMOX1 protein]		 CTD PMID:20934533 PMID:26945724 PMID:28583816 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase affects localization
multiple interactions		 EXP ferrous sulfate affects the localization of HRAS protein
ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]		 CTD PMID:17172471 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]] CTD PMID:18655187 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta decreases expression ISO ferrous sulfate results in decreased expression of IL10RB mRNA CTD PMID:19428942 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of IL1B protein]		 CTD PMID:23692848 PMID:28583816 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO ferrous sulfate results in increased expression of IL1RN mRNA CTD PMID:19428942 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il36rn interleukin 36 receptor antagonist decreases expression ISO ferrous sulfate results in decreased expression of IL36RN mRNA CTD PMID:19428942 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016 		JBrowse link
G Il4 interleukin 4 increases expression ISO ferrous sulfate results in increased expression of IL4 protein CTD PMID:15963385 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression ISO ferrous sulfate results in decreased expression of IL6 protein CTD PMID:17119383 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferrous sulfate results in increased expression of JUN mRNA CTD PMID:21540303 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klk1 kallikrein 1 decreases activity ISO ferrous sulfate results in decreased activity of KLK1 protein CTD PMID:6421970 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Lep leptin increases expression ISO ferrous sulfate results in increased expression of LEP mRNA CTD PMID:21540303 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lta lymphotoxin alpha increases expression
decreases expression		 ISO ferrous sulfate results in increased expression of LTA mRNA
ferrous sulfate results in decreased expression of LTA mRNA		 CTD PMID:19428942 PMID:21540303 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions
increases phosphorylation		 EXP ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein] CTD PMID:17172471 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 multiple interactions EXP MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 affects localization
increases activity
multiple interactions		 EXP ferrous sulfate affects the localization of MAP3K7 protein
ferrous sulfate results in increased activity of MAP3K7 protein
ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]		 CTD PMID:17172471 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein] CTD PMID:17172471 PMID:19608791 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein] CTD PMID:17172471 PMID:19608791 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA; Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; Resveratrol analog inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA] CTD PMID:22099153 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression		 ISO
EXP		 [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]
Diltiazem promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]		 CTD PMID:23692848 PMID:27095094 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions		 EXP ferrous sulfate results in increased expression of MT1A mRNA
[Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT1A protein; ferrous sulfate results in increased expression of and affects the localization of MT1A protein		 CTD PMID:17241390 PMID:19679144 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A multiple interactions EXP [Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT2A protein; ferrous sulfate results in increased expression of and affects the localization of MT2A protein CTD PMID:17241390 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions EXP [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MYB protein CTD PMID:7593635 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO
EXP		 ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of and affects the localization of NFE2L2 protein]]
ferrous sulfate results in increased expression of NFE2L2 mRNA
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of NFE2L2 protein]; ferrous sulfate results in increased expression of and affects the localization of NFE2L2 protein		 CTD PMID:26945724 PMID:28583816 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein]		 CTD PMID:17879260 PMID:22099153 PMID:23692848 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein]		 CTD PMID:17172471 PMID:17879260 PMID:28583816 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein] CTD PMID:23692848 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 EXP ferrous sulfate results in increased expression of NQO1 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NQO1 protein]		 CTD PMID:28583816 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 increases expression ISO ferrous sulfate results in increased expression of PMEPA1 mRNA CTD PMID:21540303 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; [Ascorbic Acid co-treated with ferrous sulfate] results in decreased activity of PON1 protein CTD PMID:12871208 PMID:15375178 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP ferrous sulfate results in increased expression of PTGS2 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of PTGS2 protein]		 CTD PMID:28583816 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO
EXP		 [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]
ferrous sulfate affects the localization of RELA protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of RELA protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein]		 CTD PMID:17879260 PMID:22099153 PMID:23692848 PMID:28583816 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Selplg selectin P ligand increases expression ISO ferrous sulfate results in increased expression of SELPLG mRNA CTD PMID:21540303 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 decreases expression ISO ferrous sulfate results in decreased expression of SLC11A2 mRNA CTD PMID:10966897 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased abundance of Reactive Oxygen Species]; SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron] CTD PMID:19913091 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Snca synuclein alpha multiple interactions ISO ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]; ferrous sulfate promotes the reaction [SNCA protein results in increased abundance of Reactive Oxygen Species] CTD PMID:27424009 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases activity		 ISO ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]
ferrous sulfate results in decreased activity of SOD1 protein		 CTD PMID:27424009 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases activity
decreases expression		 ISO ferrous sulfate results in increased activity of SOD2 protein
ferrous sulfate results in decreased expression of SOD2 protein		 CTD PMID:27424009 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO ferrous sulfate results in decreased expression of SPP1 mRNA CTD PMID:19428942 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases phosphorylation EXP ferrous sulfate results in increased phosphorylation of STAT1 protein CTD PMID:17607690 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [ferrous sulfate co-treated with Copper Sulfate] promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein] CTD PMID:10364193 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tas1r3 taste 1 receptor member 3 affects response to substance ISO TAS1R3 protein affects the susceptibility to ferrous sulfate CTD PMID:19244541 NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742 		JBrowse link
G Tf transferrin multiple interactions
increases expression		 ISO
EXP		 ferrous sulfate promotes the reaction [TF protein results in increased uptake of Iron]
ferrous sulfate results in increased expression of TF protein		 CTD PMID:11335103 PMID:28993186 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor decreases expression ISO
EXP		 ferrous sulfate results in decreased expression of TFRC mRNA
ferrous sulfate results in decreased expression of TFRC protein		 CTD PMID:10966897 PMID:16039939 PMID:28993186 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression		 EXP Diltiazem inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Verapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] CTD PMID:27095094 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein] CTD PMID:23692848 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein] CTD PMID:23692848 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion		 ISO
EXP		 ferrous sulfate results in increased expression of TNF mRNA; ferrous sulfate results in increased expression of TNF protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; tetramethylthiourea inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; U 0126 inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]
ferrous sulfate inhibits the reaction [Deferoxamine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]		 CTD PMID:7539275 PMID:15550384 PMID:15963385 PMID:17172471 PMID:19428942 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tradd TNFRSF1A-associated via death domain decreases expression ISO ferrous sulfate results in decreased expression of TRADD mRNA CTD PMID:33554279 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 affects response to substance ISO TRPM5 protein affects the susceptibility to ferrous sulfate CTD PMID:19244541 NCBI chr 1:198,254,956...198,277,824
Ensembl chr 1:198,255,723...198,277,654 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO ferrous sulfate results in increased activity of TRPV1 protein CTD PMID:17567713 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Xcr1 X-C motif chemokine receptor 1 decreases expression ISO ferrous sulfate results in decreased expression of XCR1 mRNA CTD PMID:19428942 NCBI chr 8:123,479,454...123,516,168
Ensembl chr 8:123,479,590...123,487,226 		JBrowse link
iron(3+) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 multiple interactions ISO ferric sulfate inhibits the reaction [Nickel results in increased activity of ACO1 protein] CTD PMID:16877034 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases activity		 EXP Capsaicin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein] CTD PMID:16956363 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 EXP Capsaicin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein] CTD PMID:16956363 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferric sulfate inhibits the reaction [Nickel results in increased stability of HIF1A protein] CTD PMID:16877034 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
iron(III) citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin increases secretion
multiple interactions
increases expression		 ISO ferric citrate results in increased secretion of ALB protein
Alcohols inhibits the reaction [ferric citrate results in increased expression of ALB mRNA]; Alcohols inhibits the reaction [ferric citrate results in increased secretion of ALB protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased secretion of ALB protein]		 CTD PMID:24025710 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression
multiple interactions		 ISO ferric citrate results in increased expression of ALDOB mRNA
Alcohols inhibits the reaction [ferric citrate results in increased expression of ALDOB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALDOB mRNA]		 CTD PMID:24025710 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO ferric citrate results in decreased expression of AQP4 mRNA CTD PMID:29959986 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Car9 carbonic anhydrase 9 decreases expression ISO ferric citrate results in decreased expression of CA9 mRNA CTD PMID:29959986 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO ferric citrate results in decreased expression of CCL2 mRNA CTD PMID:29959986 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression ISO ferric citrate results in decreased expression of CFTR mRNA CTD PMID:29959986 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Crp C-reactive protein increases expression ISO ferric citrate results in increased expression of CRP mRNA CTD PMID:29959986 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 ISO Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP2E1 mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP2E1 mRNA] CTD PMID:24025710 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO ferric citrate results in increased expression of CYP3A4 mRNA; ferric citrate results in increased expression of CYP3A4 protein
Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA]; Alcohols promotes the reaction [ferric citrate results in increased expression of CYP3A4 protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP3A4 mRNA]; ferric citrate promotes the reaction [Alcohols results in increased expression of CYP3A4 protein]		 CTD PMID:24025710 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of DDIT3 mRNA CTD PMID:29959986 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO ferric citrate results in decreased expression of EDN1 mRNA CTD PMID:29959986 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Epo erythropoietin increases expression ISO ferric citrate results in increased expression of EPO mRNA CTD PMID:29959986 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G F10 coagulation factor X decreases activity ISO ferric citrate results in decreased activity of F10 protein CTD PMID:6421970 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin decreases activity ISO ferric citrate results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions		 ISO ferric citrate results in increased expression of FTH1 mRNA
[trigonelline co-treated with ferric citrate] results in increased expression of FTH1 mRNA		 CTD PMID:29959986 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of FTL mRNA CTD PMID:29959986 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO ferric citrate results in increased expression of GCLM mRNA CTD PMID:29959986 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein]		 CTD PMID:16527254 PMID:17015263 PMID:17364964 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ferric citrate results in increased expression of HMOX1 mRNA CTD PMID:29959986 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO ferric citrate results in decreased expression of IL1A mRNA CTD PMID:29959986 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Klk1 kallikrein 1 decreases activity ISO ferric citrate results in decreased activity of KLK1 protein CTD PMID:6421970 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO ferric citrate affects the localization of NFE2L2 protein
trigonelline inhibits the reaction [ferric citrate affects the localization of NFE2L2 protein]		 CTD PMID:29959986 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO ferric citrate results in increased expression of NQO1 mRNA; ferric citrate results in increased expression of NQO1 protein
trigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein]		 CTD PMID:29959986 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferric citrate inhibits the reaction [Deferoxamine results in increased expression of PTGS2 protein] CTD PMID:16527254 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO ferric citrate results in decreased expression of SERPINE1 mRNA CTD PMID:29959986 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO ferric citrate results in increased expression of SQSTM1 mRNA CTD PMID:29959986 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tf transferrin increases expression ISO ferric citrate results in increased expression of TF mRNA CTD PMID:24025710 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions		 ISO ferric citrate results in increased expression of TFRC protein
ferric citrate inhibits the reaction [Quercetin results in increased expression of TFRC protein]		 CTD PMID:17364964 PMID:29959986 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO ferric citrate results in decreased expression of TNF mRNA CTD PMID:29959986 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO ferric citrate results in increased expression of TXNRD1 mRNA CTD PMID:29959986 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
iron(III) nitrilotriacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein] CTD PMID:18385176 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC1 mRNA CTD PMID:18617210 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC2 mRNA CTD PMID:18617210 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC4 mRNA CTD PMID:18617210 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Anxa2 annexin A2 increases expression EXP ferric nitrilotriacetate results in increased expression of ANXA2 mRNA CTD PMID:10854235 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP ferric nitrilotriacetate results in increased expression of BAX mRNA CTD PMID:23208426 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP ferric nitrilotriacetate results in increased expression of BBC3 mRNA CTD PMID:23208426 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bik BCL2-interacting killer increases expression EXP ferric nitrilotriacetate results in increased expression of BIK mRNA CTD PMID:23208426 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296