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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ractopamine
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Accession:CHEBI:82644 term browser browse the term
Definition:A diastereoisomeric mixture of approximately equal amounts of all four possible diastereoisomers of 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol. A beta-adrenergic agonist, it is used (generally as the hydrochloride salt) as a feed additive for use in pigs and other livestock to promote protein deposition, resulting in leaner meat. The R,R diastereoisomer, butopamine, is responsible for most of the leanness-enhancing effects. While use of ractopamine has been banned in over 120 countries including throughout the EU, in the US it used in an estimated 80% of all beef, pork and turkey production.
Synonyms:related_synonym: (+-)-all-rac-p-hydroxy-alpha-({[3-(p-hydroxyphenyl)-1-methylpropyl]amino}methyl)benzyl alcohol;   ractopamina;   ractopaminum
 xref: CAS:97825-25-7
 xref_mesh: MESH:C060897
 xref: PMID:12597381;   PMID:24128546;   PMID:24200573;   PMID:24444392;   PMID:24465573;   PMID:24548851;   PMID:24569651;   PMID:24621596;   PMID:24799633;   PMID:24853343;   PMID:25057027;   Wikipedia:Ractopamine


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ractopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO ractopamine binds to and results in increased activity of ESR1 protein CTD PMID:24928891 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO ractopamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21560
    chemical entity 21558
      chemical substance 12317
        mixture 11155
          diastereoisomeric mixture 433
            ractopamine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 21560
    subatomic particle 21546
      composite particle 21546
        hadron 21546
          baryon 21546
            nucleon 21546
              atomic nucleus 21546
                atom 21546
                  main group element atom 21449
                    main group molecular entity 21449
                      s-block molecular entity 20956
                        hydrogen molecular entity 20881
                          hydrides 20097
                            inorganic hydride 18045
                              pnictogen hydride 18008
                                nitrogen hydride 17827
                                  azane 17724
                                    ammonia 17723
                                      organic amino compound 17722
                                        secondary amino compound 6599
                                          4-(1-hydroxy-2-\{[4-(4-hydroxyphenyl)butan-2-yl]amino\}ethyl)phenol 2
                                            butopamine 2
                                              ractopamine 2
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