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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ractopamine
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Accession:CHEBI:82644 term browser browse the term
Definition:A diastereoisomeric mixture of approximately equal amounts of all four possible diastereoisomers of 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol. A beta-adrenergic agonist, it is used (generally as the hydrochloride salt) as a feed additive for use in pigs and other livestock to promote protein deposition, resulting in leaner meat. The R,R diastereoisomer, butopamine, is responsible for most of the leanness-enhancing effects. While use of ractopamine has been banned in over 120 countries including throughout the EU, in the US it used in an estimated 80% of all beef, pork and turkey production.
Synonyms:related_synonym: (+-)-all-rac-p-hydroxy-alpha-({[3-(p-hydroxyphenyl)-1-methylpropyl]amino}methyl)benzyl alcohol;   ractopamina;   ractopaminum
 xref: CAS:97825-25-7
 xref_mesh: MESH:C060897
 xref: PMID:12597381;   PMID:24128546;   PMID:24200573;   PMID:24444392;   PMID:24465573;   PMID:24548851;   PMID:24569651;   PMID:24621596;   PMID:24799633;   PMID:24853343;   PMID:25057027;   Wikipedia:Ractopamine


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ractopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 multiple interactions EXP ractopamine binds to and results in increased activity of ESR1 protein CTD PMID:24928891 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP ractopamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24382
    chemical entity 24350
      chemical substance 13165
        mixture 11973
          diastereoisomeric mixture 416
            ractopamine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 24382
    subatomic particle 24339
      composite particle 24339
        hadron 24339
          baryon 24339
            nucleon 24339
              atomic nucleus 24339
                atom 24339
                  main group element atom 24188
                    main group molecular entity 24188
                      s-block molecular entity 23442
                        hydrogen molecular entity 23272
                          hydrides 21914
                            inorganic hydride 19149
                              pnictogen hydride 19121
                                nitrogen hydride 18797
                                  azane 18685
                                    ammonia 18684
                                      organic amino compound 18683
                                        secondary amino compound 6657
                                          4-(1-hydroxy-2-\{[4-(4-hydroxyphenyl)butan-2-yl]amino\}ethyl)phenol 2
                                            butopamine 2
                                              ractopamine 2
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