The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An organic heterotricyclic compound that is 3a,4,8,9a-tetrahydro-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione that is substituted at positions 3, 6, and 9a by hexanoyl, (1E)-prop-1-en-1-yl and methyl groups, respectively (the 3S,3aR,9aR diastereoisomer). One of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mould rice), it is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.
monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]
monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]]
monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]] monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]
monascin inhibits the reaction [Ovalbumin results in increased expression of IL6 mRNA]; monascin inhibits the reaction [Ovalbumin results in increased expression of IL6 protein]; monascin inhibits the reaction [Ovalbumin results in increased secretion of IL6 protein]
monascin affects the localization of NFE2L2 protein monascin results in increased expression of NFE2L2 mRNA monascin inhibits the reaction [S100B protein results in decreased expression of NFE2L2 protein]; monascin promotes the reaction [S100B protein affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]] monascin results in increased phosphorylation of NFE2L2 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [monascin results in increased expression of NFE2L2 mRNA]; PPARG mutant form inhibits the reaction [monascin results in increased expression of NFE2L2 mRNA]
monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Tretinoin inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]]
monascin affects the reaction [PPARA protein affects the oxidation of Fatty Acids]; monascin binds to and results in increased activity of PPARA protein monascin results in increased expression of PPARA mRNA
monascin affects the localization of PPARG protein monascin results in decreased phosphorylation of PPARG protein monascin results in increased expression of PPARG protein PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [monascin results in increased expression of NFE2L2 mRNA] PPARG protein results in increased susceptibility to monascin
monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]; monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]; monascin inhibits the reaction [S100B protein results in decreased expression of NFE2L2 protein]; monascin inhibits the reaction [S100B protein results in increased expression of and affects the localization of NCF1 protein]; monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]; monascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein]; monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]; monascin promotes the reaction [S100B protein affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]]
monascin inhibits the reaction [[Ovalbumin co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of TNF protein]; monascin inhibits the reaction [[Ovalbumin co-treated with MK-886] results in increased expression of TNF protein]; monascin inhibits the reaction [Ovalbumin results in increased expression of TNF mRNA]; monascin inhibits the reaction [Ovalbumin results in increased expression of TNF protein]; monascin inhibits the reaction [Ovalbumin results in increased secretion of TNF protein]; monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]] monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]
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