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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Tris(1-aziridinyl)phosphine oxide
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Accession:CHEBI:82546 term browser browse the term
Definition:A phosphoramide that has formula C6H12N3OP.
Synonyms:related_synonym: APO;   Formula=C6H12N3OP;   InChI=1S/C6H12N3OP/c10-11(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2;   InChIKey=FYAMXEPQQLNQDM-UHFFFAOYSA-N;   SMILES=O=P(N1CC1)(N1CC1)N1CC1;   TEPA
 xref: CAS:545-55-1;   KEGG:C19543
 xref_mesh: MESH:D013721


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Tris(1-aziridinyl)phosphine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccs copper chaperone for superoxide dismutase multiple interactions
increases expression		 ISO [cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; Copper Sulfate inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein] CTD PMID:19039664 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects export
affects response to substance		 ISO CYP2B6 gene SNP affects the export of Triethylenephosphoramide
CYP2B6 protein affects the susceptibility to Triethylenephosphoramide		 CTD PMID:19076156 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects export
affects response to substance		 ISO CYP3A4 gene SNP affects the export of Triethylenephosphoramide
CYP3A4 protein affects the susceptibility to Triethylenephosphoramide		 CTD PMID:19076156 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects export
affects response to substance		 ISO CYP3A5 gene SNP affects the export of Triethylenephosphoramide
CYP3A5 protein affects the susceptibility to Triethylenephosphoramide		 CTD PMID:19076156 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects export
affects response to substance		 ISO GSTA1 gene SNP affects the export of Triethylenephosphoramide
GSTA1 protein affects the susceptibility to Triethylenephosphoramide		 CTD PMID:19076156 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects export
affects response to substance		 ISO GSTP1 gene SNP affects the export of Triethylenephosphoramide
GSTP1 protein affects the susceptibility to Triethylenephosphoramide		 CTD PMID:19076156 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:19039664 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpx hemopexin multiple interactions ISO [cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:19039664 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        NMR chemical shift reference compound 17958
          phosphoric acid 11430
            phosphoramide 1058
              Tris(1-aziridinyl)phosphine oxide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      chalcogen 19534
                        oxygen atom 19509
                          oxygen molecular entity 19509
                            hydroxides 19320
                              oxoacid 18744
                                pnictogen oxoacid 13224
                                  phosphorus oxoacid 12429
                                    phosphoric acids 11430
                                      phosphoric acid 11430
                                        phosphoramide 1058
                                          Tris(1-aziridinyl)phosphine oxide 8
paths to the root