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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tris(1-aziridinyl)phosphine oxide
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Accession:CHEBI:82546 term browser browse the term
Definition:A phosphoramide that has formula C6H12N3OP.
Synonyms:related_synonym: APO;   Formula=C6H12N3OP;   InChI=1S/C6H12N3OP/c10-11(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2;   InChIKey=FYAMXEPQQLNQDM-UHFFFAOYSA-N;   SMILES=O=P(N1CC1)(N1CC1)N1CC1;   TEPA
 xref: CAS:545-55-1;   KEGG:C19543
 xref_mesh: MESH:D013721


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Tris(1-aziridinyl)phosphine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccs copper chaperone for superoxide dismutase multiple interactions
increases expression
ISO [cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; Copper Sulfate inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein] CTD PMID:19039664 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects export
affects response to substance
ISO CYP2B6 gene SNP affects the export of Triethylenephosphoramide
CYP2B6 protein affects the susceptibility to Triethylenephosphoramide
CTD PMID:19076156 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects export
affects response to substance
ISO CYP3A4 gene SNP affects the export of Triethylenephosphoramide
CYP3A4 protein affects the susceptibility to Triethylenephosphoramide
CTD PMID:19076156 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects export
affects response to substance
ISO CYP3A5 gene SNP affects the export of Triethylenephosphoramide
CYP3A5 protein affects the susceptibility to Triethylenephosphoramide
CTD PMID:19076156 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects export
affects response to substance
ISO GSTA1 gene SNP affects the export of Triethylenephosphoramide
GSTA1 protein affects the susceptibility to Triethylenephosphoramide
CTD PMID:19076156 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects export
affects response to substance
ISO GSTP1 gene SNP affects the export of Triethylenephosphoramide
GSTP1 protein affects the susceptibility to Triethylenephosphoramide
CTD PMID:19076156 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:19039664 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpx hemopexin multiple interactions ISO [cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:19039664 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        solvent 16539
          phosphoric acid 7952
            phosphoramide 1016
              Tris(1-aziridinyl)phosphine oxide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      chalcogen 19394
                        oxygen atom 19357
                          oxygen molecular entity 19357
                            hydroxides 19080
                              oxoacid 18279
                                pnictogen oxoacid 10309
                                  phosphorus oxoacid 9231
                                    phosphoric acids 7952
                                      phosphoric acid 7952
                                        phosphoramide 1016
                                          Tris(1-aziridinyl)phosphine oxide 8
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