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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Piplartine
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Accession:CHEBI:8241 term browser browse the term
Definition:A cinnamamide that has formula C17H19NO5.
Synonyms:related_synonym: Formula=C17H19NO5;   InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+;   InChIKey=VABYUUZNAVQNPG-BQYQJAHWSA-N;   Piperlongumine;   SMILES=COc1cc(cc(OC)c1OC)\\C=C\\C(=O)N1CCC=CC1=O
 xref: CAS:20069-09-4;   HMDB:HMDB0030341;   KEGG:C10166;   KNApSAcK:C00002066
 xref_mesh: MESH:C479506


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Piplartine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO Piplartine decreases expression of BUB1B mRNA in B cells RGD PMID:23764397 RGD:27372888 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO piplartine results in decreased expression of CCND1 protein CTD PMID:19501152 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO piplartine results in decreased expression of CDK2 protein CTD PMID:19501152 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [piplartine co-treated with Curcumin] results in decreased activity of MAPK1 protein CTD PMID:19501152 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [piplartine co-treated with Curcumin] results in decreased activity of MAPK3 protein CTD PMID:19501152 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
decreases activity
ISO piplartine inhibits the reaction [Curcumin results in increased activity of RAF1 protein]
piplartine results in decreased activity of RAF1 protein
CTD PMID:19501152 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          carbon atom 19630
            organic molecular entity 19630
              olefinic compound 15494
                cinnamic acids 2421
                  cinnamamides 1337
                    Piplartine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                alpha,beta-unsaturated carboxylic acid amide 6702
                                                  enamide 6702
                                                    cinnamamides 1337
                                                      Piplartine 6
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