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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Methylthiouracil
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Accession:CHEBI:82346 term browser browse the term
Definition:A pyrimidone that has formula C5H6N2OS.
Synonyms:related_synonym: 6-Methyl-2-thiouracil;   Formula=C5H6N2OS;   InChI=1S/C5H6N2OS/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9);   InChIKey=HWGBHCRJGXAGEU-UHFFFAOYSA-N;   SMILES=Cc1cc(=O)[nH]c(=S)[nH]1;   thiomecil;   thiothymin
 xref: CAS:56-04-2;   Drug_Central:1773;   KEGG:C19265;   KEGG:D07231
 xref_mesh: MESH:D008779



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Methylthiouracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ADAM17 protein]; Methylthiouracil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein] CTD PMID:26298005 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 mRNA; [Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 protein; rosiglitazone promotes the reaction [[Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 mRNA]; rosiglitazone promotes the reaction [[Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 protein] CTD PMID:21269478 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 mRNA]; Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:26298005 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:26298005 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein] CTD PMID:26298005 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:26298005 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:26298005 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Procr protein C receptor multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PROCR protein modified form]; Methylthiouracil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PROCR protein modified form]; Methylthiouracil inhibits the reaction [TNF protein results in increased expression of PROCR protein modified form] CTD PMID:26298005 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] CTD PMID:26298005 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sele selectin E multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE mRNA]; Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein] CTD PMID:26298005 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein] CTD PMID:26298005 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein] CTD PMID:26298005 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:26298005 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Methylthiouracil inhibits the reaction [TNF protein results in increased expression of PROCR protein modified form] CTD PMID:26298005 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased secretion of TSHB protein] CTD PMID:26298005 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 mRNA]; Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:26298005 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      atom 20054
        nonmetal atom 19945
          nitrogen atom 18932
            nitrogen molecular entity 18932
              organonitrogen compound 18703
                organonitrogen heterocyclic compound 17731
                  diazines 12356
                    pyrimidines 12187
                      pyrimidone 8864
                        Methylthiouracil 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteromonocyclic compound 17145
                                    diazines 12356
                                      pyrimidines 12187
                                        pyrimidone 8864
                                          Methylthiouracil 16
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