CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 3,3'-Dichlorobenzidine
Accession: CHEBI:82315
browse the term
Definition: A monochlorobenzene that has formula C12H10Cl2N2.
Synonyms: related_synonym: Formula=C12H10Cl2N2; InChI=1S/C12H10Cl2N2/c13-9-5-7(1-3-11(9)15)8-2-4-12(16)10(14)6-8/h1-6H,15-16H2; InChIKey=HUWXDEQWWKGHRV-UHFFFAOYSA-N; SMILES=Nc1ccc(cc1Cl)-c1ccc(N)c(Cl)c1
xref: CAS:91-94-1; KEGG:C19225
xref_mesh: MESH:D015101
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Ahr
aryl hydrocarbon receptor
multiple interactions
EXP
3,3'-Dichlorobenzidine binds to and results in decreased activity of AHR protein
CTD
PMID:2555073
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ar
androgen receptor
multiple interactions affects localization
ISO
3,3'-Dichlorobenzidine analog binds to and results in increased activity of AR protein; 3,3'-Dichlorobenzidine binds to and results in decreased activity of AR protein; 3,3'-Dichlorobenzidine inhibits the reaction [Metribolone results in increased activity of AR protein] 3,3'-Dichlorobenzidine analog affects the localization of AR protein
CTD
PMID:15950433 PMID:18324785 PMID:28478275
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Bax
BCL2 associated X, apoptosis regulator
affects expression
ISO
3,3'-Dichlorobenzidine affects the expression of BAX protein
CTD
PMID:24604609
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
affects expression
ISO
3,3'-Dichlorobenzidine affects the expression of BCL2 protein
CTD
PMID:24604609
NCBI chr13:22,689,783...22,853,920
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Casp3
caspase 3
increases activity
ISO
3,3'-Dichlorobenzidine results in increased activity of CASP3 protein
CTD
PMID:24604609
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
ISO
3,3'-Dichlorobenzidine results in increased activity of CASP9 protein
CTD
PMID:24604609
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
increases metabolic processing multiple interactions
ISO EXP
CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine]
CTD
PMID:9310344
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
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Hspa4
heat shock protein family A (Hsp70) member 4
affects expression
ISO
3,3'-Dichlorobenzidine affects the expression of HSPA4 protein
CTD
PMID:24604609
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
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Por
cytochrome p450 oxidoreductase
affects metabolic processing
EXP
POR protein affects the metabolism of 3,3'-Dichlorobenzidine
CTD
PMID:3130202
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ruvbl2
RuvB-like AAA ATPase 2
affects expression
ISO
3,3'-Dichlorobenzidine affects the expression of RUVBL2 protein
CTD
PMID:24604609
NCBI chr 1:95,902,014...95,915,364
Ensembl chr 1:95,901,701...95,915,342
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
affects expression
ISO
3,3'-Dichlorobenzidine affects the expression of YWHAQ protein
CTD
PMID:24604609
NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
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