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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzo[c]phenanthrene
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Accession:CHEBI:82292 term browser browse the term
Definition:An ortho-fused polycyclic arene resulting from the symmetrical fusion of the C1-C2 bonds of two naphthalene units.
Synonyms:related_synonym: 3,4-Benzphenanthrene;   3,4-benzophenanthrene;   BcPh;   Formula=C18H12;   InChI=1S/C18H12/c1-3-7-16-13(5-1)9-11-15-12-10-14-6-2-4-8-17(14)18(15)16/h1-12H;   InChIKey=TUAHORSUHVUKBD-UHFFFAOYSA-N;   SMILES=C12=C3C(=CC=C1C=CC4=C2C=CC=C4)C=CC=C3;   benzo-3,4-phenanthrene;   tetrahelicene
 xref: CAS:195-19-7;   KEGG:C19197
 xref_mesh: MESH:C002615
 xref: PMID:11409939;   PMID:3107851;   PMID:3592667;   PMID:6586652;   Reaxys:1909296;   Wikipedia:Benzo(c)phenanthrene



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benzo[c]phenanthrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased susceptibility to benzo(c)phenanthrene CTD PMID:9168260 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO [CYP1A1 protein co-treated with Trichloroepoxypropane] results in increased metabolism of benzo(c)phenanthrene; EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of benzo(c)phenanthrene]
benzo(c)phenanthrene results in increased expression of CYP1A1 protein
[[benzo(c)phenanthrene results in increased expression of CYP1A1 protein] promotes the reaction [CYP1A1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]] which results in increased chemical synthesis of 9,10-Dimethyl-1,2-benzanthracene analog; [benzo(c)phenanthrene promotes the reaction [CYP1A1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]] which results in increased chemical synthesis of 9,10-Dimethyl-1,2-benzanthracene analog; [CYP1A1 protein co-treated with Trichloroepoxypropane] results in increased metabolism of benzo(c)phenanthrene; EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of benzo(c)phenanthrene]
CYP1A1 protein results in increased activity of benzo(c)phenanthrene
CTD PMID:8961944 PMID:9168260 PMID:15606143 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with Trichloroepoxypropane] results in increased metabolism of benzo(c)phenanthrene; EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benzo(c)phenanthrene] CTD PMID:8961944 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO benzo(c)phenanthrene results in increased expression of CYP1B1 protein
[[benzo(c)phenanthrene results in increased expression of CYP1B1 protein] promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]] which results in increased chemical synthesis of 9,10-Dimethyl-1,2-benzanthracene analog
CTD PMID:9168260 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [benzo(c)phenanthrene binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:23845848 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of benzo(c)phenanthrene]; EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benzo(c)phenanthrene] CTD PMID:8961944 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
multiple interactions
ISO GSTP1 gene polymorphism affects the metabolism of benzo(c)phenanthrene analog
GSTP1 protein affects the metabolism of [benzo(c)phenanthrene co-treated with Glutathione]
CTD PMID:9403173 PMID:9850062 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis ISO benzo(c)phenanthrene analog results in increased mutagenesis of HRAS gene CTD PMID:7955041 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [benzo(c)phenanthrene binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; benzo(c)phenanthrene binds to and results in increased activity of NR1I2 protein CTD PMID:23845848 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        aetiopathogenetic role 19275
          carcinogenic agent 18552
            polycyclic arene 16993
              ortho-fused polycyclic arene 9717
                benzo[c]phenanthrene 9
                  hydroxybenzo[c]phenanthrene + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            organic hydride 18653
                              organic fundamental parent 18653
                                hydrocarbon 18389
                                  cyclic hydrocarbon 17191
                                    arene 17171
                                      polycyclic arene 16993
                                        ortho-fused polycyclic arene 9717
                                          benzo[c]phenanthrene 9
                                            hydroxybenzo[c]phenanthrene + 0
paths to the root