CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Tungsten carbide
Accession: CHEBI:82283
browse the term
Synonyms: related_synonym: WC
xref: CAS:12070-12-1; KEGG:C19183
xref_mesh: MESH:C002802
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Abcb6
ATP binding cassette subfamily B member 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ABCB6 mRNA
CTD
PMID:18078969
NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526
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Adora2b
adenosine A2B receptor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ADORA2B mRNA
CTD
PMID:18078969
NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091
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Ak3
adenylate kinase 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of AK3 mRNA
CTD
PMID:18078969
NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183
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Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA tungsten carbide results in decreased expression of AKR1C1 mRNA
CTD
PMID:20105288
NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of ALDH1A1 mRNA
CTD
PMID:20105288
NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500
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Aldh1l2
aldehyde dehydrogenase 1 family, member L2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of ALDH1L2 mRNA
CTD
PMID:18078969
NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:22,141,842...22,193,398
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Alpk2
alpha-kinase 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of ALPK2 mRNA
CTD
PMID:18078969
NCBI chr18:61,045,717...61,161,703
Ensembl chr18:61,045,380...61,175,985
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Angptl4
angiopoietin-like 4
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of ANGPTL4 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of ANGPTL4 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681
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Apoe
apolipoprotein E
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of APOE mRNA
CTD
PMID:18078969
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
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Aqp9
aquaporin 9
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of AQP9 mRNA
CTD
PMID:18078969
NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240
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Asb2
ankyrin repeat and SOCS box-containing 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of ASB2 mRNA
CTD
PMID:20105288
NCBI chr 6:128,239,550...128,275,833
Ensembl chr 6:128,239,552...128,266,321
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Ascl2
achaete-scute family bHLH transcription factor 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ASCL2 mRNA
CTD
PMID:18078969
NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856
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Asgr1
asialoglycoprotein receptor 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ASGR1 mRNA
CTD
PMID:18078969
NCBI chr10:55,274,299...55,278,323
Ensembl chr10:55,274,706...55,278,322
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Atl1
atlastin GTPase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ATL1 mRNA
CTD
PMID:23052192
NCBI chr 6:94,113,149...94,210,955
Ensembl chr 6:94,112,877...94,211,219
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Atp10b
ATPase phospholipid transporting 10B
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of ATP10B mRNA tungsten carbide results in decreased expression of ATP10B mRNA
CTD
PMID:20105288
NCBI chr10:27,996,729...28,252,801
Ensembl chr10:27,910,295...28,251,450
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BAX mRNA
CTD
PMID:18078969
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bbc3
Bcl-2 binding component 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BBC3 mRNA
CTD
PMID:18078969
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666
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Bnip3
BCL2 interacting protein 3
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of BNIP3 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3 mRNA tungsten carbide results in increased expression of BNIP3 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962
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Bnip3l
BCL2 interacting protein 3 like
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3L mRNA
CTD
PMID:18078969
NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282
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Brf2
BRF2 general transcription factor 3B subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BRF2 mRNA
CTD
PMID:23052192
NCBI chr16:71,626,146...71,635,909
Ensembl chr16:71,623,238...71,635,903
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Ca9
carbonic anhydrase 9
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of CA9 mRNA tungsten carbide results in increased expression of CA9 mRNA
CTD
PMID:20105288
NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626
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Calca
calcitonin-related polypeptide alpha
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CALCA mRNA
CTD
PMID:18078969
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
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Calcb
calcitonin-related polypeptide, beta
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CALCB mRNA
CTD
PMID:23052192
NCBI chr 1:178,399,634...178,404,654
Ensembl chr 1:178,399,785...178,404,654
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Cat
catalase
multiple interactions
ISO
CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]
CTD
PMID:20528745 PMID:23758151
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CCL2 mRNA
CTD
PMID:18078969
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
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Ccl20
C-C motif chemokine ligand 20
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CCL20 mRNA
CTD
PMID:18078969
NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
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Cd300a
Cd300a molecule
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CD300A mRNA
CTD
PMID:18078969
NCBI chr10:100,428,826...100,441,693
Ensembl chr10:100,428,826...100,442,958
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Cdh2
cadherin 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of CDH2 mRNA
CTD
PMID:20105288
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
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Cidec
cell death-inducing DFFA-like effector c
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CIDEC mRNA
CTD
PMID:18078969
NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806
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Clec3a
C-type lectin domain family 3, member A
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of CLEC3A mRNA tungsten carbide results in decreased expression of CLEC3A mRNA
CTD
PMID:20105288
NCBI chr19:59,313,746...59,321,126
Ensembl chr19:59,313,570...59,321,126
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Clec4e
C-type lectin domain family 4, member E
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CLEC4E mRNA
CTD
PMID:18078969
NCBI chr 4:158,292,624...158,298,607
Ensembl chr 4:158,293,311...158,298,467
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Csrp2
cysteine and glycine-rich protein 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CSRP2 mRNA
CTD
PMID:18078969
NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238
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Cst6
cystatin E/M
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of CST6 mRNA
CTD
PMID:20105288
NCBI chr 1:212,084,676...212,086,384
Ensembl chr 1:212,084,676...212,086,384
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Cth
cystathionine gamma-lyase
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CTH mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of CTH mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CYP1B1 mRNA
CTD
PMID:18078969
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
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Dcn
decorin
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of DCN mRNA
CTD
PMID:20105288
NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926
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Ddah2
DDAH family member 2, ADMA-independent
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of DDAH2 mRNA
CTD
PMID:18078969
NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183
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Dmrt2
doublesex and mab-3 related transcription factor 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of DMRT2 mRNA
CTD
PMID:20105288
NCBI chr 1:232,743,935...232,750,431
Ensembl chr 1:232,743,942...232,750,431
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Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of DNAJB4 mRNA
CTD
PMID:23052192
NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042
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Dnajc12
DnaJ heat shock protein family (Hsp40) member C12
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of DNAJC12 mRNA
CTD
PMID:18078969
NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,222,298...25,266,251
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Dpysl4
dihydropyrimidinase-like 4
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of DPYSL4 mRNA
CTD
PMID:18078969
NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523
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Dsg4
desmoglein 4
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of DSG4 mRNA tungsten carbide results in decreased expression of DSG4 mRNA
CTD
PMID:20105288
NCBI chr18:11,995,902...12,032,908
Ensembl chr18:11,995,902...12,032,908
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E2f7
E2F transcription factor 7
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of E2F7 mRNA
CTD
PMID:18078969
NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:48,037,749...48,079,055
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E2f8
E2F transcription factor 8
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of E2F8 mRNA
CTD
PMID:23052192
NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009
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Edn2
endothelin 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of EDN2 mRNA
CTD
PMID:20105288
NCBI chr 5:139,036,576...139,042,074
Ensembl chr 5:139,036,492...139,043,070
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Egln3
egl-9 family hypoxia-inducible factor 3
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of EGLN3 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of EGLN3 mRNA tungsten carbide results in increased expression of EGLN3 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015
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Eno2
enolase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of ENO2 mRNA
CTD
PMID:20105288
NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220
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Fas
Fas cell surface death receptor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FAS mRNA
CTD
PMID:18078969
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
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Faslg
Fas ligand
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FASL mRNA
CTD
PMID:18078969
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
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Fbxw10
F-box and WD repeat domain containing 10
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FBXW10 mRNA
CTD
PMID:23052192
NCBI chr10:48,012,555...48,051,136
Ensembl chr10:47,958,677...48,051,136
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Fdxr
ferredoxin reductase
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FDXR mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr10:101,006,845...101,015,582
Ensembl chr10:101,006,849...101,015,542
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Fmod
fibromodulin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of FMOD mRNA
CTD
PMID:18078969
NCBI chr13:48,045,567...48,056,184
Ensembl chr13:47,990,774...48,056,183
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Fn1
fibronectin 1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of FN1 mRNA
CTD
PMID:20105288
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
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G0s2
G0/G1switch 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of G0S2 mRNA
CTD
PMID:18078969
NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293
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Galk2
galactokinase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of GALK2 mRNA
CTD
PMID:20105288
NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:133,563,538...133,696,528
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Gbe1
1,4-alpha-glucan branching enzyme 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of GBE1 mRNA
CTD
PMID:18078969
NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of GCLM mRNA
CTD
PMID:23052192
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
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Gdf15
growth differentiation factor 15
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which affects the expression of GDF15 mRNA
CTD
PMID:20105288
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022
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Gpi
glucose-6-phosphate isomerase
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of GPI mRNA
CTD
PMID:20105288
NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261
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Gpt2
glutamic--pyruvic transaminase 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of GPT2 mRNA
CTD
PMID:23052192
NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917
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Gpx7
glutathione peroxidase 7
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of GPX7 mRNA
CTD
PMID:20105288
NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:128,372,875...128,381,725
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of and results in increased stability of HIF1A protein
CTD
PMID:23052192
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
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Hk2
hexokinase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of HK2 mRNA
CTD
PMID:20105288
NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275
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Hmox1
heme oxygenase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HMOX1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of HMOX1 protein
CTD
PMID:18078969 PMID:23052192
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HSPA1A mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979
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Hspa1l
heat shock protein family A (Hsp70) member 1 like
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HSPA1L mRNA
CTD
PMID:18078969
NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877
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Htra3
HtrA serine peptidase 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HTRA3 mRNA
CTD
PMID:23052192
NCBI chr14:79,293,535...79,321,936
Ensembl chr14:79,293,541...79,321,936
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Il1b
interleukin 1 beta
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of IL1B mRNA
CTD
PMID:18078969
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il2
interleukin 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of IL2 mRNA
CTD
PMID:18078969
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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Il6
interleukin 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of IL6 mRNA
CTD
PMID:18078969
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Inhba
inhibin subunit beta A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of INHBA mRNA
CTD
PMID:18078969
NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508
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Iqgap2
IQ motif containing GTPase activating protein 2
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of IQGAP2 mRNA tungsten carbide results in decreased expression of IQGAP2 mRNA
CTD
PMID:20105288
NCBI chr 2:28,629,558...28,904,649
Ensembl chr 2:28,629,558...28,904,649
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Isx
intestine-specific homeobox
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of ISX mRNA tungsten carbide results in decreased expression of ISX mRNA
CTD
PMID:20105288
NCBI chr19:13,222,834...13,245,506
Ensembl chr19:13,223,385...13,245,501
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Itgb8
integrin subunit beta 8
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of ITGB8 mRNA
CTD
PMID:18078969
NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:146,165,484...146,351,245
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein]
CTD
PMID:19747498
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
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Krt1
keratin 1
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNA tungsten carbide results in decreased expression of KRT1 mRNA
CTD
PMID:20105288
NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537
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Lamp3
lysosomal-associated membrane protein 3
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of LAMP3 mRNA
CTD
PMID:20105288
NCBI chr11:94,657,817...94,726,451
Ensembl chr11:94,661,399...94,726,195
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Loxl2
lysyl oxidase-like 2
increases expression multiple interactions
ISO
tungsten carbide results in increased expression of LOXL2 mRNA [tungsten carbide binds to Cobalt] which results in increased expression of LOXL2 mRNA
CTD
PMID:20105288
NCBI chr15:51,091,547...51,182,843
Ensembl chr15:51,069,997...51,182,842
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Lratd2
LRAT domain containing 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of LRATD2 mRNA
CTD
PMID:18078969
NCBI chr 7:94,270,753...94,276,445
Ensembl chr 7:94,073,513...94,277,046
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Lyz2
lysozyme 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of LYZ mRNA
CTD
PMID:18078969
NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011
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Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of MAGI2 mRNA tungsten carbide results in decreased expression of MAGI2 mRNA
CTD
PMID:20105288
NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:15,278,518...16,762,199
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Mal
mal, T-cell differentiation protein
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of MAL mRNA tungsten carbide results in decreased expression of MAL mRNA
CTD
PMID:20105288
NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD
PMID:19747498
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD
PMID:19747498
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Met
MET proto-oncogene, receptor tyrosine kinase
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of MET mRNA
CTD
PMID:18078969
NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821
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Mif
macrophage migration inhibitory factor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of MIF mRNA
CTD
PMID:18078969
NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121 Ensembl chr20:134,041,774...134,042,121
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Mir21
microRNA 21
multiple interactions
ISO
[tungsten carbide analog co-treated with Cobalt analog] results in increased expression of MIR21 mRNA
CTD
PMID:23758151
NCBI chr10:71,902,600...71,902,691
G
Mmp1
matrix metallopeptidase 1
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of MMP1 mRNA tungsten carbide results in decreased expression of MMP1 mRNA
CTD
PMID:20105288
NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of MMP9 mRNA
CTD
PMID:18078969
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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Mt3
metallothionein 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of MT3 mRNA
CTD
PMID:18078969
NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080
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Nap1l2
nucleosome assembly protein 1-like 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NAP1L2 mRNA
CTD
PMID:23052192
NCBI chr X:72,239,849...72,242,247
Ensembl chr X:72,238,310...72,242,464
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein; CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]
CTD
PMID:20528745
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA
CTD
PMID:18078969
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
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Nol3
nucleolar protein 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NOL3 mRNA
CTD
PMID:18078969
NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NQO1 mRNA [[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]
CTD
PMID:20528745 PMID:23052192
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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Nupr1
nuclear protein 1, transcriptional regulator
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NUPR1 mRNA
CTD
PMID:18078969
NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
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Olfm4
olfactomedin 4
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of OLFM4 mRNA tungsten carbide results in decreased expression of OLFM4 mRNA
CTD
PMID:20105288
NCBI chr15:61,790,889...61,838,773
Ensembl chr15:61,671,271...61,838,764
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Orc6
origin recognition complex, subunit 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ORC6 mRNA
CTD
PMID:23052192
NCBI chr19:37,931,085...37,938,856
Ensembl chr19:37,931,090...37,938,856
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Osbpl6
oxysterol binding protein-like 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of OSBPL6 mRNA
CTD
PMID:18078969
NCBI chr 3:81,751,020...81,948,186
Ensembl chr 3:81,750,982...81,946,615
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Osm
oncostatin M
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of OSM mRNA
CTD
PMID:18078969
NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827
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Pdcd4
programmed cell death 4
multiple interactions
ISO
[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein; Acetylcysteine inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]; CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]; U 0126 inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]
CTD
PMID:23758151
NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189
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Pdk1
pyruvate dehydrogenase kinase 1
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PDK1 mRNA tungsten carbide results in increased expression of PDK1 mRNA
CTD
PMID:20105288
NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145
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Perp
p53 apoptosis effector related to PMP22
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of PERP mRNA
CTD
PMID:18078969
NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:15,361,778...15,374,687
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Pfkfb4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PFKFB4 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of PFKFB4 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468
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Phlda3
pleckstrin homology-like domain, family A, member 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of PHLDA3 mRNA
CTD
PMID:23052192
NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621
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Pir
pirin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of PIR mRNA
CTD
PMID:23052192
NCBI chr X:33,740,428...33,851,049
Ensembl chr X:33,740,429...33,851,049
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Pla2g7
phospholipase A2 group VII
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of PLA2G7 mRNA
CTD
PMID:18078969
NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747
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Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PLOD2 mRNA
CTD
PMID:20105288
NCBI chr 8:101,964,318...102,047,022
Ensembl chr 8:101,964,318...102,047,022
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Ppfia4
PTPRF interacting protein alpha 4
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PPFIA4 mRNA tungsten carbide results in increased expression of PPFIA4 mRNA
CTD
PMID:20105288
NCBI chr13:48,305,844...48,354,329
Ensembl chr13:48,305,848...48,354,279
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Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PPP1R3C mRNA
CTD
PMID:20105288
NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835
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Pros1
protein S
decreases expression multiple interactions
ISO
tungsten carbide results in decreased expression of PROS1 mRNA [tungsten carbide binds to Cobalt] which results in decreased expression of PROS1 mRNA
CTD
PMID:20105288
NCBI chr11:13,676,310...13,757,858
Ensembl chr11:13,676,769...13,757,852
G
Psat1
phosphoserine aminotransferase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of PSAT1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of PSAT1 mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PTGS2 mRNA; [tungsten carbide co-treated with Cobalt] results in decreased expression of PTGS2 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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Ptprz1
protein tyrosine phosphatase, receptor type Z1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of PTPRZ1 mRNA
CTD
PMID:20105288
NCBI chr 4:52,363,006...52,560,905
Ensembl chr 4:52,363,295...52,560,903
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of RELA protein
CTD
PMID:19747498
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Rgs3
regulator of G-protein signaling 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RGS3 mRNA
CTD
PMID:23052192
NCBI chr 5:81,037,588...81,177,446
Ensembl chr 5:81,056,068...81,177,445
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Rimkla
ribosomal modification protein rimK-like family member A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RIMKLA mRNA
CTD
PMID:18078969
NCBI chr 5:138,357,463...138,384,132
Ensembl chr 5:138,359,743...138,384,060
G
Ripk2
receptor-interacting serine-threonine kinase 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of RIPK2 mRNA
CTD
PMID:18078969
NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663
G
Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RRAD mRNA
CTD
PMID:18078969
NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871
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Rrm2
ribonucleotide reductase regulatory subunit M2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA
CTD
PMID:23052192
NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370
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RT1-DMb
RT1 class II, locus DMb
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of HLA-DMB mRNA
CTD
PMID:20105288
NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,695,010...4,702,246
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RT1-Ha
RT1 class II, locus Ha
decreases expression
ISO
tungsten carbide results in decreased expression of HLA-DPA1 mRNA
CTD
PMID:20105288
NCBI chr20:4,762,425...4,772,439
Ensembl chr20:4,763,033...4,772,141
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Runx1
RUNX family transcription factor 1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNA
CTD
PMID:20105288
NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925
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S100b
S100 calcium binding protein B
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of S100B mRNA
CTD
PMID:18078969
NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081
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Sash1
SAM and SH3 domain containing 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SASH1 mRNA
CTD
PMID:18078969
NCBI chr 1:4,940,207...5,238,777
Ensembl chr 1:4,940,207...5,238,530
G
Sgk1
serum/glucocorticoid regulated kinase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SGK1 mRNA
CTD
PMID:18078969
NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231
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Sirt1
sirtuin 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA
CTD
PMID:18078969
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
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Slc1a2
solute carrier family 1 member 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SLC1A2 mRNA
CTD
PMID:18078969
NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249
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Smpdl3a
sphingomyelin phosphodiesterase, acid-like 3A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SMPDL3A mRNA
CTD
PMID:18078969
NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260
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Sorcs3
sortilin-related VPS10 domain containing receptor 3
affects expression
ISO
tungsten carbide affects the expression of SORCS3 mRNA
CTD
PMID:20105288
NCBI chr 1:257,040,442...257,675,259
Ensembl chr 1:257,040,473...257,675,259
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Sox2
SRY-box transcription factor 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of SOX2 mRNA
CTD
PMID:20105288
NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350
G
Spp1
secreted phosphoprotein 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of SPP1 mRNA
CTD
PMID:18078969
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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Sqstm1
sequestosome 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of SQSTM1 mRNA
CTD
PMID:18078969
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
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Taf9b
TATA-box binding protein associated factor 9b
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of TAF9B mRNA
CTD
PMID:20105288
NCBI chr X:75,354,823...75,366,166
Ensembl chr X:75,354,825...75,366,414
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Thbd
thrombomodulin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of THBD mRNA
CTD
PMID:18078969
NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582
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Tlr2
toll-like receptor 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA
CTD
PMID:18078969
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
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Tmem45a
transmembrane protein 45A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TMEM45A mRNA
CTD
PMID:18078969
NCBI chr11:57,181,686...57,268,630
Ensembl chr11:57,182,785...57,282,722
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Tnf
tumor necrosis factor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TNF mRNA
CTD
PMID:18078969
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
G
Tnfaip3
TNF alpha induced protein 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TNFAIP3 mRNA
CTD
PMID:18078969
NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979
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Tnfaip6
TNF alpha induced protein 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of TNFAIP6 mRNA
CTD
PMID:18078969
NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796
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Tnfsf12
TNF superfamily member 12
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of TNFSF12 mRNA
CTD
PMID:18078969
NCBI chr10:54,902,616...54,912,628
Ensembl chr10:54,902,616...54,911,913
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Tp53
tumor protein p53
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of and results in increased stability of TP53 protein
CTD
PMID:23052192
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
G
Triap1
TP53 regulated inhibitor of apoptosis 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TRIAP1 mRNA
CTD
PMID:18078969
NCBI chr12:46,928,273...46,930,766
Ensembl chr12:46,928,273...46,930,766
G
Tsga10
testis specific 10
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TSGA10 mRNA
CTD
PMID:18078969
NCBI chr 9:47,487,007...47,594,201
Ensembl chr 9:47,487,007...47,593,980
G
Ttll7
tubulin tyrosine ligase like 7
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of TTLL7 mRNA tungsten carbide results in decreased expression of TTLL7 mRNA
CTD
PMID:20105288
NCBI chr 2:238,425,786...238,549,296
Ensembl chr 2:238,426,076...238,545,960
G
Txnrd1
thioredoxin reductase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TXNRD1 mRNA
CTD
PMID:23052192
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
G
Uchl1
ubiquitin C-terminal hydrolase L1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of UCHL1 mRNA
CTD
PMID:23052192
NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417
G
Vasn
vasorin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of VASN mRNA
CTD
PMID:23052192
NCBI chr10:11,424,174...11,434,681
Ensembl chr10:11,417,327...11,450,704
G
Vldlr
very low density lipoprotein receptor
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of VLDLR mRNA
CTD
PMID:20105288
NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154
G
Vwce
von Willebrand factor C and EGF domains
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of VWCE mRNA
CTD
PMID:18078969
NCBI chr 1:216,703,742...216,753,284
Ensembl chr 1:216,707,351...216,738,337
G
Wdr64
WD repeat domain 64
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of WDR64 mRNA
CTD
PMID:20105288
NCBI chr13:90,156,824...90,280,608
Ensembl chr13:90,156,862...90,279,233
G
Zfand2a
zinc finger AN1-type containing 2A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ZFAND2A mRNA
CTD
PMID:23052192
NCBI chr12:20,275,435...20,286,513
Ensembl chr12:20,275,450...20,286,513
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