CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Tungsten carbide
Accession: CHEBI:82283
browse the term
Synonyms: related_synonym: WC
xref: CAS:12070-12-1; KEGG:C19183
xref_mesh: MESH:C002802
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Abcb6
ATP binding cassette subfamily B member 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ABCB6 mRNA
CTD
PMID:18078969
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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Adora2b
adenosine A2B receptor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ADORA2B mRNA
CTD
PMID:18078969
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Ak3
adenylate kinase 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of AK3 mRNA
CTD
PMID:18078969
NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
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Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA tungsten carbide results in decreased expression of AKR1C1 mRNA
CTD
PMID:20105288
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of ALDH1A1 mRNA
CTD
PMID:20105288
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh1l2
aldehyde dehydrogenase 1 family, member L2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of ALDH1L2 mRNA
CTD
PMID:18078969
NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776
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Alpk2
alpha-kinase 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of ALPK2 mRNA
CTD
PMID:18078969
NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258
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Angptl4
angiopoietin-like 4
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of ANGPTL4 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of ANGPTL4 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Apoe
apolipoprotein E
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of APOE mRNA
CTD
PMID:18078969
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Aqp9
aquaporin 9
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of AQP9 mRNA
CTD
PMID:18078969
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Asb2
ankyrin repeat and SOCS box-containing 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of ASB2 mRNA
CTD
PMID:20105288
NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854
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Ascl2
achaete-scute family bHLH transcription factor 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ASCL2 mRNA
CTD
PMID:18078969
NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406
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Asgr1
asialoglycoprotein receptor 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ASGR1 mRNA
CTD
PMID:18078969
NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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Atl1
atlastin GTPase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ATL1 mRNA
CTD
PMID:23052192
NCBI chr 6:88,377,168...88,475,242
Ensembl chr 6:88,377,239...88,475,204
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Atp10b
ATPase phospholipid transporting 10B
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of ATP10B mRNA tungsten carbide results in decreased expression of ATP10B mRNA
CTD
PMID:20105288
NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BAX mRNA
CTD
PMID:18078969
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbc3
Bcl-2 binding component 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BBC3 mRNA
CTD
PMID:18078969
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Bnip3
BCL2 interacting protein 3
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of BNIP3 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3 mRNA tungsten carbide results in increased expression of BNIP3 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Bnip3l
BCL2 interacting protein 3 like
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3L mRNA
CTD
PMID:18078969
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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Brf2
BRF2, RNA polymerase III transcription initiation factor subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of BRF2 mRNA
CTD
PMID:23052192
NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059
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Calca
calcitonin-related polypeptide alpha
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CALCA mRNA
CTD
PMID:18078969
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Calcb
calcitonin-related polypeptide, beta
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CALCB mRNA
CTD
PMID:23052192
NCBI chr 1:168,965,383...168,970,259
Ensembl chr 1:168,966,465...168,970,125
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Car9
carbonic anhydrase 9
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of CA9 mRNA tungsten carbide results in increased expression of CA9 mRNA
CTD
PMID:20105288
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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Cat
catalase
multiple interactions
ISO
CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]
CTD
PMID:20528745 PMID:23758151
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CCL2 mRNA
CTD
PMID:18078969
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CCL20 mRNA
CTD
PMID:18078969
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Cd300a
Cd300a molecule
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CD300A mRNA
CTD
PMID:18078969
NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
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Cdh2
cadherin 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of CDH2 mRNA
CTD
PMID:20105288
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cidec
cell death-inducing DFFA-like effector c
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CIDEC mRNA
CTD
PMID:18078969
NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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Clec3a
C-type lectin domain family 3, member A
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of CLEC3A mRNA tungsten carbide results in decreased expression of CLEC3A mRNA
CTD
PMID:20105288
NCBI chr19:42,404,628...42,412,008
Ensembl chr19:42,404,628...42,412,008
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Clec4e
C-type lectin domain family 4, member E
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CLEC4E mRNA
CTD
PMID:18078969
NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767
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Csrp2
cysteine and glycine-rich protein 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of CSRP2 mRNA
CTD
PMID:18078969
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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Cst6
cystatin E/M
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of CST6 mRNA
CTD
PMID:20105288
NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030
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Cth
cystathionine gamma-lyase
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CTH mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of CTH mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of CYP1B1 mRNA
CTD
PMID:18078969
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Dcn
decorin
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of DCN mRNA
CTD
PMID:20105288
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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Ddah2
DDAH family member 2, ADMA-independent
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of DDAH2 mRNA
CTD
PMID:18078969
NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
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Dmrt2
doublesex and mab-3 related transcription factor 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of DMRT2 mRNA
CTD
PMID:20105288
NCBI chr 1:223,317,543...223,324,131
Ensembl chr 1:223,317,642...223,324,131
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Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of DNAJB4 mRNA
CTD
PMID:23052192
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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Dnajc12
DnaJ heat shock protein family (Hsp40) member C12
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of DNAJC12 mRNA
CTD
PMID:18078969
NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
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Dpysl4
dihydropyrimidinase-like 4
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of DPYSL4 mRNA
CTD
PMID:18078969
NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
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Dsg4
desmoglein 4
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of DSG4 mRNA tungsten carbide results in decreased expression of DSG4 mRNA
CTD
PMID:20105288
NCBI chr18:11,720,844...11,757,927
Ensembl chr18:11,720,975...11,756,234
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E2f7
E2F transcription factor 7
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of E2F7 mRNA
CTD
PMID:18078969
NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
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E2f8
E2F transcription factor 8
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of E2F8 mRNA
CTD
PMID:23052192
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
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Edn2
endothelin 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of EDN2 mRNA
CTD
PMID:20105288
NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
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Egln3
egl-9 family hypoxia-inducible factor 3
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of EGLN3 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of EGLN3 mRNA tungsten carbide results in increased expression of EGLN3 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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Eno2
enolase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of ENO2 mRNA
CTD
PMID:20105288
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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Fas
Fas cell surface death receptor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FAS mRNA
CTD
PMID:18078969
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FASL mRNA
CTD
PMID:18078969
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fbxw10
F-box and WD repeat domain containing 10
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FBXW10 mRNA
CTD
PMID:23052192
NCBI chr10:47,513,313...47,551,909
Ensembl chr10:47,486,297...47,551,907
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Fdxr
ferredoxin reductase
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of FDXR mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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Fmod
fibromodulin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of FMOD mRNA
CTD
PMID:18078969
NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
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Fn1
fibronectin 1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of FN1 mRNA
CTD
PMID:20105288
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G0s2
G0/G1switch 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of G0S2 mRNA
CTD
PMID:18078969
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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Galk2
galactokinase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of GALK2 mRNA
CTD
PMID:20105288
NCBI chr 3:113,110,057...113,243,014
Ensembl chr 3:113,110,030...113,233,306
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Gbe1
1,4-alpha-glucan branching enzyme 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of GBE1 mRNA
CTD
PMID:18078969
NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of GCLM mRNA
CTD
PMID:23052192
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Gdf15
growth differentiation factor 15
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which affects the expression of GDF15 mRNA
CTD
PMID:20105288
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gpi
glucose-6-phosphate isomerase
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of GPI mRNA
CTD
PMID:20105288
NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
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Gpt2
glutamic--pyruvic transaminase 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of GPT2 mRNA
CTD
PMID:23052192
NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
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Gpx7
glutathione peroxidase 7
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of GPX7 mRNA
CTD
PMID:20105288
NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of and results in increased stability of HIF1A protein
CTD
PMID:23052192
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hk2
hexokinase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of HK2 mRNA
CTD
PMID:20105288
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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Hmox1
heme oxygenase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HMOX1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of HMOX1 protein
CTD
PMID:18078969 PMID:23052192
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HSPA1A mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa1l
heat shock protein family A (Hsp70) member 1 like
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HSPA1L mRNA
CTD
PMID:18078969
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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Htra3
HtrA serine peptidase 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of HTRA3 mRNA
CTD
PMID:23052192
NCBI chr14:75,068,917...75,097,315
Ensembl chr14:75,068,917...75,097,315
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Il1b
interleukin 1 beta
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of IL1B mRNA
CTD
PMID:18078969
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of IL2 mRNA
CTD
PMID:18078969
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il6
interleukin 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of IL6 mRNA
CTD
PMID:18078969
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inhba
inhibin subunit beta A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of INHBA mRNA
CTD
PMID:18078969
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Iqgap2
IQ motif containing GTPase activating protein 2
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of IQGAP2 mRNA tungsten carbide results in decreased expression of IQGAP2 mRNA
CTD
PMID:20105288
NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
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Isx
intestine-specific homeobox
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of ISX mRNA tungsten carbide results in decreased expression of ISX mRNA
CTD
PMID:20105288
NCBI chr19:13,217,637...13,239,754
Ensembl chr19:13,218,552...13,239,760
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Itgb8
integrin subunit beta 8
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of ITGB8 mRNA
CTD
PMID:18078969
NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein]
CTD
PMID:19747498
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Krt1
keratin 1
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNA tungsten carbide results in decreased expression of KRT1 mRNA
CTD
PMID:20105288
NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
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Lamp3
lysosomal-associated membrane protein 3
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of LAMP3 mRNA
CTD
PMID:20105288
NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784
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Loxl2
lysyl oxidase-like 2
increases expression multiple interactions
ISO
tungsten carbide results in increased expression of LOXL2 mRNA [tungsten carbide binds to Cobalt] which results in increased expression of LOXL2 mRNA
CTD
PMID:20105288
NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067
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Lratd2
LRAT domain containing 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of LRATD2 mRNA
CTD
PMID:18078969
NCBI chr 7:92,376,713...92,387,045
Ensembl chr 7:92,362,194...92,388,189
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Lyz2
lysozyme 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of LYZ mRNA
CTD
PMID:18078969
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of MAGI2 mRNA tungsten carbide results in decreased expression of MAGI2 mRNA
CTD
PMID:20105288
NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240
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Mal
mal, T-cell differentiation protein
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of MAL mRNA tungsten carbide results in decreased expression of MAL mRNA
CTD
PMID:20105288
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD
PMID:19747498
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD
PMID:19747498
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Met
MET proto-oncogene, receptor tyrosine kinase
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of MET mRNA
CTD
PMID:18078969
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mif
macrophage migration inhibitory factor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of MIF mRNA
CTD
PMID:18078969
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
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Mir21
microRNA 21
multiple interactions
ISO
[tungsten carbide analog co-treated with Cobalt analog] results in increased expression of MIR21 mRNA
CTD
PMID:23758151
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Mmp1
matrix metallopeptidase 1
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of MMP1 mRNA tungsten carbide results in decreased expression of MMP1 mRNA
CTD
PMID:20105288
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of MMP9 mRNA
CTD
PMID:18078969
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mt3
metallothionein 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of MT3 mRNA
CTD
PMID:18078969
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Nap1l2
nucleosome assembly protein 1-like 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NAP1L2 mRNA
CTD
PMID:23052192
NCBI chr X:68,174,051...68,176,449
Ensembl chr X:68,173,987...68,176,666
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein; CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]
CTD
PMID:20528745
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA
CTD
PMID:18078969
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nol3
nucleolar protein 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NOL3 mRNA
CTD
PMID:18078969
NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NQO1 mRNA [[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]
CTD
PMID:20528745 PMID:23052192
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nupr1
nuclear protein 1, transcriptional regulator
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of NUPR1 mRNA
CTD
PMID:18078969
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Olfm4
olfactomedin 4
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of OLFM4 mRNA tungsten carbide results in decreased expression of OLFM4 mRNA
CTD
PMID:20105288
NCBI chr15:55,385,100...55,429,687
Ensembl chr15:55,407,148...55,429,681
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Orc6
origin recognition complex, subunit 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ORC6 mRNA
CTD
PMID:23052192
NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662
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Osbpl6
oxysterol binding protein-like 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of OSBPL6 mRNA
CTD
PMID:18078969
NCBI chr 3:61,343,776...61,541,170
Ensembl chr 3:61,343,809...61,537,102
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Osm
oncostatin M
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of OSM mRNA
CTD
PMID:18078969
NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
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Pdcd4
programmed cell death 4
multiple interactions
ISO
[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein; Acetylcysteine inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]; CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]; U 0126 inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]
CTD
PMID:23758151
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pdk1
pyruvate dehydrogenase kinase 1
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PDK1 mRNA tungsten carbide results in increased expression of PDK1 mRNA
CTD
PMID:20105288
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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Perp
p53 apoptosis effector related to PMP22
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of PERP mRNA
CTD
PMID:18078969
NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
G
Pfkfb4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PFKFB4 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of PFKFB4 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
G
Phlda3
pleckstrin homology-like domain, family A, member 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of PHLDA3 mRNA
CTD
PMID:23052192
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Pir
pirin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of PIR mRNA
CTD
PMID:23052192
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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Pla2g7
phospholipase A2 group VII
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of PLA2G7 mRNA
CTD
PMID:18078969
NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
G
Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PLOD2 mRNA
CTD
PMID:20105288
NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
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Ppfia4
PTPRF interacting protein alpha 4
multiple interactions increases expression
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PPFIA4 mRNA tungsten carbide results in increased expression of PPFIA4 mRNA
CTD
PMID:20105288
NCBI chr13:45,753,827...45,802,305
Ensembl chr13:45,753,827...45,802,261
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Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PPP1R3C mRNA
CTD
PMID:20105288
NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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Pros1
protein S
decreases expression multiple interactions
ISO
tungsten carbide results in decreased expression of PROS1 mRNA [tungsten carbide binds to Cobalt] which results in decreased expression of PROS1 mRNA
CTD
PMID:20105288
NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
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Psat1
phosphoserine aminotransferase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of PSAT1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of PSAT1 mRNA
CTD
PMID:18078969 PMID:23052192
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of PTGS2 mRNA; [tungsten carbide co-treated with Cobalt] results in decreased expression of PTGS2 mRNA
CTD
PMID:18078969 PMID:20105288
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Ptprz1
protein tyrosine phosphatase, receptor type Z1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of PTPRZ1 mRNA
CTD
PMID:20105288
NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of RELA protein
CTD
PMID:19747498
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rgs3
regulator of G-protein signaling 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RGS3 mRNA
CTD
PMID:23052192
NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
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Rimkla
ribosomal modification protein rimK-like family member A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RIMKLA mRNA
CTD
PMID:18078969
NCBI chr 5:133,072,179...133,098,840
Ensembl chr 5:133,073,960...133,098,792
G
Ripk2
receptor-interacting serine-threonine kinase 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of RIPK2 mRNA
CTD
PMID:18078969
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
G
Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RRAD mRNA
CTD
PMID:18078969
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
G
Rrm2
ribonucleotide reductase regulatory subunit M2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA
CTD
PMID:23052192
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
G
RT1-DMb
RT1 class II, locus DMb
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of HLA-DMB mRNA
CTD
PMID:20105288
NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
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RT1-Ha
RT1 class II, locus Ha
decreases expression
ISO
tungsten carbide results in decreased expression of HLA-DPA1 mRNA
CTD
PMID:20105288
NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244
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Runx1
RUNX family transcription factor 1
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNA
CTD
PMID:20105288
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
G
S100b
S100 calcium binding protein B
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of S100B mRNA
CTD
PMID:18078969
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
G
Sash1
SAM and SH3 domain containing 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SASH1 mRNA
CTD
PMID:18078969
NCBI chr 1:3,119,915...3,418,536
Ensembl chr 1:3,121,332...3,439,870
G
Sgk1
serum/glucocorticoid regulated kinase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SGK1 mRNA
CTD
PMID:18078969
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Sirt1
sirtuin 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA
CTD
PMID:18078969
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc1a2
solute carrier family 1 member 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SLC1A2 mRNA
CTD
PMID:18078969
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
G
Smpdl3a
sphingomyelin phosphodiesterase, acid-like 3A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of SMPDL3A mRNA
CTD
PMID:18078969
NCBI chr20:37,132,592...37,155,567
Ensembl chr20:37,132,592...37,155,567
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Sorcs3
sortilin-related VPS10 domain containing receptor 3
affects expression
ISO
tungsten carbide affects the expression of SORCS3 mRNA
CTD
PMID:20105288
NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:247,099,408...247,734,027
G
Sox2
SRY-box transcription factor 2
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of SOX2 mRNA
CTD
PMID:20105288
NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
G
Spp1
secreted phosphoprotein 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of SPP1 mRNA
CTD
PMID:18078969
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Sqstm1
sequestosome 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of SQSTM1 mRNA
CTD
PMID:18078969
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Taf9b
TATA-box binding protein associated factor 9b
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of TAF9B mRNA
CTD
PMID:20105288
NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604
G
Thbd
thrombomodulin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of THBD mRNA
CTD
PMID:18078969
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
G
Tlr2
toll-like receptor 2
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA
CTD
PMID:18078969
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tmem45a
transmembrane protein 45A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TMEM45A mRNA
CTD
PMID:18078969
NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526
G
Tnf
tumor necrosis factor
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TNF mRNA
CTD
PMID:18078969
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip3
TNF alpha induced protein 3
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TNFAIP3 mRNA
CTD
PMID:18078969
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Tnfaip6
TNF alpha induced protein 6
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of TNFAIP6 mRNA
CTD
PMID:18078969
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Tnfsf12
TNF superfamily member 12
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in decreased expression of TNFSF12 mRNA
CTD
PMID:18078969
NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
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Tp53
tumor protein p53
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of and results in increased stability of TP53 protein
CTD
PMID:23052192
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Triap1
TP53 regulated inhibitor of apoptosis 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TRIAP1 mRNA
CTD
PMID:18078969
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
G
Tsga10
testis specific 10
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TSGA10 mRNA
CTD
PMID:18078969
NCBI chr 9:39,991,203...40,098,259
Ensembl chr 9:39,991,830...40,098,232
G
Ttll7
tubulin tyrosine ligase like 7
multiple interactions decreases expression
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of TTLL7 mRNA tungsten carbide results in decreased expression of TTLL7 mRNA
CTD
PMID:20105288
NCBI chr 2:235,765,786...235,889,047
Ensembl chr 2:235,765,835...235,885,047
G
Txnrd1
thioredoxin reductase 1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of TXNRD1 mRNA
CTD
PMID:23052192
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
G
Uchl1
ubiquitin C-terminal hydrolase L1
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of UCHL1 mRNA
CTD
PMID:23052192
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
G
Vasn
vasorin
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of VASN mRNA
CTD
PMID:23052192
NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357
G
Vldlr
very low density lipoprotein receptor
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in increased expression of VLDLR mRNA
CTD
PMID:20105288
NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
G
Vwce
von Willebrand factor C and EGF domains
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of VWCE mRNA
CTD
PMID:18078969
NCBI chr 1:207,280,714...207,327,215
Ensembl chr 1:207,282,356...207,312,986
G
Wdr64
WD repeat domain 64
multiple interactions
ISO
[tungsten carbide binds to Cobalt] which results in decreased expression of WDR64 mRNA
CTD
PMID:20105288
NCBI chr13:87,624,588...87,746,749
Ensembl chr13:87,624,607...87,747,327
G
Zfand2a
zinc finger AN1-type containing 2A
multiple interactions
ISO
[tungsten carbide co-treated with Cobalt] results in increased expression of ZFAND2A mRNA
CTD
PMID:23052192
NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all