Tungsten carbide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Tungsten carbide	go back to main search page
Accession:	CHEBI:82283	browse the term
Synonyms:	related_synonym:	WC
	xref:	CAS:12070-12-1; KEGG:C19183
	xref_mesh:	MESH:C002802

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Rat (152 ) Mouse (152 ) Human (156 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (152)

Tungsten carbide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 6

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of ABCB6 mRNA

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

adenosine A2B receptor

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of ADORA2B mRNA

NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091

G

adenylate kinase 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of AK3 mRNA

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

aldo-keto reductase family 1, member C1

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA
tungsten carbide results in decreased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member L2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of ALDH1L2 mRNA

NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:22,141,842...22,193,398

G

alpha-kinase 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of ALPK2 mRNA

NCBI chr18:61,045,717...61,161,703
Ensembl chr18:61,045,380...61,175,985

G

angiopoietin-like 4

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of ANGPTL4 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of ANGPTL4 mRNA

PMID:18078969 PMID:20105288

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

apolipoprotein E

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

aquaporin 9

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

ankyrin repeat and SOCS box-containing 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of ASB2 mRNA

NCBI chr 6:128,239,550...128,275,833
Ensembl chr 6:128,239,552...128,266,321

G

achaete-scute family bHLH transcription factor 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of ASCL2 mRNA

NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856

G

asialoglycoprotein receptor 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of ASGR1 mRNA

NCBI chr10:55,274,299...55,278,323
Ensembl chr10:55,274,706...55,278,322

G

atlastin GTPase 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of ATL1 mRNA

NCBI chr 6:94,113,149...94,210,955
Ensembl chr 6:94,112,877...94,211,219

G

ATPase phospholipid transporting 10B

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of ATP10B mRNA
tungsten carbide results in decreased expression of ATP10B mRNA

NCBI chr10:27,996,729...28,252,801
Ensembl chr10:27,910,295...28,251,450

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

BCL2 interacting protein 3

multiple interactions
increases expression

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of BNIP3 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3 mRNA
tungsten carbide results in increased expression of BNIP3 mRNA

PMID:18078969 PMID:20105288

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BCL2 interacting protein 3 like

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

BRF2 general transcription factor 3B subunit

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of BRF2 mRNA

NCBI chr16:71,626,146...71,635,909
Ensembl chr16:71,623,238...71,635,903

G

carbonic anhydrase 9

multiple interactions
increases expression

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of CA9 mRNA
tungsten carbide results in increased expression of CA9 mRNA

NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626

G

calcitonin-related polypeptide alpha

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of CALCA mRNA

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

calcitonin-related polypeptide, beta

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of CALCB mRNA

NCBI chr 1:178,399,634...178,404,654
Ensembl chr 1:178,399,785...178,404,654

G

catalase

multiple interactions

ISO

CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]

PMID:20528745 PMID:23758151

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

Cd300a molecule

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of CD300A mRNA

NCBI chr10:100,428,826...100,441,693
Ensembl chr10:100,428,826...100,442,958

G

cadherin 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of CDH2 mRNA

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cell death-inducing DFFA-like effector c

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of CIDEC mRNA

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806

G

C-type lectin domain family 3, member A

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of CLEC3A mRNA
tungsten carbide results in decreased expression of CLEC3A mRNA

NCBI chr19:59,313,746...59,321,126
Ensembl chr19:59,313,570...59,321,126

G

C-type lectin domain family 4, member E

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of CLEC4E mRNA

NCBI chr 4:158,292,624...158,298,607
Ensembl chr 4:158,293,311...158,298,467

G

cysteine and glycine-rich protein 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

cystatin E/M

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of CST6 mRNA

NCBI chr 1:212,084,676...212,086,384
Ensembl chr 1:212,084,676...212,086,384

G

cystathionine gamma-lyase

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of CTH mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of CTH mRNA

PMID:18078969 PMID:23052192

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

decorin

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

DDAH family member 2, ADMA-independent

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of DDAH2 mRNA

NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183

G

doublesex and mab-3 related transcription factor 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of DMRT2 mRNA

NCBI chr 1:232,743,935...232,750,431
Ensembl chr 1:232,743,942...232,750,431

G

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

DnaJ heat shock protein family (Hsp40) member C12

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of DNAJC12 mRNA

NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,222,298...25,266,251

G

dihydropyrimidinase-like 4

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of DPYSL4 mRNA

NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523

G

desmoglein 4

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of DSG4 mRNA
tungsten carbide results in decreased expression of DSG4 mRNA

NCBI chr18:11,995,902...12,032,908
Ensembl chr18:11,995,902...12,032,908

G

E2F transcription factor 7

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of E2F7 mRNA

NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:48,037,749...48,079,055

G

E2F transcription factor 8

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

endothelin 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of EDN2 mRNA

NCBI chr 5:139,036,576...139,042,074
Ensembl chr 5:139,036,492...139,043,070

G

egl-9 family hypoxia-inducible factor 3

multiple interactions
increases expression

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of EGLN3 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of EGLN3 mRNA
tungsten carbide results in increased expression of EGLN3 mRNA

PMID:18078969 PMID:20105288

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015

G

enolase 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

Fas cell surface death receptor

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of FASL mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box and WD repeat domain containing 10

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of FBXW10 mRNA

NCBI chr10:48,012,555...48,051,136
Ensembl chr10:47,958,677...48,051,136

G

ferredoxin reductase

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of FDXR mRNA

PMID:18078969 PMID:23052192

NCBI chr10:101,006,845...101,015,582
Ensembl chr10:101,006,849...101,015,542

G

fibromodulin

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of FMOD mRNA

NCBI chr13:48,045,567...48,056,184
Ensembl chr13:47,990,774...48,056,183

G

fibronectin 1

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

G0/G1switch 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

galactokinase 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of GALK2 mRNA

NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:133,563,538...133,696,528

G

1,4-alpha-glucan branching enzyme 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of GBE1 mRNA

NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

growth differentiation factor 15

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which affects the expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

glucose-6-phosphate isomerase

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of GPI mRNA

NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261

G

glutamic--pyruvic transaminase 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of GPT2 mRNA

NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917

G

glutathione peroxidase 7

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of GPX7 mRNA

NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:128,372,875...128,381,725

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of and results in increased stability of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hexokinase 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

heme oxygenase 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of HMOX1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of HMOX1 protein

PMID:18078969 PMID:23052192

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of HSPA1A mRNA

PMID:18078969 PMID:23052192

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of HSPA1L mRNA

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

HtrA serine peptidase 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of HTRA3 mRNA

NCBI chr14:79,293,535...79,321,936
Ensembl chr14:79,293,541...79,321,936

G

interleukin 1 beta

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of IL2 mRNA

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 6

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inhibin subunit beta A

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

IQ motif containing GTPase activating protein 2

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of IQGAP2 mRNA
tungsten carbide results in decreased expression of IQGAP2 mRNA

NCBI chr 2:28,629,558...28,904,649
Ensembl chr 2:28,629,558...28,904,649

G

intestine-specific homeobox

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of ISX mRNA
tungsten carbide results in decreased expression of ISX mRNA

NCBI chr19:13,222,834...13,245,506
Ensembl chr19:13,223,385...13,245,501

G

integrin subunit beta 8

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of ITGB8 mRNA

NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:146,165,484...146,351,245

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

keratin 1

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNA
tungsten carbide results in decreased expression of KRT1 mRNA

NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537

G

lysosomal-associated membrane protein 3

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of LAMP3 mRNA

NCBI chr11:94,657,817...94,726,451
Ensembl chr11:94,661,399...94,726,195

G

lysyl oxidase-like 2

increases expression
multiple interactions

ISO

tungsten carbide results in increased expression of LOXL2 mRNA
[tungsten carbide binds to Cobalt] which results in increased expression of LOXL2 mRNA

NCBI chr15:51,091,547...51,182,843
Ensembl chr15:51,069,997...51,182,842

G

LRAT domain containing 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of LRATD2 mRNA

NCBI chr 7:94,270,753...94,276,445
Ensembl chr 7:94,073,513...94,277,046

G

lysozyme 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of LYZ mRNA

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of MAGI2 mRNA
tungsten carbide results in decreased expression of MAGI2 mRNA

NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:15,278,518...16,762,199

G

mal, T-cell differentiation protein

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of MAL mRNA
tungsten carbide results in decreased expression of MAL mRNA

NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423

G

mitogen activated protein kinase 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MET proto-oncogene, receptor tyrosine kinase

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

macrophage migration inhibitory factor

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of MIF mRNA

NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121

G

microRNA 21

multiple interactions

ISO

[tungsten carbide analog co-treated with Cobalt analog] results in increased expression of MIR21 mRNA

NCBI chr10:71,902,600...71,902,691

G

matrix metallopeptidase 1

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of MMP1 mRNA
tungsten carbide results in decreased expression of MMP1 mRNA

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 9

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

metallothionein 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of MT3 mRNA

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080

G

nucleosome assembly protein 1-like 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of NAP1L2 mRNA

NCBI chr X:72,239,849...72,242,247
Ensembl chr X:72,238,310...72,242,464

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein; CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nucleolar protein 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of NOL3 mRNA

NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of NQO1 mRNA
[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; CAT protein inhibits the reaction [[[tungsten carbide co-treated with Cobalt] results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA]

PMID:20528745 PMID:23052192

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear protein 1, transcriptional regulator

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

olfactomedin 4

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of OLFM4 mRNA
tungsten carbide results in decreased expression of OLFM4 mRNA

NCBI chr15:61,790,889...61,838,773
Ensembl chr15:61,671,271...61,838,764

G

origin recognition complex, subunit 6

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of ORC6 mRNA

NCBI chr19:37,931,085...37,938,856
Ensembl chr19:37,931,090...37,938,856

G

oxysterol binding protein-like 6

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of OSBPL6 mRNA

NCBI chr 3:81,751,020...81,948,186
Ensembl chr 3:81,750,982...81,946,615

G

oncostatin M

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of OSM mRNA

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827

G

programmed cell death 4

multiple interactions

ISO

[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein; Acetylcysteine inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]; CAT protein inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]; U 0126 inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189

G

pyruvate dehydrogenase kinase 1

multiple interactions
increases expression

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of PDK1 mRNA
tungsten carbide results in increased expression of PDK1 mRNA

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145

G

p53 apoptosis effector related to PMP22

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of PERP mRNA

NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:15,361,778...15,374,687

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of PFKFB4 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of PFKFB4 mRNA

PMID:18078969 PMID:20105288

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

pleckstrin homology-like domain, family A, member 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

pirin

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of PIR mRNA

NCBI chr X:33,740,428...33,851,049
Ensembl chr X:33,740,429...33,851,049

G

phospholipase A2 group VII

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of PLA2G7 mRNA

NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of PLOD2 mRNA

NCBI chr 8:101,964,318...102,047,022
Ensembl chr 8:101,964,318...102,047,022

G

PTPRF interacting protein alpha 4

multiple interactions
increases expression

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of PPFIA4 mRNA
tungsten carbide results in increased expression of PPFIA4 mRNA

NCBI chr13:48,305,844...48,354,329
Ensembl chr13:48,305,848...48,354,279

G

protein phosphatase 1, regulatory subunit 3C

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of PPP1R3C mRNA

NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835

G

protein S

decreases expression
multiple interactions

ISO

tungsten carbide results in decreased expression of PROS1 mRNA
[tungsten carbide binds to Cobalt] which results in decreased expression of PROS1 mRNA

NCBI chr11:13,676,310...13,757,858
Ensembl chr11:13,676,769...13,757,852

G

phosphoserine aminotransferase 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of PSAT1 mRNA; [tungsten carbide co-treated with Cobalt] results in increased expression of PSAT1 mRNA

PMID:18078969 PMID:23052192

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of PTGS2 mRNA; [tungsten carbide co-treated with Cobalt] results in decreased expression of PTGS2 mRNA

PMID:18078969 PMID:20105288

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, receptor type Z1

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of PTPRZ1 mRNA

NCBI chr 4:52,363,006...52,560,905
Ensembl chr 4:52,363,295...52,560,903

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulator of G-protein signaling 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of RGS3 mRNA

NCBI chr 5:81,037,588...81,177,446
Ensembl chr 5:81,056,068...81,177,445

G

ribosomal modification protein rimK-like family member A

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of RIMKLA mRNA

NCBI chr 5:138,357,463...138,384,132
Ensembl chr 5:138,359,743...138,384,060

G

receptor-interacting serine-threonine kinase 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of RIPK2 mRNA

NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of RRAD mRNA

NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871

G

ribonucleotide reductase regulatory subunit M2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370

G

RT1 class II, locus DMb

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of HLA-DMB mRNA

NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,695,010...4,702,246

G

RT1 class II, locus Ha

decreases expression

ISO

tungsten carbide results in decreased expression of HLA-DPA1 mRNA

NCBI chr20:4,762,425...4,772,439
Ensembl chr20:4,763,033...4,772,141

G

RUNX family transcription factor 1

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNA

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925

G

S100 calcium binding protein B

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of S100B mRNA

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

SAM and SH3 domain containing 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of SASH1 mRNA

NCBI chr 1:4,940,207...5,238,777
Ensembl chr 1:4,940,207...5,238,530

G

serum/glucocorticoid regulated kinase 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

sirtuin 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 1 member 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of SLC1A2 mRNA

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

sphingomyelin phosphodiesterase, acid-like 3A

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of SMPDL3A mRNA

NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260

G

sortilin-related VPS10 domain containing receptor 3

affects expression

ISO

tungsten carbide affects the expression of SORCS3 mRNA

NCBI chr 1:257,040,442...257,675,259
Ensembl chr 1:257,040,473...257,675,259

G

SRY-box transcription factor 2

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of SOX2 mRNA

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

secreted phosphoprotein 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sequestosome 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

TATA-box binding protein associated factor 9b

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of TAF9B mRNA

NCBI chr X:75,354,823...75,366,166
Ensembl chr X:75,354,825...75,366,414

G

thrombomodulin

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of THBD mRNA

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582

G

toll-like receptor 2

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

transmembrane protein 45A

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of TMEM45A mRNA

NCBI chr11:57,181,686...57,268,630
Ensembl chr11:57,182,785...57,282,722

G

tumor necrosis factor

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of TNF mRNA

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF alpha induced protein 6

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

G

TNF superfamily member 12

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in decreased expression of TNFSF12 mRNA

NCBI chr10:54,902,616...54,912,628
Ensembl chr10:54,902,616...54,911,913

G

tumor protein p53

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of and results in increased stability of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

TP53 regulated inhibitor of apoptosis 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of TRIAP1 mRNA

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:46,928,273...46,930,766

G

testis specific 10

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of TSGA10 mRNA

NCBI chr 9:47,487,007...47,594,201
Ensembl chr 9:47,487,007...47,593,980

G

tubulin tyrosine ligase like 7

multiple interactions
decreases expression

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of TTLL7 mRNA
tungsten carbide results in decreased expression of TTLL7 mRNA

NCBI chr 2:238,425,786...238,549,296
Ensembl chr 2:238,426,076...238,545,960

G

thioredoxin reductase 1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

ubiquitin C-terminal hydrolase L1

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

vasorin

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of VASN mRNA

NCBI chr10:11,424,174...11,434,681
Ensembl chr10:11,417,327...11,450,704

G

very low density lipoprotein receptor

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in increased expression of VLDLR mRNA

NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154

G

von Willebrand factor C and EGF domains

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of VWCE mRNA

NCBI chr 1:216,703,742...216,753,284
Ensembl chr 1:216,707,351...216,738,337

G

WD repeat domain 64

multiple interactions

ISO

[tungsten carbide binds to Cobalt] which results in decreased expression of WDR64 mRNA

NCBI chr13:90,156,824...90,280,608
Ensembl chr13:90,156,862...90,279,233

G

zinc finger AN1-type containing 2A

multiple interactions

ISO

[tungsten carbide co-treated with Cobalt] results in increased expression of ZFAND2A mRNA

NCBI chr12:20,275,435...20,286,513
Ensembl chr12:20,275,450...20,286,513

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
atom	20860
nonmetal atom	20766
carbon atom	20710
organic molecular entity	20710
Tungsten carbide	152
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
Tungsten carbide	152

paths to the root