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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pindolol
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Accession:CHEBI:8214 term browser browse the term
Definition:A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Synonyms:exact_synonym: 1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol
 related_synonym: 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol;   1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol;   1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol;   4-(2-hydroxy-3-isopropylaminopropoxy)-indole;   Betapindol;   Blockin L;   Blocklin-L;   Calvisken;   Cardilate;   Carvisken;   Decreten;   Durapindol;   Formula=C14H20N2O2;   Glauco-Visken;   InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3;   InChIKey=JZQKKSLKJUAGIC-UHFFFAOYSA-N;   Pectobloc;   Pinbetol;   Prinodolol;   Pynastin;   SMILES=CC(C)NCC(O)COc1cccc2[nH]ccc12;   Visken;   pindololum
 xref: Beilstein:1536506;   CAS:13523-86-9;   DrugBank:DB00960;   Drug_Central:2176;   HMDB:HMDB0015095;   KEGG:C07445;   KEGG:D00513;   LINCS:LSM-1953
 xref_mesh: MESH:D010869
 xref: PMID:11022403;   PMID:11050366;   PMID:11185947;   PMID:11379796;   PMID:23020995;   Patent:NL6601040;   Reaxys:1536506;   Wikipedia:Pindolol


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pindolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 increases expression
affects binding
increases activity
multiple interactions
ISO
EXP
Pindolol results in increased expression of ADRB1 protein
Pindolol binds to ADRB1 protein
Pindolol results in increased activity of ADRB1 protein
[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; CGP 20712A affects the reaction [Pindolol results in increased activity of ADRB1 protein]; Pindolol binds to and results in decreased activity of ADRB1 protein; Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Pindolol binds to and results in decreased activity of ADRB1 protein; Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
CTD PMID:2175014 PMID:2462161 PMID:2888869 PMID:12761341 PMID:14730417 PMID:15060759 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression
affects binding
multiple interactions
ISO
EXP
Pindolol results in decreased expression of ADRB2 protein
Pindolol binds to ADRB2 protein
Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Pindolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Pindolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Pindolol binds to and results in decreased activity of ADRB2 protein; Pindolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
CTD PMID:2175014 PMID:2462161 PMID:14730417 PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP
ISO
Pindolol binds to and results in increased activity of ADRB3 protein
[Pindolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Pindolol binds to and results in increased activity of ADRB3 protein; Pindolol inhibits the reaction [cyanopindolol binds to ADRB3 protein]
CTD PMID:1682311 PMID:7815362 PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Agt angiotensinogen multiple interactions ISO Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein] CTD PMID:7104148 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP Pindolol binds to and affects the activity of HTR1A protein; Pindolol binds to and results in decreased activity of HTR1A protein CTD PMID:2207497 PMID:9809859 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding EXP Pindolol binds to HTR1B protein CTD PMID:11888550 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Prl prolactin multiple interactions ISO
EXP
Pindolol inhibits the reaction [Buspirone results in increased secretion of PRL protein] CTD PMID:18194152 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ren renin multiple interactions
decreases activity
decreases expression
ISO Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]
Pindolol results in decreased activity of REN protein
Pindolol results in decreased expression of REN protein
CTD PMID:791319 PMID:973972 PMID:7104148 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link

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  CHEBI ontology 19773
    role 19719
      application 19403
        pharmaceutical 19303
          drug 19303
            cardiovascular drug 7668
              vasodilator agent 5812
                pindolol 10
                  (R)-(+)-pindolol 0
                  (S)-(-)-pindolol 0
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  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19426
                        hydrogen molecular entity 19420
                          hydrides 18753
                            inorganic hydride 17457
                              pnictogen hydride 17433
                                nitrogen hydride 17280
                                  azane 17015
                                    ammonia 17014
                                      organic amino compound 17013
                                        secondary amino compound 6582
                                          secondary amine 1710
                                            pindolol 10
                                              (R)-(+)-pindolol 0
                                              (S)-(-)-pindolol 0
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