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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:leptophos
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Accession:CHEBI:82137 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-leptophos. It is an organothiophosphate insecticide that shows neurotoxic effect in humans.
Synonyms:exact_synonym: rac-O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate
 related_synonym: (RS)-O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate;   (RS)-leptophos;   Abar;   Formula=C13H10BrCl2O2PS;   Fosvel;   K62-105;   MBCP;   NK 711;   OMS 1438;   Oleophosvel;   Phosvel;   VCS 5-D;   VCS-506;   Velsicol 506;   Velsicol VCS-506;   racemic leptophos
 xref: AGR:IND89026816;   CAS:21609-90-5;   FooDB:FDB008471;   HMDB:HMDB0031798;   KEGG:C19003
 xref_mesh: MESH:D010773
 xref: PMID:12537969;   PMID:12742374;   PMID:15492452;   PMID:21152278;   PMID:21428349;   PMID:21432420;   PMID:2430007;   PMID:2431660;   PMID:2449553;   PMID:2472490;   PMID:2473232;   PMID:2481746;   PMID:318517;   PMID:4369913;   PMID:4841433;   PMID:6178187;   PMID:6188603;   PMID:64240;   PMID:72768;   PMID:7685784;   PMID:8720167;   PMID:91399;   PMID:91400;   PMID:9198007;   PPDB:1520;   Pesticides:leptophos;   Reaxys:2152663;   Wikipedia:Leptophos



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leptophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Leptophos metabolite results in decreased activity of ACHE protein; Leptophos results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Leptophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Leptophos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Leptophos results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Leptophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Leptophos results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19747
    role 19720
      biological role 19718
        aetiopathogenetic role 19086
          neurotoxin 18004
            leptophos 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19747
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19693
                    p-block element atom 19693
                      chalcogen 19488
                        oxygen atom 19465
                          oxygen molecular entity 19465
                            hydroxides 19260
                              oxoacid 18639
                                pnictogen oxoacid 11781
                                  phosphorus oxoacid 10753
                                    phosphorus oxoacid derivative 10274
                                      phosphonic acid derivative 2340
                                        phosphonate 168
                                          organic phosphonate 168
                                            O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate 6
                                              (R)-leptophos 6
                                                leptophos 6
paths to the root