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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:picrotoxinin
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Accession:CHEBI:8206 term browser browse the term
Definition:A picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin.
Synonyms:exact_synonym: (1R,3R,5S,8S,9R,12S,13R,14R)-1-hydroxy-13-methyl-14-(prop-1-en-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1(9,12).0(3,5).0(5,13)]tetradecane-6,11-dione
 related_synonym: Formula=C15H16O6;   InChI=1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8-,9-,10-,13-,14-,15+/m1/s1;   InChIKey=PIMZUZSSNYHVCU-YKWPQBAZSA-N;   SMILES=[C@]123[C@]4([C@@]([C@@H]5[C@H](C(C)=C)[C@H]([C@]4(OC1=O)[H])OC5=O)(O)C[C@]2(O3)[H])C;   picrotoxinine
 xref: CAS:17617-45-7;   KEGG:C09529;   KNApSAcK:C00003350;   LIPID_MAPS_instance:LMPR0103540001
 xref_mesh: MESH:C022961
 xref: PDBeChem:RI5;   PMID:12770091;   PMID:17405877;   PMID:17675213;   PMID:17714449;   PMID:18031737;   PMID:21505038;   PMID:25238029;   PMID:27423910;   PMID:7916140;   Reaxys:42745


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picrotoxinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 decreases expression ISO picrotoxinin results in decreased expression of ESR1 protein CTD PMID:21278053 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP picrotoxinin results in increased expression of FOS mRNA; picrotoxinin results in increased expression of FOS protein CTD PMID:7534335 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]] CTD PMID:29038840 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 increases response to substance
multiple interactions
EXP
ISO
GABRB2 protein results in increased susceptibility to picrotoxinin
picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]
CTD PMID:29038840 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions
increases response to substance
ISO picrotoxinin binds to GABRB3 protein
picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]
GABRB3 protein results in increased susceptibility to picrotoxinin
CTD PMID:16537435, PMID:29038840 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 multiple interactions EXP picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABRR3 protein] CTD PMID:10635063 NCBI chr11:43,046,987...43,099,754
Ensembl chr11:43,046,987...43,099,412
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO picrotoxinin results in increased phosphorylation of MAPK1 protein CTD PMID:21278053 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO picrotoxinin results in increased phosphorylation of MAPK3 protein CTD PMID:21278053 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
picrotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 increases expression
decreases expression
EXP Picrotoxin results in increased expression of ABCC8 mRNA; Picrotoxin results in increased expression of ABCC8 protein
Picrotoxin results in decreased expression of ABCC8 mRNA
CTD PMID:18021373 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP Picrotoxin results in decreased expression of ACSL5 mRNA CTD PMID:15170462 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 decreases expression EXP Picrotoxin results in decreased expression of ACSL6 mRNA CTD PMID:15170462 NCBI chr10:39,654,771...39,717,592
Ensembl chr10:39,655,455...39,719,312
JBrowse link
G Adcy4 adenylate cyclase 4 increases expression EXP Picrotoxin results in increased expression of ADCY4 mRNA CTD PMID:15170462 NCBI chr15:34,453,917...34,469,779
Ensembl chr15:34,453,915...34,469,746
JBrowse link
G Adra1b adrenoceptor alpha 1B increases expression EXP Picrotoxin results in increased expression of ADRA1B mRNA CTD PMID:15170462 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression EXP Picrotoxin results in increased expression of ADRA2A mRNA CTD PMID:15170462 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression EXP Picrotoxin results in increased expression of ADRB2 mRNA CTD PMID:15170462 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Picrotoxin results in increased expression of AGTR1A mRNA CTD PMID:15170462 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP Picrotoxin results in decreased expression of AGTR2 mRNA CTD PMID:15170462 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Alad aminolevulinate dehydratase decreases activity
multiple interactions
ISO Picrotoxin results in decreased activity of ALAD protein
carvacryl acetate inhibits the reaction [Picrotoxin results in decreased activity of ALAD protein]
CTD PMID:25490531 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression EXP Picrotoxin results in increased expression of ALDOB mRNA CTD PMID:15170462 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression EXP Picrotoxin results in increased expression of ALOX12 mRNA CTD PMID:15170462 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Picrotoxin results in increased expression of ALOX5AP mRNA CTD PMID:15170462 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta decreases expression EXP Picrotoxin results in decreased expression of ATP5F1D mRNA CTD PMID:15170462 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP decreases expression EXP Picrotoxin results in decreased expression of ATP5PO mRNA CTD PMID:15170462 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Picrotoxin results in decreased expression of BCL2L1 mRNA CTD PMID:15170462 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases methylation
ISO
EXP
Picrotoxin results in increased expression of BDNF mRNA
Picrotoxin results in increased expression of BDNF protein
Picrotoxin results in decreased methylation of BDNF promoter
CTD PMID:11279263, PMID:18184782 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Calb1 calbindin 1 decreases expression EXP Picrotoxin results in decreased expression of CALB1 protein CTD PMID:15382257 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Calb2 calbindin 2 decreases expression EXP Picrotoxin results in decreased expression of CALB2 protein CTD PMID:15382257 NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
JBrowse link
G Casp2 caspase 2 increases expression EXP Picrotoxin results in increased expression of CASP2 mRNA CTD PMID:15170462 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Cckar cholecystokinin A receptor increases expression EXP Picrotoxin results in increased expression of CCKAR mRNA CTD PMID:15170462 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Cckbr cholecystokinin B receptor increases expression EXP Picrotoxin results in increased expression of CCKBR mRNA CTD PMID:15170462 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccnd2 cyclin D2 decreases expression EXP Picrotoxin results in decreased expression of CCND2 mRNA CTD PMID:15170462 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Picrotoxin results in increased expression of CCND3 mRNA CTD PMID:15170462 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression EXP Picrotoxin results in increased expression of CCR2 mRNA CTD PMID:15170462
G Chrm1 cholinergic receptor, muscarinic 1 increases expression EXP Picrotoxin results in increased expression of CHRM1 mRNA CTD PMID:15170462 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases expression EXP Picrotoxin results in increased expression of CHRM2 mRNA CTD PMID:15170462 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Picrotoxin results in increased expression of CHRM3 mRNA CTD PMID:15170462 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Picrotoxin results in increased expression of CPT1A mRNA CTD PMID:15170462 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP Picrotoxin results in increased expression of CPT1B mRNA CTD PMID:15170462 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Picrotoxin results in increased expression of CXCR4 mRNA CTD PMID:15170462 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression EXP Picrotoxin results in decreased expression of DECR1 mRNA CTD PMID:15170462 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Picrotoxin results in decreased expression of DHCR7 mRNA CTD PMID:15170462 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Picrotoxin results in increased expression of DRD4 mRNA CTD PMID:15170462 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn3 endothelin 3 multiple interactions EXP Picrotoxin inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Ednrb endothelin receptor type B decreases expression EXP Picrotoxin results in decreased expression of EDNRB mRNA CTD PMID:15170462 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Picrotoxin results in increased expression of FOS; Picrotoxin results in increased expression of FOS mRNA CTD PMID:1380685, PMID:9500968 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Picrotoxin results in increased expression of FOSL1 mRNA CTD PMID:15170462 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Picrotoxin results in increased expression of FSHR mRNA CTD PMID:15170462 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Fzd2 frizzled class receptor 2 increases expression EXP Picrotoxin results in increased expression of FZD2 mRNA CTD PMID:15170462 NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions EXP 1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Picrotoxin affects the localization of GABBR2 protein]; Picrotoxin results in decreased expression of and affects the localization of GABBR2 protein CTD PMID:24482233 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP
delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:9316872, PMID:14637376, PMID:17054655 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198, PMID:14637376 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO
EXP
Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:14637376, PMID:17054655 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP
delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:9316872, PMID:14637376, PMID:17054655 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Picrotoxin results in increased expression of GAD1 mRNA CTD PMID:15170462 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 increases response to substance
increases expression
ISO
EXP
GAD2 gene mutant form results in increased susceptibility to Picrotoxin
Picrotoxin results in increased expression of GAD2 mRNA; Picrotoxin results in increased expression of GAD2 protein
CTD PMID:8954991, PMID:15170462, PMID:15382257 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Picrotoxin binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Picrotoxin results in decreased expression of GNAI1 mRNA CTD PMID:15170462 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Picrotoxin results in decreased expression of GNAI2 mRNA CTD PMID:15170462 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gng8 G protein subunit gamma 8 increases expression EXP Picrotoxin results in increased expression of GNG8 mRNA CTD PMID:15170462 NCBI chr 1:78,818,360...78,822,224
Ensembl chr 1:78,818,404...78,822,224
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression EXP Picrotoxin results in increased expression of GNRHR mRNA CTD PMID:15170462 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression EXP Picrotoxin results in decreased expression of GPD1 mRNA CTD PMID:15170462 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP Picrotoxin results in decreased expression of HADHB mRNA CTD PMID:15170462 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 increases expression EXP Picrotoxin results in increased expression of HTR6 mRNA CTD PMID:15170462 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Picrotoxin results in decreased expression of IDI1 mRNA CTD PMID:15170462 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases expression
increases expression
EXP Picrotoxin results in decreased expression of KCNJ11 mRNA; Picrotoxin results in decreased expression of KCNJ11 protein
Picrotoxin results in increased expression of KCNJ11 mRNA; Picrotoxin results in increased expression of KCNJ11 protein
CTD PMID:18021373 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression EXP Picrotoxin results in decreased expression of KRAS mRNA CTD PMID:15170462 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Ldhb lactate dehydrogenase B decreases expression EXP Picrotoxin results in decreased expression of LDHB mRNA CTD PMID:15170462 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Ldhc lactate dehydrogenase C increases expression EXP Picrotoxin results in increased expression of LDHC mRNA CTD PMID:15170462 NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor increases expression EXP Picrotoxin results in increased expression of LHCGR mRNA CTD PMID:15170462 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Lpl lipoprotein lipase decreases expression EXP Picrotoxin results in decreased expression of LPL mRNA CTD PMID:15170462 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lta4h leukotriene A4 hydrolase increases expression EXP Picrotoxin results in increased expression of LTA4H mRNA CTD PMID:15170462 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Mc4r melanocortin 4 receptor increases expression EXP Picrotoxin results in increased expression of MC4R mRNA CTD PMID:15170462 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Mvk mevalonate kinase increases expression EXP Picrotoxin results in increased expression of MVK mRNA CTD PMID:15170462 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 decreases expression EXP Picrotoxin results in decreased expression of NDUFS6 mRNA CTD PMID:15170462 NCBI chr 2:26,471,173...26,471,587
Ensembl chr 2:26,471,173...26,471,584
JBrowse link
G Npy1r neuropeptide Y receptor Y1 increases expression EXP Picrotoxin results in increased expression of NPY1R mRNA CTD PMID:15170462 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Oprk1 opioid receptor, kappa 1 increases expression EXP Picrotoxin results in increased expression of OPRK1 mRNA CTD PMID:15170462 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 increases expression EXP Picrotoxin results in increased expression of OPRM1 mRNA CTD PMID:15170462 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pde4d phosphodiesterase 4D increases expression EXP Picrotoxin results in increased expression of PDE4D mRNA CTD PMID:15170462 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression EXP Picrotoxin results in decreased expression of PFKP mRNA CTD PMID:15170462 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression EXP Picrotoxin results in decreased expression of PGAM1 mRNA CTD PMID:15170462 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Pgam2 phosphoglycerate mutase 2 increases expression EXP Picrotoxin results in increased expression of PGAM2 mRNA CTD PMID:15170462 NCBI chr14:86,045,005...86,047,116
Ensembl chr14:86,044,969...86,047,162
JBrowse link
G Prkcd protein kinase C, delta decreases expression EXP Picrotoxin results in decreased expression of PRKCD mRNA CTD PMID:15170462 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon decreases expression EXP Picrotoxin results in decreased expression of PRKCE mRNA CTD PMID:15170462 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression EXP Picrotoxin results in decreased expression of PSMA3 mRNA CTD PMID:15170462 NCBI chr 6:93,423,029...93,444,223
Ensembl chr 6:93,423,002...93,444,240
JBrowse link
G Psma4 proteasome 20S subunit alpha 4 decreases expression EXP Picrotoxin results in decreased expression of PSMA4 mRNA CTD PMID:15170462 NCBI chr 8:59,532,456...59,539,916
Ensembl chr 8:59,532,389...59,539,920
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 increases expression EXP Picrotoxin results in increased expression of PSMB8 mRNA CTD PMID:15170462 NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 decreases expression EXP Picrotoxin results in decreased expression of PSMC3 mRNA CTD PMID:15170462 NCBI chr 3:79,876,938...79,882,319
Ensembl chr 3:79,876,938...79,882,319
JBrowse link
G Pvalb parvalbumin decreases expression EXP Picrotoxin results in decreased expression of PVALB protein CTD PMID:15382257 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Ryr2 ryanodine receptor 2 increases expression EXP Picrotoxin results in increased expression of RYR2 mRNA CTD PMID:21113126 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Smad1 SMAD family member 1 decreases expression EXP Picrotoxin results in decreased expression of SMAD1 mRNA CTD PMID:15170462 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad3 SMAD family member 3 increases expression EXP Picrotoxin results in increased expression of SMAD3 mRNA CTD PMID:15170462 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad7 SMAD family member 7 decreases expression EXP Picrotoxin results in decreased expression of SMAD7 mRNA CTD PMID:15170462 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Sqle squalene epoxidase decreases expression EXP Picrotoxin results in decreased expression of SQLE mRNA CTD PMID:15170462 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression EXP Picrotoxin results in increased expression of SSTR2 mRNA CTD PMID:15170462 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 increases expression EXP Picrotoxin results in increased expression of TGFBR3 mRNA CTD PMID:15170462 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases expression EXP Picrotoxin results in decreased expression of TRHR mRNA CTD PMID:15170462 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression EXP Picrotoxin results in increased expression of TSHR mRNA CTD PMID:15170462 NCBI chr 6:115,170,290...115,306,871
Ensembl chr 6:115,170,865...115,306,871
JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Picrotoxin results in increased expression of UCP2 mRNA CTD PMID:15170462 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ucp3 uncoupling protein 3 increases expression EXP Picrotoxin results in increased expression of UCP3 mRNA CTD PMID:15170462 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          antagonist 16197
            GABA antagonist 3494
              picrotoxinin 100
                picrotin + 94
                picrotoxin 94
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          gamma-lactone 1214
                                            picrotoxinin 100
                                              picrotin + 94
                                              picrotoxin 94
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.