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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propamocarb
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Accession:CHEBI:82033 term browser browse the term
Definition:A carbamate ester that is the propyl ester of 3-(dimethylamino)propylcarbamic acid. It is a systemic fungicide, used (normally as the hydrochloride salt) for the control of soil, root and leaf diseases caused by oomycetes, particularly Phytophthora and Pythium species.
Synonyms:related_synonym: Formula=C9H20N2O2;   InChI=1S/C9H20N2O2/c1-4-8-13-9(12)10-6-5-7-11(2)3/h4-8H2,1-3H3,(H,10,12);   InChIKey=WZZLDXDUQPOXNW-UHFFFAOYSA-N;   Propyl (3-(dimethylamino)propyl)carbamate;   SMILES=CCCOC(=O)NCCCN(C)C;   propamocarbe;   propyl 3-(dimethylamino)propylcarbamate;   propyl N-[3-(dimethylamino)propyl]carbamate
 xref: CAS:24579-73-5;   KEGG:C18885
 xref_mesh: MESH:C033205
 xref: PMID:14985943;   PMID:15204535;   PMID:22699710;   PMID:24791956;   PPDB:1546;   Patent:BE708057;   Patent:EP1254894;   Patent:US3649674;   Pesticides:propamocarb;   Reaxys:2080745;   Wikipedia:Propamocarb



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propamocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO propamocarb results in decreased expression of ACACA mRNA CTD PMID:29137890 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ache acetylcholinesterase decreases expression ISO propamocarb results in decreased expression of ACHE protein CTD PMID:30251769 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acly ATP citrate lyase decreases expression ISO propamocarb results in decreased expression of ACLY mRNA CTD PMID:29137890 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO propamocarb results in decreased expression of ACOX1 mRNA CTD PMID:29137890 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CD36 protein]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMGCR mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMGCS1 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 protein]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IFNG mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IFNG protein]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL10 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1A mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1A protein]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1B mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1B protein]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL6 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of LDLR mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of SCARB1 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TNF mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TNF protein]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 protein] CTD PMID:34426332 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CD36 protein] CTD PMID:34426332 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO propamocarb results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression ISO propamocarb results in decreased expression of DGAT2 mRNA CTD PMID:29137890 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO propamocarb results in decreased expression of DRD2 mRNA CTD PMID:30251769 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein
propamocarb results in increased activity of ESR1 protein
CTD PMID:26812056 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein
propamocarb results in increased activity of ESR2 protein
CTD PMID:26812056 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression ISO propamocarb results in decreased expression of FABP2 mRNA CTD PMID:29137890 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
JBrowse link
G Fasn fatty acid synthase decreases expression ISO propamocarb results in decreased expression of FASN mRNA CTD PMID:29137890 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Ffar3 free fatty acid receptor 3 decreases expression ISO propamocarb results in decreased expression of FFAR3 mRNA CTD PMID:29137890 NCBI chr 1:86,105,388...86,106,728
Ensembl chr 1:86,104,920...86,106,849
JBrowse link
G Gk glycerol kinase decreases expression ISO propamocarb results in decreased expression of GK mRNA CTD PMID:29137890 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression ISO propamocarb results in decreased expression of GPAM mRNA CTD PMID:29137890 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
multiple interactions
ISO propamocarb results in increased expression of HMGCR mRNA
propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMGCR mRNA]
CTD PMID:34426332 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression
multiple interactions
ISO propamocarb results in increased expression of HMGCS1 mRNA
propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMGCS1 mRNA]; propamocarb promotes the reaction [Dietary Fats results in increased expression of HMGCS1 mRNA]
CTD PMID:34426332 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 protein]; propamocarb promotes the reaction [Dietary Fats results in increased expression of ICAM1 mRNA]
propamocarb results in increased expression of ICAM1 mRNA
CTD PMID:34426332 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO propamocarb results in increased expression of IFNG protein
propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IFNG mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IFNG protein]
CTD PMID:34426332 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL10 mRNA] CTD PMID:34426332 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1A mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1A protein] CTD PMID:34426332 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO propamocarb results in increased expression of IL1B protein
propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1B mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL1B protein]; propamocarb promotes the reaction [Dietary Fats results in increased expression of IL1B mRNA]; propamocarb promotes the reaction [Dietary Fats results in increased expression of IL1B protein]
CTD PMID:34426332 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO propamocarb results in increased expression of IL6 mRNA; propamocarb results in increased expression of IL6 protein
propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL6 mRNA]; propamocarb promotes the reaction [Dietary Fats results in increased expression of IL6 protein]
CTD PMID:34426332 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of LDLR mRNA] CTD PMID:34426332 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lpl lipoprotein lipase increases expression ISO propamocarb results in increased expression of LPL mRNA CTD PMID:29137890 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mlxipl MLX interacting protein-like decreases expression ISO propamocarb results in decreased expression of MLXIPL mRNA CTD PMID:29137890 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO propamocarb results in decreased expression of PKLR mRNA CTD PMID:29137890 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO propamocarb results in decreased expression of PPARG mRNA CTD PMID:29137890 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
increases expression
ISO propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of SCARB1 mRNA]; propamocarb promotes the reaction [Dietary Fats results in increased expression of SCARB1 mRNA]
propamocarb results in increased expression of SCARB1 mRNA
CTD PMID:34426332 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO propamocarb results in decreased expression of SCD1 mRNA CTD PMID:29137890 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO propamocarb results in decreased expression of SLC27A2 mRNA CTD PMID:29137890 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO propamocarb results in decreased expression of SREBF1 mRNA CTD PMID:29137890 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO propamocarb results in increased expression of TNF mRNA; propamocarb results in increased expression of TNF protein
[Dietary Fats co-treated with propamocarb] results in increased expression of TNF protein; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TNF mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TNF protein]; propamocarb promotes the reaction [Dietary Fats results in increased expression of TNF mRNA]
CTD PMID:34426332 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tph2 tryptophan hydroxylase 2 decreases expression ISO propamocarb results in decreased expression of TPH2 mRNA CTD PMID:30251769 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions
ISO propamocarb results in increased expression of VCAM1 mRNA
propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 mRNA]; propamocarb affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 protein]; propamocarb promotes the reaction [Dietary Fats results in increased expression of VCAM1 mRNA]
CTD PMID:34426332 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19874
    role 19844
      biological role 19842
        xenobiotic 18722
          propamocarb 36
Path 2
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      monocarboxylic acid 18000
                                        fatty acid 16833
                                          fatty acid derivative 8980
                                            fatty alcohol 6135
                                              primary fatty alcohol 5798
                                                short-chain primary fatty alcohol 5789
                                                  propan-1-ol 179
                                                    propamocarb 36
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