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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:captafol
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Accession:CHEBI:81938 term browser browse the term
Definition:A dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community.
Synonyms:exact_synonym: 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
 related_synonym: (tetrachloroethylthio)tetrahydrophthalimide;   1,2,3,6-tetrahydro-N-(1,1,2,2-tetrachloroethylthio)phthalimide;   3a,4,7,7a-tetrahydro-2-[(1,1,2,2-tetrachloroethyl)thio]-1H-isoindole-1,3(2H)-dione;   3a,4,7,7a-tetrahydro-N-(1,1,2,2-tetrachloroethanesulphenyl)phthalimide;   Captaspor;   Difolatan;   Difosan;   Folcid;   Formula=C10H9Cl4NO2S;   Haipen;   InChI=1S/C10H9Cl4NO2S/c11-9(12)10(13,14)18-15-7(16)5-3-1-2-4-6(5)8(15)17/h1-2,5-6,9H,3-4H2;   InChIKey=JHRWWRDRBPCWTF-UHFFFAOYSA-N;   Kenofol;   Merpafol;   N-(1,1,2,2-tetrachloroethylthio)-Delta(4)-tetrahydrophthalimide;   N-1,1,2,2-tetrachloroethylmercapto-4-cyclohexene-1,2-carboximide;   N-[(1,1,2,2-tetrachloroethyl)sulfenyl]-4-cyclohexene-1,2-dicarboximide;   SMILES=ClC(Cl)C(Cl)(Cl)SN1C(=O)C2CC=CCC2C1=O;   Sanspor;   Terrazol
 xref: CAS:2425-06-1;   HMDB:HMDB0031669;   KEGG:C18754
 xref_mesh: MESH:C001614
 xref: PMID:159800;   PMID:1842583;   PMID:21822319;   PMID:8426061;   PPDB:113;   Patent:BE633205;   Pesticides:captafol;   Reaxys:1543712;   Reaxys:234872;   Wikipedia:Captafol


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captafol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 decreases activity ISO captafol results in decreased activity of DIO1 protein CTD PMID:29228274, PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO captafol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO captafol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO hexylglutathione inhibits the reaction [captafol results in decreased activity of GSTP1 protein] CTD PMID:8678907 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
EXP captafol results in increased expression of PCNA protein
Cysteine inhibits the reaction [captafol results in increased expression of PCNA protein]
CTD PMID:9022123 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO captafol results in decreased activity of TOP1 protein CTD PMID:12113771 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO captafol results in decreased activity of TOP2A protein CTD PMID:12113771 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pesticide 16264
          antifungal agrochemical 7530
            captafol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      benzopyrrole 9340
                                        isoindoles 544
                                          captafol 7
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