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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:captafol
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Accession:CHEBI:81938 term browser browse the term
Definition:A dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community.
Synonyms:exact_synonym: 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
 related_synonym: (tetrachloroethylthio)tetrahydrophthalimide;   1,2,3,6-tetrahydro-N-(1,1,2,2-tetrachloroethylthio)phthalimide;   3a,4,7,7a-tetrahydro-2-[(1,1,2,2-tetrachloroethyl)thio]-1H-isoindole-1,3(2H)-dione;   3a,4,7,7a-tetrahydro-N-(1,1,2,2-tetrachloroethanesulphenyl)phthalimide;   Captaspor;   Difolatan;   Difosan;   Folcid;   Formula=C10H9Cl4NO2S;   Haipen;   InChI=1S/C10H9Cl4NO2S/c11-9(12)10(13,14)18-15-7(16)5-3-1-2-4-6(5)8(15)17/h1-2,5-6,9H,3-4H2;   InChIKey=JHRWWRDRBPCWTF-UHFFFAOYSA-N;   Kenofol;   Merpafol;   N-(1,1,2,2-tetrachloroethylthio)-Delta(4)-tetrahydrophthalimide;   N-1,1,2,2-tetrachloroethylmercapto-4-cyclohexene-1,2-carboximide;   N-[(1,1,2,2-tetrachloroethyl)sulfenyl]-4-cyclohexene-1,2-dicarboximide;   SMILES=ClC(Cl)C(Cl)(Cl)SN1C(=O)C2CC=CCC2C1=O;   Sanspor;   Terrazol
 xref: CAS:2425-06-1;   HMDB:HMDB0031669;   KEGG:C18754
 xref_mesh: MESH:C001614
 xref: PMID:159800;   PMID:1842583;   PMID:21822319;   PMID:8426061;   PPDB:113;   Patent:BE633205;   Pesticides:captafol;   Reaxys:1543712;   Reaxys:234872;   Wikipedia:Captafol



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captafol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 decreases activity ISO captafol results in decreased activity of DIO1 protein CTD PMID:29228274 PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO captafol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO captafol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO hexylglutathione inhibits the reaction [captafol results in decreased activity of GSTP1 protein] CTD PMID:8678907 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
EXP captafol results in increased expression of PCNA protein
Cysteine inhibits the reaction [captafol results in increased expression of PCNA protein]
CTD PMID:9022123 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO captafol results in decreased expression of TFF1 mRNA CTD PMID:33352482 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO captafol results in decreased activity of TOP1 protein CTD PMID:12113771 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO captafol results in decreased activity of TOP2A protein CTD PMID:12113771 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pesticide 17131
          antifungal agrochemical 8764
            captafol 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  organic heteropolycyclic compound 18039
                                    organic heterobicyclic compound 16857
                                      benzopyrrole 9560
                                        isoindoles 1127
                                          captafol 8
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