CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: octhilinone
Accession: CHEBI:81936
browse the term
Definition: A member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group. A fungicide and antibacterial agent, it is used for treatment of canker and other fungal and bacterial diseases in fruit trees. It is no longer approved for use within the European Union.
Synonyms: exact_synonym: 2-octyl-1,2-thiazol-3(2H)-one
related_synonym: 2-Octyl-3(2H)-isothiazolone; 2-Octyl-3-isothiazolinone; 2-Octyl-3-isothiazolone; 2-Octyl-3-isothioazolone; 2-Octyl-4-isothiazolin-3-one; 2-n-Octyl-4-isothiazolin-3-one; 2-octyl-2H-isothiazol-3-one; Formula=C11H19NOS; InChI=1S/C11H19NOS/c1-2-3-4-5-6-7-9-12-11(13)8-10-14-12/h8,10H,2-7,9H2,1H3; InChIKey=JPMIIZHYYWMHDT-UHFFFAOYSA-N; Octyl-3(2H)-isothiazolone; Octyl-4-isothiazol-3-one; SMILES=CCCCCCCCn1sccc1=O
xref: AGR:IND87046906; CAS:26530-20-1; KEGG:C18752
xref_mesh: MESH:C035331
xref: PMID:20960358; PMID:23182288; PPDB:489; Pesticides:octhilinone; Reaxys:1211137
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Casp3
caspase 3
increases activity
ISO
2-n-octyl-4-isothiazolin-3-one results in increased activity of CASP3 protein
CTD
PMID:33806369
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cldn5
claudin 5
decreases expression
ISO
2-n-octyl-4-isothiazolin-3-one results in decreased expression of CLDN5 protein
CTD
PMID:33806369
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Dio1
iodothyronine deiodinase 1
decreases activity
ISO
2-n-octyl-4-isothiazolin-3-one results in decreased activity of DIO1 protein
CTD
PMID:30561685
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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Dio2
iodothyronine deiodinase 2
decreases activity
ISO
2-n-octyl-4-isothiazolin-3-one results in decreased activity of DIO2 protein
CTD
PMID:30561685
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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Dio3
iodothyronine deiodinase 3
decreases activity
ISO
2-n-octyl-4-isothiazolin-3-one results in decreased activity of DIO3 protein
CTD
PMID:30561685
NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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Tjp1
tight junction protein 1
decreases expression
ISO
2-n-octyl-4-isothiazolin-3-one results in decreased expression of TJP1 protein
CTD
PMID:33806369
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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