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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:enilconazole
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Accession:CHEBI:81927 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-enilconazole. A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals. In veterinary medicine, it is used topically for the treatment of fungal skin infections in cattle, dogs, and horses; it is also used by inhalation for the treatment of aspergillosis in ostriches.
Synonyms:exact_synonym: rac-1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
 related_synonym: (+-)-1-(beta-(Allyloxy)-2,4-dichlorophenethyl)-imidazole;   (RS)-enilconazole;   1-[2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl]-1H-imidazole;   Allyl-1-(2,4-dichlorophenyl)-2-imidazol-1-ylethyl ether;   Chloramizol;   Formula=C14H14Cl2N2O;   Imazalil;   R 23,979;   R 23979;   chloramizole;   enilconazol;   enilconazolum;   rac-enilconazole;   racemic enilconazole
 xref: CAS:35554-44-0;   HMDB:HMDB0031794;   KEGG:C18739;   KEGG:D03997
 xref_mesh: MESH:C017435
 xref: PMID:23813824;   PMID:23952944;   PMID:24039133;   PMID:24123539;   PMID:24334985;   Pesticides:imazalil;   Reaxys:545683;   Wikipedia:Enilconazole


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enilconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases expression ISO enilconazole results in decreased expression of ABCB11 mRNA CTD PMID:29451352 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases expression ISO enilconazole results in decreased expression of ABCC2 mRNA CTD PMID:29451352 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 decreases expression
multiple interactions
increases expression		 ISO enilconazole results in decreased expression of ABCC3 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ABCC3 mRNA
enilconazole results in increased expression of ABCC3 mRNA		 CTD PMID:29451352 PMID:33426623 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCD3 ATP binding cassette subfamily D member 3 decreases expression ISO enilconazole results in decreased expression of ABCD3 mRNA CTD PMID:30853599 NCBI chr 1:94,385,131...94,518,663
Ensembl chr 1:94,418,389...94,518,666 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 decreases expression EXP enilconazole results in decreased expression of ACOX1 mRNA CTD PMID:32201337 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide decreases expression
multiple interactions		 EXP enilconazole results in decreased expression of ADH1A mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of ADH1A mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of ADH1A mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of ADH1A mRNA		 CTD PMID:32201337 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003 		JBrowse link
G ADK adenosine kinase increases expression EXP enilconazole results in increased expression of ADK mRNA CTD PMID:32201337 NCBI chr10:74,151,221...74,709,290
Ensembl chr10:74,151,202...74,709,963 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 multiple interactions
increases expression
decreases expression		 EXP
ISO		 [thiacloprid co-treated with enilconazole] results in decreased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ALDH1A1 mRNA
enilconazole results in increased expression of ALDH1A1 mRNA
enilconazole results in decreased expression of ALDH1A1 mRNA		 CTD PMID:32201337 PMID:33426623 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member decreases expression
multiple interactions		 EXP enilconazole results in decreased expression of ALDH2 mRNA
[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of ALDH2 mRNA; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of and results in decreased activity of ALDH2 protein		 CTD PMID:32201337 PMID:34830855 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ANO1 anoctamin 1 decreases expression ISO enilconazole results in decreased expression of ANO1 mRNA CTD PMID:29106682 NCBI chr11:69,965,997...70,189,530
Ensembl chr11:69,985,907...70,189,530 		JBrowse link
G ANXA10 annexin A10 increases expression EXP enilconazole results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr 4:168,092,537...168,187,736
Ensembl chr 4:168,092,537...168,187,736 		JBrowse link
G AR androgen receptor multiple interactions
decreases expression
affects binding		 EXP
ISO		 Dihydrotestosterone inhibits the reaction [enilconazole results in increased activity of AR protein]; enilconazole inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; enilconazole inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; enilconazole inhibits the reaction [Metribolone results in increased activity of AR protein]
enilconazole results in decreased expression of AR mRNA
enilconazole binds to AR protein		 CTD PMID:15064155 PMID:18324785 PMID:21310686 PMID:30853599 PMID:33049310 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARG1 arginase 1 decreases expression EXP enilconazole results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 increases expression EXP enilconazole results in increased expression of ATP8B1 mRNA CTD PMID:32201337 NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315 		JBrowse link
G CAT catalase increases expression ISO enilconazole results in increased expression of CAT mRNA CTD PMID:29451352 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 increases expression EXP enilconazole results in increased expression of CCL5 mRNA CTD PMID:32201337 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CES2 carboxylesterase 2 multiple interactions
decreases expression		 EXP [enilconazole co-treated with thiacloprid] results in increased expression of CES2 protein
enilconazole results in decreased expression of CES2 mRNA		 CTD PMID:32201337 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096 		JBrowse link
G CFTR CF transmembrane conductance regulator affects binding
decreases expression		 ISO enilconazole binds to CFTR protein
enilconazole results in decreased expression of CFTR mRNA; enilconazole results in decreased expression of CFTR protein		 CTD PMID:29106682 PMID:32814239 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
G COMT catechol-O-methyltransferase increases expression EXP enilconazole results in increased expression of COMT protein CTD PMID:32201337 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 affects expression ISO enilconazole affects the expression of CYP11A1 mRNA CTD PMID:30853599 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression ISO enilconazole results in increased expression of CYP17A1 mRNA CTD PMID:30853599 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity
affects secretion		 EXP
ISO		 enilconazole results in decreased activity of CYP19A1 protein
enilconazole affects the secretion of CYP19A1 mRNA		 CTD PMID:10806373 PMID:15554355 PMID:26141389 PMID:30853599 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity
increases expression
multiple interactions		 EXP enilconazole results in increased activity of CYP1A1 protein
enilconazole results in increased expression of CYP1A1 mRNA; enilconazole results in increased expression of CYP1A1 protein
enilconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:19070657 PMID:21762035 PMID:32194361 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
affects expression		 EXP [clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP1A2 mRNA
enilconazole affects the expression of CYP1A2 mRNA		 CTD PMID:32201337 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression
multiple interactions		 EXP enilconazole results in increased expression of CYP1B1 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein		 CTD PMID:32201337 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 increases expression ISO enilconazole results in increased expression of CYP27A1 mRNA CTD PMID:32814239 NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
decreases expression		 EXP [clothianidin co-treated with enilconazole] results in decreased expression of CYP2A6 protein; [enilconazole co-treated with thiacloprid] results in decreased expression of CYP2A6 protein
enilconazole results in decreased expression of CYP2A6 mRNA; enilconazole results in decreased expression of CYP2A6 protein		 CTD PMID:32201337 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression
affects expression
multiple interactions		 ISO
EXP		 enilconazole results in increased expression of CYP2B10
enilconazole affects the expression of CYP2B6 mRNA
[enilconazole co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B9 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B6 mRNA		 CTD PMID:27853109 PMID:32201337 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases expression EXP enilconazole results in decreased expression of CYP2C19 mRNA; enilconazole results in decreased expression of CYP2C19 protein CTD PMID:32194361 PMID:32201337 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases expression EXP enilconazole results in decreased expression of CYP2C9 mRNA CTD PMID:32201337 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
decreases expression		 EXP [clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA
enilconazole results in decreased expression of CYP2E1 mRNA		 CTD PMID:32201337 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases expression
affects expression
decreases activity		 EXP [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A4 mRNA
enilconazole results in increased expression of CYP3A4 protein
enilconazole affects the expression of CYP3A4 mRNA
enilconazole results in decreased activity of CYP3A4 protein		 CTD PMID:21762035 PMID:25028461 PMID:32201337 PMID:34273450 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases expression
multiple interactions		 EXP enilconazole results in increased expression of CYP3A5 mRNA; enilconazole results in increased expression of CYP3A5 protein
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A5 protein		 CTD PMID:32201337 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 decreases expression EXP enilconazole results in decreased expression of CYP3A7 mRNA CTD PMID:32201337 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 decreases activity EXP enilconazole results in decreased activity of CYP51A1 protein CTD PMID:16989930 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 ISO
EXP		 enilconazole results in decreased expression of CYP7A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP7A1 mRNA
enilconazole results in decreased expression of CYP7A1 mRNA; enilconazole results in decreased expression of CYP7A1 protein		 CTD PMID:29451352 PMID:32194361 PMID:32201337 PMID:32814239 PMID:33426623 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 decreases expression EXP enilconazole results in decreased expression of CYP7B1 mRNA CTD PMID:32201337 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO enilconazole results in increased expression of CYP8B1 mRNA CTD PMID:32814239 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898 		JBrowse link
G DEFA3 defensin alpha 3 decreases expression ISO enilconazole results in decreased expression of DEFA3 mRNA CTD PMID:32814239 NCBI chr 8:7,015,869...7,018,297
Ensembl chr 8:7,015,869...7,018,297 		JBrowse link
G DNM1 dynamin 1 decreases expression EXP enilconazole results in decreased expression of DNM1 mRNA CTD PMID:32201337 NCBI chr 9:128,203,379...128,255,244
Ensembl chr 9:128,191,655...128,255,248 		JBrowse link
G ELN elastin decreases expression
multiple interactions		 ISO enilconazole results in decreased expression of ELN mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of ELN mRNA		 CTD PMID:33426623 NCBI chr 7:74,028,173...74,069,907
Ensembl chr 7:74,027,789...74,069,907 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP enilconazole binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 decreases expression
multiple interactions		 ISO
EXP		 enilconazole results in decreased expression of ESR2 mRNA
enilconazole binds to and results in increased activity of ESR2 protein		 CTD PMID:30853599 PMID:33049310 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FABP6 fatty acid binding protein 6 decreases expression ISO enilconazole results in decreased expression of FABP6 mRNA CTD PMID:32814239 NCBI chr 5:160,187,381...160,238,722
Ensembl chr 5:160,187,367...160,238,735 		JBrowse link
G FAS Fas cell surface death receptor increases expression EXP enilconazole results in increased expression of FAS mRNA CTD PMID:32201337 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FGF19 fibroblast growth factor 19 decreases expression
increases expression		 ISO enilconazole results in decreased expression of FGF15 mRNA
enilconazole results in increased expression of FGF15 mRNA		 CTD PMID:29451352 PMID:32814239 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP enilconazole results in decreased expression of G6PC1 mRNA CTD PMID:32194361 PMID:32201337 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G GPX1 glutathione peroxidase 1 increases expression ISO enilconazole results in increased expression of GPX1 mRNA CTD PMID:29451352 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX2 glutathione peroxidase 2 decreases expression ISO enilconazole results in decreased expression of GPX2 mRNA CTD PMID:29451352 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746 		JBrowse link
G GSR glutathione-disulfide reductase increases expression ISO enilconazole results in increased expression of GSR mRNA CTD PMID:29451352 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSS glutathione synthetase decreases expression ISO enilconazole results in decreased expression of GSS mRNA CTD PMID:29451352 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027 		JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase decreases expression EXP enilconazole results in decreased expression of HAAO mRNA CTD PMID:32201337 NCBI chr 2:42,767,089...42,792,583
Ensembl chr 2:42,767,089...42,792,593 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase affects expression ISO enilconazole affects the expression of HMGCR mRNA CTD PMID:30853599 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 affects expression ISO enilconazole affects the expression of HMGCS1 mRNA CTD PMID:30853599 NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512 		JBrowse link
G HSD17B13 hydroxysteroid 17-beta dehydrogenase 13 decreases expression ISO enilconazole results in decreased expression of HSD17B13 mRNA CTD PMID:30853599 NCBI chr 4:87,303,794...87,322,882
Ensembl chr 4:87,303,789...87,322,886 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects expression ISO enilconazole affects the expression of HSD3B1 mRNA CTD PMID:30853599 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G IFNG interferon gamma increases expression ISO enilconazole results in increased expression of IFNG mRNA CTD PMID:27393971 PMID:32814239 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL17A interleukin 17A multiple interactions
increases expression		 ISO enilconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]
enilconazole results in increased expression of IL17A mRNA		 CTD PMID:22289359 PMID:32814239 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1A interleukin 1 alpha increases expression ISO enilconazole results in increased expression of IL1A mRNA CTD PMID:32814239 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta increases expression ISO enilconazole results in increased expression of IL1B mRNA CTD PMID:27393971 PMID:32814239 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL22 interleukin 22 increases expression ISO enilconazole results in increased expression of IL22 mRNA CTD PMID:27393971 PMID:32814239 NCBI chr12:68,248,242...68,253,604
Ensembl chr12:68,248,242...68,253,604 		JBrowse link
G IL6 interleukin 6 increases expression ISO
EXP		 enilconazole results in increased expression of IL6 mRNA CTD PMID:27393971 PMID:32201337 PMID:32814239 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP enilconazole results in increased expression of JUN mRNA CTD PMID:32201337 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KHK ketohexokinase decreases expression EXP enilconazole results in decreased expression of KHK mRNA CTD PMID:32201337 NCBI chr 2:27,086,772...27,100,762
Ensembl chr 2:27,086,772...27,100,762 		JBrowse link
G KLF4 KLF transcription factor 4 affects expression
decreases expression		 ISO enilconazole affects the expression of KLF4 mRNA
enilconazole results in decreased expression of KLF4 mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482 		JBrowse link
G KY kyphoscoliosis peptidase decreases expression
multiple interactions		 ISO enilconazole results in decreased expression of KY mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of KY mRNA		 CTD PMID:33426623 NCBI chr 3:134,599,923...134,651,022
Ensembl chr 3:134,599,923...134,651,636 		JBrowse link
G LCN2 lipocalin 2 increases expression ISO enilconazole results in increased expression of LCN2 CTD PMID:27393971 NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453 		JBrowse link
G LHB luteinizing hormone subunit beta decreases expression ISO enilconazole results in decreased expression of LHB protein CTD PMID:36410587 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G LPL lipoprotein lipase increases expression EXP enilconazole results in increased expression of LPL mRNA CTD PMID:32201337 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G LY6D lymphocyte antigen 6 family member D decreases expression EXP enilconazole results in decreased expression of LY6D mRNA CTD PMID:32201337 NCBI chr 8:142,784,882...142,786,539
Ensembl chr 8:142,784,882...142,786,539 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression EXP enilconazole results in increased expression of MAPK8 mRNA CTD PMID:32201337 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MEGF11 multiple EGF like domains 11 multiple interactions
decreases expression		 ISO [enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of MEGF11 mRNA
enilconazole results in decreased expression of MEGF11 mRNA		 CTD PMID:33426623 NCBI chr15:65,895,299...66,253,750
Ensembl chr15:65,895,079...66,253,756 		JBrowse link
G MEP1B meprin A subunit beta affects expression
decreases expression		 ISO enilconazole affects the expression of MEP1B mRNA
enilconazole results in decreased expression of MEP1B mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr18:32,190,039...32,220,404
Ensembl chr18:32,185,069...32,220,404 		JBrowse link
G MLXIPL MLX interacting protein like decreases expression EXP enilconazole results in decreased expression of MLXIPL mRNA CTD PMID:32201337 NCBI chr 7:73,593,202...73,647,907
Ensembl chr 7:73,593,194...73,624,543 		JBrowse link
G MME membrane metalloendopeptidase increases expression
multiple interactions		 ISO enilconazole results in increased expression of MME mRNA
[enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of MME mRNA		 CTD PMID:33426623 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
G MTTP microsomal triglyceride transfer protein decreases expression EXP enilconazole results in decreased expression of MTTP mRNA CTD PMID:32201337 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997 		JBrowse link
G MUC1 mucin 1, cell surface associated affects expression
decreases expression		 ISO enilconazole affects the expression of MUC1 mRNA
enilconazole results in decreased expression of MUC1 mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916 		JBrowse link
G MUC17 mucin 17, cell surface associated decreases expression ISO enilconazole results in decreased expression of MUC17 mRNA CTD PMID:32814239 NCBI chr 7:101,020,081...101,058,859
Ensembl chr 7:101,020,072...101,058,859 		JBrowse link
G MUC2 mucin 2, oligomeric mucus/gel-forming affects expression
decreases expression		 ISO enilconazole affects the expression of MUC2 mRNA
enilconazole results in decreased expression of MUC2 mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr11:1,074,874...1,110,508
Ensembl chr11:1,074,875...1,110,511 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions
decreases expression		 EXP [clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA
enilconazole results in decreased expression of NR0B2 mRNA		 CTD PMID:32201337 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 decreases expression
increases expression		 ISO enilconazole results in decreased expression of NR1H4 mRNA
enilconazole results in increased expression of NR1H4 mRNA		 CTD PMID:29451352 PMID:32814239 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity		 EXP
ISO		 [enilconazole co-treated with methidathion] results in increased activity of NR1I2 protein; enilconazole binds to and results in increased activity of NR1I2 protein; enilconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
enilconazole results in increased activity of NR1I2 protein		 CTD PMID:16565514 PMID:17438109 PMID:21115097 PMID:25028461 PMID:29973476 More... NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions
affects response to substance		 ISO enilconazole binds to and results in increased activity of NR1I3 protein; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]
NR1I3 protein affects the susceptibility to enilconazole		 CTD PMID:18832183 PMID:27853109 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 decreases expression EXP enilconazole results in decreased expression of PDK4 mRNA CTD PMID:32201337 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516 		JBrowse link
G PNPLA3 patatin like phospholipase domain containing 3 decreases expression EXP enilconazole results in decreased expression of PNPLA3 mRNA CTD PMID:32201337 NCBI chr22:43,923,805...43,947,582
Ensembl chr22:43,923,792...43,964,488 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP
ISO		 enilconazole binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression EXP enilconazole results in decreased expression of PPARGC1A mRNA CTD PMID:32201337 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [enilconazole binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RARA retinoic acid receptor alpha increases activity EXP enilconazole results in increased activity of RARA protein CTD PMID:20143881 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G RARG retinoic acid receptor gamma increases activity EXP enilconazole results in increased activity of RARG protein CTD PMID:20143881 NCBI chr12:53,210,569...53,232,209
Ensembl chr12:53,210,567...53,232,980 		JBrowse link
G RETNLB resistin like beta affects expression ISO enilconazole affects the expression of RETNLB mRNA CTD PMID:29106682 NCBI chr 3:108,755,638...108,757,410
Ensembl chr 3:108,743,424...108,757,410 		JBrowse link
G RGCC regulator of cell cycle increases expression EXP enilconazole results in increased expression of RGCC mRNA CTD PMID:32201337 NCBI chr13:41,457,550...41,470,871
Ensembl chr13:41,457,550...41,470,871 		JBrowse link
G RORA RAR related orphan receptor A multiple interactions ISO enilconazole binds to and results in decreased activity of RORA protein CTD PMID:22289359 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G S100P S100 calcium binding protein P increases expression EXP enilconazole results in increased expression of S100P mRNA; enilconazole results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170 		JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP enilconazole results in decreased expression of SCD mRNA CTD PMID:32201337 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression ISO enilconazole results in decreased expression of SLC10A1 mRNA CTD PMID:29451352 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SLC10A2 solute carrier family 10 member 2 increases expression ISO enilconazole results in increased expression of SLC10A2 mRNA CTD PMID:32814239 NCBI chr13:103,043,998...103,066,417
Ensembl chr13:103,043,998...103,066,417 		JBrowse link
G SLC12A2 solute carrier family 12 member 2 decreases expression ISO enilconazole results in decreased expression of SLC12A2 mRNA; enilconazole results in decreased expression of SLC12A2 protein CTD PMID:29106682 PMID:32814239 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677 		JBrowse link
G SLC22A5 solute carrier family 22 member 5 decreases expression ISO
EXP		 enilconazole results in decreased expression of SLC22A5 mRNA; enilconazole results in decreased expression of SLC22A5 protein CTD PMID:36150497 NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613 		JBrowse link
G SLC26A3 solute carrier family 26 member 3 decreases expression ISO enilconazole results in decreased expression of SLC26A3 mRNA; enilconazole results in decreased expression of SLC26A3 protein CTD PMID:29106682 PMID:32814239 NCBI chr 7:107,765,469...107,803,223
Ensembl chr 7:107,765,467...107,803,225 		JBrowse link
G SLC26A6 solute carrier family 26 member 6 decreases expression ISO enilconazole results in decreased expression of SLC26A6 mRNA; enilconazole results in decreased expression of SLC26A6 protein CTD PMID:29106682 PMID:32814239 NCBI chr 3:48,625,723...48,635,461
Ensembl chr 3:48,625,723...48,635,493 		JBrowse link
G SLC6A1 solute carrier family 6 member 1 multiple interactions ISO [enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA CTD PMID:33426623 NCBI chr 3:10,992,748...11,039,247
Ensembl chr 3:10,992,186...11,039,247 		JBrowse link
G SLC9A3 solute carrier family 9 member A3 decreases expression ISO enilconazole results in decreased expression of SLC9A3 mRNA CTD PMID:29106682 PMID:32814239 NCBI chr 5:470,456...524,449
Ensembl chr 5:470,456...524,449 		JBrowse link
G SLCO4A1 solute carrier organic anion transporter family member 4A1 increases expression EXP enilconazole results in increased expression of SLCO4A1 mRNA CTD PMID:32201337 NCBI chr20:62,642,503...62,690,740
Ensembl chr20:62,642,503...62,685,785 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression ISO enilconazole results in increased expression of SOD1 mRNA CTD PMID:29451352 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 decreases expression ISO enilconazole results in decreased expression of SOD2 mRNA CTD PMID:29451352 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G STAR steroidogenic acute regulatory protein affects expression
decreases expression		 ISO enilconazole affects the expression of STAR mRNA
enilconazole results in decreased expression of STAR mRNA		 CTD PMID:30853599 PMID:36410587 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G SULT1B1 sulfotransferase family 1B member 1 decreases expression EXP enilconazole results in decreased expression of SULT1B1 mRNA CTD PMID:32201337 NCBI chr 4:69,721,167...69,760,620
Ensembl chr 4:69,721,167...69,787,961 		JBrowse link
G SULT1C2 sulfotransferase family 1C member 2 increases expression EXP enilconazole results in increased expression of SULT1C2 mRNA CTD PMID:32201337 NCBI chr 2:108,288,895...108,309,915
Ensembl chr 2:108,288,639...108,309,915 		JBrowse link
G TFF3 trefoil factor 3 decreases expression EXP enilconazole results in decreased expression of TFF3 mRNA CTD PMID:32201337 NCBI chr21:42,311,667...42,315,409
Ensembl chr21:42,311,667...42,315,409 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP enilconazole binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G TNF tumor necrosis factor increases expression ISO enilconazole results in increased expression of TNF mRNA CTD PMID:27393971 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 decreases expression EXP enilconazole results in decreased expression of UGT2B7 mRNA CTD PMID:32201337 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      chemical substance 15508
        mixture 14678
          racemate 12884
            enilconazole 114
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  heteroarene 18790
                                    monocyclic heteroarene 16149
                                      azole 15707
                                        diazole 11203
                                          imidazoles 10358
                                            1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole 114
                                              (S)-enilconazole 114
                                                enilconazole 114
paths to the root