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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ioxynil
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Accession:CHEBI:81821 term browser browse the term
Definition:A nitrile that is benzonitrile substituted by a hydroxy group at position 4 and iodo groups at positions 3 and 5.
Synonyms:exact_synonym: 4-hydroxy-3,5-diiodobenzonitrile
 related_synonym: Actril;   Bentrol;   Formula=C7H3I2NO;   InChI=1S/C7H3I2NO/c8-5-1-4(3-10)2-6(9)7(5)11/h1-2,11H;   InChIKey=NRXQIUSYPAHGNM-UHFFFAOYSA-N;   Loxynil;   SMILES=Oc1c(I)cc(cc1I)C#N
 xref: CAS:1689-83-4;   KEGG:C18546
 xref_mesh: MESH:C008161
 xref: PMID:22893975;   PMID:24449421;   PPDB:402;   Pesticides:ioxynil;   Reaxys:2364041


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ioxynil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 multiple interactions
affects localization
decreases activity
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [ioxynil analog results in decreased activity of GJA1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog affects the phosphorylation of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil analog results in decreased expression of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil results in decreased expression of GJA1 protein]; ioxynil analog results in decreased expression of and affects the phosphorylation of GJA1 protein; ioxynil results in decreased expression of and affects the phosphorylation of GJA1 protein
ioxynil affects the localization of GJA1 protein; ioxynil analog affects the localization of GJA1 protein
ioxynil analog results in decreased activity of GJA1 protein; ioxynil results in decreased activity of GJA1 protein
CTD PMID:20510257 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
increases activity
EXP ioxynil results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog results in increased activity of MAPK1 protein]
CTD PMID:20510257 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases activity
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog results in increased activity of MAPK3 protein]
ioxynil results in decreased phosphorylation of MAPK3 protein
CTD PMID:20510257 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        xenobiotic 18391
          ioxynil 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic aromatic compound 19155
                                  phenols 18140
                                    halophenol 1811
                                      iodophenol 413
                                        ioxynil 3
paths to the root