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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ioxynil
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Accession:CHEBI:81821 term browser browse the term
Definition:A nitrile that is benzonitrile substituted by a hydroxy group at position 4 and iodo groups at positions 3 and 5.
Synonyms:exact_synonym: 4-hydroxy-3,5-diiodobenzonitrile
 related_synonym: Actril;   Bentrol;   Formula=C7H3I2NO;   InChI=1S/C7H3I2NO/c8-5-1-4(3-10)2-6(9)7(5)11/h1-2,11H;   InChIKey=NRXQIUSYPAHGNM-UHFFFAOYSA-N;   Loxynil;   SMILES=Oc1c(I)cc(cc1I)C#N
 xref: CAS:1689-83-4;   KEGG:C18546
 xref_mesh: MESH:C008161
 xref: PMID:22893975;   PMID:24449421;   PPDB:402;   Pesticides:ioxynil;   Reaxys:2364041



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ioxynil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 multiple interactions
affects localization
decreases activity
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [ioxynil analog results in decreased activity of GJA1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog affects the phosphorylation of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil analog results in decreased expression of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil results in decreased expression of GJA1 protein]; ioxynil analog results in decreased expression of and affects the phosphorylation of GJA1 protein; ioxynil results in decreased expression of and affects the phosphorylation of GJA1 protein
ioxynil affects the localization of GJA1 protein; ioxynil analog affects the localization of GJA1 protein
ioxynil analog results in decreased activity of GJA1 protein; ioxynil results in decreased activity of GJA1 protein
CTD PMID:20510257 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
increases activity
EXP ioxynil results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog results in increased activity of MAPK1 protein]
CTD PMID:20510257 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
decreases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog results in increased activity of MAPK3 protein]
ioxynil results in decreased phosphorylation of MAPK3 protein
CTD PMID:20510257 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20069
    role 20021
      biological role 20020
        xenobiotic 18665
          ioxynil 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20069
    subatomic particle 20068
      composite particle 20068
        hadron 20068
          baryon 20068
            nucleon 20068
              atomic nucleus 20068
                atom 20068
                  main group element atom 19969
                    p-block element atom 19969
                      carbon group element atom 19892
                        carbon atom 19885
                          organic molecular entity 19885
                            organic molecule 19833
                              organic cyclic compound 19587
                                organic aromatic compound 19428
                                  phenols 18649
                                    halophenol 2492
                                      iodophenol 423
                                        ioxynil 3
paths to the root