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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flutolanil
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Accession:CHEBI:81792 term browser browse the term
Definition:A member of the class of benzamides, obtained by formal condensation of the carboxy group of 2-(trifluoromethyl)benzoic acid with the amino group of 3-(ispropyloxy)aniline. A fungicide used to control a range of pathogens especially Rhizoctonia spp. on rice, turf and other crops.
Synonyms:exact_synonym: N-[3-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)benzamide
 related_synonym: 3'-isopropoxy-2-trifloromethylbenzoic acid anilide;   Formula=C17H16F3NO2;   InChI=1S/C17H16F3NO2/c1-11(2)23-13-7-5-6-12(10-13)21-16(22)14-8-3-4-9-15(14)17(18,19)20/h3-11H,1-2H3,(H,21,22);   InChIKey=PTCGDEVVHUXTMP-UHFFFAOYSA-N;   Moncut;   N-(3-(1-Methylethoxy)phenyl)-2-(trifluoromethyl)benzamide;   N-(3-isopropoxyphenyl)-2-(trifluoromethyl)benzamide;   NNF-136;   SMILES=CC(C)Oc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1;   alpha,alpha,alpha-Trifluoro-3'-isopropoxy-o-toluanilide;   o-trifluoromethyl-m'-isopropoxybenzoic anilide
 xref: CAS:66332-96-5;   KEGG:C18502
 xref_mesh: MESH:C475882
 xref: MetaCyc:CPD-15890;   PDBeChem:FTN;   PMID:21587472;   PPDB:352;   Pesticides:flutolanil;   Reaxys:2163858


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flutolanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO flutolanil results in increased expression of CYP3A4 mRNA CTD PMID:17293382 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions 		ISO flutolanil results in decreased expression of ESR1 protein
flutolanil binds to and results in increased activity of ESR1 protein 		CTD PMID:17904202 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO flutolanil binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Pgr progesterone receptor increases expression ISO flutolanil results in increased expression of PGR mRNA CTD PMID:17904202 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO flutolanil results in increased activity of PPARG protein CTD PMID:20143881 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO flutolanil results in increased expression of TFF1 mRNA CTD PMID:17904202 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      application 20622
        pesticide 18475
          antifungal agrochemical 12185
            flutolanil 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20207
                              organochalcogen compound 19905
                                organooxygen compound 19807
                                  carbon oxoacid 19157
                                    carboxylic acid 19154
                                      carboacyl group 18089
                                        univalent carboacyl group 18071
                                          carbamoyl group 17906
                                            carboxamide 17925
                                              monocarboxylic acid amide 15956
                                                arenecarboxamide 8280
                                                  benzamides 8285
                                                    flutolanil 6
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