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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flutolanil
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Accession:CHEBI:81792 term browser browse the term
Definition:A member of the class of benzamides, obtained by formal condensation of the carboxy group of 2-(trifluoromethyl)benzoic acid with the amino group of 3-(ispropyloxy)aniline. A fungicide used to control a range of pathogens especially Rhizoctonia spp. on rice, turf and other crops.
Synonyms:exact_synonym: N-[3-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)benzamide
 related_synonym: 3'-isopropoxy-2-trifloromethylbenzoic acid anilide;   Formula=C17H16F3NO2;   InChI=1S/C17H16F3NO2/c1-11(2)23-13-7-5-6-12(10-13)21-16(22)14-8-3-4-9-15(14)17(18,19)20/h3-11H,1-2H3,(H,21,22);   InChIKey=PTCGDEVVHUXTMP-UHFFFAOYSA-N;   Moncut;   N-(3-(1-Methylethoxy)phenyl)-2-(trifluoromethyl)benzamide;   N-(3-isopropoxyphenyl)-2-(trifluoromethyl)benzamide;   NNF-136;   SMILES=CC(C)Oc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1;   alpha,alpha,alpha-Trifluoro-3'-isopropoxy-o-toluanilide;   o-trifluoromethyl-m'-isopropoxybenzoic anilide
 xref: CAS:66332-96-5;   KEGG:C18502
 xref_mesh: MESH:C475882
 xref: MetaCyc:CPD-15890;   PDBeChem:FTN;   PMID:21587472;   PPDB:352;   Pesticides:flutolanil;   Reaxys:2163858


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flutolanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO flutolanil results in increased expression of CYP3A4 mRNA CTD PMID:17293382 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions		 ISO flutolanil results in decreased expression of ESR1 protein
flutolanil binds to and results in increased activity of ESR1 protein		 CTD PMID:17904202 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO flutolanil binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pgr progesterone receptor increases expression ISO flutolanil results in increased expression of PGR mRNA CTD PMID:17904202 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO flutolanil results in increased activity of PPARG protein CTD PMID:20143881 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO flutolanil results in increased expression of TFF1 mRNA CTD PMID:17904202 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pesticide 18096
          antifungal agrochemical 12057
            flutolanil 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbon oxoacid 18687
                                    carboxylic acid 18684
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17579
                                            carboxamide 17579
                                              monocarboxylic acid amide 15749
                                                arenecarboxamide 8259
                                                  benzamides 8259
                                                    flutolanil 6
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