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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fludioxonil
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Accession:CHEBI:81763 term browser browse the term
Definition:A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.
Synonyms:exact_synonym: 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile
 related_synonym: Formula=C12H6F2N2O2;   InChI=1S/C12H6F2N2O2/c13-12(14)17-10-3-1-2-8(11(10)18-12)9-6-16-5-7(9)4-15/h1-3,5-6,16H;   InChIKey=MUJOIMFVNIBMKC-UHFFFAOYSA-N;   SMILES=C1=CC=C2C(=C1C3=CNC=C3C#N)OC(O2)(F)F
 xref: CAS:131341-86-1;   KEGG:C18462
 xref_mesh: MESH:C108339
 xref: PMID:23052036;   PMID:23256745;   PMID:23436777;   PMID:23799251;   PMID:24423402;   PMID:24598029;   PMID:24635026;   PPDB:330;   Pesticides:fludioxonil;   Reaxys:8393936


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fludioxonil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 multiple interactions
decreases expression
ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA; [tebuconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA
fludioxonil results in decreased expression of ACOX1 mRNA
CTD PMID:33575850 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acox2 acyl-CoA oxidase 2 multiple interactions
decreases expression
ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA; [propiconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA
fludioxonil results in decreased expression of ACOX2 mRNA
CTD PMID:33575850 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO fludioxonil binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Anxa10 annexin A10 increases expression ISO fludioxonil results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO fludioxonil inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; fludioxonil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
fludioxonil binds to AR protein
CTD PMID:21310686 PMID:23436777 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 decreases expression ISO fludioxonil results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO fludioxonil results in increased expression of BCL2 mRNA
fludioxonil results in decreased expression of BCL2 protein
MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]
CTD PMID:23052036 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO [pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA
fludioxonil results in increased expression of CASP3 mRNA
CTD PMID:22880100 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase affects binding ISO fludioxonil binds to CAT protein CTD PMID:32278787 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
increases expression
ISO ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; Estradiol inhibits the reaction [fludioxonil results in increased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCND1 protein]
fludioxonil results in increased expression of CCND1 mRNA; fludioxonil results in increased expression of CCND1 protein
CTD PMID:23052036 PMID:23436777 PMID:27539251 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO fludioxonil results in increased expression of CCNE1 protein
fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCNE1 protein]
CTD PMID:27539251 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO fludioxonil results in decreased expression of CDH1 protein
fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein]
CTD PMID:27539251 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in increased expression of CDH2 protein] CTD PMID:27539251 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDKN1A protein] CTD PMID:27539251 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in increased expression of CTSD protein] CTD PMID:27539251 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO fludioxonil results in increased expression of CYP1A1 mRNA; fludioxonil results in increased expression of CYP1A1 protein
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA; [propiconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA; [tebuconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA
CTD PMID:32194361 PMID:33575850 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO fludioxonil results in increased expression of CYP1A2 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA; [propiconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA; [tebuconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA
CTD PMID:33575850 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA; [propiconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA; [tebuconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA
fludioxonil results in increased expression of CYP2B6 mRNA
CTD PMID:33575850 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO fludioxonil results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO fludioxonil results in decreased activity of CYP3A4 protein
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA
CTD PMID:25028461 PMID:33575850 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO fludioxonil results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects binding ISO fludioxonil binds to ERBB2 protein CTD PMID:32278787 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
decreases expression
ISO [fludioxonil co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR1 protein; ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; fludioxonil binds to and results in increased activity of ESR1 protein; fludioxonil inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
fludioxonil results in increased activity of ESR1 protein
fludioxonil results in decreased expression of ESR1 mRNA
CTD PMID:20143881 PMID:23052036 PMID:23436777 PMID:26812056 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
decreases expression
increases expression
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR2 protein; fludioxonil binds to and results in increased activity of ESR2 protein; fludioxonil inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]
fludioxonil results in increased activity of ESR2 protein
fludioxonil results in decreased expression of ESR2 mRNA
fludioxonil results in increased expression of ESR2 mRNA
CTD PMID:23052036 PMID:23436777 PMID:26812056 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO fludioxonil results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO fludioxonil results in increased expression of GPX1 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA
CTD PMID:22880100 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein
fludioxonil results in increased phosphorylation of H2AX protein
CTD PMID:22389207 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases activity ISO fludioxonil results in increased activity of HSD11B2 protein CTD PMID:31927052 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Mir200a microRNA 200a increases expression ISO fludioxonil results in increased expression of MIR200A mRNA CTD PMID:23052036 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA] CTD PMID:23052036 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir22 microRNA 22 decreases expression ISO fludioxonil results in decreased expression of MIR22 mRNA CTD PMID:23052036 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mlxipl MLX interacting protein-like decreases expression
multiple interactions
ISO fludioxonil results in decreased expression of MLXIPL mRNA
[difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA; [tebuconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA
CTD PMID:33575850 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression
ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; fludioxonil binds to and results in increased activity of NR1I2 protein
fludioxonil results in decreased expression of NR1I2 mRNA
CTD PMID:25028461 PMID:33049310 PMID:33575850 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression
multiple interactions
ISO fludioxonil results in decreased expression of NR1I3 mRNA
[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA; [propiconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA; [tebuconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA
CTD PMID:33575850 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO fludioxonil results in increased expression of NRF1 mRNA CTD PMID:23436777 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO fludioxonil results in increased expression of PARP1 protein CTD PMID:23052036 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO fludioxonil results in increased expression of PCNA protein CTD PMID:27539251 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
multiple interactions
ISO fludioxonil results in decreased expression of PDCD4 mRNA; fludioxonil results in decreased expression of PDCD4 protein
MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]
CTD PMID:23052036 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
decreases expression
ISO fludioxonil results in increased expression of PGR mRNA
Estradiol inhibits the reaction [fludioxonil results in increased expression of PGR mRNA]
fludioxonil results in decreased expression of PGR mRNA
CTD PMID:23052036 PMID:23436777 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fludioxonil binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO fludioxonil results in decreased expression of PTEN mRNA CTD PMID:23052036 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [fludioxonil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO fludioxonil results in decreased expression of RARB mRNA CTD PMID:23436777 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO fludioxonil results in increased activity of RXRB protein CTD PMID:20143881 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein] CTD PMID:27539251 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO fludioxonil binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions ISO [Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA CTD PMID:23052036 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007
JBrowse link

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    role 19769
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            fludioxonil 47
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
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              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  heteroarene 16530
                                    monocyclic heteroarene 13437
                                      azole 12628
                                        pyrroles 5887
                                          fludioxonil 47
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