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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fludioxonil
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Accession:CHEBI:81763 term browser browse the term
Definition:A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.
Synonyms:exact_synonym: 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile
 related_synonym: Formula=C12H6F2N2O2;   InChI=1S/C12H6F2N2O2/c13-12(14)17-10-3-1-2-8(11(10)18-12)9-6-16-5-7(9)4-15/h1-3,5-6,16H;   InChIKey=MUJOIMFVNIBMKC-UHFFFAOYSA-N;   SMILES=C1=CC=C2C(=C1C3=CNC=C3C#N)OC(O2)(F)F
 xref: CAS:131341-86-1;   KEGG:C18462
 xref_mesh: MESH:C108339
 xref: PMID:23052036;   PMID:23256745;   PMID:23436777;   PMID:23799251;   PMID:24423402;   PMID:24598029;   PMID:24635026;   PPDB:330;   Pesticides:fludioxonil;   Reaxys:8393936


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fludioxonil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO fludioxonil binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO fludioxonil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
fludioxonil binds to AR protein
CTD PMID:21310686, PMID:23436777 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO fludioxonil results in increased expression of BCL2 mRNA
fludioxonil results in decreased expression of BCL2 protein
MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]
CTD PMID:23052036 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO [pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA
fludioxonil results in increased expression of CASP3 mRNA
CTD PMID:22880100 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase affects binding ISO fludioxonil binds to CAT protein CTD PMID:32278787 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
increases expression
ISO ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; Estradiol inhibits the reaction [fludioxonil results in increased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCND1 protein]
fludioxonil results in increased expression of CCND1 mRNA; fludioxonil results in increased expression of CCND1 protein
CTD PMID:23052036, PMID:23436777, PMID:27539251 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO fludioxonil results in increased expression of CCNE1 protein
fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCNE1 protein]
CTD PMID:27539251 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO fludioxonil results in decreased expression of CDH1 protein
fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein]
CTD PMID:27539251 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in increased expression of CDH2 protein] CTD PMID:27539251 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDKN1A protein] CTD PMID:27539251 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in increased expression of CTSD protein] CTD PMID:27539251 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects binding ISO fludioxonil binds to ERBB2 protein CTD PMID:32278787 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
decreases expression
ISO [fludioxonil co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR1 protein; ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; fludioxonil binds to and results in increased activity of ESR1 protein; fludioxonil inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
fludioxonil results in increased activity of ESR1 protein
fludioxonil results in decreased expression of ESR1 mRNA
CTD PMID:20143881, PMID:23052036, PMID:23436777, PMID:26812056 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
decreases expression
increases expression
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR2 protein; fludioxonil inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]
fludioxonil results in increased activity of ESR2 protein
fludioxonil results in decreased expression of ESR2 mRNA
fludioxonil results in increased expression of ESR2 mRNA
CTD PMID:23052036, PMID:23436777, PMID:26812056 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO fludioxonil results in increased expression of GPX1 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA
CTD PMID:22880100 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein
fludioxonil results in increased phosphorylation of H2AX protein
CTD PMID:22389207 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases activity ISO fludioxonil results in increased activity of HSD11B2 protein CTD PMID:31927052 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Mir200a microRNA 200a increases expression ISO fludioxonil results in increased expression of MIR200A mRNA CTD PMID:23052036 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA] CTD PMID:23052036 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir22 microRNA 22 decreases expression ISO fludioxonil results in decreased expression of MIR22 mRNA CTD PMID:23052036 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO fludioxonil results in increased expression of NRF1 mRNA CTD PMID:23436777 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO fludioxonil results in increased expression of PARP1 protein CTD PMID:23052036 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO fludioxonil results in increased expression of PCNA protein CTD PMID:27539251 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
multiple interactions
ISO fludioxonil results in decreased expression of PDCD4 mRNA; fludioxonil results in decreased expression of PDCD4 protein
MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]
CTD PMID:23052036 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
decreases expression
ISO fludioxonil results in increased expression of PGR mRNA
Estradiol inhibits the reaction [fludioxonil results in increased expression of PGR mRNA]
fludioxonil results in decreased expression of PGR mRNA
CTD PMID:23052036, PMID:23436777 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO fludioxonil results in decreased expression of PTEN mRNA CTD PMID:23052036 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [fludioxonil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO fludioxonil results in decreased expression of RARB mRNA CTD PMID:23436777 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO fludioxonil results in increased activity of RXRB protein CTD PMID:20143881 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein] CTD PMID:27539251 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions ISO [Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA CTD PMID:23052036 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          antifungal agrochemical 7529
            fludioxonil 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  heteroarene 16445
                                    monocyclic heteroarene 13300
                                      azole 12468
                                        pyrroles 5866
                                          fludioxonil 32
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.