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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:81731 term browser browse the term
Definition:An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for controlling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.
Synonyms:exact_synonym: O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl phosphorothioate
 related_synonym: Basilex;   Formula=C9H11Cl2O3PS;   Grancer;   InChI=1S/C9H11Cl2O3PS/c1-6-4-7(10)9(8(11)5-6)14-15(16,12-2)13-3/h4-5H,1-3H3;   InChIKey=OBZIQQJJIKNWNO-UHFFFAOYSA-N;   O-(2,6-dichloro-4-methylphenyl)phosphorothioic acid O,O-dimethyl ester;   O-2,6-dichloro-p-tolyl O,O-dimethyl phosphorothioate;   Risolex;   Rizolex;   S-3349;   SMILES=COP(=S)(OC)Oc1c(Cl)cc(C)cc1Cl;   tolclofos-Me
 xref: AGR:IND87036376;   AGR:IND89044092;   AGR:IND89050261;   AGR:IND90053822;   AGR:IND92055792;   CAS:57018-04-9;   KEGG:C18407
 xref_mesh: MESH:C426783
 xref: PMID:11258873;   PPDB:644;   Patent:DE2501040;   Patent:GB1467561;   Pesticides:tolclofos-methyl;   Reaxys:2136521

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tolclofos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [tolclofos-methyl results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO tolclofos-methyl results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO tolclofos-methyl results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tolclofos-methyl binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO tolclofos-methyl results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    role 19767
      application 19445
        pesticide 16593
          antifungal agrochemical 8076
            tolclofos-methyl 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      chalcogen 19407
                        oxygen atom 19368
                          oxygen molecular entity 19368
                            hydroxides 19094
                              oxoacid 18243
                                pnictogen oxoacid 10301
                                  phosphorus oxoacid 9222
                                    phosphoric acids 7942
                                      phosphoric acid 7942
                                        phosphoric acid derivative 7622
                                          phosphate 7622
                                            organic phosphate 7621
                                              organic thiophosphate 2894
                                                tolclofos-methyl 5
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