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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,2',4,5'-Tetrabromodiphenyl ether
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Accession:CHEBI:81583 term browser browse the term
Definition:An organobromine compound that has formula C12H6Br4O.
Synonyms:related_synonym: BDE 49;   Formula=C12H6Br4O;   InChI=1S/C12H6Br4O/c13-7-2-4-11(10(16)5-7)17-12-6-8(14)1-3-9(12)15/h1-6H;   InChIKey=QWVDUBDYUPHNHY-UHFFFAOYSA-N;   PBDE 49;   SMILES=Brc1ccc(Oc2cc(Br)ccc2Br)c(Br)c1
 xref: CAS:243982-82-3;   KEGG:C18204
 xref_mesh: MESH:C572625


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2,2',4,5'-Tetrabromodiphenyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to ALB protein] CTD PMID:29283575 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of 2,2',4,5'-tetrabromodiphenyl ether analog CTD PMID:23249762 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether analog binds to and results in decreased activity of ESR1 protein CTD PMID:23603053 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether analog inhibits the reaction [Estradiol analog binds to GPER1 protein] CTD PMID:29790728 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Hdc histidine decarboxylase increases expression EXP 2,2',4,5'-tetrabromodiphenyl ether metabolite results in increased expression of HDC mRNA CTD PMID:29357290 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO 2,2',4,5'-tetrabromodiphenyl ether analog results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr 1:40,086,513...40,100,966
Ensembl chr 1:40,086,470...40,101,840
JBrowse link
G Slc25a25 solute carrier family 25 member 25 increases expression EXP 2,2',4,5'-tetrabromodiphenyl ether metabolite results in increased expression of SLC25A25 mRNA CTD PMID:29357290 NCBI chr 3:11,442,396...11,476,186
Ensembl chr 3:11,442,397...11,452,529
JBrowse link
G Ttr transthyretin multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein] CTD PMID:29283575 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        main group molecular entity 19670
          p-block molecular entity 19670
            halogen molecular entity 18012
              bromine molecular entity 5474
                organobromine compound 5399
                  2,2',4,5'-Tetrabromodiphenyl ether 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  ether 15937
                                    aromatic ether 15393
                                      2,2',4,5'-Tetrabromodiphenyl ether 9
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