Erythropoietin - Ontology Report - Rat Genome Database

Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of COX4I1 protein]

NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068

CREB1

cAMP responsive element binding protein 1

increases phosphorylation

ISO

Erythropoietin increases phosphorylation in Creb1 protein in ventral horn of spinal cord

RGD

PMID:17368520

RGD:155226865

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

citrate synthase

multiple interactions

Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of CS protein]

NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391

ITGAM

integrin subunit alpha M

decreases expression

ISO

Erythropoietin decreases expression of Itgam protein in hypoxic microglial cells

RGD

PMID:33104828

RGD:329902063

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

NRF1

nuclear respiratory factor 1

increases expression
multiple interactions

Erythropoietin results in increased expression of NRF1 protein
Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of NRF1 protein]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of NRF1 protein]]

NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082

PPARGC1A

PPARG coactivator 1 alpha

multiple interactions

Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased acetylation of PPARGC1A protein]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]]

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

SIRT1

sirtuin 1

multiple interactions

Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein]; Erythropoietin results in increased expression of and results in increased activity of SIRT1 protein; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of NRF1 protein]]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of VDAC1 protein]]

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

SOD2

superoxide dismutase 2

multiple interactions
increases expression

Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]
Erythropoietin results in increased expression of SOD2 protein

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

TFAM

transcription factor A, mitochondrial

multiple interactions

Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]]

NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220

VDAC1

voltage dependent anion channel 1

multiple interactions

Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of VDAC1 protein]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of VDAC1 protein]]