Tributyltin oxide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Tributyltin oxide	go back to main search page
Accession:	CHEBI:81543	browse the term
Definition:	An inorganic molecular entity that has formula C24H54OSn2.
Synonyms:	related_synonym:	TBTO
	xref:	CAS:56-35-9
	xref_mesh:	MESH:C005961
	xref:	PPDB:2585; kegg.compound:C18149
	chemrof_inchikey:	APQHKWPGGHMYKJ-UHFFFAOYSA-N
	chemrof_formula:	C24H54OSn2
	chemrof_smiles:	CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[O][Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC
	chemrof_inchi:	InChI=1S/6C4H9.O.2Sn/c61-3-4-2;;;/h61,3-4H2,2H3;;;

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Genes (555)

Tributyltin oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate aminotransferase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of AADAT mRNA

NCBI chr16:34,520,236...34,566,388
Ensembl chr16:34,520,238...34,566,540

G

AP2 associated kinase 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of AAK1 protein

NCBI chr 4:120,845,012...121,009,170
Ensembl chr 4:120,858,557...121,004,236

G

ATP binding cassette subfamily A member 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ABCA1 mRNA

PMID:23824090 PMID:24356939 PMID:25270620

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily A member 5

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of ABCA5 protein

NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,739,610...95,808,424

G

ATP binding cassette subfamily G member 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ABCG1 mRNA

PMID:23824090 PMID:24356939 PMID:25270620

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

ABI family, member 3

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ABI3 mRNA

NCBI chr10:81,266,571...81,277,561
Ensembl chr10:81,266,571...81,277,561

G

ankyrin repeat and BTB domain containing 3

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ABTB3 mRNA

NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:19,923,814...20,198,110

G

acetyl-CoA carboxylase alpha

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of ACACA protein

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA dehydrogenase medium chain

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of ACADM mRNA

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

ATP citrate lyase

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of ACLY protein

NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631

G

actin, alpha 1, skeletal muscle

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of ACTA1 protein

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178

G

actinin, alpha 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ACTN1 mRNA

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172

G

ADAM metallopeptidase domain 19

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ADAM19 mRNA

NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455

G

ADAM-like, decysin 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ADAMDEC1 mRNA

NCBI chr15:47,076,011...47,097,065
Ensembl chr15:47,076,019...47,097,065

G

aldo-keto reductase family 1 member B10

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of AKR1B10 mRNA

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

aldo-keto reductase family 1, member C2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

AKT serine/threonine kinase 1

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of AKT1 mRNA

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

alkB homolog 5, RNA demethylase

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of ALKBH5 protein

NCBI chr10:45,844,411...45,865,853
Ensembl chr10:45,843,656...45,869,658

G

angiogenin

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ANG mRNA

NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106

G

ankyrin repeat domain 10

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ANKRD10 mRNA

NCBI chr16:84,566,021...84,591,849
Ensembl chr16:84,568,506...84,591,846

G

apoptotic peptidase activating factor 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of APAF1 mRNA

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

amyloid P component, serum

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of APCS mRNA

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

Apol9a-Apol7a readthrough

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of APOL3 mRNA

NCBI chr 7:111,011,645...111,019,326
Ensembl chr 7:111,011,645...111,017,084

G

anti-silencing function 1A histone chaperone

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ASF1A mRNA

NCBI chr20:33,436,632...33,451,478
Ensembl chr20:33,436,707...33,449,639

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

astacin like metalloendopeptidase

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of ASTL protein

NCBI chr 3:135,016,444...135,032,177
Ensembl chr 3:135,016,444...135,032,177

G

activating transcription factor 3

affects localization
increases expression

ISO
EXP

bis(tri-n-butyltin)oxide affects the localization of ATF3 protein
bis(tri-n-butyltin)oxide results in increased expression of ATF3 mRNA
bis(tri-n-butyltin)oxide results in increased expression of ATF3 mRNA; bis(tri-n-butyltin)oxide results in increased expression of ATF3 protein

PMID:21601586 PMID:22434021 PMID:22613032 PMID:23253260

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of ATF4 mRNA

PMID:17553608 PMID:21601586 PMID:22434021

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 5

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

activating transcription factor 6

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ATF6 mRNA

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

antioxidant 1 copper chaperone

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ATOX1 mRNA

NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585

G

ATP synthase F1 subunit gamma

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of ATP5F1C mRNA

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

ATP synthase membrane subunit e

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of ATP5ME mRNA

NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,464,800...1,465,988

G

Axl receptor tyrosine kinase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of AXL mRNA

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

beta-1,4-galactosyltransferase 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of B4GALT1 mRNA

NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:60,731,602...60,778,445

G

beta-1,4-galactosyltransferase 4

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of B4GALT4 mRNA

NCBI chr11:75,501,358...75,527,291
Ensembl chr11:75,501,366...75,527,177

G

BTB domain and CNC homolog 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BACH2 mRNA

NCBI chr 5:51,428,802...51,779,030
Ensembl chr 5:51,434,870...51,774,234

G

BAG cochaperone 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BAG3 mRNA

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

branched chain amino acid transaminase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288

G

BCL10, immune signaling adaptor

increases expression

EXP
ISO

bis(tri-n-butyltin)oxide results in increased expression of BCL10 mRNA

PMID:17553608 PMID:22434021

NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:237,501,134...237,511,829

G

BCL11 transcription factor A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BCL11A mRNA

NCBI chr14:102,230,147...102,325,289
Ensembl chr14:102,231,113...102,325,623

G

BCL2, apoptosis regulator

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of BCL2 mRNA

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of BCL2L1 mRNA

PMID:21601586 PMID:22434021

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

brain expressed X-linked 3

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of BEX3 mRNA

NCBI chr X:104,064,896...104,066,425
Ensembl chr X:104,064,515...104,075,906

G

biglycan

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of BGN mRNA

NCBI chr X:156,348,633...156,360,797
Ensembl chr X:156,348,615...156,360,799

G

BH3 interacting domain death agonist

increases expression
decreases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of BID mRNA
bis(tri-n-butyltin)oxide results in decreased expression of BID mRNA

PMID:17553608 PMID:22434021

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

BCL2-interacting killer

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of BIK mRNA

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

baculoviral IAP repeat-containing 3

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of BIRC3 mRNA

PMID:17553608 PMID:24247028

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

decreases expression

EXP
ISO

bis(tri-n-butyltin)oxide results in decreased expression of BIRC5 mRNA

PMID:17553608 PMID:17942131

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BLM RecQ like helicase

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of BLM mRNA

NCBI chr 1:143,819,072...143,905,300
Ensembl chr 1:143,819,090...143,905,210

G

BCL2 interacting protein 3 like

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

BRCA1, DNA repair associated

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

butyrophilin like 10

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of BTNL10 mRNA

NCBI chr10:44,193,623...44,202,715
Ensembl chr10:44,193,673...44,202,701

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of BUB1 mRNA

PMID:17942131 PMID:18958704

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of BUB1B mRNA

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:126,017,045...126,069,796

G

bystin-like

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of BYSL protein

NCBI chr 9:20,880,341...20,890,092
Ensembl chr 9:20,880,026...20,890,900

G

complement C2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of C2 mRNA

NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,955,776...3,981,740

G

calmodulin 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CALM2 mRNA

NCBI chr 6:12,845,170...12,857,830
Ensembl chr15:64,519,554...64,520,657
Ensembl chr 6:64,519,554...64,520,657

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CAMK2N1 mRNA

NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:155,957,878...155,961,058

G

calmodulin regulated spectrin-associated protein family, member 2

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of CAMSAP2 protein

NCBI chr13:50,274,950...50,354,298
Ensembl chr13:50,274,950...50,354,298

G

caspase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CASP1 mRNA

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 2

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases cleavage
increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased cleavage of CASP3 protein
bis(tri-n-butyltin)oxide results in increased phosphorylation of CASP3 protein

PMID:22174045 PMID:22613032

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CASP8 mRNA

PMID:24247028 PMID:25270620

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

chromobox 3

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of CBX3 protein

NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:81,876,649...81,889,911

G

coiled-coil domain containing 87

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCDC87 mRNA

NCBI chr 1:211,564,419...211,567,115
Ensembl chr 1:211,475,789...211,568,008

G

C-C motif chemokine ligand 4

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 5

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCL5 mRNA

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cyclin A2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCNA2 mRNA

PMID:17942131 PMID:18958704

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCNB1 mRNA

PMID:17942131 PMID:18958704

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCNB2 mRNA

PMID:17942131 PMID:18958704

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin D3

decreases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in decreased expression of CCND3 mRNA

PMID:17553608 PMID:18958704

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin E2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin G2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CCNG2 mRNA

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206

G

cyclin H

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of CCNH mRNA

NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860

G

Cd247 molecule

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of CD3Z mRNA

NCBI chr13:80,576,264...80,651,422
Ensembl chr13:80,576,202...80,655,248

G

CD27 molecule

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CD27 mRNA

NCBI chr 4:159,716,932...159,721,823
Ensembl chr 4:159,716,935...159,721,823

G

CD3 delta subunit of T-cell receptor complex

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of CD3D mRNA

NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:54,175,155...54,196,722

G

CD44 molecule

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

Cd5 molecule

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of CD5 protein

NCBI chr 1:216,790,245...216,811,209
Ensembl chr 1:216,790,245...216,811,209

G

CD55 molecule (Cromer blood group)

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CD55 mRNA

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

Cd69 molecule

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CD69 mRNA

PMID:21601586 PMID:24247028

NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:164,411,485...164,419,509

G

CD86 molecule

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

CD8 subunit beta

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of CD8B mRNA

NCBI chr 4:104,870,911...104,886,838
Ensembl chr 4:104,870,893...104,886,868

G

cell division cycle 25B

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of CDC25B mRNA

NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:138,860,130...138,870,492

G

cell division cycle associated 3

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CDCA3 mRNA

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:159,321,014...159,325,068

G

cell division cycle associated 7 like

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CDCA7L mRNA

NCBI chr 6:144,936,885...144,982,844
Ensembl chr 6:144,908,171...144,982,843

G

cadherin 15

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CDH15 mRNA

NCBI chr19:67,812,169...67,834,986
Ensembl chr19:67,812,164...67,834,985

G

cadherin 16

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CDH16 mRNA

NCBI chr19:367,202...377,710
Ensembl chr19:367,274...388,934

G

cyclin-dependent kinase 1

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 2 associated protein 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CDK2AP1 mRNA

NCBI chr12:37,910,718...37,919,446
Ensembl chr12:37,910,718...37,919,446

G

cyclin-dependent kinase 5 regulatory subunit 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CDKN1A mRNA

PMID:18958704 PMID:24247028

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2C

decreases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in decreased expression of CDKN2C mRNA

PMID:17553608 PMID:18958704

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:129,639,736...129,644,891

G

cerebellar degeneration-related protein 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CDR2 mRNA

NCBI chr 1:184,934,128...184,959,036
Ensembl chr 1:184,934,129...184,968,863

G

CCAAT/enhancer binding protein beta

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of CEBPB mRNA

PMID:17553608 PMID:18958704

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

centromere protein K

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CENPK mRNA

NCBI chr 2:37,094,163...37,155,158
Ensembl chr 2:37,094,248...37,119,488

G

centrosomal protein 43

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CEP43 mRNA

NCBI chr 1:55,080,983...55,111,509
Ensembl chr 1:55,082,712...55,111,509

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CHAC1 mRNA

PMID:23253260 PMID:25270620

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361

G

chromodomain helicase DNA binding protein 4

decreases expression
decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CHD4 protein
bis(tri-n-butyltin)oxide results in decreased phosphorylation of CHD4 protein

PMID:19552622 PMID:22174045

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

CHM Rab escort protein

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of CHM protein

NCBI chr X:82,395,463...82,554,249
Ensembl chr X:82,396,816...82,568,642

G

cell death-inducing DFFA-like effector a

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382

G

cold inducible RNA binding protein

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CIRBP mRNA

NCBI chr 7:10,184,515...10,189,623

G

cytoskeleton associated protein 5

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CKAP5 mRNA

NCBI chr 3:97,946,966...98,049,050
Ensembl chr 3:97,947,031...98,049,049

G

CDC28 protein kinase regulatory subunit 1B

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CKS1B mRNA

NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:177,130,777...177,135,365

G

C-type lectin domain containing 7A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CLEC7A mRNA

NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:164,588,754...164,599,919

G

chloride intracellular channel 4

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

cytidine/uridine monophosphate kinase 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CMPK2 mRNA

NCBI chr 6:48,802,150...48,813,652
Ensembl chr 6:48,802,321...48,813,652

G

cochlin

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of COCH mRNA

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:74,766,419...74,780,502

G

collagen type XVIII alpha 1 chain

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of COL18A1 mRNA

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112

G

collagen type VI alpha 1 chain

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of COL6A1 mRNA

NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107

G

collagen type VI alpha 3 chain

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of COL6A3 mRNA

NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:98,809,171...98,886,990

G

collagen type IX alpha 3 chain

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of COL9A3 mRNA

NCBI chr 3:188,089,337...188,112,034
Ensembl chr 3:188,089,403...188,112,270

G

coenzyme Q8A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of COQ8A mRNA

NCBI chr13:94,436,680...94,465,535
Ensembl chr13:94,436,546...94,463,378

G

cytochrome c oxidase subunit 5A

increases expression
decreases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of COX5A mRNA
bis(tri-n-butyltin)oxide results in decreased expression of COX5A mRNA

PMID:17553608 PMID:18958704

NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279

G

cytochrome c oxidase subunit 6A1

increases expression
decreases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of COX6A1 mRNA
bis(tri-n-butyltin)oxide results in decreased expression of COX6A1 mRNA

PMID:17553608 PMID:18958704

NCBI chr12:46,922,709...46,925,762
Ensembl chr12:46,912,648...46,925,768

G

cytochrome c oxidase subunit 7A1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of COX7A1 mRNA

NCBI chr 1:94,549,663...94,572,330
Ensembl chr 1:94,569,216...94,570,889

G

cytochrome c oxidase subunit 7A2

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of COX7A2 mRNA

NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:55,514,261...55,514,512
Ensembl chr 8:55,514,261...55,514,512

G

CREB binding protein

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CREBBP mRNA

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

cAMP responsive element modulator

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

crystallin zeta like 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CRYZL1 mRNA

NCBI chr11:44,419,099...44,464,366
Ensembl chr11:44,419,103...44,463,793

G

casein kinase 1, epsilon

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of CSNK1E mRNA

NCBI chr 7:112,863,726...112,887,338
Ensembl chr 7:112,863,731...112,884,101

G

catenin alpha 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CTNNA1 mRNA

NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,999,820...27,135,007

G

catenin beta 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CTNNB1 mRNA

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin E

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CTSE mRNA

NCBI chr13:45,644,168...45,666,722
Ensembl chr13:45,644,147...45,666,722

G

cut-like homeobox 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of CUX1 mRNA

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:25,743,733...26,062,497

G

C-X-C motif chemokine ligand 10

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CXCL10 mRNA

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine receptor 4

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome c, somatic

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CYCS mRNA

PMID:18958704 PMID:22434021 PMID:24247028

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CYP11A1 mRNA

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases expression

ISO

bis(tri-n-butyltin)oxide promotes the reaction [bisphenol A results in decreased activity of CYP19A1 protein]; bis(tri-n-butyltin)oxide promotes the reaction [Chlordecone results in decreased activity of CYP19A1 protein]; bis(tri-n-butyltin)oxide promotes the reaction [nonylphenol results in decreased activity of CYP19A1 protein]; bisphenol A promotes the reaction [bis(tri-n-butyltin)oxide results in decreased activity of CYP19A1 protein]; Chlordecone promotes the reaction [bis(tri-n-butyltin)oxide results in decreased activity of CYP19A1 protein]; nonylphenol promotes the reaction [bis(tri-n-butyltin)oxide results in decreased activity of CYP19A1 protein]
bis(tri-n-butyltin)oxide results in decreased expression of CYP19A1 mRNA

PMID:17599374 PMID:28936609

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CYP1A1 mRNA; bis(tri-n-butyltin)oxide results in increased expression of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CYP1A2 mRNA; bis(tri-n-butyltin)oxide results in increased expression of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of CYP2B13 mRNA

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, subfamily 2, polypeptide 11

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of CYP2C mRNA

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 4, subfamily x, polypeptide 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of CYP4X1 protein

NCBI chr 5:133,888,439...133,923,254
Ensembl chr 5:133,888,439...133,919,642

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytohesin 4

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of CYTH4 mRNA

NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:112,032,775...112,057,204

G

death-associated protein kinase 3

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of DAPK3 mRNA

NCBI chr 7:9,174,903...9,183,272
Ensembl chr 7:9,174,904...9,183,272

G

DDB1 and CUL4 associated factor 8

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of DCAF8 protein

NCBI chr13:87,141,940...87,199,859
Ensembl chr13:87,142,525...87,202,099

G

DNA-damage inducible transcript 3

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of DDIT3 mRNA; bis(tri-n-butyltin)oxide results in increased expression of DDIT3 protein

PMID:21601586 PMID:22434021 PMID:22613032 PMID:23253260

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DExD-box helicase 21

decreases expression
decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of DDX21 protein
bis(tri-n-butyltin)oxide results in decreased phosphorylation of DDX21 protein

PMID:19552622 PMID:22174045

NCBI chr20:31,077,044...31,097,238
Ensembl chr20:31,077,045...31,097,238

G

death effector domain containing 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of DEDD2 mRNA

NCBI chr 1:89,916,906...89,934,663
Ensembl chr 1:89,919,524...89,936,804

G

defensin alpha 5

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of DEFA5 mRNA

NCBI chr16:77,044,994...77,047,318
Ensembl chr16:77,044,994...77,047,318

G

desmin

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of DES protein

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

diacylglycerol kinase zeta

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of DGKZ mRNA

NCBI chr 3:98,359,804...98,401,847
Ensembl chr 3:98,359,804...98,401,951

G

dyskerin pseudouridine synthase 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of DKC1 protein

NCBI chr  X:157,751,651...157,757,796
Ensembl chr  Y:380,743...385,405
Ensembl chr  X:380,743...385,405

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

DnaJ heat shock protein family (Hsp40) member C1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of DNAJC1 mRNA

NCBI chr17:85,863,651...86,020,954
Ensembl chr17:85,863,651...86,020,432

G

dynamin 2

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of DNM2 mRNA

NCBI chr 8:28,254,344...28,336,297
Ensembl chr 8:28,254,529...28,336,295

G

DNA methyltransferase 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of DNMT1 protein

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

dihydropyrimidinase-like 2

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of DPYSL2 protein

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065

G

dual specificity phosphatase 5

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 6

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

deoxyuridine triphosphatase

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of DUT mRNA

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956

G

dynein cytoplasmic 1 light intermediate chain 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of DYNC1LI1 protein

NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:123,254,859...123,289,167

G

enoyl-CoA hydratase, short chain 1

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of ECHS1 mRNA

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

ER degradation enhancing alpha-mannosidase like protein 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EDEM1 mRNA

PMID:21601586 PMID:22434021

NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060

G

EGF containing fibulin extracellular matrix protein 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EFEMP2 mRNA

NCBI chr 1:212,211,057...212,218,739
Ensembl chr 1:212,210,972...212,218,739

G

early growth response 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 2A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EIF2A mRNA

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EIF2S1 mRNA

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 2 subunit beta

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of EIF2S2 protein

NCBI chr 3:163,834,846...163,855,733
Ensembl chr 3:163,834,851...163,855,570

G

eukaryotic translation initiation factor 4B

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of EIF4B protein

NCBI chr 7:135,085,259...135,107,054
Ensembl chr 7:135,085,066...135,107,064

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of EIF4EBP1 protein

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 4 gamma 1

decreases expression
decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of EIF4G1 protein
bis(tri-n-butyltin)oxide results in decreased phosphorylation of EIF4G1 protein

PMID:19552622 PMID:22174045

NCBI chr11:93,726,322...93,746,387
Ensembl chr11:93,726,322...93,746,367

G

ELOVL fatty acid elongase 6

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ELOVL6 mRNA

NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:220,738,064...220,845,549

G

endomucin

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EMCN mRNA

NCBI chr 2:228,564,445...228,644,370
Ensembl chr 2:228,564,430...228,645,155

G

Eph receptor B3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EPHB3 mRNA

NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775

G

erythropoietin receptor

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of EPOR mRNA

NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:28,765,746...28,770,322

G

endoplasmic reticulum to nucleus signaling 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ERN1 mRNA

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

endoplasmic reticulum oxidoreductase 1 beta

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ERO1B mRNA

NCBI chr17:92,913,696...92,987,401
Ensembl chr17:92,814,368...92,987,555

G

ETS proto-oncogene 1, transcription factor

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

ecotropic viral integration site 2A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EVI2A mRNA

NCBI chr10:64,983,727...64,987,627
Ensembl chr10:64,983,705...64,999,516

G

Enah/Vasp-like

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of EVL protein

NCBI chr 6:133,238,547...133,358,730
Ensembl chr 6:133,238,547...133,358,729

G

exosome component 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of EXOSC2 mRNA

NCBI chr 3:35,360,652...35,370,948
Ensembl chr 3:35,360,666...35,371,373

G

exosome component 7

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of EXOSC7 mRNA

NCBI chr 8:131,650,988...131,676,399
Ensembl chr 8:131,651,050...131,696,825

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of EZH2 mRNA

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183

G

ezrin

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

coagulation factor XII

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of F12 mRNA

NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664

G

fatty acid binding protein 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FABP3 mRNA

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

family with sequence similarity 133, member B

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of FAM133B mRNA

NCBI chr 4:31,544,458...31,571,056
Ensembl chr 4:31,544,458...31,570,780

G

family with sequence similarity 171, member B

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FAM171B mRNA

NCBI chr 3:89,337,566...89,392,973
Ensembl chr 3:89,337,661...89,392,971

G

Fas cell surface death receptor

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fibrillin 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FBN1 mRNA

NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283

G

F-box and leucine-rich repeat protein 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FBXL2 mRNA

NCBI chr 8:122,794,870...122,843,265
Ensembl chr 8:122,794,870...122,854,798

G

F-box protein 30

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FBXO30 mRNA

NCBI chr 1:7,475,636...7,491,719
Ensembl chr 1:7,475,575...7,493,199

G

F-box and WD repeat domain containing 8

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of FBXW8 protein

NCBI chr12:44,087,375...44,177,985
Ensembl chr12:44,087,375...44,177,985

G

Fc gamma receptor 2A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FCGR3 mRNA

NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394

G

FKBP prolyl isomerase 4

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of FKBP4 protein

NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:163,389,464...163,397,918

G

FKBP prolyl isomerase 7

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of FKBP7 mRNA

NCBI chr 3:82,016,647...82,030,913
Ensembl chr 3:82,016,513...82,028,573

G

gamma-aminobutyric acid type A receptor subunit gamma 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GABRG3 mRNA

NCBI chr 1:116,763,332...117,386,770
Ensembl chr 1:116,763,129...117,382,536

G

growth arrest and DNA-damage-inducible, alpha

increases expression

EXP
ISO

bis(tri-n-butyltin)oxide results in increased expression of GADD45A mRNA

PMID:17553608 PMID:24247028

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, beta

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GADD45B mRNA

PMID:22434021 PMID:24247028

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

GTPase activating protein and VPS9 domains 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of GAPVD1 protein

NCBI chr 3:38,365,854...38,439,403
Ensembl chr 3:38,365,854...38,439,390

G

GATA binding protein 3

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of GATA3 mRNA

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670

G

golgi brefeldin A resistant guanine nucleotide exchange factor 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of GBF1 protein

NCBI chr 1:254,959,784...255,088,479
Ensembl chr 1:254,960,001...255,088,471

G

GTP cyclohydrolase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GCH1 mRNA

NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412

G

glutamate cysteine ligase, modifier subunit

increases expression
decreases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GCLM mRNA
bis(tri-n-butyltin)oxide results in decreased expression of GCLM mRNA

PMID:21601586 PMID:26198647

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GCNT3 mRNA

NCBI chr 8:79,570,081...79,577,389
Ensembl chr 8:79,566,753...79,581,595

G

gem (nuclear organelle) associated protein 4

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of GEMIN4 mRNA

NCBI chr10:61,560,172...61,571,765
Ensembl chr10:61,564,657...61,596,532

G

growth factor independent 1 transcriptional repressor

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of GFI1 mRNA

NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,187,286...2,196,730

G

growth factor independent 1B transcriptional repressor

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of GFI1B mRNA

NCBI chr 3:32,338,213...32,350,963
Ensembl chr 3:32,338,214...32,350,916

G

glutamine fructose-6-phosphate transaminase 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of GFPT1 protein

NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:121,054,045...121,103,799

G

GDNF family receptor alpha 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GFRA3 mRNA

NCBI chr18:26,571,952...26,600,225
Ensembl chr18:26,571,921...26,600,225

G

geminin, DNA replication inhibitor

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of GMNN mRNA

PMID:17942131 PMID:18958704

NCBI chr17:40,729,760...40,738,077
Ensembl chr17:40,729,824...40,738,068

G

glycerol-3-phosphate dehydrogenase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GPD2 mRNA

NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593

G

G protein-coupled receptor 45

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of GPR45 protein

NCBI chr 9:52,713,825...52,801,826
Ensembl chr 9:52,783,090...52,801,941

G

G protein-coupled receptor, class C, group 5, member A

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of GPRC5A protein

NCBI chr 4:169,634,896...169,653,627
Ensembl chr 4:169,634,748...169,653,625

G

glutathione peroxidase 1

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405

G

glutathione peroxidase 6

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GPX6 mRNA

NCBI chr17:48,104,197...48,111,816
Ensembl chr17:48,104,197...48,111,007

G

glutathione peroxidase 7

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GPX7 mRNA

NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:128,372,875...128,381,725

G

glutathione peroxidase 8

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GPX8 mRNA

NCBI chr 2:46,409,646...46,413,401
Ensembl chr 2:46,409,139...46,413,406

G

GRB2-related adaptor protein 2

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of GRAP2 protein

NCBI chr 7:113,997,356...114,071,073
Ensembl chr 7:113,997,307...114,075,367

G

glutathione S-transferase theta 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of GSTT2 mRNA

NCBI chr20:12,819,053...12,822,724
Ensembl chr20:12,818,540...12,822,718

G

glycophorin A

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of GYPA mRNA

NCBI chr19:44,354,669...44,370,304
Ensembl chr19:44,354,706...44,370,291

G

H1.2 linker histone, cluster member

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of H1F2 protein

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

hydroxyacyl-CoA dehydrogenase

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of HADH mRNA

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446

G

histone deacetylase 3

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of HDAC3 mRNA

NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of HERPUD1 mRNA

PMID:21601586 PMID:22434021

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081

G

hes family bHLH transcription factor 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of HES1 mRNA

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hexokinase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

high mobility group box 2

decreases expression
decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of HMGB2 mRNA
bis(tri-n-butyltin)oxide results in decreased phosphorylation of HMGB2 protein

PMID:17942131 PMID:22174045

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

heme oxygenase 1

increases expression

EXP
ISO

bis(tri-n-butyltin)oxide results in increased expression of HMOX1 mRNA

PMID:17553608 PMID:25270620

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hepatocyte nuclear factor 4, alpha

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of HNF4A protein

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

heterogeneous nuclear ribonucleoprotein A2/B1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of HNRNPA2B1 protein

NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572

G

heterogeneous nuclear ribonucleoprotein D

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of HNRNPD protein

NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066

G

heterogeneous nuclear ribonucleoprotein D-like

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of HNRNPDL mRNA

NCBI chr14:9,861,716...9,867,945
Ensembl chr14:9,861,716...9,867,945

G

heterogeneous nuclear ribonucleoprotein U

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of HNRNPU protein

NCBI chr13:92,609,791...92,618,580
Ensembl chr13:92,605,216...92,618,612

G

hemopexin

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of HPX mRNA

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

heat shock transcription factor 2

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of HSF2 mRNA

NCBI chr20:37,366,301...37,393,922
Ensembl chr20:37,366,279...37,401,022

G

heat shock protein 90 alpha family class B member 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of HSP90AB1 protein

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of HSPA1A mRNA

PMID:17553608 PMID:22434021

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 8

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

integrin-binding sialoprotein

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IBSP mRNA

NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,744,501...5,775,299

G

intercellular adhesion molecule 4, Landsteiner-Wiener blood group

decreases expression
increases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ICAM4 mRNA
bis(tri-n-butyltin)oxide results in increased expression of ICAM4 mRNA

PMID:17942131 PMID:18958704

NCBI chr 8:27,842,255...27,843,351
Ensembl chr 8:27,842,255...27,844,371

G

inhibitor of DNA binding 4

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ID4 mRNA

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492

G

interferon induced transmembrane protein 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IFITM3 mRNA

NCBI chr 1:205,540,649...205,541,758
Ensembl chr 1:205,481,168...205,547,920

G

interferon gamma

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon-related developmental regulator 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

insulin-like growth factor 2 receptor

increases expression
decreases phosphorylation

EXP
ISO

bis(tri-n-butyltin)oxide results in increased expression of IGF2R mRNA
bis(tri-n-butyltin)oxide results in decreased phosphorylation of IGF2R protein

PMID:17553608 PMID:22174045

NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265

G

insulin-like growth factor binding protein 7

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IGFBP7 mRNA

NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620

G

interleukin 11 receptor subunit alpha 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IL11RA1 mRNA

NCBI chr 5:61,727,650...61,737,265
Ensembl chr 5:61,727,931...61,737,264

G

interleukin 13

multiple interactions

EXP

bis(tri-n-butyltin)oxide inhibits the reaction [Allergens results in decreased expression of IL13 protein]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 13 receptor subunit alpha 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IL13RA2 mRNA

NCBI chr X:115,814,620...115,886,080
Ensembl chr X:115,814,622...115,841,455

G

interleukin 18 receptor 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IL18R1 mRNA

NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:50,223,200...50,257,367

G

interleukin 2

multiple interactions
increases expression

ISO
EXP

[bis(tri-n-butyltin)oxide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
bis(tri-n-butyltin)oxide results in increased expression of IL2 mRNA

PMID:9465272 PMID:15588918

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 24

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 2 receptor subunit alpha

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of IL2RA mRNA

PMID:9465272 PMID:10454224

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 36, alpha

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of IL36A mRNA

NCBI chr 3:27,395,146...27,399,695
Ensembl chr 3:27,395,146...27,399,695

G

interleukin 4

multiple interactions

EXP

bis(tri-n-butyltin)oxide inhibits the reaction [Allergens results in increased expression of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

multiple interactions

EXP

bis(tri-n-butyltin)oxide inhibits the reaction [Allergens results in increased expression of IL5 protein]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin enhancer binding factor 3

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of ILF3 mRNA

NCBI chr 8:28,198,454...28,236,634
Ensembl chr 8:28,198,543...28,236,612

G

inner centromere protein

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of INCENP mRNA

PMID:17942131 PMID:18958704

NCBI chr 1:215,945,558...216,017,247
Ensembl chr 1:215,948,283...215,977,084

G

inhibitor of growth family, member 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ING1 mRNA

NCBI chr16:84,639,378...84,649,498
Ensembl chr16:84,639,381...84,647,616

G

INSM transcriptional repressor 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of INSM1 mRNA

NCBI chr 3:154,093,310...154,096,243
Ensembl chr 3:154,092,734...154,096,047

G

interferon regulatory factor 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

interferon regulatory factor 2 binding protein 2

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of IRF2BP2 protein

NCBI chr19:71,456,689...71,462,368
Ensembl chr19:71,456,689...71,462,368

G

interferon regulatory factor 2 binding protein-like

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of IRF2BPL protein

NCBI chr 6:112,258,149...112,262,264
Ensembl chr 6:112,258,188...112,263,280

G

interferon stimulated exonuclease gene 20

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ISG20 mRNA

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401

G

integrin subunit alpha 4

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ITGA4 mRNA

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

integrin subunit alpha L

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ITGAL mRNA

NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225

G

integrin subunit beta 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ITGB2 mRNA

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

inter-alpha-trypsin inhibitor heavy chain 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ITIH2 mRNA

NCBI chr17:73,285,281...73,321,555
Ensembl chr17:73,285,270...73,321,547

G

junctional adhesion molecule 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of JAM3 mRNA

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of JUNB mRNA

PMID:17553608 PMID:22434021

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

potassium voltage-gated channel subfamily H member 6

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of KCNH6 mRNA

NCBI chr10:91,449,025...91,471,012
Ensembl chr10:91,449,651...91,470,506

G

Kelch-like ECH-associated protein 1

affects localization

ISO

bis(tri-n-butyltin)oxide affects the localization of KEAP1 protein

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

kinesin family member 20A

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,504,072...26,512,909

G

kinesin family member 20B

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of KIF20B protein

NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:241,840,987...241,896,451

G

KLF transcription factor 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of KLF1 mRNA

NCBI chr19:40,155,476...40,158,651
Ensembl chr19:40,155,480...40,158,607

G

KLF transcription factor 10

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

KLF transcription factor 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of KLF2 mRNA

NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768

G

KLF transcription factor 9

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of KLF9 mRNA

NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:230,126,646...230,151,641

G

kallikrein B1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of KLKB1 mRNA

NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339

G

keratin 10

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of KRT10 protein

NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,834,840...84,839,160

G

laminin subunit alpha 4

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of LAMA4 mRNA

NCBI chr20:43,946,898...44,087,972
Ensembl chr20:43,946,898...44,087,972

G

laminin subunit beta 1

decreases expression
increases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of LAMB1 mRNA
bis(tri-n-butyltin)oxide results in increased expression of LAMB1 mRNA

PMID:18958704 PMID:26314263

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760

G

La ribonucleoprotein 1, translational regulator

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of LARP1 protein

NCBI chr10:42,691,833...42,746,816
Ensembl chr10:42,691,600...42,746,816

G

linker for activation of T cells

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of LAT mRNA

NCBI chr 1:190,367,111...190,372,515
Ensembl chr 1:190,367,109...190,372,153

G

lymphocyte cytosolic protein 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of LCP2 mRNA

NCBI chr10:19,146,846...19,193,750
Ensembl chr10:19,146,554...19,193,744

G

DNA ligase 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of LIG1 mRNA

NCBI chr 1:83,243,043...83,281,707
Ensembl chr 1:83,219,545...83,281,708

G

leucine rich repeat containing 34

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of LRRC34 mRNA

NCBI chr 2:114,680,787...114,702,961
Ensembl chr 2:114,680,094...114,702,961

G

lysophospholipase 1

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of LYPLA1 mRNA

NCBI chr 5:19,477,408...19,506,568
Ensembl chr 5:19,477,409...19,506,522

G

lysozyme 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of LYZ2 mRNA

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011

G

MAF bZIP transcription factor G

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159

G

mal, T-cell differentiation protein

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of MAL mRNA

NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423

G

mitogen activated protein kinase 1

decreases expression
decreases phosphorylation

EXP
ISO

bis(tri-n-butyltin)oxide results in decreased expression of MAPK1 mRNA
bis(tri-n-butyltin)oxide results in decreased phosphorylation of MAPK1 protein

PMID:17553608 PMID:22174045

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen-activated protein kinase 12

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MAPK12 mRNA

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 14

decreases expression
increases expression

EXP
ISO

bis(tri-n-butyltin)oxide results in decreased expression of MAPK14 mRNA
bis(tri-n-butyltin)oxide results in increased expression of MAPK14 mRNA

PMID:17553608 PMID:26314263

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

matrin 3

decreases phosphorylation
decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of MATR3 protein
bis(tri-n-butyltin)oxide results in decreased expression of MATR3 protein

PMID:22174045 PMID:24375594

NCBI chr18:27,428,190...27,474,421
Ensembl chr18:27,432,179...27,470,421

G

minichromosome maintenance complex component 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MCM2 mRNA

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:122,903,682...122,918,094

G

minichromosome maintenance complex component 3

decreases expression
decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MCM3 mRNA
bis(tri-n-butyltin)oxide results in decreased phosphorylation of MCM3 protein

PMID:18958704 PMID:22174045

NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746

G

minichromosome maintenance complex component 4

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of MCM4 protein

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:98,762,634...98,776,536

G

minichromosome maintenance complex component 5

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MCM5 mRNA

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,488,813...13,517,758

G

mesoderm specific transcript

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of MEST mRNA

NCBI chr 4:60,321,814...60,332,288
Ensembl chr 4:60,316,102...60,333,509

G

methionyl aminopeptidase 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of METAP2 mRNA

NCBI chr 7:30,299,433...30,327,477
Ensembl chr 7:30,299,433...30,327,521

G

alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of MGAT1 mRNA

NCBI chr10:34,064,548...34,083,833
Ensembl chr10:34,062,837...34,095,975

G

matrix Gla protein

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of MGP mRNA

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859

G

microsomal glutathione S-transferase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

marker of proliferation Ki-67

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MKI67 mRNA

PMID:17942131 PMID:18958704

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

mitochondrial ribosomal protein S12

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of MRPS12 mRNA

NCBI chr 1:93,153,424...93,156,422
Ensembl chr 1:93,153,425...93,159,629

G

moesin

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of MSN protein

NCBI chr X:65,005,546...65,073,512
Ensembl chr X:65,005,458...65,075,129

G

metadherin

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of MTDH protein

NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584

G

mucin 13, cell surface associated

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of MUC13 protein

NCBI chr11:80,462,350...80,489,773
Ensembl chr11:80,465,737...80,485,474

G

MYB proto-oncogene, transcription factor

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of MYB mRNA

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

MYB proto-oncogene like 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MYBL2 mRNA

PMID:17942131 PMID:25270620

NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:172,116,550...172,153,221

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

MYCN proto-oncogene, bHLH transcription factor

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MYCN mRNA

NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:41,446,684...41,452,508

G

myosin heavy chain 10

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MYH10 mRNA

NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,893,166...54,024,036

G

myosin, heavy chain 9

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of MYH9 protein

NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:111,224,291...111,304,963

G

asparaginyl-tRNA synthetase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NARS1 mRNA

NCBI chr18:60,259,506...60,275,782
Ensembl chr18:60,259,516...60,275,782

G

non-SMC condensin I complex, subunit G

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NCAPG mRNA

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:69,616,473...69,645,445

G

nuclear cap binding protein subunit 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of NCBP1 protein

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665

G

nucleolin

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of NCL protein

NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083

G

NADH:ubiquinone oxidoreductase subunit A1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NDUFA1 mRNA

NCBI chr X:121,289,904...121,293,555
Ensembl chr X:121,289,925...121,293,555

G

Ndufa4, mitochondrial complex associated

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NDUFA4 mRNA

NCBI chr 4:40,968,391...40,975,559
Ensembl chr 4:40,968,391...40,975,559

G

NADH:ubiquinone oxidoreductase core subunit S7

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NDUFS7 mRNA

NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:10,103,227...10,110,691

G

NADH:ubiquinone oxidoreductase core subunit V2

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of NDUFV2 protein

NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520

G

neurofilament heavy chain

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

neurofilament light chain

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NEFL mRNA

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

NIMA-related kinase 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NEK2 mRNA

NCBI chr13:105,936,809...105,950,054
Ensembl chr13:105,936,788...105,950,056

G

negative elongation factor complex member A

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of NELFA protein

NCBI chr14:81,033,470...81,057,546
Ensembl chr14:81,033,514...81,058,719

G

neurofibromin 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

nuclear factor of activated T-cells 1

affects localization

ISO

bis(tri-n-butyltin)oxide affects the localization of NFATC1 protein

PMID:21601586 PMID:22434021

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NFE2 like bZIP transcription factor 2

increases expression
increases activity

EXP
ISO

bis(tri-n-butyltin)oxide results in increased expression of NFE2L2 mRNA
bis(tri-n-butyltin)oxide results in increased activity of NFE2L2 protein

PMID:17553608 PMID:30203046

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NFKBIA mRNA

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NHERF family PDZ scaffold protein 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of NHERF1 protein

NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579

G

nipsnap homolog 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NIPSNAP2 mRNA

NCBI chr12:32,542,171...32,580,345
Ensembl chr12:32,547,819...32,580,303

G

NK6 homeobox 3

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NKX6-3 mRNA

NCBI chr16:75,570,931...75,576,144
Ensembl chr16:75,570,931...75,576,144

G

NME/NM23 family member 8

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NME8 mRNA

NCBI chr17:49,932,861...50,000,610
Ensembl chr17:49,932,860...50,000,608

G

nucleotide-binding oligomerization domain containing 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NOD1 mRNA

NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:85,391,151...85,441,674

G

nucleolar and coiled-body phosphoprotein 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NOLC1 mRNA

NCBI chr 1:254,870,195...254,881,070
Ensembl chr 1:254,870,319...254,881,069

G

NOP58 ribonucleoprotein

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of NOP58 protein

NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909

G

neural proliferation, differentiation and control, 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NPDC1 mRNA

NCBI chr 3:28,618,601...28,624,591

G

nephrocystin 3

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of NPHP3 protein

NCBI chr 8:113,500,708...113,541,179
Ensembl chr 8:113,500,509...113,541,179

G

nucleophosmin 1

decreases expression
increases phosphorylation

EXP
ISO

bis(tri-n-butyltin)oxide results in decreased expression of NPM1 mRNA
bis(tri-n-butyltin)oxide results in increased phosphorylation of NPM1 protein

PMID:17553608 PMID:22174045

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

neuropeptide Y

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NPY mRNA

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

nuclear receptor subfamily 0, group B, member 2

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group D, member 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 1, group H, member 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of NR1H3 mRNA

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group I, member 3

increases activity

ISO

bis(tri-n-butyltin)oxide results in increased activity of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 3, group C, member 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of NR4A1 mRNA; bis(tri-n-butyltin)oxide results in increased expression of NR4A1 protein

PMID:17553608 PMID:21601586 PMID:22613032 PMID:24247028

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 3

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

nudix hydrolase 4

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of NUDT4 mRNA

NCBI chr 7:32,074,978...32,091,491
Ensembl chr 7:32,075,002...32,091,491

G

O-GlcNAcase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of OGA mRNA

NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855

G

origin recognition complex, subunit 6

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ORC6 mRNA

NCBI chr19:37,931,085...37,938,856
Ensembl chr19:37,931,090...37,938,856

G

oncostatin M receptor

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of OSMR mRNA

NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561

G

par-6 family cell polarity regulator beta

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PARD6B mRNA

NCBI chr 3:177,209,429...177,230,509
Ensembl chr 3:177,209,258...177,230,510

G

Parkinsonism associated deglycase

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PARK7 mRNA

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

PDZ binding kinase

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:44,198,544...44,209,570

G

phosphoenolpyruvate carboxykinase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PCK2 mRNA

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864

G

programmed cell death 5

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of PDCD5 protein

NCBI chr 1:97,442,755...97,448,084
Ensembl chr 1:97,442,755...97,449,844

G

phosphodiesterase 4D interacting protein

affects expression

ISO

bis(tri-n-butyltin)oxide affects the expression of PDE4DIP mRNA

NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869

G

platelet derived growth factor C

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PDGFC mRNA

NCBI chr 2:168,613,409...168,791,575
Ensembl chr 2:168,614,353...168,791,573

G

PDZ and LIM domain 4

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of PDLIM4 protein

NCBI chr10:38,699,444...38,713,696
Ensembl chr10:38,699,444...38,713,659

G

phosphoglycerate mutase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PGAM2 mRNA

NCBI chr14:84,895,763...84,897,874
Ensembl chr14:84,895,744...84,897,894

G

prohibitin 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PHB1 mRNA

NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233

G

phosphatidylinositol 4-kinase beta

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of PI4KB protein

NCBI chr 2:185,229,392...185,261,697
Ensembl chr 2:185,228,799...185,261,693

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PIK3CA mRNA

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PIK3CB mRNA

NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PIK3CD mRNA

NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PIK3CG mRNA

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509

G

phosphatidylinositol transfer protein, alpha

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PITPNA mRNA

NCBI chr10:60,929,050...60,969,614
Ensembl chr10:60,929,007...60,971,830

G

PLAG1 like zinc finger 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PLAGL1 mRNA

NCBI chr 1:9,297,066...9,337,394
Ensembl chr 1:9,330,204...9,337,394

G

phospholipase C, gamma 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PLCG2 mRNA

NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684

G

plectin

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PLEC protein

NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089

G

perilipin 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

phospholipid phosphatase 1

decreases expression
increases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PPAP2A mRNA
bis(tri-n-butyltin)oxide results in increased expression of PLPP1 mRNA

PMID:18958704 PMID:26314263

NCBI chr 2:46,172,202...46,233,632
Ensembl chr 2:46,172,197...46,234,676

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PMAIP1 mRNA

PMID:21601586 PMID:24247028

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

DNA polymerase alpha 1, catalytic subunit

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of POLA1 mRNA

NCBI chr X:62,028,475...62,342,455
Ensembl chr X:62,028,476...62,342,355

G

DNA polymerase epsilon 2, accessory subunit

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of POLE2 mRNA

NCBI chr 6:93,410,713...93,448,782
Ensembl chr 6:93,410,758...93,435,361

G

RNA polymerase I subunit B

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of POLR1B mRNA

NCBI chr 3:136,787,130...136,811,608
Ensembl chr 3:136,787,107...136,811,607

G

porcupine O-acyltransferase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PORCN mRNA

NCBI chr X:16,957,811...16,970,440
Ensembl chr X:16,957,810...16,970,439

G

peroxisome proliferator activated receptor alpha

increases activity

ISO

bis(tri-n-butyltin)oxide results in increased activity of PPARA protein

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

peptidylprolyl isomerase H

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PPIH mRNA

NCBI chr 5:138,191,624...138,209,625
Ensembl chr 5:138,191,624...138,209,580

G

peroxiredoxin 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of PRDX1 protein

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

peroxiredoxin 2

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

proteoglycan 2, pro eosinophil major basic protein

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PRG2 mRNA

NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:90,469,176...90,472,752

G

DNA primase subunit 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PRIM2 mRNA

NCBI chr 9:43,188,350...43,400,482
Ensembl chr 9:43,188,350...43,398,990

G

protein kinase AMP-activated catalytic subunit alpha 1

increases expression
increases phosphorylation

EXP
ISO

bis(tri-n-butyltin)oxide results in increased expression of PRKAA1 mRNA
bis(tri-n-butyltin)oxide results in increased phosphorylation of PRKAA1 protein

PMID:17553608 PMID:22174045

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase cAMP-dependent type I regulatory subunit alpha

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of PRKAR1A protein

NCBI chr10:95,120,537...95,139,028
Ensembl chr10:95,120,487...95,139,025

G

protein kinase C, beta

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PRKCB mRNA

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, theta

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PRKCQ mRNA

NCBI chr17:72,156,215...72,288,508
Ensembl chr17:72,156,215...72,288,508

G

protein arginine methyltransferase 3

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PRMT3 mRNA

NCBI chr 1:108,628,899...108,718,803
Ensembl chr 1:108,626,749...108,718,803

G

protein S

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PROS1 mRNA

NCBI chr11:13,676,310...13,757,858
Ensembl chr11:13,676,769...13,757,852

G

pre-mRNA processing factor 18

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of PRPF18 mRNA

NCBI chr17:78,539,004...78,570,483
Ensembl chr17:78,539,839...78,600,250

G

pre-mRNA processing factor 3

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of PRPF3 protein

NCBI chr 2:186,067,980...186,092,427
Ensembl chr 2:186,067,162...186,092,427

G

protogenin

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PRTG mRNA

NCBI chr 8:82,429,106...82,538,612
Ensembl chr 8:82,429,132...82,538,602

G

prosaposin

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of PSAP mRNA

NCBI chr20:28,756,951...28,783,422
Ensembl chr20:28,757,181...28,783,421

G

phosphoserine aminotransferase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PSAT1 mRNA

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

PC4 and SRSF1 interacting protein 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of PSIP1 protein

NCBI chr 5:102,892,929...102,925,191
Ensembl chr 5:102,892,932...102,925,170

G

proteasome 20S subunit alpha 3

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of PSMA3 protein

NCBI chr 6:95,219,714...95,239,745
Ensembl chr 6:95,219,629...95,241,032

G

proteasome 20S subunit alpha 8

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PSMA8 mRNA

NCBI chr18:6,138,226...6,202,802
Ensembl chr18:6,138,226...6,202,802

G

proteasome activator subunit 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PSME1 mRNA

NCBI chr15:33,038,962...33,041,849
Ensembl chr15:33,038,597...33,041,848

G

phosphoserine phosphatase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PSPH mRNA

NCBI chr12:32,527,091...32,541,182
Ensembl chr12:32,519,269...32,541,180

G

phosphatase and tensin homolog

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PTEN mRNA

PMID:24247028 PMID:26314263

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin E receptor 3

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PTGER3 mRNA

NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846

G

prothymosin alpha

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PTMA protein

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276

G

pleiotrophin

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of PTN mRNA

NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482

G

protein tyrosine phosphatase, non-receptor type 11

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of PTPN11 mRNA

NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577

G

protein tyrosine phosphatase, non-receptor type 6

increases phosphorylation
increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased phosphorylation of PTPN6 protein
bis(tri-n-butyltin)oxide results in increased expression of PTPN6 mRNA

PMID:17553608 PMID:22174045

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069

G

protein tyrosine phosphatase, receptor type, C

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of PTPRC protein

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746

G

RAB1A, member RAS oncogene family

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RAB1A protein

NCBI chr14:98,623,582...98,648,766
Ensembl chr14:98,623,635...98,661,582

G

Rab40b, member RAS oncogene family

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of RAB40B mRNA

NCBI chr10:107,129,801...107,157,375
Ensembl chr10:107,129,801...107,157,457

G

RAD21 cohesin complex component

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RAD21 mRNA

NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:85,177,716...85,204,657

G

RAD23 homolog B, nucleotide excision repair protein

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RAD23B mRNA

NCBI chr 5:74,885,518...74,923,621
Ensembl chr 5:74,885,516...74,962,426

G

RALY heterogeneous nuclear ribonucleoprotein

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of RALY protein

NCBI chr 3:163,766,183...163,830,726
Ensembl chr 3:163,766,478...163,830,740

G

Rap1 GTPase-activating protein

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RAP1GAP mRNA

NCBI chr 5:155,157,511...155,222,622
Ensembl chr 5:155,157,558...155,222,622

G

Ras association domain family member 5

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of RASSF5 mRNA

NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277

G

RNA binding motif protein 14

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RBM14 mRNA

NCBI chr 1:211,476,298...211,535,077
Ensembl chr 1:211,523,972...211,535,065

G

RNA binding motif protein 39

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of RBM39 protein

NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397

G

RNA binding motif protein, X-linked

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of RBMX protein

NCBI chr X:140,342,544...140,352,121
Ensembl chr X:140,345,571...140,352,035

G

regulator of chromosome condensation 2

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of RCC2 protein

NCBI chr 5:158,277,476...158,300,294
Ensembl chr 5:158,277,476...158,300,294

G

RELA proto-oncogene, NF-kB subunit

increases expression
multiple interactions

ISO

bis(tri-n-butyltin)oxide results in increased expression of RELA mRNA
bis(tri-n-butyltin)oxide results in increased phosphorylation of and affects the localization of RELA protein
bis(tri-n-butyltin)oxide results in increased expression of RELA protein

PMID:22434021 PMID:22613032

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulated endocrine-specific protein 18

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of RESP18 mRNA

NCBI chr 9:84,213,844...84,220,186
Ensembl chr 9:84,213,467...84,221,299

G

replication factor C subunit 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of RFC1 protein

NCBI chr14:43,319,768...43,395,028
Ensembl chr14:43,319,935...43,395,026

G

regulator of G-protein signaling 14

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RGS14 mRNA

NCBI chr17:9,254,112...9,268,233
Ensembl chr17:9,254,149...9,268,233

G

regulator of G-protein signaling 2

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

ras homolog family member B

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of RHOB mRNA

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

ras homolog family member H

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RHOH mRNA

NCBI chr14:42,694,860...42,725,690
Ensembl chr14:42,693,413...42,749,967

G

Rhox homeobox family member 5

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of RHOX5 mRNA

NCBI chr X:121,401,888...121,407,643

G

receptor-interacting serine-threonine kinase 3

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of RIPK3 mRNA

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

ribonuclease A family member 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of EAR1 mRNA

NCBI chr15:26,985,399...26,986,269
Ensembl chr15:26,985,271...26,986,400

G

Rho-associated coiled-coil containing protein kinase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ROCK1 mRNA

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

retinoid isomerohydrolase RPE65

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of RPE65 mRNA

NCBI chr 2:251,425,228...251,457,209
Ensembl chr 2:251,425,368...251,457,156

G

ribosomal protein L19

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RPL19 mRNA

NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352

G

ribosomal protein L27A

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RPL27A mRNA

NCBI chr 1:172,971,957...172,977,591

G

ribosomal protein L7

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RPL7 mRNA

NCBI chr 5:8,000,446...8,003,454
Ensembl chr 5:7,850,630...8,003,451

G

ribosomal protein L8

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RPL8 mRNA

NCBI chr 7:110,506,815...110,509,106
Ensembl chr 7:110,506,800...110,509,103
Ensembl chr 3:110,506,800...110,509,103

G

ribosomal protein S10

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RPS10 protein

NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150

G

ribosomal protein S11

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RPS11 mRNA

NCBI chr 1:104,742,153...104,744,261
Ensembl chr 1:104,742,155...104,744,337

G

ribosomal protein S16

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RPS16 mRNA

NCBI chr 1:92,770,658...92,773,603
Ensembl chr19:56,922,246...56,923,020
Ensembl chr 1:56,922,246...56,923,020

G

ribosomal protein S6

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of RPS6 protein

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of RPS6KB1 protein
bis(tri-n-butyltin)oxide results in decreased expression of and results in decreased phosphorylation of RPS6KB1 protein

PMID:22174045 PMID:24375594

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

ribonucleotide reductase catalytic subunit M1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RRM1 mRNA

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:166,235,900...166,260,944

G

ribonucleotide reductase regulatory subunit M2

decreases expression
decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RRM2 mRNA
bis(tri-n-butyltin)oxide results in decreased phosphorylation of RRM2 protein

PMID:17942131 PMID:22174045

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370

G

ribosomal L1 domain containing 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of RSL1D1 mRNA

NCBI chr10:4,931,839...4,943,726
Ensembl chr10:4,904,792...4,946,566

G

RT1 class II, locus Ba

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of H2-AA mRNA

NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653

G

RT1 class II, locus Bb

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of H2-AB1 mRNA

NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118

G

RT1 class II, locus Db1

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of RT1-DB1 mRNA

NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165

G

RT1 class Ib, locus M3, gene 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of H2-M3 mRNA

NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,329,225...1,333,366

G

RT1 class Ib, locus N3

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of RT1-N3 mRNA

NCBI chr20:2,666,469...2,670,355
Ensembl chr20:2,666,464...2,670,348

G

stearoyl-CoA desaturase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

stearoyl-Coenzyme A desaturase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SCD2 mRNA

NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874

G

stimulator of chondrogenesis 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SCRG1 mRNA

NCBI chr16:37,770,739...37,799,010
Ensembl chr16:37,770,739...37,799,010

G

selenoprotein T

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SELENOT mRNA

NCBI chr 2:144,954,324...144,971,375
Ensembl chr 2:144,954,312...144,971,369

G

SUMO specific peptidase 2

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of SENP2 mRNA

NCBI chr11:92,487,259...92,522,795
Ensembl chr11:92,485,931...92,522,735

G

septin 8

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SEPTIN8 mRNA

NCBI chr10:38,185,454...38,214,502
Ensembl chr10:38,185,335...38,214,504

G

septin 9

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of SEPTIN9 protein

NCBI chr10:102,908,557...103,077,789
Ensembl chr10:102,908,560...103,077,788

G

stress-associated endoplasmic reticulum protein 1

affects expression

ISO

bis(tri-n-butyltin)oxide affects the expression of SERP1 mRNA

NCBI chr 2:144,907,204...144,911,187
Ensembl chr 2:144,907,205...144,911,187

G

serpin family H member 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SERPINH1 mRNA

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976

G

sarcoglycan, gamma

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SGCG mRNA

NCBI chr15:39,564,920...39,611,149
Ensembl chr15:39,564,923...39,611,149

G

small glutamine rich tetratricopeptide repeat co-chaperone alpha

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of SGTA protein

NCBI chr 7:9,304,381...9,321,157
Ensembl chr 7:9,304,197...9,321,669

G

SH2 domain containing 1A

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SH2D1A mRNA

NCBI chr X:126,239,191...126,267,425
Ensembl chr X:126,239,200...126,267,424

G

SH3 and SYLF domain containing 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SH3YL1 mRNA

NCBI chr 6:53,250,036...53,293,406
Ensembl chr 6:53,249,610...53,293,404

G

shisa family member 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SHISA2 mRNA

NCBI chr15:37,982,913...37,987,211
Ensembl chr15:37,982,169...37,988,535

G

serine hydroxymethyltransferase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SHMT2 mRNA

NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:65,244,247...65,249,567

G

siah E3 ubiquitin protein ligase 2

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SIAH2 mRNA

NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873

G

signal-induced proliferation-associated 1

decreases expression
increases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SIPA1 mRNA
bis(tri-n-butyltin)oxide results in increased expression of SIPA1 mRNA

PMID:18958704 PMID:24247028

NCBI chr 1:212,367,867...212,379,952
Ensembl chr 1:212,367,867...212,377,497

G

signal-induced proliferation-associated 1 like 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SIPA1L1 mRNA

NCBI chr 6:107,570,569...107,849,613
Ensembl chr 6:107,737,392...107,848,160

G

SKI-like proto-oncogene

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SKIL mRNA

NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:114,175,534...114,201,974

G

S-phase kinase associated protein 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SKP2 mRNA

PMID:18958704 PMID:25270620

NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438

G

stem-loop histone mRNA binding protein

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SLBP mRNA

NCBI chr14:81,295,479...81,306,446
Ensembl chr14:81,296,223...81,306,447

G

solute carrier family 16 member 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of SLC16A1 protein

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 29 member 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SLC29A1 mRNA

NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:22,902,471...22,914,620

G

solute carrier family 2 member 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SLC2A1 mRNA

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 30 member 6

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SLC30A6 mRNA

NCBI chr 6:26,772,804...26,802,656
Ensembl chr 6:26,772,804...26,802,656

G

solute carrier family 7 member 11

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

STE20-like kinase

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of SLK protein

NCBI chr 1:256,415,013...256,470,942
Ensembl chr 1:256,415,013...256,467,829

G

structural maintenance of chromosomes 1A

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of SMC1A protein

NCBI chr X:24,582,732...24,627,462
Ensembl chr X:24,582,690...24,627,462

G

single-pass membrane protein with coiled-coil domains 4

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SMCO4 mRNA

NCBI chr 8:20,594,633...20,646,916
Ensembl chr 8:20,627,338...20,646,916

G

sphingomyelin phosphodiesterase, acid-like 3A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SMPDL3A mRNA

NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260

G

synuclein alpha

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SNCA mRNA

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

stannin

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of SNN mRNA

NCBI chr10:5,079,885...5,088,565
Ensembl chr 1:82,440,586...82,441,390
Ensembl chr10:82,440,586...82,441,390

G

sorting nexin 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of SNX1 protein

NCBI chr 8:75,515,780...75,565,487
Ensembl chr 8:75,525,181...75,565,561

G

superoxide dismutase 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

SON DNA and RNA binding protein

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of SON mRNA

NCBI chr11:44,336,818...44,409,127
Ensembl chr11:44,377,976...44,409,127

G

SPO11 initiator of meiotic double strand breaks

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SPO11 mRNA

NCBI chr 3:182,173,615...182,189,273
Ensembl chr 3:182,175,861...182,189,276

G

spectrin, alpha, non-erythrocytic 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of SPTAN1 protein

NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:33,607,210...33,703,889

G

spectrin, beta, non-erythrocytic 1

decreases expression
decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SPTBN1 protein
bis(tri-n-butyltin)oxide results in decreased phosphorylation of SPTBN1 protein

PMID:19552622 PMID:22174045

NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836

G

steroid 5 alpha-reductase 2

decreases activity

ISO

bis(tri-n-butyltin)oxide results in decreased activity of SRD5A2 protein

NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588

G

sterol regulatory element binding transcription factor 1

increases expression

EXP
ISO

bis(tri-n-butyltin)oxide results in increased expression of SREBF1 mRNA

PMID:17553608 PMID:25270620

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

serine and arginine rich splicing factor 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SRSF2 protein

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141

G

serine and arginine rich splicing factor 5

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of SRSF5 protein

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

serine and arginine rich splicing factor 6

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of SRSF6 mRNA

NCBI chr 3:172,009,072...172,014,395
Ensembl chr 3:172,009,061...172,014,392

G

STAG2 cohesin complex component

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of STAG2 mRNA

NCBI chr X:125,839,660...125,971,209
Ensembl chr X:125,840,401...125,971,209

G

signal transducer and activator of transcription 5B

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of STAT5B mRNA

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990

G

serine/threonine kinase 17b

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of STK17B mRNA

NCBI chr 9:62,801,912...62,832,511
Ensembl chr 9:62,803,005...62,832,511

G

serine/threonine kinase 4

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of STK4 protein

NCBI chr 3:173,165,238...173,247,135
Ensembl chr 3:173,165,083...173,247,134

G

SUB1 regulator of transcription

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of SUB1 protein

NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:62,732,736...62,747,679

G

succinate-CoA ligase ADP-forming subunit beta

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SUCLA2 mRNA

NCBI chr15:55,161,894...55,215,031
Ensembl chr15:55,161,868...55,215,029

G

spleen associated tyrosine kinase

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of SYK mRNA

NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278

G

transforming, acidic coiled-coil containing protein 3

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TACC3 mRNA

PMID:17942131 PMID:18958704

NCBI chr14:81,275,755...81,289,894
Ensembl chr14:81,275,755...81,289,698

G

transaldolase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TALDO1 mRNA

NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:205,923,165...205,933,535

G

TRAF family member-associated NFKB activator

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of TANK mRNA

NCBI chr 3:66,522,834...66,598,864
Ensembl chr 3:66,537,175...66,598,864

G

transporter 1, ATP binding cassette subfamily B member

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TAP1 mRNA

NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,658,172...4,668,810

G

Tax1 binding protein 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of TAX1BP1 mRNA

NCBI chr 4:83,152,549...83,208,463
Ensembl chr 4:83,110,062...83,209,657

G

transcription elongation factor A1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of TCEA1 protein

NCBI chr 5:19,414,351...19,466,629
Ensembl chr15:12,831,339...12,834,156
Ensembl chr 5:12,831,339...12,834,156

G

t-complex 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TCP1 protein

NCBI chr 1:50,376,848...50,384,527
Ensembl chr 1:50,376,848...50,384,527

G

Thy-1 cell surface antigen

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of THY1 mRNA

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

transmembrane protein 254

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TMEM254 mRNA

NCBI chr16:1,510,705...1,514,591
Ensembl chr16:1,510,709...1,514,343

G

thymopoietin

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of TMPO protein

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

TNF alpha induced protein 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 1A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TNFRSF1A mRNA

PMID:18958704 PMID:24247028

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 9

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TNFRSF9 mRNA

NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831

G

TNF superfamily member 11

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TNFSF11 mRNA

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

TNF superfamily member 13

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TNFSF13 mRNA

NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,898,805...54,901,815

G

TNF superfamily member 9

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TNFSF9 mRNA

NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339

G

DNA topoisomerase II beta

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of TOP2B protein

NCBI chr15:11,482,089...11,542,464
Ensembl chr15:11,482,089...11,542,464

G

TPD52 like 2

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of TPD52L2 protein

NCBI chr 3:188,972,321...188,995,721
Ensembl chr 3:188,975,970...188,995,713

G

tribbles pseudokinase 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 10

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TRIM10 mRNA

NCBI chr20:1,694,771...1,703,724
Ensembl chr20:1,694,779...1,703,469

G

tRNA methyltransferase 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of TRMT1 mRNA

NCBI chr19:40,361,583...40,374,971
Ensembl chr19:40,361,583...40,374,622

G

TruB pseudouridine synthase family member 2

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TRUB2 mRNA

NCBI chr 3:33,447,101...33,457,712
Ensembl chr 3:33,431,628...33,457,726

G

tubulin, beta 5 class I

decreases expression
increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TUBB5 mRNA
bis(tri-n-butyltin)oxide results in increased phosphorylation of TUBB5 protein

PMID:18958704 PMID:22174045

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

thioredoxin domain containing 11

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of TXNDC11 mRNA

NCBI chr10:5,022,464...5,079,958
Ensembl chr10:5,022,435...5,079,950

G

thioredoxin reductase 1

increases expression

ISO
EXP

bis(tri-n-butyltin)oxide results in increased expression of TXNRD1 mRNA

PMID:17553608 PMID:21601586

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

ubiquitin-like modifier activating enzyme 1

decreases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in decreased phosphorylation of UBA1 protein

NCBI chr X:4,062,216...4,084,192
Ensembl chr X:4,062,182...4,084,246

G

UBX domain protein 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of UBXN1 protein

NCBI chr 1:215,194,418...215,198,343
Ensembl chr 1:215,174,216...215,198,343

G

UDP glycosyltransferase 8

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of UGT8 mRNA

NCBI chr 2:216,938,884...217,007,167
Ensembl chr 2:216,938,990...217,007,167

G

upstream transcription factor 2, c-fos interacting

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of USF2 mRNA

NCBI chr 1:95,302,109...95,321,334
Ensembl chr 1:95,302,105...95,313,119

G

ubiquitin specific peptidase 15

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of USP15 mRNA

NCBI chr 7:60,643,611...60,805,137
Ensembl chr 7:60,643,613...60,734,099

G

vav guanine nucleotide exchange factor 1

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of VAV1 mRNA

NCBI chr 9:2,248,856...2,295,905
Ensembl chr 9:2,248,914...2,296,922

G

vav guanine nucleotide exchange factor 3

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of VAV3 mRNA

NCBI chr 2:199,699,861...200,042,344
Ensembl chr 2:199,700,445...200,042,343

G

voltage-dependent anion channel 1

decreases expression

EXP

bis(tri-n-butyltin)oxide results in decreased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

vascular endothelial growth factor A

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

very low density lipoprotein receptor

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of VLDLR mRNA

NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154

G

V-set pre-B cell surrogate light chain 1A

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of VPREB1 mRNA

NCBI chr11:97,631,174...97,632,051
Ensembl chr11:97,629,102...97,632,051

G

X-box binding protein 1

increases expression

ISO

bis(tri-n-butyltin)oxide results in increased expression of XBP1 mRNA

PMID:21601586 PMID:22434021

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

X-linked inhibitor of apoptosis

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of XIAP mRNA

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of YWHAH mRNA

NCBI chr14:81,920,819...81,930,202
Ensembl chr14:81,920,590...81,947,930

G

zinc finger CCHC-type and RNA binding motif containing 1

increases phosphorylation

ISO

bis(tri-n-butyltin)oxide results in increased phosphorylation of ZCRB1 protein

NCBI chr 7:126,404,675...126,418,012
Ensembl chr 7:126,404,193...126,418,012

G

zinc finger E-box binding homeobox 1

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of ZEB1 mRNA

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745

G

zinc finger protein 207

decreases expression

ISO

bis(tri-n-butyltin)oxide results in decreased expression of ZFP207 mRNA

NCBI chr10:65,883,630...65,895,895
Ensembl chr10:65,883,599...65,895,895

G

zinc finger protein 36

increases expression

EXP

bis(tri-n-butyltin)oxide results in increased expression of ZFP36 mRNA

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
molecular entity	20871
inorganic molecular entity	20168
Tributyltin oxide	555

paths to the root