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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:endrin
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Accession:CHEBI:81526 term browser browse the term
Definition:An organochlorine compound resulting from the epoxidation of the double bond of isodrin. It is the endo, endo stereoisomer of dieldrin. It is an insecticide mainly used on field crops such as cotton and grains and has also been used as a rodenticide to control mice and voles. The product is banned in many countries since it is a persistent organic pollutant.
Synonyms:exact_synonym: rel-(1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene
 related_synonym: (1R,2S,3R,6S,7R,8S,9S,11R)-3,4,5,6,13,13-Hexachloro-10-oxapentacyclo[6.3.1.1(3,6).0(2,7).0(9,11)]tridec-4-ene;   (1R,4S,4aS,5S,6S,7R,8R,8aR)-1,2,3,4,10,10-hexachloro-1,4,4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene;   (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene;   (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-rel-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth[2,3-b]oxirene;   1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo,endo-1,4:5,8-dimethanonaphthalene;   1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-exo-1,4-exo-5,8-dimethanonaphthalene;   EN 57;   Endrex;   Endricol;   Formula=C12H8Cl6O;   Hexacrin;   Hexadrin;   InChI=1S/C12H8Cl6O/c13-8-9(14)11(16)5-3-1-2(6-7(3)19-6)4(5)10(8,15)12(11,17)18/h2-7H,1H2/t2-,3+,4-,5+,6-,7+,10-,11+;   InChIKey=DFBKLUNHFCTMDC-GKRDHZSOSA-N;   Mendrin;   Nendrin;   OMS 197;   Oktanex;   SMILES=[H][C@]12O[C@@]1([H])[C@@]1([H])C[C@]2([H])[C@]2([H])[C@@]1([H])[C@]1(Cl)C(Cl)=C(Cl)[C@@]2(Cl)C1(Cl)Cl;   Stardrin;   compound 269;   endrine;   experimental insecticide 269;   isodrin epoxide
 xref: AGR:IND606456156;   CAS:72-20-8;   Chemspider:21782117;   FooDB:FDB003234;   HMDB:HMDB0031211;   KEGG:C18124
 xref_mesh: MESH:D004732
 xref: PMID:10385688;   PMID:10523931;   PMID:1455427;   PMID:19268453;   PMID:2497330;   PMID:28918582;   PMID:29425943;   PMID:29784328;   PMID:3062692;   PMID:32897838;   PMID:3588147;   PMID:7397023;   PPDB:266;   Pesticides:endrin;   Reaxys:91397;   Wikipedia:Endrin



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endrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alk ALK receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
JBrowse link
G Ar androgen receptor multiple interactions ISO Endrin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA CTD PMID:28263720 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases activity
decreases expression
ISO Endrin results in decreased activity of CEBPA protein
Endrin results in decreased expression of CEBPA protein
CTD PMID:10385688 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cycs cytochrome c, somatic increases reduction ISO Endrin results in increased reduction of CYCS protein CTD PMID:12049837 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Endrin results in increased expression of CYP26A1 mRNA
AGN 193109 inhibits the reaction [Endrin results in increased expression of CYP26A1 mRNA]
CTD PMID:15589975 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Endrin results in increased expression of CYP2B6 protein CTD PMID:15548381 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Endrin results in increased expression of CYP3A4 protein CTD PMID:15548381 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Epha3 Eph receptor A3 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA CTD PMID:28263720 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Epha8 Eph receptor A8 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA CTD PMID:28263720 NCBI chr 5:149,166,107...149,193,498
Ensembl chr 5:149,166,697...149,193,399
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
ISO Endrin binds to and results in increased activity of ESR1 protein
Endrin results in increased activity of ESR1 protein
CTD PMID:15064155 PMID:16626760 PMID:26022396 PMID:26139245 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
ISO Endrin binds to and results in decreased activity of ESR2 protein
Endrin results in increased activity of ESR2 protein
CTD PMID:16626760 PMID:26139245 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA CTD PMID:28263720 NCBI chr 1:257,315,682...257,552,004 JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Endrin results in increased activity of GSR protein CTD PMID:2276583 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Endrin results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA CTD PMID:28263720 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lrrc2 leucine rich repeat containing 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA CTD PMID:28263720 NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185
JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA CTD PMID:28263720 NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects activity ISO Endrin affects the activity of NFKB1 protein CTD PMID:10385688 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO Endrin binds to and results in increased activity of NR1I2 protein
Endrin results in increased activity of NR1I2 protein
CTD PMID:15548381 PMID:16054614 PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Endrin results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO Endrin results in increased activity of NR3C1 protein CTD PMID:19927138 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA CTD PMID:28263720 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA CTD PMID:28263720 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Endrin inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plxnd1 plexin D1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA CTD PMID:28263720 NCBI chr 4:149,002,784...149,043,097
Ensembl chr 4:149,002,784...149,043,244
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Endrin results in decreased expression of PPARG protein CTD PMID:10385688 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Endrin results in increased expression of RARB mRNA CTD PMID:15589975 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarg retinoic acid receptor, gamma increases expression
increases activity
ISO Endrin results in increased expression of RARG mRNA
Endrin results in increased activity of RARG protein
CTD PMID:15589975 PMID:30639747 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Ret ret proto-oncogene multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA CTD PMID:28263720 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO Endrin binds to RORA protein CTD PMID:32278787 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Tp53 tumor protein p53 affects response to substance ISO TRP53 protein affects the susceptibility to Endrin CTD PMID:10802220 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions EXP Endrin inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP] CTD PMID:2467674 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

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Path 1
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  CHEBI ontology 19800
    role 19751
      biological role 19751
        xenobiotic 18436
          endrin 34
Path 2
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    saturated organic heteromonocyclic parent 9797
                                      oxirane 9768
                                        epoxide 9767
                                          endrin 34
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