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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,3,3',4,4',5-Hexachlorobiphenyl
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Accession:CHEBI:81522 term browser browse the term
Definition:A hexachlorobiphenyl that has formula C12H4Cl6.
Synonyms:related_synonym: Formula=C12H4Cl6;   InChI=1S/C12H4Cl6/c13-7-2-1-5(3-8(7)14)6-4-9(15)11(17)12(18)10(6)16/h1-4H;   InChIKey=LCXMEXLGMKFLQO-UHFFFAOYSA-N;   PCB 156;   SMILES=Clc1ccc(cc1Cl)-c1cc(Cl)c(Cl)c(Cl)c1Cl
 xref: CAS:38380-08-4;   KEGG:C18120
 xref_mesh: MESH:C087667


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2,3,3',4,4',5-Hexachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
affects binding
ISO
EXP
2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of AHR protein
2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of AHR protein; 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; 2,3,3',4,4',5-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
2,3,3',4,4',5-hexachlorobiphenyl binds to AHR protein
CTD PMID:10448124 PMID:11339718 PMID:12850102 PMID:15352264 PMID:20728228 PMID:25654323 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of AHRR mRNA CTD PMID:29738842 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of ALDH3A1 mRNA CTD PMID:29738842 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Ar androgen receptor multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA CTD PMID:16396990 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA CTD PMID:16396990 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO
EXP
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA; 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A1 protein
2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of CYP1A1 protein
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; [Tetrachlorodibenzodioxin co-treated with 2,3,3',4,4',5-hexachlorobiphenyl] results in increased expression of CYP1A1 protein
CTD PMID:10986007 PMID:11339718 PMID:15352264 PMID:16750337 PMID:18493746 PMID:23674508 PMID:25654323 PMID:29738842 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions
increases expression
decreases activity
ISO
EXP
2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of CYP1A2 protein
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A2 mRNA
2,3,3',4,4',5-hexachlorobiphenyl results in decreased activity of CYP1A2 protein
CTD PMID:10986007 PMID:15659567 PMID:18493746 PMID:23674508 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO
EXP
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:23674508 PMID:25654323 PMID:29738842 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to ESR1 protein CTD PMID:16293362 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of MAPK1 protein CTD PMID:16293362 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of MAPK3 protein CTD PMID:16293362 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
multiple interactions
ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of NR1I3 protein
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]
CTD PMID:19746742 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of TIPARP mRNA CTD PMID:29738842 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      chemical role 19255
        environmental contaminant 18593
          persistent organic pollutant 15811
            polychlorobiphenyl 5780
              hexachlorobiphenyl 2022
                2,3,3',4,4',5-Hexachlorobiphenyl 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            organic hydride 18358
                              organic fundamental parent 18358
                                hydrocarbon 18075
                                  halohydrocarbon 14045
                                    haloarene 6184
                                      chloroarene 5782
                                        chlorobiphenyl 5782
                                          polychlorobiphenyl 5780
                                            hexachlorobiphenyl 2022
                                              2,3,3',4,4',5-Hexachlorobiphenyl 14
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