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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,3,4,3',4'-Pentachlorobiphenyl
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Accession:CHEBI:81518 term browser browse the term
Definition:A pentachlorobiphenyl that has formula C12H5Cl5.
Synonyms:related_synonym: Formula=C12H5Cl5;   InChI=1S/C12H5Cl5/c13-8-3-1-6(5-10(8)15)7-2-4-9(14)12(17)11(7)16/h1-5H;   InChIKey=WIDHRBRBACOVOY-UHFFFAOYSA-N;   PCB 105;   SMILES=Clc1ccc(cc1Cl)-c1ccc(Cl)c(Cl)c1Cl
 xref: CAS:32598-14-4;   KEGG:C18116
 xref_mesh: MESH:C067940


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2,3,4,3',4'-Pentachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
ISO
EXP
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of AHR protein
2,3,3',4,4'-pentachlorobiphenyl affects the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; 2,3,3',4,4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
2,3,3',4,4'-pentachlorobiphenyl binds to and results in increased activity of AHR protein
CTD PMID:10448124 PMID:12850102 PMID:20435555 PMID:20961953 PMID:25654323 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor multiple interactions ISO 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO
EXP
2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA; 2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of CYP1A1 protein
CTD PMID:10986007 PMID:16750337 PMID:18493746 PMID:25654323 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
decreases response to substance
multiple interactions
increases activity
ISO
EXP
2,3,3',4,4'-pentachlorobiphenyl results in decreased activity of CYP1A2 protein
CYP1A2 results in decreased susceptibility to 2,3,3',4,4'-pentachlorobiphenyl
2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
2,3,3',4,4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of CYP1A2 protein
CTD PMID:10986007 PMID:15659567 PMID:18493746 PMID:20961953 PMID:21571617 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 PMID:29738842 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases response to substance EXP CYP2B1 protein results in increased susceptibility to 2,3,3',4,4'-pentachlorobiphenyl CTD PMID:10640525 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects response to substance ISO CYP2B6 gene SNP affects the susceptibility to 2,3,3',4,4'-pentachlorobiphenyl CTD PMID:25839716 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity
ISO 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of NR1I3 protein
CTD PMID:19746742 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis
ISO 1,2-dichloroethylene inhibits the reaction [2,3,3',4,4'-pentachlorobiphenyl results in increased mutagenesis of PIGA gene] CTD PMID:32199159 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO 2,3,3',4,4'-pentachlorobiphenyl results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 2,3,3',4,4'-pentachlorobiphenyl affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link

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  CHEBI ontology 19840
    role 19790
      chemical role 19308
        environmental contaminant 18635
          persistent organic pollutant 15815
            polychlorobiphenyl 5786
              pentachlorobiphenyl 2594
                2,3,4,3',4'-Pentachlorobiphenyl 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    main group molecular entity 19730
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18743
                            organic hydride 18298
                              organic fundamental parent 18298
                                hydrocarbon 18025
                                  halohydrocarbon 14043
                                    haloarene 6189
                                      chloroarene 5788
                                        chlorobiphenyl 5788
                                          polychlorobiphenyl 5786
                                            pentachlorobiphenyl 2594
                                              2,3,4,3',4'-Pentachlorobiphenyl 11
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