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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,4,5,3',4',5'-Hexachlorobiphenyl
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Accession:CHEBI:81517 term browser browse the term
Definition:A hexachlorobiphenyl that has formula C12H4Cl6.
Synonyms:related_synonym: Formula=C12H4Cl6;   InChI=1S/C12H4Cl6/c13-7-1-5(2-8(14)11(7)17)6-3-9(15)12(18)10(16)4-6/h1-4H;   InChIKey=ZHLICBPIXDOFFG-UHFFFAOYSA-N;   PCB 169;   SMILES=Clc1cc(cc(Cl)c1Cl)-c1cc(Cl)c(Cl)c(Cl)c1
 xref: CAS:32774-16-6;   KEGG:C18115
 xref_mesh: MESH:C027309


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3,4,5,3',4',5'-Hexachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adtrp androgen-dependent TFPI-regulating protein multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of ADTRP mRNA CTD PMID:30744511 NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
increases activity		 ISO
EXP		 3,4,5,3',4',5'-hexachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]
3,4,5,3',4',5'-hexachlorobiphenyl binds to AHR protein
3,4,5,3',4',5'-hexachlorobiphenyl binds to and affects the localization of AHR protein; 3,4,5,3',4',5'-hexachlorobiphenyl binds to and results in increased activity of AHR protein; 3,4,5,3',4',5'-hexachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [3,4,5,3',4',5'-hexachlorobiphenyl binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
3,4,5,3',4',5'-hexachlorobiphenyl results in increased activity of AHR protein		 CTD PMID:11339718 PMID:12850102 PMID:15099731 PMID:20728228 PMID:20961953 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahsp alpha hemoglobin stabilizing protein multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of AHSP mRNA CTD PMID:30744511 NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:182,880,076...182,885,506 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of AKR1C1 mRNA CTD PMID:30744511 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of AKR1C2 mRNA CTD PMID:30744511 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Ascl5 achaete-scute family bHLH transcription factor 5 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of ASCL5 mRNA CTD PMID:30744511 NCBI chr13:47,491,799...47,493,269
Ensembl chr13:47,492,026...47,492,592 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of CASP12 mRNA CTD PMID:30744511 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Cfap95 cilia and flagella associated protein 95 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of CFAP95 mRNA CTD PMID:30744511 NCBI chr 1:221,123,786...221,242,963
Ensembl chr 1:221,131,813...221,242,963 		JBrowse link
G Cib2 calcium and integrin binding family member 2 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of CIB2 mRNA CTD PMID:30744511 NCBI chr 8:54,930,265...54,947,157 JBrowse link
G Cldn1 claudin 1 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of CLDN1 mRNA CTD PMID:30744511 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of COMT mRNA CTD PMID:30744511 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cpn2 carboxypeptidase N subunit 2 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of CPN2 mRNA CTD PMID:30744511 NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA CTD PMID:16396990 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA CTD PMID:16396990 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO
EXP		 3,4,5,3',4',5'-hexachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]
3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA
[3,4,5,3',4',5'-hexachlorobiphenyl binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA
[3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of CYP1A1 mRNA; [Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in increased expression of CYP1A1 protein
3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP1A1 protein		 CTD PMID:11339718 PMID:21292640 PMID:21781905 PMID:25654323 PMID:29738842 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
decreases response to substance		 ISO
EXP		 3,4,5,3',4',5'-hexachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
3,4,5,3',4',5'-hexachlorobiphenyl results in decreased activity of CYP1A2 protein
CYP1A2 results in decreased susceptibility to 3,4,5,3',4',5'-hexachlorobiphenyl		 CTD PMID:15659567 PMID:20961953 PMID:21571617 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 PMID:29738842 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of CYP4A2 mRNA CTD PMID:30744511 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165 		JBrowse link
G Esm1 endothelial cell-specific molecule 1 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of ESM1 mRNA CTD PMID:30744511 NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804 		JBrowse link
G Fam13a family with sequence similarity 13, member A multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of FAM13A mRNA CTD PMID:30744511 NCBI chr 4:88,056,521...88,155,782
Ensembl chr 4:88,058,403...88,155,860 		JBrowse link
G Gng13 G protein subunit gamma 13 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of GNG13 mRNA CTD PMID:30744511 NCBI chr10:14,741,179...14,743,083
Ensembl chr10:14,741,239...14,743,083 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of HAMP mRNA CTD PMID:30744511 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of HBA-A3 mRNA CTD PMID:30744511 NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481 		JBrowse link
G Nat8 N-acetyltransferase 8 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of NAT8 mRNA CTD PMID:30744511 NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763 		JBrowse link
G Nat8f2 N-acetyltransferase 8 (GCN5-related) family member 2 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of NAT8F2 mRNA CTD PMID:30744511 NCBI chr 4:118,319,984...118,323,159
Ensembl chr 4:118,319,988...118,324,395 		JBrowse link
G Pgpep1 pyroglutamyl-peptidase I multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of PGPEP1 mRNA CTD PMID:30744511 NCBI chr16:18,770,563...18,782,968
Ensembl chr16:18,771,021...18,783,478 		JBrowse link
G Plaat1 phospholipase A and acyltransferase 1 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of HRASLS mRNA CTD PMID:30744511 NCBI chr11:71,517,492...71,537,142
Ensembl chr11:71,517,493...71,527,020 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of RGS4 mRNA CTD PMID:30744511 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Slc35c2 solute carrier family 35 member C2 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in increased expression of SLC35C2 mRNA CTD PMID:30744511 NCBI chr 3:154,012,262...154,023,549
Ensembl chr 3:154,012,416...154,023,488 		JBrowse link
G Tmem150c transmembrane protein 150C multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of TMEM150C mRNA CTD PMID:30744511 NCBI chr14:9,454,999...9,525,300
Ensembl chr14:9,508,515...9,525,298 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of TPT1 mRNA CTD PMID:30744511 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B multiple interactions EXP [3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with Dibenzofurans, Polychlorinated co-treated with Polychlorinated Dibenzodioxins] results in decreased expression of UGT2B mRNA CTD PMID:30744511 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      chemical role 19442
        environmental contaminant 18846
          persistent organic pollutant 16700
            polychlorobiphenyl 6020
              hexachlorobiphenyl 2041
                3,4,5,3',4',5'-Hexachlorobiphenyl 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            organic hydride 18674
                              organic fundamental parent 18674
                                hydrocarbon 18410
                                  halohydrocarbon 15496
                                    haloarene 6410
                                      chloroarene 6022
                                        chlorobiphenyl 6022
                                          polychlorobiphenyl 6020
                                            hexachlorobiphenyl 2041
                                              3,4,5,3',4',5'-Hexachlorobiphenyl 32
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