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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,2,3,7,8-Pentachlorodibenzodioxin
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Accession:CHEBI:81501 term browser browse the term
Definition:A dibenzodioxine that has formula C12H3Cl5O2.
Synonyms:related_synonym: 1,2,3,7,8-PeCDD;   1,2,3,7,8-Pentachlorodibenzo-p-dioxin;   Formula=C12H3Cl5O2;   InChI=1S/C12H3Cl5O2/c13-4-1-7-8(2-5(4)14)19-12-9(18-7)3-6(15)10(16)11(12)17/h1-3H;   InChIKey=FSPZPQQWDODWAU-UHFFFAOYSA-N;   PCDD 54;   SMILES=Clc1cc2Oc3cc(Cl)c(Cl)c(Cl)c3Oc2cc1Cl
 xref: CAS:40321-76-4;   KEGG:C18099
 xref_mesh: MESH:C051452


show annotations for term's descendants           Sort by:
1,2,3,7,8-Pentachlorodibenzodioxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects response to substance
increases activity		 ISO
EXP		 AHR mRNA affects the susceptibility to 1,2,3,7,8-pentachlorodibenzo-p-dioxin
1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased activity of AHR protein		 CTD PMID:19447902 PMID:25654323 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO
EXP		 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of AHRR mRNA CTD PMID:24472611 PMID:25654323 PMID:29738842 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression EXP 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of ALDH3A1 mRNA CTD PMID:29738842 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Areg amphiregulin increases expression ISO 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of AREG mRNA CTD PMID:16929009 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO
EXP		 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 mRNA
1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 mRNA; 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 protein		 CTD PMID:19041680 PMID:19447902 PMID:23674508 PMID:24472611 PMID:25654323 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A2 mRNA CTD PMID:23674508 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases expression 		ISO
EXP		 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1B1 mRNA
1,2,3,7,8-Pentachlorodibenzodioxin increases expression of CYP1B1 mRNA in lung epithelial cell 		CTD
RGD		 PMID:23674508 PMID:24472611 PMID:25654323 PMID:29738842 PMID:19358281 RGD:152177688 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Fgf9 fibroblast growth factor 9 increases expression ISO 1,2,3,7,8-Pentachlorodibenzodioxin increases expression of FGF9 mRNA in lung epithelial cell RGD PMID:19358281 RGD:152177688 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Il5 interleukin 5 increases expression
decreases expression		 ISO 1,2,3,7,8-pentachlorodibenzo-p-dioxin analog results in increased expression of IL5 mRNA
1,2,3,7,8-pentachlorodibenzo-p-dioxin analog results in decreased expression of IL5 protein; 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in decreased expression of IL5 protein		 CTD PMID:19041680 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP
ISO		 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of TIPARP mRNA CTD PMID:29738842 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        xenobiotic 18731
          dibenzodioxine 15133
            polychlorinated dibenzodioxine 15132
              1,2,3,7,8-Pentachlorodibenzodioxin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  organic heteropolycyclic compound 18301
                                    organic heterotricyclic compound 15641
                                      dibenzodioxine 15133
                                        polychlorinated dibenzodioxine 15132
                                          1,2,3,7,8-Pentachlorodibenzodioxin 10
paths to the root