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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Dimaprit
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Accession:CHEBI:81389 term browser browse the term
Definition:An imidothiocarbamic ester that has formula C6H15N3S.
Synonyms:related_synonym: Formula=C6H15N3S;   InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8);   InChIKey=OLHQOJYVQUNWPL-UHFFFAOYSA-N;   SMILES=CN(C)CCCSC(N)=N
 xref: CAS:65119-89-3;   KEGG:C17930;   LINCS:LSM-5390
 xref_mesh: MESH:D017259


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Dimaprit term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule multiple interactions ISO [Dimaprit binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein CTD PMID:14499251 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein] CTD PMID:12538815 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO Dimaprit results in decreased expression of FOS protein
[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]		 CTD PMID:9187264 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
increases activity		 ISO
EXP		 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dimaprit results in increased expression of HRH2 mRNA]; [Dimaprit binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein; [Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased abundance of Cyclic AMP; [Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; Dimaprit binds to and results in increased activity of HRH2 protein; Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP]]; Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Dinoprostone results in increased abundance of Cyclic AMP]]; Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; HRH2 protein promotes the reaction [Dimaprit results in increased expression of IL16 protein]
Dimaprit binds to and results in increased activity of HRH2 protein; HRH2 protein promotes the reaction [Dimaprit results in increased expression of IL6 mRNA]
Dimaprit results in increased activity of HRH2 protein
Dimaprit binds to and results in increased activity of HRH2 protein; Ranitidine inhibits the reaction [Dimaprit binds to and results in increased activity of HRH2 protein]		 CTD PMID:9187264 PMID:9657254 PMID:12235264 PMID:14499251 PMID:16143415 More... NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Dimaprit inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma affects expression
multiple interactions		 ISO Dimaprit affects the expression of IFNG protein
Dimaprit inhibits the reaction [IL18 protein results in increased expression of IFNG protein]
Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]; Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]		 CTD PMID:11752121 PMID:12364868 PMID:17346280 PMID:19277450 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Dimaprit inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] CTD PMID:11752121 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Dimaprit inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Dimaprit inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il16 interleukin 16 increases expression
multiple interactions		 ISO Dimaprit results in increased expression of IL16 protein
HRH2 protein promotes the reaction [Dimaprit results in increased expression of IL16 protein]		 CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Dimaprit inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; Dimaprit inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; Dimaprit inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Dimaprit inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; Dimaprit inhibits the reaction [IL18 protein results in increased expression of TNF protein] CTD PMID:11752121 PMID:12364868 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:19277450 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]] CTD PMID:19277450 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 affects expression ISO Dimaprit affects the expression of IL5 protein CTD PMID:17346280 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Dimaprit results in increased expression of IL6 mRNA
HRH2 protein promotes the reaction [Dimaprit results in increased expression of IL6 mRNA]		 CTD PMID:9657254 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Dimaprit results in decreased expression of JUN protein CTD PMID:9187264 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Dimaprit results in decreased expression of MYC protein CTD PMID:9187264 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ntf3 neurotrophin 3 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimaprit results in increased expression of NTF3 protein]; [methylhistaprodifen co-treated with Dimaprit co-treated with imetit] results in increased expression of NTF3 protein; [methylhistaprodifen co-treated with Dimaprit] results in increased expression of NTF3 protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dimaprit results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cimetidine inhibits the reaction [Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Dimaprit binds to and results in increased activity of TNF protein; Dimaprit inhibits the reaction [IL18 protein results in increased expression of TNF protein]; Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Dimaprit binds to and results in increased activity of TNF protein; Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]; Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]		 CTD PMID:9088875 PMID:11752121 PMID:12538815 PMID:19277450 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          sulfur atom 17687
            sulfur molecular entity 17715
              organosulfur compound 17334
                imidothiocarbamic ester 83
                  Dimaprit 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  ester 17247
                                    imidothiocarbamic ester 83
                                      Dimaprit 19
paths to the root