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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosalone
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Accession:CHEBI:8121 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide.
Synonyms:exact_synonym: S-[(6-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)methyl] O,O-diethyl phosphorodithioate
 related_synonym: 3-[O,O-(Diethyldithiophosphoryl)methyl]-6-chlorobenzoxazolinone;   Agria 1060 A;   Formula=C12H15ClNO4PS2;   InChI=1S/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3;   InChIKey=IOUNQDKNJZEDEP-UHFFFAOYSA-N;   Phosphorodithioic acid, S-((6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl) O,O-diethyl ester;   S-[(6-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)methyl] O,O-diethyl dithiophosphate;   SMILES=CCOP(=S)(OCC)SCn1c2ccc(Cl)cc2oc1=O
 xref: Beilstein:694650;   CAS:2310-17-0;   HMDB:HMDB0041985;   KEGG:C11028;   LINCS:LSM-25642
 xref_mesh: MESH:C003117
 xref: PMID:15132335;   PMID:24053362;   PPDB:520;   Patent:CA1048929;   Patent:JP2006213665;   Reaxys:694650;   Wikipedia:Phosalone



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phosalone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] results in decreased activity of ABCB1 protein; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone results in decreased activity of ABCB1 protein]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [phosalone results in decreased activity of ABCB1 protein]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [Endosulfan results in decreased activity of ABCB1 protein]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole results in decreased activity of ABCB1 protein]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [phosalone results in decreased activity of ABCB1 protein] CTD PMID:21783720 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ache acetylcholinesterase decreases activity ISO phosalone metabolite results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [phosalone results in increased activity of AR protein]; phosalone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:15064155 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO phosalone binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions
increases activity
EXP Ellagic Acid inhibits the reaction [phosalone results in increased activity of GAL protein] CTD PMID:27965107 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL1B protein] CTD PMID:27965107 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL6 protein] CTD PMID:27965107 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression
multiple interactions
EXP phosalone results in increased expression of MAPK14 protein
Ellagic Acid inhibits the reaction [phosalone results in increased expression of MAPK14 protein]
CTD PMID:27965107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phosalone binds to and results in increased activity of NR1I2 protein
[Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased activity of NR1I2 protein; phosalone binds to and results in increased activity of NR1I2 protein
CTD PMID:21115097 PMID:25028461 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO phosalone results in increased activity of NR1I3 protein CTD PMID:20143881 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO phosalone binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO phosalone results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression
EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 protein]
phosalone results in increased expression of RB1 mRNA; phosalone results in increased expression of RB1 protein
CTD PMID:27965107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of RELA protein] CTD PMID:27965107 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Si sucrase-isomaltase decreases activity EXP phosalone results in decreased activity of SI protein CTD PMID:92405 NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260
JBrowse link
G Tert telomerase reverse transcriptase decreases activity
multiple interactions
EXP phosalone results in decreased activity of TERT protein
Ellagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]
CTD PMID:27965107 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of TNF protein] CTD PMID:27965107 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
EXP phosalone results in increased expression of TP53 mRNA; phosalone results in increased expression of TP53 protein
Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 protein]
CTD PMID:27965107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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Path 1
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  CHEBI ontology 19831
    role 19807
      application 19650
        agrochemical 16289
          phosalone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      benzoxazole 124
                                        1,3-benzoxazoles 49
                                          phosalone 19
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