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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenytoin
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Accession:CHEBI:8107 term browser browse the term
Definition:A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Synonyms:related_synonym: 5,5-Diphenyl-imidazolidine-2,4-dione;   5,5-diphenylimidazolidine-2,4-dione;   5,5-diphenyltetrahydro-1H-2,4-imidazoledione;   DILANTIN;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19);   InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N;   PHENTYTOIN;   SMILES=O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1;   fenitoina;   phenytoine;   phenytoinum
 alt_id: CHEBI:100921
 xref: Beilstein:384532;   CAS:57-41-0;   DrugBank:DB00252;   Drug_Central:2152;   HMDB:HMDB0014397;   KEGG:C07443;   KEGG:D00512;   LINCS:LSM-5663
 xref_mesh: MESH:D010672
 xref: PMID:10698828;   PMID:12952753;   PMID:15246836;   PMID:15744730;   PMID:16303054;   PMID:7105825;   PMID:7602118;   PMID:9186244;   Patent:WO2012174723;   Reaxys:384532;   Wikipedia:Phenytoin


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phenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas achalasia, adrenocortical insufficiency, alacrimia decreases expression ISO Phenytoin results in decreased expression of AAAS mRNA CTD PMID:20345932 NCBI chr15:102,338,247...102,350,759
Ensembl chr15:102,338,252...102,350,771
JBrowse link
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 decreases expression EXP Phenytoin results in decreased expression of ABCA1 mRNA CTD PMID:15136057 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects response to substance
multiple interactions
increases expression
increases transport
affects abundance
increases metabolic processing
decreases activity
ISO
EXP
ABCB1 protein affects the susceptibility to Phenytoin
Amino Acids, Peptides, and Proteins inhibits the reaction [Phenytoin results in increased expression of ABCB1 protein]; Phenytoin results in increased expression of and results in increased activity of ABCB1A protein
ABCB1A protein results in increased transport of Phenytoin
ABCB1 protein affects the abundance of Phenytoin
ABCB1 protein results in increased metabolism of Phenytoin
Phenytoin results in decreased activity of ABCB1 protein
CTD PMID:8001500 PMID:10580886 PMID:14749549 PMID:15569486 PMID:16220110 PMID:17045309 PMID:17376120 PMID:17529887 PMID:18408562 PMID:18440557 PMID:18473823 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B affects abundance EXP ABCB1B protein affects the abundance of Phenytoin CTD PMID:12122045 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
increases expression
ISO KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein] CTD PMID:18473823 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects transport
multiple interactions
increases expression
affects response to substance
ISO ABCC2 protein affects the transport of Phenytoin
KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]
ABCC2 protein affects the susceptibility to Phenytoin
CTD PMID:12663688 PMID:14636316 PMID:17376120 PMID:18473823 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression ISO Phenytoin results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression EXP Phenytoin results in decreased expression of ABCG1 mRNA CTD PMID:15136057 NCBI chr17:31,057,694...31,117,984
Ensembl chr17:31,057,675...31,117,988
JBrowse link
G Abhd5 abhydrolase domain containing 5 increases expression ISO Phenytoin results in increased expression of ABHD5 mRNA CTD PMID:20345932 NCBI chr 9:122,351,616...122,381,524
Ensembl chr 9:122,351,608...122,381,524
JBrowse link
G Ablim1 actin-binding LIM protein 1 decreases expression EXP Phenytoin results in decreased expression of ABLIM1 mRNA CTD PMID:15136057 NCBI chr19:57,032,733...57,315,344
Ensembl chr19:57,032,733...57,314,919
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 decreases expression ISO Phenytoin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Ache acetylcholinesterase increases activity EXP Phenytoin results in increased activity of ACHE protein CTD PMID:16946593 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Adam8 a disintegrin and metallopeptidase domain 8 decreases expression ISO Phenytoin results in decreased expression of ADAM8 mRNA CTD PMID:14741686 NCBI chr 7:139,978,932...139,995,207
Ensembl chr 7:139,978,932...139,992,562
JBrowse link
G Adamts9 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 increases expression ISO Phenytoin results in increased expression of ADAMTS9 mRNA CTD PMID:20345932 NCBI chr 6:92,772,699...92,944,450
Ensembl chr 6:92,772,699...92,943,492
JBrowse link
G Adgrb3 adhesion G protein-coupled receptor B3 increases expression ISO Phenytoin results in increased expression of ADGRB3 mRNA CTD PMID:20345932 NCBI chr 1:25,067,476...25,834,772
Ensembl chr 1:25,067,476...25,829,707
JBrowse link
G Adrb3 adrenergic receptor, beta 3 decreases expression ISO Phenytoin results in decreased expression of ADRB3 mRNA CTD PMID:20345932 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Afp alpha fetoprotein decreases expression ISO
EXP
Phenytoin results in decreased expression of AFP mRNA CTD PMID:14741686 PMID:26272751 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 decreases expression ISO Phenytoin results in decreased expression of AGAP3 mRNA CTD PMID:20345932 NCBI chr 5:24,452,177...24,502,047
Ensembl chr 5:24,452,177...24,502,047
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases expression
EXP
ISO
CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]
CTD PMID:17505019 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akap10 A kinase (PRKA) anchor protein 10 increases expression ISO Phenytoin results in increased expression of AKAP10 mRNA CTD PMID:20345932 NCBI chr11:61,865,203...61,930,308
Ensembl chr11:61,871,307...61,930,252
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression ISO Phenytoin results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 decreases expression ISO Phenytoin results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 9:71,215,789...71,296,243
Ensembl chr 9:71,215,789...71,296,243
JBrowse link
G Amn1 antagonist of mitotic exit network 1 increases expression ISO Phenytoin results in increased expression of AMN1 mRNA CTD PMID:20345932 NCBI chr 6:149,157,261...149,188,712
Ensembl chr 6:149,157,147...149,188,712
JBrowse link
G Anxa4 annexin A4 increases expression ISO Phenytoin results in increased expression of ANXA4 mRNA CTD PMID:14741686 NCBI chr 6:86,736,840...86,793,634
Ensembl chr 6:86,736,840...86,793,584
JBrowse link
G Anxa5 annexin A5 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 3:36,448,923...36,475,887
Ensembl chr 3:36,448,923...36,475,894
JBrowse link
G Apoa1 apolipoprotein A-I increases expression EXP Phenytoin results in increased expression of APOA1 mRNA CTD PMID:15136057 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Apoa4 apolipoprotein A-IV increases expression EXP Phenytoin results in increased expression of APOA4 mRNA CTD PMID:15136057 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Apoe apolipoprotein E increases expression EXP Phenytoin results in increased expression of APOE mRNA CTD PMID:15136057 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
increases activity
EXP
ISO
[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Phenytoin results in increased expression of AR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Phenytoin results in increased expression of AR mRNA; Phenytoin results in increased expression of AR protein
Phenytoin results in increased activity of AR protein
CTD PMID:19226368 PMID:19490052 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO Phenytoin results in increased expression of ARFIP1 mRNA CTD PMID:20345932 NCBI chr 3:84,496,093...84,582,751
Ensembl chr 3:84,496,426...85,887,518
Ensembl chr 3:84,496,426...85,887,518
JBrowse link
G Arhgap39 Rho GTPase activating protein 39 increases expression ISO Phenytoin results in increased expression of ARHGAP39 mRNA CTD PMID:20345932 NCBI chr15:76,723,985...76,818,166
Ensembl chr15:76,723,985...76,818,170
JBrowse link
G Armc8 armadillo repeat containing 8 increases expression ISO Phenytoin results in increased expression of ARMC8 mRNA CTD PMID:20345932 NCBI chr 9:99,478,385...99,568,907
Ensembl chr 9:99,478,372...99,568,899
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein CTD PMID:21224054 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression ISO Phenytoin results in decreased expression of ATPAF1 mRNA CTD PMID:20345932 NCBI chr 4:115,784,828...115,811,923
Ensembl chr 4:115,784,812...115,822,655
JBrowse link
G B4galt7 xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) decreases expression ISO Phenytoin results in decreased expression of B4GALT7 mRNA CTD PMID:20345932 NCBI chr13:55,599,896...55,610,443
Ensembl chr13:55,599,896...55,610,443
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA CTD PMID:21224054 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO
EXP
Phenytoin results in increased expression of and affects the localization of BCL2 protein
Phenytoin results in decreased expression of BCL2 mRNA
CTD PMID:9118846 PMID:10695937 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA CTD PMID:21224054 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO Phenytoin results in decreased expression of BMP1 mRNA CTD PMID:14741686 NCBI chr14:70,474,555...70,520,716
Ensembl chr14:70,474,558...70,520,234
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression EXP Phenytoin results in increased expression of BMP4 mRNA CTD PMID:16141649 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G C2 complement component 2 (within H-2S) decreases expression ISO Phenytoin results in decreased expression of C2 mRNA CTD PMID:20345932 NCBI chr17:34,862,602...34,882,100
Ensembl chr17:34,862,604...34,898,265
JBrowse link
G Cacybp calcyclin binding protein increases expression ISO Phenytoin results in increased expression of CACYBP mRNA CTD PMID:20345932 NCBI chr 1:160,202,367...160,212,892
Ensembl chr 1:160,202,367...160,212,875
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha decreases expression ISO Phenytoin results in decreased expression of CALCA protein CTD PMID:2470235 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Phenytoin results in decreased expression of CALM2 mRNA CTD PMID:14741686 NCBI chr17:87,433,401...87,446,935
Ensembl chr12:100,199,435...100,209,814
Ensembl chr17:100,199,435...100,209,814
JBrowse link
G Capn5 calpain 5 decreases expression ISO Phenytoin results in decreased expression of CAPN5 mRNA CTD PMID:14741686 NCBI chr 7:98,121,559...98,178,946
Ensembl chr 7:98,121,559...98,178,274
JBrowse link
G Car6 carbonic anhydrase 6 increases expression ISO Phenytoin results in increased expression of CAR6 mRNA CTD PMID:20345932 NCBI chr 4:150,187,015...150,201,135
Ensembl chr 4:150,187,015...150,201,332
JBrowse link
G Caskin1 CASK interacting protein 1 affects expression ISO Phenytoin affects the expression of CASKIN1 mRNA CTD PMID:20345932 NCBI chr17:24,487,897...24,508,909
Ensembl chr17:24,488,601...24,508,671
JBrowse link
G Cat catalase decreases response to substance ISO CAT protein results in decreased susceptibility to Phenytoin CTD PMID:21252394 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbll1 Casitas B-lineage lymphoma-like 1 increases expression ISO Phenytoin results in increased expression of CBLL1 mRNA CTD PMID:20345932 NCBI chr12:31,484,829...31,500,676
Ensembl chr12:31,484,829...31,499,616
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression ISO Phenytoin results in increased expression of CCL2 protein CTD PMID:14578793 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccnc cyclin C increases expression ISO Phenytoin results in increased expression of CCNC mRNA CTD PMID:20345932 NCBI chr 4:21,727,701...21,759,922
Ensembl chr 4:21,727,701...21,759,922
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA
Phenytoin results in decreased expression of CCND1 mRNA
CTD PMID:14741686 PMID:21224054 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccng1 cyclin G1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr11:40,748,552...40,755,309
Ensembl chr11:40,748,552...40,755,311
JBrowse link
G Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) decreases expression ISO Phenytoin results in decreased expression of CD47 mRNA CTD PMID:17381134 NCBI chr16:49,851,328...49,912,503
Ensembl chr16:49,800,533...49,915,010
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Phenytoin results in decreased expression of CDH2 mRNA CTD PMID:9118846 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP Phenytoin results in decreased expression of CDK1 mRNA CTD PMID:26272751 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) decreases expression
multiple interactions
ISO
EXP
Phenytoin results in decreased expression of CDKN1A mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein
CTD PMID:14741686 PMID:21224054 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdx2 caudal type homeobox 2 increases expression ISO Phenytoin results in increased expression of CDX2 mRNA CTD PMID:20345932 NCBI chr 5:147,300,900...147,307,249
Ensembl chr 5:147,300,805...147,307,270
JBrowse link
G Cela2a chymotrypsin-like elastase family, member 2A decreases expression ISO Phenytoin results in decreased expression of CELA2A mRNA CTD PMID:14741686 NCBI chr 4:141,814,954...141,826,005
Ensembl chr 4:141,814,962...141,826,160
JBrowse link
G Cep57 centrosomal protein 57 increases expression ISO Phenytoin results in increased expression of CEP57 mRNA CTD PMID:20345932 NCBI chr 9:13,807,783...13,827,407
Ensembl chr 9:13,807,792...13,827,107
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist decreases expression EXP Phenytoin results in decreased expression of CER1 mRNA CTD PMID:26272751 NCBI chr 4:82,881,751...82,885,151
Ensembl chr 4:82,881,751...82,885,148
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Ckm creatine kinase, muscle increases expression ISO Phenytoin results in increased expression of CKM protein CTD PMID:6682525 NCBI chr 7:19,411,094...19,421,583
Ensembl chr 7:19,404,776...19,422,841
JBrowse link
G Clcn6 chloride channel, voltage-sensitive 6 decreases expression ISO Phenytoin results in decreased expression of CLCN6 mRNA CTD PMID:20345932 NCBI chr 4:148,004,259...148,038,813
Ensembl chr 4:148,004,259...148,038,821
JBrowse link
G Cmpk1 cytidine monophosphate (UMP-CMP) kinase 1 increases expression ISO Phenytoin results in increased expression of CMPK1 mRNA CTD PMID:20345932 NCBI chr 4:114,960,613...114,987,228
Ensembl chr 4:114,959,336...114,987,241
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 increases expression ISO Phenytoin results in increased expression of CNOT7 mRNA CTD PMID:20345932 NCBI chr 8:40,492,538...40,515,847
Ensembl chr 8:40,492,540...40,515,847
JBrowse link
G Col11a1 collagen, type XI, alpha 1 increases expression ISO Phenytoin results in increased expression of COL11A1 mRNA CTD PMID:14741686 NCBI chr 3:114,030,479...114,220,756
Ensembl chr 3:114,030,540...114,220,718
JBrowse link
G Col18a1 collagen, type XVIII, alpha 1 decreases expression ISO Phenytoin results in decreased expression of COL18A1 mRNA CTD PMID:14741686 NCBI chr10:77,052,178...77,166,530
Ensembl chr10:77,052,178...77,166,548
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression
decreases expression
ISO Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
Phenytoin results in increased expression of COL1A1 mRNA
Phenytoin results in decreased expression of COL1A1 mRNA
CTD PMID:8971655 PMID:14741686 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 increases expression
affects expression
ISO
EXP
Phenytoin results in increased expression of COL1A2 mRNA
Phenytoin affects the expression of COL1A2 mRNA
CTD PMID:14741686 PMID:24704097 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Col6a1 collagen, type VI, alpha 1 decreases expression
increases expression
ISO Phenytoin results in decreased expression of COL6A1 mRNA
Phenytoin results in increased expression of COL6A1 mRNA
CTD PMID:8224229 PMID:14741686 NCBI chr10:76,708,792...76,726,044
Ensembl chr10:76,708,792...76,726,168
JBrowse link
G Col6a2 collagen, type VI, alpha 2 increases expression ISO Phenytoin results in increased expression of COL6A2 mRNA CTD PMID:8224229 NCBI chr10:76,595,756...76,623,630
Ensembl chr10:76,595,762...76,623,630
JBrowse link
G Col6a3 collagen, type VI, alpha 3 increases expression ISO Phenytoin results in increased expression of COL6A3 mRNA CTD PMID:8224229 NCBI chr 1:90,766,860...90,844,001
Ensembl chr 1:90,765,923...90,843,971
JBrowse link
G Cp ceruloplasmin decreases expression ISO Phenytoin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 3:19,956,933...20,009,750
Ensembl chr 3:19,957,054...20,009,145
JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 increases expression ISO Phenytoin results in increased expression of CPSF6 mRNA CTD PMID:20345932 NCBI chr10:117,344,667...117,376,998
Ensembl chr10:117,344,673...117,380,015
JBrowse link
G Crh corticotropin releasing hormone affects expression ISO Phenytoin affects the expression of CRH mRNA CTD PMID:20345932 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Crppa CDP-L-ribitol pyrophosphorylase A increases expression ISO Phenytoin results in increased expression of CRPPA mRNA CTD PMID:20345932 NCBI chr12:36,380,575...36,689,503
Ensembl chr12:36,381,450...36,689,503
JBrowse link
G Ctsb cathepsin B increases expression
decreases activity
ISO Phenytoin results in increased expression of CTSB mRNA
Phenytoin results in decreased activity of CTSB protein
CTD PMID:10914799 PMID:14741686 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Ctsl cathepsin L decreases activity
increases expression
ISO Phenytoin results in decreased activity of CTSL protein
Phenytoin results in increased expression of CTSL mRNA
CTD PMID:10914799 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Cul4a cullin 4A increases expression ISO Phenytoin results in increased expression of CUL4A mRNA CTD PMID:20345932 NCBI chr 8:13,105,623...13,147,940
Ensembl chr 8:13,105,621...13,147,940
JBrowse link
G Cx3cl1 chemokine (C-X3-C motif) ligand 1 increases expression ISO Phenytoin results in increased expression of CX3CL1 mRNA CTD PMID:20345932 NCBI chr 8:94,772,180...94,782,427
Ensembl chr 8:94,772,009...94,782,427
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA CTD PMID:21224054 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 multiple interactions EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA] CTD PMID:23986454 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Phenytoin results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Phenytoin results in increased expression of CYP1A1 mRNA CTD PMID:9860486 PMID:17381134 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA CTD PMID:21224054 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 NCBI chr 7:26,835,339...26,843,264
Ensembl chr 7:26,835,305...26,843,548
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases expression
increases expression
increases activity
multiple interactions
ISO
EXP
Phenytoin results in decreased expression of CYP2B1 mRNA
Phenytoin results in decreased expression of CYP2B10 protein
Phenytoin results in increased expression of CYP2B6 mRNA; Phenytoin results in increased expression of CYP2B6 protein
Phenytoin results in increased activity of CYP2B6 protein
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein; pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]
Phenytoin results in increased expression of CYP2B1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
CTD PMID:9819145 PMID:10945841 PMID:12571232 PMID:12695351 PMID:14977870 PMID:15123723 PMID:17041008 PMID:17954527 PMID:18206661 PMID:18332078 PMID:19226368 PMID:21224054 PMID:21924250 PMID:23850985 PMID:28289823 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Phenytoin results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 multiple interactions
increases expression
EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA
Phenytoin results in increased expression of CYP2B9 protein
CTD PMID:19226368 PMID:19903449 PMID:21224054 NCBI chr 7:26,173,350...26,210,661
Ensembl chr 7:26,173,411...26,210,661
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 affects expression
multiple interactions
increases expression
EXP Phenytoin affects the expression of CYP2C29 mRNA
[Phenytoin results in decreased activity of CYP2C29 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]
Phenytoin results in increased expression of CYP2C protein; Phenytoin results in increased expression of CYP2C29 mRNA; Phenytoin results in increased expression of CYP2C29 protein
CTD PMID:12051692 PMID:15155833 PMID:19136022 PMID:19903449 PMID:21766881 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c37 cytochrome P450, family 2. subfamily c, polypeptide 37 multiple interactions
increases expression
affects expression
EXP NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]
Phenytoin affects the expression of CYP2C37 mRNA
CTD PMID:16936065 PMID:19136022 NCBI chr19:39,992,424...40,012,243
Ensembl chr19:39,992,424...40,012,243
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
increases metabolic processing
affects metabolic processing
increases hydroxylation
decreases metabolic processing
decreases hydroxylation
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CYP2C19 protein results in increased metabolism of Phenytoin
CYP2C19 protein affects the metabolism of Phenytoin
CYP2C19 protein results in increased hydroxylation of Phenytoin
CYP2C19 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C19 gene polymorphism results in decreased hydroxylation of Phenytoin
CTD PMID:9146858 PMID:9333104 PMID:9579299 PMID:9860067 PMID:15569425 PMID:15855726 PMID:16220110 PMID:16789993 PMID:18511451 PMID:23397584 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions
increases metabolic processing
increases expression
increases activity
increases hydroxylation
affects metabolic processing
increases response to substance
decreases hydroxylation
decreases metabolic processing
ISO [Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]
CYP2C9 protein results in increased metabolism of Phenytoin
Phenytoin results in increased activity of CYP2C9 protein
CYP2C9 protein results in increased hydroxylation of Phenytoin
CYP2C9 protein affects the metabolism of Phenytoin; CYP2C9 protein alternative form affects the metabolism of Phenytoin
CYP2C9 gene polymorphism results in increased susceptibility to Phenytoin
CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin
CYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin; CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin
CTD PMID:2025243 PMID:9110362 PMID:9860067 PMID:10208645 PMID:10510154 PMID:10850388 PMID:11234294 PMID:11434505 PMID:11503012 PMID:11668218 PMID:11740344 PMID:14600250 PMID:14659971 PMID:15855726 PMID:16220110 PMID:16873909 PMID:17961958 PMID:19082874 PMID:19202563 PMID:19715737 PMID:20405111 PMID:23397584 PMID:27163851 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions
increases metabolic processing
increases expression
increases activity
increases hydroxylation
affects metabolic processing
increases response to substance
decreases hydroxylation
decreases metabolic processing
ISO [Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]
CYP2C9 protein results in increased metabolism of Phenytoin
Phenytoin results in increased activity of CYP2C9 protein
CYP2C9 protein results in increased hydroxylation of Phenytoin
CYP2C9 protein affects the metabolism of Phenytoin; CYP2C9 protein alternative form affects the metabolism of Phenytoin
CYP2C9 gene polymorphism results in increased susceptibility to Phenytoin
CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin
CYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin; CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin
CTD PMID:2025243 PMID:9110362 PMID:9860067 PMID:10208645 PMID:10510154 PMID:10850388 PMID:11234294 PMID:11434505 PMID:11503012 PMID:11668218 PMID:11740344 PMID:14600250 PMID:14659971 PMID:15855726 PMID:16220110 PMID:16873909 PMID:17961958 PMID:19082874 PMID:19202563 PMID:19715737 PMID:20405111 PMID:23397584 PMID:27163851 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
increases expression
ISO NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]
Phenytoin results in decreased expression of CYP2E1 mRNA
Phenytoin results in increased expression of CYP2E1 mRNA; Phenytoin results in increased expression of CYP2E1 protein
CTD PMID:17381134 PMID:18206661 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
increases expression
EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA]
Phenytoin results in increased expression of CYP3A11 mRNA; Phenytoin results in increased expression of CYP3A11 protein
CTD PMID:17505019 PMID:19226368 PMID:19490052 PMID:19903449 PMID:21224054 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases expression ISO
EXP
Phenytoin results in increased expression of CYP3A5 mRNA
Phenytoin results in increased expression of CYP3A13 mRNA
CTD PMID:12673034 PMID:19903449 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein CTD PMID:21224054 NCBI chr 5:145,773,983...145,805,891
Ensembl chr 5:145,773,983...145,805,874
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA CTD PMID:21224054 NCBI chr 4:115,518,287...115,533,649
Ensembl chr 4:115,518,264...115,533,649
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B decreases expression ISO Phenytoin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 4:115,411,624...115,439,034
Ensembl chr 4:115,411,624...115,439,034
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA CTD PMID:21224054 NCBI chr 4:115,486,200...115,496,158
Ensembl chr 4:115,486,200...115,496,142
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA CTD PMID:21224054 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 increases expression ISO Phenytoin results in increased expression of CYP7B1 mRNA CTD PMID:20345932 NCBI chr 3:18,071,944...18,243,890
Ensembl chr 3:18,071,950...18,243,338
JBrowse link
G Dap3 death associated protein 3 increases expression ISO Phenytoin results in increased expression of DAP3 mRNA CTD PMID:14741686 NCBI chr 3:88,920,803...88,951,213
Ensembl chr 3:88,920,803...88,951,181
JBrowse link
G Dapk2 death-associated protein kinase 2 decreases expression ISO Phenytoin results in decreased expression of DAPK2 mRNA CTD PMID:14741686 NCBI chr 9:66,158,226...66,272,242
Ensembl chr 9:66,158,223...66,272,242
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA CTD PMID:21224054 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dhx9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 increases expression ISO Phenytoin results in increased expression of DHX9 mRNA CTD PMID:20345932 NCBI chr 1:153,455,756...153,487,688
Ensembl chr 1:153,455,758...153,487,660
JBrowse link
G Dmtn dematin actin binding protein decreases expression ISO Phenytoin results in decreased expression of DMTN mRNA CTD PMID:20345932 NCBI chr14:70,602,184...70,636,048
Ensembl chr14:70,601,263...70,636,048
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 4:40,722,468...40,734,965
Ensembl chr 4:40,722,150...40,737,149
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA CTD PMID:21224054 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G Ebpl emopamil binding protein-like increases expression ISO Phenytoin results in increased expression of EBPL mRNA CTD PMID:20345932 NCBI chr14:61,339,763...61,360,445
Ensembl chr14:61,331,742...61,360,439
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA CTD PMID:21224054 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Egr3 early growth response 3 increases expression ISO Phenytoin results in increased expression of EGR3 mRNA CTD PMID:20345932 NCBI chr14:70,077,317...70,082,613
Ensembl chr14:70,077,203...70,082,614
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A increases expression ISO Phenytoin results in increased expression of EIF1A mRNA CTD PMID:20345932 NCBI chr18:46,597,704...46,610,225
Ensembl chr18:46,597,701...46,616,456
JBrowse link
G Emx2 empty spiracles homeobox 2 decreases expression EXP Phenytoin results in decreased expression of EMX2 mRNA CTD PMID:9118846 NCBI chr19:59,458,690...59,465,357
Ensembl chr19:59,458,372...59,465,357
JBrowse link
G Enpep glutamyl aminopeptidase decreases expression
increases expression
ISO Phenytoin results in decreased expression of ENPEP mRNA
Phenytoin results in increased expression of ENPEP mRNA
CTD PMID:17381134 NCBI chr 3:129,269,177...129,332,749
Ensembl chr 3:129,269,175...129,332,720
JBrowse link
G Eomes eomesodermin increases expression ISO Phenytoin results in increased expression of EOMES mRNA CTD PMID:14741686 NCBI chr 9:118,478,186...118,486,132
Ensembl chr 9:118,478,212...118,486,132
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal affects response to substance
increases expression
ISO EPHX1 gene polymorphism affects the susceptibility to Phenytoin
Phenytoin results in increased expression of EPHX1 mRNA
CTD PMID:17381134 PMID:19952982 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic decreases expression ISO Phenytoin results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases expression EXP Phenytoin results in increased expression of ESR1 mRNA; Phenytoin results in increased expression of ESR1 protein CTD PMID:19490052 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Phenytoin results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 1:14,168,953...14,311,035
Ensembl chr 1:14,168,954...14,310,235
JBrowse link
G F10 coagulation factor X decreases expression ISO Phenytoin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr 8:13,037,308...13,056,676
Ensembl chr 8:13,037,308...13,056,676
JBrowse link
G F2 coagulation factor II multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions
decreases expression
EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA
Phenytoin results in decreased expression of FASL mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fbxl3 F-box and leucine-rich repeat protein 3 increases expression ISO Phenytoin results in increased expression of FBXL3 mRNA CTD PMID:20345932 NCBI chr14:103,080,239...103,099,566
Ensembl chr14:103,080,239...103,099,566
JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO Phenytoin results in increased expression of FBXO30 mRNA CTD PMID:20345932 NCBI chr10:11,281,330...11,305,750
Ensembl chr10:11,281,330...11,298,052
JBrowse link
G Fgf12 fibroblast growth factor 12 increases expression ISO Phenytoin results in increased expression of FGF12 mRNA CTD PMID:20345932 NCBI chr16:28,157,783...28,753,243
Ensembl chr16:28,160,098...28,753,068
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO Phenytoin results in increased expression of FGF5 mRNA CTD PMID:14741686 NCBI chr 5:98,254,184...98,277,033
Ensembl chr 5:98,254,184...98,277,030
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Phenytoin results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr19:45,736,491...45,742,941
Ensembl chr19:45,736,798...45,742,915
JBrowse link
G Fgf9 fibroblast growth factor 9 increases expression ISO Phenytoin results in increased expression of FGF9 mRNA CTD PMID:14741686 NCBI chr14:58,070,671...58,112,854
Ensembl chr14:58,070,547...58,112,720
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Phenytoin results in increased expression of FGFR2 mRNA; Phenytoin results in increased expression of FGFR2 protein CTD PMID:11352631 NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Phenytoin results in increased expression of FLRT2 mRNA CTD PMID:14741686 NCBI chr12:95,692,006...95,785,215
Ensembl chr12:95,692,226...95,785,215
JBrowse link
G Fmo1 flavin containing monooxygenase 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA CTD PMID:21224054 NCBI chr 1:162,829,561...162,866,610
Ensembl chr 1:162,829,561...162,866,610
JBrowse link
G Fmo4 flavin containing monooxygenase 4 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA CTD PMID:21224054 NCBI chr 1:162,793,188...162,816,072
Ensembl chr 1:162,793,188...162,813,972
JBrowse link
G Fmod fibromodulin decreases expression ISO Phenytoin results in decreased expression of FMOD mRNA CTD PMID:14741686 NCBI chr 1:134,037,254...134,048,280
Ensembl chr 1:134,037,254...134,048,277
JBrowse link
G Fmr1 FMRP translational regulator 1 increases expression ISO Phenytoin results in increased expression of FMR1 mRNA CTD PMID:20345932 NCBI chr  X:68,678,536...68,717,963
Ensembl chr  X:68,678,541...68,717,963
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Phenytoin results in increased expression of FN1 mRNA CTD PMID:14741686 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Fndc3a fibronectin type III domain containing 3A increases expression ISO Phenytoin results in increased expression of FNDC3A mRNA CTD PMID:20345932 NCBI chr14:72,537,948...72,710,701
Ensembl chr14:72,537,946...72,710,003
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases expression
ISO [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]
Phenytoin results in decreased expression of FOS protein
CTD PMID:7789465 PMID:8758711 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Phenytoin results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr 8:121,116,171...121,118,895
Ensembl chr 8:121,116,171...121,118,895
JBrowse link
G Foxp3 forkhead box P3 multiple interactions
decreases expression
EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
Phenytoin results in decreased expression of FOXP3 mRNA
CTD PMID:23986454 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Frs3 fibroblast growth factor receptor substrate 3 decreases expression ISO Phenytoin results in decreased expression of FRS3 mRNA CTD PMID:14741686 NCBI chr17:47,687,607...47,704,286
Ensembl chr17:47,689,030...47,704,286
JBrowse link
G G6pc glucose-6-phosphatase, catalytic decreases expression ISO Phenytoin results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked affects response to substance EXP G6PDX protein affects the susceptibility to Phenytoin CTD PMID:10627286 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA CTD PMID:21224054 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
decreases expression
EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Phenytoin results in decreased expression of GATA3 mRNA
CTD PMID:23986454 NCBI chr 2:9,857,078...9,887,953
Ensembl chr 2:9,857,078...9,890,034
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Phenytoin results in increased expression of GCLM mRNA CTD PMID:20345932 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) decreases activity EXP Phenytoin results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Gnl2 guanine nucleotide binding protein-like 2 (nucleolar) increases expression ISO Phenytoin results in increased expression of GNL2 mRNA CTD PMID:20345932 NCBI chr 4:125,029,989...125,055,382
Ensembl chr 4:125,016,585...125,055,380
JBrowse link
G Gnpda2 glucosamine-6-phosphate deaminase 2 increases expression ISO Phenytoin results in increased expression of GNPDA2 mRNA CTD PMID:20345932 NCBI chr 5:69,574,998...69,592,332
Ensembl chr 5:69,573,108...69,592,340
JBrowse link
G Gpm6a glycoprotein m6a increases expression ISO Phenytoin results in increased expression of GPM6A mRNA CTD PMID:20345932 NCBI chr 8:54,779,434...55,060,878
Ensembl chr 8:54,954,843...55,060,871
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA CTD PMID:21224054 NCBI chr12:76,792,335...76,795,554
Ensembl chr12:76,792,333...76,795,554
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) increases expression ISO Phenytoin results in increased expression of GRIN1 mRNA CTD PMID:20345932 NCBI chr 2:25,291,177...25,319,187
Ensembl chr 2:25,291,181...25,319,187
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression
decreases expression
ISO Phenytoin results in increased expression of GSTA2 mRNA
Phenytoin results in decreased expression of GSTA2 mRNA
CTD PMID:17381134 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Phenytoin results in decreased expression of GSTK1 mRNA CTD PMID:14741686 NCBI chr 6:42,245,935...42,250,441
Ensembl chr 6:42,245,935...42,250,447
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression
multiple interactions
ISO
EXP
Phenytoin results in increased expression of GSTM1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein
CTD PMID:17381134 PMID:21224054 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression ISO Phenytoin results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA CTD PMID:21224054 NCBI chr 3:107,895,854...107,898,685
Ensembl chr 3:107,895,821...107,898,686
JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases expression ISO Phenytoin results in decreased expression of GSTO1 mRNA CTD PMID:14741686 NCBI chr19:47,854,973...47,864,790
Ensembl chr19:47,854,970...47,864,790
JBrowse link
G Gusb glucuronidase, beta multiple interactions
decreases activity
EXP Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]
Phenytoin results in decreased activity of GUSB protein
CTD PMID:6696821 NCBI chr 5:129,989,011...130,003,049
Ensembl chr 5:129,989,011...130,003,049
JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 affects response to substance ISO HLA-B gene polymorphism affects the susceptibility to Phenytoin CTD PMID:20235791 NCBI chr17:37,480,851...37,483,554
Ensembl chr17:37,480,851...37,483,552
JBrowse link
G Hdac7 histone deacetylase 7 increases expression EXP Phenytoin results in increased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr15:97,792,661...97,844,502
Ensembl chr15:97,792,664...97,844,502
JBrowse link
G Helz helicase with zinc finger domain increases expression ISO Phenytoin results in increased expression of HELZ mRNA CTD PMID:20345932 NCBI chr11:107,546,963...107,693,826
Ensembl chr11:107,547,930...107,693,826
JBrowse link
G Hexim1 hexamethylene bis-acetamide inducible 1 increases expression ISO Phenytoin results in increased expression of HEXIM1 mRNA CTD PMID:20345932 NCBI chr11:103,116,325...103,119,725
Ensembl chr11:103,116,231...103,119,725
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein CTD PMID:23986454 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Phenytoin results in increased expression of HMOX1 mRNA
CTD PMID:17381134 PMID:21224054 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression ISO Phenytoin results in increased expression of HNRNPA2B1 mRNA CTD PMID:20345932 NCBI chr 6:51,460,434...51,470,048
Ensembl chr 6:51,460,932...51,469,894
JBrowse link
G Hook3 hook microtubule tethering protein 3 increases expression ISO Phenytoin results in increased expression of HOOK3 mRNA CTD PMID:20345932 NCBI chr 8:26,021,421...26,119,618
Ensembl chr 8:26,021,421...26,119,224
JBrowse link
G Hoxa2 homeobox A2 decreases expression EXP Phenytoin results in decreased expression of HOXA2 mRNA; Phenytoin results in decreased expression of HOXA2 protein CTD PMID:10789828 NCBI chr 6:52,162,417...52,164,831
Ensembl chr 6:52,162,417...52,164,831
JBrowse link
G Hoxb7 homeobox B7 increases expression ISO Phenytoin results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr11:96,285,604...96,290,163
Ensembl chr11:96,286,623...96,290,162
JBrowse link
G Hoxb9 homeobox B9 increases expression ISO Phenytoin results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr11:96,271,330...96,276,595
Ensembl chr11:96,271,457...96,276,595
JBrowse link
G Hspa1l heat shock protein 1-like multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA CTD PMID:21224054 NCBI chr17:34,972,703...34,979,228
Ensembl chr17:34,972,703...34,979,285
JBrowse link
G Hspa8 heat shock protein 8 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA CTD PMID:21224054 NCBI chr 9:40,801,276...40,805,202
Ensembl chr 9:40,800,984...40,810,087
JBrowse link
G Hspb1 heat shock protein 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA CTD PMID:21224054 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA CTD PMID:21224054 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA CTD PMID:21224054 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Ifng interferon gamma decreases expression EXP Phenytoin results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Phenytoin results in increased expression of IFNGR1 mRNA CTD PMID:14741686 NCBI chr10:19,591,949...19,610,229
Ensembl chr10:19,591,949...19,610,229
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression ISO Phenytoin results in increased expression of IFNGR2 mRNA CTD PMID:14741686 NCBI chr16:91,547,059...91,564,007
Ensembl chr16:91,547,072...91,565,623
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Phenytoin results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP Phenytoin results in increased expression of IGF2 mRNA CTD PMID:9988880 NCBI chr 7:142,650,768...142,666,816
Ensembl chr 7:142,650,766...142,666,816
JBrowse link
G Ihh Indian hedgehog increases expression EXP Phenytoin results in increased expression of IHH mRNA CTD PMID:16141649 NCBI chr 1:74,945,315...74,951,672
Ensembl chr 1:74,945,315...74,951,672
JBrowse link
G Il17a interleukin 17A multiple interactions EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein
CTD PMID:8971655 PMID:21224054 PMID:23986454 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr10:128,296,140...128,298,084
Ensembl chr10:128,296,139...128,298,752
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA
Phenytoin results in increased expression of IL6 mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression EXP Phenytoin results in decreased expression of IL6RA mRNA CTD PMID:15136057 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression ISO Phenytoin results in increased expression of INPP5F mRNA CTD PMID:20345932 NCBI chr 7:128,611,181...128,696,436
Ensembl chr 7:128,611,328...128,696,425
JBrowse link
G Insr insulin receptor increases expression ISO Phenytoin results in increased expression of INSR mRNA CTD PMID:14741686 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Ipp IAP promoted placental gene increases expression ISO Phenytoin results in increased expression of IPP mRNA CTD PMID:20345932 NCBI chr 4:116,507,512...116,543,410
Ensembl chr 4:116,507,549...116,538,243
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Phenytoin results in increased expression of IRF9 mRNA CTD PMID:20345932 NCBI chr14:55,603,985...55,610,030
Ensembl chr14:55,603,571...55,610,030
JBrowse link
G Itga2 integrin alpha 2 decreases expression ISO Phenytoin results in decreased expression of ITGA2 protein CTD PMID:15948689 NCBI chr13:114,833,081...114,932,100
Ensembl chr13:114,833,081...114,932,100
JBrowse link
G Itga8 integrin alpha 8 increases expression ISO Phenytoin results in increased expression of ITGA8 mRNA CTD PMID:14741686 NCBI chr 2:12,106,632...12,301,985
Ensembl chr 2:12,106,632...12,301,922
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression ISO Phenytoin results in decreased expression of ITGB1 protein CTD PMID:15948689 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Itgb3bp integrin beta 3 binding protein (beta3-endonexin) increases expression ISO Phenytoin results in increased expression of ITGB3BP mRNA CTD PMID:20345932 NCBI chr 4:99,767,406...99,829,215
Ensembl chr 4:99,765,402...99,929,813
JBrowse link
G Jun jun proto-oncogene decreases expression EXP Phenytoin results in decreased expression of JUN mRNA CTD PMID:9118846 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 increases expression ISO Phenytoin results in increased expression of KCND2 mRNA CTD PMID:20345932 NCBI chr 6:21,215,346...21,729,805
Ensembl chr 6:21,215,503...21,729,805
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Phenytoin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Kctd3 potassium channel tetramerisation domain containing 3 increases expression ISO Phenytoin results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr 1:188,971,095...189,007,898
Ensembl chr 1:188,971,095...189,007,841
JBrowse link
G Kdr kinase insert domain protein receptor increases expression EXP Phenytoin results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Khdrbs2 KH domain containing, RNA binding, signal transduction associated 2 increases expression ISO Phenytoin results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 1:32,172,602...32,705,224
Ensembl chr 1:32,172,714...32,658,568
JBrowse link
G Klf2 Kruppel-like factor 2 (lung) increases expression ISO Phenytoin results in increased expression of KLF2 mRNA CTD PMID:20345932 NCBI chr 8:72,319,062...72,321,654
Ensembl chr 8:72,319,033...72,321,656
JBrowse link
G Klhl2 kelch-like 2, Mayven increases expression ISO Phenytoin results in increased expression of KLHL2 mRNA CTD PMID:20345932 NCBI chr 8:64,739,673...64,850,169
Ensembl chr 8:64,739,675...64,850,017
JBrowse link
G Klhl7 kelch-like 7 increases expression ISO Phenytoin results in increased expression of KLHL7 mRNA CTD PMID:20345932 NCBI chr 5:24,100,565...24,163,369
Ensembl chr 5:24,100,605...24,160,792
JBrowse link
G Krit1 KRIT1, ankyrin repeat containing increases expression ISO Phenytoin results in increased expression of KRIT1 mRNA CTD PMID:20345932 NCBI chr 5:3,803,156...3,844,515
Ensembl chr 5:3,803,184...3,845,564
JBrowse link
G Krt2 keratin 2 increases expression ISO Phenytoin results in increased expression of KRT2 mRNA CTD PMID:14741686 NCBI chr15:101,810,689...101,818,956
Ensembl chr15:101,810,689...101,818,169
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity ISO Phenytoin results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 2:30,185,124...30,206,295
Ensembl chr 2:30,185,124...30,205,847
JBrowse link
G Lama2 laminin, alpha 2 increases expression ISO Phenytoin results in increased expression of LAMA2 mRNA CTD PMID:20345932 NCBI chr10:26,981,285...27,617,191
Ensembl chr10:26,980,036...27,619,758
JBrowse link
G Lap3 leucine aminopeptidase 3 affects expression ISO Phenytoin affects the expression of LAP3 mRNA CTD PMID:20345932 NCBI chr 5:45,493,374...45,512,691
Ensembl chr 5:45,493,374...45,512,691
JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression EXP Phenytoin results in increased expression of LCAT mRNA CTD PMID:15136057 NCBI chr 8:105,939,551...105,943,402
Ensembl chr 8:105,939,551...105,943,382
JBrowse link
G Ldb2 LIM domain binding 2 increases expression ISO Phenytoin results in increased expression of LDB2 mRNA CTD PMID:20345932 NCBI chr 5:44,435,955...44,799,759
Ensembl chr 5:44,472,132...44,799,680
JBrowse link
G Lpin1 lipin 1 increases expression ISO Phenytoin results in increased expression of LPIN1 mRNA CTD PMID:14741686 NCBI chr12:16,535,669...16,653,903
Ensembl chr12:16,535,669...16,646,966
JBrowse link
G Lrba LPS-responsive beige-like anchor increases expression ISO Phenytoin results in increased expression of LRBA mRNA CTD PMID:20345932 NCBI chr 3:86,223,456...86,782,694
Ensembl chr 3:86,224,680...86,782,692
JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated decreases expression ISO Phenytoin results in decreased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr 8:25,785,318...25,803,975
Ensembl chr 8:25,785,288...25,803,975
JBrowse link
G Ltbp4 latent transforming growth factor beta binding protein 4 increases expression ISO Phenytoin results in increased expression of LTBP4 mRNA CTD PMID:20345932 NCBI chr 7:27,305,140...27,339,720
Ensembl chr 7:27,305,136...27,337,692
JBrowse link
G Lypla1 lysophospholipase 1 increases expression ISO Phenytoin results in increased expression of LYPLA1 mRNA CTD PMID:20345932 NCBI chr 1:4,807,823...4,846,735
Ensembl chr 1:4,807,788...4,848,410
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO Phenytoin results in increased expression of MAP1B mRNA CTD PMID:14741686 NCBI chr13:99,421,464...99,516,602
Ensembl chr13:99,421,446...99,516,540
JBrowse link
G Map3k4 mitogen-activated protein kinase kinase kinase 4 increases expression ISO Phenytoin results in increased expression of MAP3K4 mRNA CTD PMID:20345932 NCBI chr17:12,227,621...12,318,796
Ensembl chr17:12,227,621...12,318,796
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Phenytoin results in decreased phosphorylation of MAPK1 protein CTD PMID:15948689 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO Phenytoin results in decreased phosphorylation of MAPK3 protein CTD PMID:15948689 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapre3 microtubule-associated protein, RP/EB family, member 3 increases expression ISO Phenytoin results in increased expression of MAPRE3 mRNA CTD PMID:20345932 NCBI chr 5:30,814,606...30,866,106
Ensembl chr 5:30,814,641...30,866,106
JBrowse link
G Mbl1 mannose-binding lectin (protein A) 1 decreases expression ISO Phenytoin results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr14:41,151,456...41,163,904
Ensembl chr14:41,151,458...41,159,601
JBrowse link
G Mdk midkine increases expression ISO Phenytoin results in increased expression of MDK mRNA CTD PMID:14741686 NCBI chr 2:91,929,805...91,932,297
Ensembl chr 2:91,929,805...91,932,297
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO Phenytoin results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Phenytoin results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr11:101,877,510...101,894,354
Ensembl chr11:101,877,510...101,894,374
JBrowse link
G Mesp1 mesoderm posterior 1 increases expression EXP Phenytoin results in increased expression of MESP1 mRNA CTD PMID:26272751 NCBI chr 7:79,792,241...79,793,590
Ensembl chr 7:79,792,241...79,793,788
JBrowse link
G Mex3d mex3 RNA binding family member D increases expression ISO Phenytoin results in increased expression of MEX3D mRNA CTD PMID:20345932 NCBI chr10:80,380,355...80,387,651
Ensembl chr10:80,380,355...80,387,659
JBrowse link
G Mgat2 mannoside acetylglucosaminyltransferase 2 increases expression ISO Phenytoin results in increased expression of MGAT2 mRNA CTD PMID:20345932 NCBI chr12:69,184,158...69,186,773
Ensembl chr12:69,184,157...69,186,770
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases methylation ISO Phenytoin results in increased methylation of MGMT promoter CTD PMID:15949900 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein CTD PMID:21224054 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression
decreases expression
ISO Phenytoin results in increased expression of MMP1 mRNA
Phenytoin results in decreased expression of MMP1 mRNA
CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Phenytoin results in decreased expression of MMP2 mRNA CTD PMID:15948689 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Phenytoin results in decreased expression of MMP3 mRNA CTD PMID:15948689 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C increases expression ISO Phenytoin results in increased expression of MRPS18C mRNA CTD PMID:20345932 NCBI chr 5:100,798,759...100,804,467
Ensembl chr 5:100,798,627...100,804,471
JBrowse link
G Mtf2 metal response element binding transcription factor 2 increases expression ISO Phenytoin results in increased expression of MTF2 mRNA CTD PMID:20345932 NCBI chr 5:108,065,660...108,109,219
Ensembl chr 5:108,065,674...108,109,004
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression ISO Phenytoin results in increased expression of MTHFD1L mRNA CTD PMID:20345932 NCBI chr10:3,972,892...4,167,081
Ensembl chr10:3,973,118...4,167,081
JBrowse link
G Mtx2 metaxin 2 increases expression ISO Phenytoin results in increased expression of MTX2 mRNA CTD PMID:20345932 NCBI chr 2:74,825,812...74,876,748
Ensembl chr 2:74,825,803...74,878,431
JBrowse link
G Myc myelocytomatosis oncogene increases expression
decreases expression
ISO
EXP
Phenytoin results in increased expression of MYC protein
Phenytoin results in decreased expression of MYC mRNA
CTD PMID:10695937 PMID:26272751 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Myo1e myosin IE increases expression EXP Phenytoin results in increased expression of MYO1E mRNA CTD PMID:26272751 NCBI chr 9:70,207,350...70,400,067
Ensembl chr 9:70,207,350...70,399,766
JBrowse link
G Nap1l2 nucleosome assembly protein 1-like 2 affects expression ISO Phenytoin affects the expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:103,184,176...103,186,653
Ensembl chr  X:103,184,176...103,186,640
JBrowse link
G Ncan neurocan increases expression ISO Phenytoin results in increased expression of NCAN mRNA CTD PMID:14741686 NCBI chr 8:70,093,085...70,120,863
Ensembl chr 8:70,093,085...70,120,873
JBrowse link
G Ncl nucleolin decreases expression ISO Phenytoin results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 1:86,344,719...86,359,455
Ensembl chr 1:86,344,719...86,359,400
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] CTD PMID:21924250 NCBI chr12:4,247,362...4,477,206
Ensembl chr12:4,247,362...4,477,182
JBrowse link
G Nelfa negative elongation factor complex member A, Whsc2 decreases expression ISO Phenytoin results in decreased expression of NELFA mRNA CTD PMID:20345932 NCBI chr 5:33,897,916...33,936,301
Ensembl chr 5:33,897,916...33,936,413
JBrowse link
G Nes nestin decreases expression EXP Phenytoin results in decreased expression of NES mRNA CTD PMID:26272751 NCBI chr 3:87,971,093...87,980,451
Ensembl chr 3:87,971,078...87,980,451
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Phenytoin results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 3:127,632,733...127,635,636
Ensembl chr 3:127,633,135...127,635,631
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
increases expression
ISO Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein]
Phenytoin results in increased expression of NFKB1 mRNA
CTD PMID:10700573 PMID:14741686 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases degradation ISO Phenytoin results in decreased degradation of NFKBIA protein CTD PMID:15948689 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Ngly1 N-glycanase 1 increases expression ISO Phenytoin results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr14:16,249,314...16,311,926
Ensembl chr14:16,249,280...16,311,926
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA CTD PMID:23986454 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA CTD PMID:21224054 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression ISO Phenytoin results in increased expression of NPAS2 mRNA CTD PMID:20345932 NCBI chr 1:39,193,702...39,363,240
Ensembl chr 1:39,193,731...39,363,236
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO Phenytoin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity
increases expression
increases activity
ISO Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin binds to and results in increased activity of NR1I2 protein; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin affects the activity of NR1I2 protein
Phenytoin results in increased expression of NR1I2 protein
Phenytoin results in increased activity of NR1I2 protein
CTD PMID:12065438 PMID:12695340 PMID:12695351 PMID:14600250 PMID:14977870 PMID:15039302 PMID:18473823 PMID:21402137 PMID:23611293 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
increases activity
increases localization
ISO
EXP
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Phenytoin results in increased expression of NR1I3 protein
NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]
Phenytoin results in increased localization of NR1I3 protein
CTD PMID:15123723 PMID:15155833 PMID:15849716 PMID:16936065 PMID:17041008 PMID:18473823 PMID:21924250 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 increases expression ISO Phenytoin results in increased expression of NR2F1 mRNA CTD PMID:20345932 NCBI chr13:78,188,971...78,198,873
Ensembl chr13:78,188,973...78,199,757
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases expression
ISO Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased expression of NR3C1 mRNA
CTD PMID:10219967 PMID:12695351 PMID:20345932 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Nrcam neuronal cell adhesion molecule decreases expression EXP Phenytoin results in decreased expression of NRCAM mRNA CTD PMID:26272751 NCBI chr12:44,328,786...44,605,194
Ensembl chr12:44,328,885...44,601,964
JBrowse link
G Nsmce3 NSE3 homolog, SMC5-SMC6 complex component increases expression ISO Phenytoin results in increased expression of NSMCE3 mRNA CTD PMID:20345932 NCBI chr 7:64,871,682...64,873,040
Ensembl chr 7:64,867,052...64,872,997
JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression ISO Phenytoin results in increased expression of NT5DC1 mRNA CTD PMID:20345932 NCBI chr10:34,303,609...34,418,589
Ensembl chr10:34,288,288...34,418,552
JBrowse link
G Ntf3 neurotrophin 3 decreases expression EXP Phenytoin results in decreased expression of NTF3 mRNA CTD PMID:7841657 NCBI chr 6:126,101,412...126,166,772
Ensembl chr 6:126,101,412...126,166,910
JBrowse link
G Nup153 nucleoporin 153 increases expression ISO Phenytoin results in increased expression of NUP153 mRNA CTD PMID:20345932 NCBI chr13:46,679,902...46,727,849
Ensembl chr13:46,679,905...46,727,940
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Phenytoin results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr10:19,356,539...19,358,604
Ensembl chr10:19,356,533...19,358,604
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin CTD PMID:7870991 NCBI chr10:6,758,593...7,038,209
Ensembl chr10:6,758,506...7,038,198
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 decreases expression EXP Phenytoin results in decreased expression of PAFAH1B1 mRNA CTD PMID:15136057 NCBI chr11:74,673,949...74,724,384
Ensembl chr11:74,673,949...74,724,670
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 decreases expression EXP Phenytoin results in decreased expression of PAFAH1B2 mRNA CTD PMID:15136057 NCBI chr 9:45,965,311...46,012,690
Ensembl chr 9:45,962,859...46,012,690
JBrowse link
G Pard6g par-6 family cell polarity regulator gamma increases expression ISO Phenytoin results in increased expression of PARD6G mRNA CTD PMID:20345932 NCBI chr18:80,046,830...80,119,640
Ensembl chr18:80,046,890...80,119,639
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase increases expression ISO Phenytoin results in increased expression of PARG mRNA CTD PMID:20345932 NCBI chr14:32,201,930...32,298,714
Ensembl chr14:32,201,949...32,297,550
JBrowse link
G Pax3 paired box 3 decreases expression EXP
ISO
Phenytoin results in decreased expression of PAX3 mRNA CTD PMID:9118846 PMID:31711903 NCBI chr 1:78,101,267...78,197,136
Ensembl chr 1:78,101,267...78,197,134
JBrowse link
G Pax6 paired box 6 increases expression ISO Phenytoin results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 2:105,668,896...105,698,410
Ensembl chr 2:105,668,900...105,697,364
JBrowse link
G Pbx1 pre B cell leukemia homeobox 1 increases expression ISO Phenytoin results in increased expression of PBX1 mRNA CTD PMID:20345932 NCBI chr 1:168,119,364...168,432,365
Ensembl chr 1:168,119,364...168,432,270
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 increases expression ISO Phenytoin results in increased expression of PCYOX1 mRNA CTD PMID:20345932 NCBI chr 6:86,386,006...86,397,150
Ensembl chr 6:86,386,006...86,397,154
JBrowse link
G Pdgfa platelet derived growth factor, alpha increases expression ISO Phenytoin results in increased expression of PDGFA mRNA CTD PMID:14741686 NCBI chr 5:138,976,014...139,000,792
Ensembl chr 5:138,976,014...138,997,370
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide increases expression ISO Phenytoin results in increased expression of PDGFB mRNA; Phenytoin results in increased expression of PDGFB protein CTD PMID:8463938 PMID:9029455 PMID:14741686 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression ISO Phenytoin results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:36,598,193...36,606,079
Ensembl chr  X:36,598,206...36,606,079
JBrowse link
G Phf14 PHD finger protein 14 increases expression ISO Phenytoin results in increased expression of PHF14 mRNA CTD PMID:20345932 NCBI chr 6:11,907,725...12,100,156
Ensembl chr 6:11,907,809...12,081,205
JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha increases expression ISO Phenytoin results in increased expression of PIP4K2A mRNA CTD PMID:14741686 NCBI chr 2:18,842,255...18,998,291
Ensembl chr 2:18,842,255...18,998,126
JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO Phenytoin results in decreased expression of PLAUR mRNA CTD PMID:14741686 NCBI chr 7:24,460,937...24,475,970
Ensembl chr 7:24,462,484...24,475,968
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Phenytoin results in increased expression of PLCL1 mRNA CTD PMID:20345932 NCBI chr 1:55,405,946...55,754,285
Ensembl chr 1:55,405,921...55,754,285
JBrowse link
G Plec plectin increases expression ISO Phenytoin results in increased expression of PLEC mRNA CTD PMID:20345932 NCBI chr15:76,170,974...76,231,378
Ensembl chr15:76,170,974...76,232,574
JBrowse link
G Pltp phospholipid transfer protein increases expression EXP Phenytoin results in increased expression of PLTP mRNA CTD PMID:15136057 NCBI chr 2:164,839,518...164,857,708
Ensembl chr 2:164,839,518...164,857,711
JBrowse link
G Plxnb2 plexin B2 decreases expression ISO Phenytoin results in decreased expression of PLXNB2 mRNA CTD PMID:14741686 NCBI chr15:89,155,546...89,182,018
Ensembl chr15:89,155,549...89,180,788
JBrowse link
G Pnn pinin increases expression ISO Phenytoin results in increased expression of PNN mRNA CTD PMID:20345932 NCBI chr12:59,066,919...59,074,017
Ensembl chr12:59,066,884...59,073,998
JBrowse link
G Pon1 paraoxonase 1 decreases expression
affects activity
EXP
ISO
Phenytoin results in decreased expression of PON1 mRNA
Phenytoin affects the activity of PON1 protein
CTD PMID:15136057 PMID:28032682 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity EXP Phenytoin results in increased activity of POR protein CTD PMID:12051692 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Pou3f1 POU domain, class 3, transcription factor 1 increases expression EXP Phenytoin results in increased expression of POU3F1 protein CTD PMID:12781989 NCBI chr 4:124,657,646...124,660,655
Ensembl chr 4:124,656,807...124,660,655
JBrowse link
G Ppil4 peptidylprolyl isomerase (cyclophilin)-like 4 increases expression ISO Phenytoin results in increased expression of PPIL4 mRNA CTD PMID:20345932 NCBI chr10:7,792,889...7,822,565
Ensembl chr10:7,792,891...7,823,135
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline] CTD PMID:21224054 NCBI chr16:15,637,444...15,842,239
Ensembl chr16:15,637,866...15,842,235
JBrowse link
G Prl prolactin decreases expression ISO Phenytoin results in decreased expression of PRL mRNA; Phenytoin results in decreased expression of PRL protein CTD PMID:3734668 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205
JBrowse link
G Prmt3 protein arginine N-methyltransferase 3 increases expression ISO Phenytoin results in increased expression of PRMT3 mRNA CTD PMID:20345932 NCBI chr 7:49,778,319...49,861,264
Ensembl chr 7:49,778,346...49,858,265
JBrowse link
G Prss12 protease, serine 12 neurotrypsin (motopsin) increases expression ISO Phenytoin results in increased expression of PRSS12 mRNA CTD PMID:14741686 NCBI chr 3:123,446,913...123,506,602
Ensembl chr 3:123,446,913...123,506,597
JBrowse link
G Psip1 PC4 and SFRS1 interacting protein 1 increases expression ISO Phenytoin results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 4:83,455,680...83,486,463
Ensembl chr 4:83,455,680...83,486,459
JBrowse link
G Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 increases expression ISO Phenytoin results in increased expression of PSMC6 mRNA CTD PMID:20345932 NCBI chr14:45,329,823...45,349,074
Ensembl chr14:45,329,788...45,349,705
JBrowse link
G Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 increases expression ISO Phenytoin results in increased expression of PSMD12 mRNA CTD PMID:20345932 NCBI chr11:107,479,528...107,498,036
Ensembl chr11:107,479,484...107,504,362
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 increases expression ISO Phenytoin results in increased expression of PTBP2 mRNA CTD PMID:20345932 NCBI chr 3:119,718,741...119,784,647
Ensembl chr 3:119,718,742...119,784,466
JBrowse link
G Ptch1 patched 1 increases expression EXP Phenytoin results in increased expression of PTCH1 mRNA CTD PMID:16141649 NCBI chr13:63,508,328...63,573,460
Ensembl chr13:63,508,328...63,573,598
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Phenytoin results in increased expression of PTGS2 mRNA CTD PMID:20345932 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pth parathyroid hormone increases expression ISO Phenytoin results in increased expression of PTH protein CTD PMID:20683115 NCBI chr 7:113,385,576...113,388,672
Ensembl chr 7:113,385,580...113,388,570
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA CTD PMID:21224054 NCBI chr11:53,649,519...53,707,319
Ensembl chr11:53,649,519...53,707,319
JBrowse link
G Rai1 retinoic acid induced 1 increases expression ISO Phenytoin results in increased expression of RAI1 mRNA CTD PMID:20345932 NCBI chr11:60,104,917...60,199,197
Ensembl chr11:60,105,013...60,199,197
JBrowse link
G Ranbp6 RAN binding protein 6 increases expression ISO Phenytoin results in increased expression of RANBP6 mRNA CTD PMID:20345932 NCBI chr19:29,808,108...29,812,974
Ensembl chr19:29,808,400...29,812,974
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 increases expression ISO Phenytoin results in increased expression of RAPGEF4 mRNA CTD PMID:20345932 NCBI chr 2:71,981,215...72,257,474
Ensembl chr 2:71,981,240...72,257,474
JBrowse link
G Rara retinoic acid receptor, alpha increases expression
decreases expression
EXP Phenytoin results in increased expression of RARA mRNA
Phenytoin results in decreased expression of RARA mRNA
CTD PMID:9118846 PMID:9988880 NCBI chr11:98,927,800...98,974,942
Ensembl chr11:98,927,818...98,974,942
JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP Phenytoin results in increased expression of RARB mRNA CTD PMID:9988880 NCBI chr14:16,430,839...17,082,331
Ensembl chr14:16,430,839...16,819,156
JBrowse link
G Rarg retinoic acid receptor, gamma increases expression EXP Phenytoin results in increased expression of RARG mRNA CTD PMID:9988880 NCBI chr15:102,234,938...102,257,522
Ensembl chr15:102,234,938...102,257,517
JBrowse link
G Rbm12 RNA binding motif protein 12 increases expression ISO Phenytoin results in increased expression of RBM12 mRNA CTD PMID:20345932 NCBI chr 2:156,094,882...156,111,965
Ensembl chr 2:156,091,958...156,111,978
JBrowse link
G Rbm3 RNA binding motif (RNP1, RRM) protein 3 increases expression ISO Phenytoin results in increased expression of RBM3 mRNA CTD PMID:20345932 NCBI chr  X:8,138,975...8,145,880
Ensembl chr  X:8,138,975...8,145,880
JBrowse link
G Rbm34 RNA binding motif protein 34 increases expression ISO Phenytoin results in increased expression of RBM34 mRNA CTD PMID:20345932 NCBI chr 8:126,947,172...126,971,127
Ensembl chr 8:126,947,172...126,971,071
JBrowse link
G Rbp2 retinol binding protein 2, cellular increases expression EXP Phenytoin results in increased expression of RBP2 mRNA CTD PMID:9118846 NCBI chr 9:98,490,537...98,509,771
Ensembl chr 9:98,486,115...98,509,781
JBrowse link
G Rdh14 retinol dehydrogenase 14 (all-trans and 9-cis) increases expression ISO Phenytoin results in increased expression of RDH14 mRNA CTD PMID:20345932 NCBI chr12:10,390,748...10,395,562
Ensembl chr12:10,390,772...10,395,562
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases activity
ISO
EXP
Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
Phenytoin results in increased activity of RELA protein
CTD PMID:10700573 PMID:15322231 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rhoa ras homolog family member A decreases expression EXP Phenytoin results in decreased expression of RHOA mRNA CTD PMID:15136057 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G Riok2 RIO kinase 2 increases expression ISO Phenytoin results in increased expression of RIOK2 mRNA CTD PMID:20345932 NCBI chr17:17,374,332...17,394,899
Ensembl chr17:17,374,309...17,394,899
JBrowse link
G Rnaseh1 ribonuclease H1 decreases expression ISO Phenytoin results in decreased expression of RNASEH1 mRNA CTD PMID:20345932 NCBI chr12:28,649,601...28,659,592
Ensembl chr12:28,649,602...28,659,589
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression ISO Phenytoin results in increased expression of RND1 mRNA CTD PMID:20345932 NCBI chr15:98,669,205...98,677,461
Ensembl chr15:98,663,421...98,677,461
JBrowse link
G Rnf115 ring finger protein 115 increases expression ISO Phenytoin results in increased expression of RNF115 mRNA CTD PMID:20345932 NCBI chr 3:96,727,597...96,791,155
Ensembl chr 3:96,727,664...96,791,638
JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase increases expression ISO Phenytoin results in increased expression of RPE mRNA CTD PMID:20345932 NCBI chr 1:66,700,797...66,719,805
Ensembl chr 1:66,700,831...66,719,805
JBrowse link
G Rpl28 ribosomal protein L28 increases expression ISO Phenytoin results in increased expression of RPL28 mRNA CTD PMID:14741686 NCBI chr 7:4,792,965...4,794,547
Ensembl chr 7:4,792,874...4,795,066
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase polypeptide 3 increases expression ISO Phenytoin results in increased expression of RPS6KA3 mRNA CTD PMID:20345932 NCBI chr  X:159,255,665...159,368,244
Ensembl chr  X:159,210,307...159,368,244
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Phenytoin results in increased expression of RPSA mRNA CTD PMID:14741686 NCBI chr 9:120,127,766...120,132,369
Ensembl chr 9:120,127,689...120,132,369
JBrowse link
G Rsrc1 arginine/serine-rich coiled-coil 1 decreases expression ISO Phenytoin results in decreased expression of RSRC1 mRNA CTD PMID:20345932 NCBI chr 3:66,981,364...67,358,403
Ensembl chr 3:66,981,390...67,358,396
JBrowse link
G Ryr2 ryanodine receptor 2, cardiac increases expression ISO Phenytoin results in increased expression of RYR2 mRNA CTD PMID:20345932 NCBI chr13:11,553,099...12,106,945
Ensembl chr13:11,553,102...12,106,945
JBrowse link
G S100a10 S100 calcium binding protein A10 (calpactin) increases expression ISO Phenytoin results in increased expression of S100A10 mRNA CTD PMID:14741686 NCBI chr 3:93,555,117...93,564,645
Ensembl chr 3:93,555,080...93,564,643
JBrowse link
G S100a4 S100 calcium binding protein A4 increases expression ISO Phenytoin results in increased expression of S100A4 mRNA CTD PMID:14741686 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA CTD PMID:23986454 NCBI chr 3:90,669,071...90,670,034
Ensembl chr 3:90,668,978...90,670,035
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) multiple interactions
increases expression
EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA
Phenytoin results in increased expression of S100A9 mRNA
CTD PMID:23986454 NCBI chr 3:90,692,630...90,695,721
Ensembl chr 3:90,692,632...90,695,721
JBrowse link
G Sart3 squamous cell carcinoma antigen recognized by T cells 3 increases expression ISO Phenytoin results in increased expression of SART3 mRNA CTD PMID:20345932 NCBI chr 5:113,742,444...113,772,400
Ensembl chr 5:113,742,446...113,772,510
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Phenytoin results in increased expression of SC5D mRNA CTD PMID:14741686 NCBI chr 9:42,251,592...42,264,300
Ensembl chr 9:42,251,595...42,264,256
JBrowse link
G Scaf1 SR-related CTD-associated factor 1 increases expression ISO Phenytoin results in increased expression of SCAF1 mRNA CTD PMID:20345932 NCBI chr 7:45,002,946...45,016,404
Ensembl chr 7:45,002,948...45,016,363
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP Phenytoin results in decreased expression of SCARB1 mRNA CTD PMID:15136057 NCBI chr 5:125,277,087...125,341,094
Ensembl chr 5:125,277,087...125,341,094
JBrowse link
G Scn1a sodium channel, voltage-gated, type I, alpha affects response to substance ISO SCN1A gene polymorphism affects the susceptibility to Phenytoin; SCN1A protein affects the susceptibility to Phenytoin CTD PMID:15805193 PMID:17001291 NCBI chr 2:66,270,781...66,440,837
Ensembl chr 2:66,270,778...66,440,840
JBrowse link
G Scn1b sodium channel, voltage-gated, type I, beta affects binding
decreases response to substance
multiple interactions
ISO Phenytoin binds to [SCN1B protein binds to SCN3A protein]
SCN1B protein mutant form results in decreased susceptibility to Phenytoin
Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr 7:31,116,524...31,127,023
Ensembl chr 7:31,116,524...31,127,003
JBrowse link
G Scn2a sodium channel, voltage-gated, type II, alpha decreases activity ISO Phenytoin results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 2:65,620,764...65,767,447
Ensembl chr 2:65,620,771...65,767,447
JBrowse link
G Scn3a sodium channel, voltage-gated, type III, alpha multiple interactions
affects binding
ISO Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
Phenytoin binds to [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr 2:65,457,118...65,567,591
Ensembl chr 2:65,457,118...65,567,627
JBrowse link
G Sdc4 syndecan 4 decreases expression EXP Phenytoin results in decreased expression of SDC4 mRNA CTD PMID:15136057 NCBI chr 2:164,424,247...164,443,188
Ensembl chr 2:164,424,247...164,443,887
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Senp7 SUMO1/sentrin specific peptidase 7 increases expression ISO Phenytoin results in increased expression of SENP7 mRNA CTD PMID:20345932 NCBI chr16:56,057,526...56,190,031
Ensembl chr16:56,048,338...56,190,012
JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 1:160,978,583...161,002,543
Ensembl chr 1:160,978,585...161,005,863
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA CTD PMID:21224054 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sh3yl1 Sh3 domain YSC-like 1 increases expression ISO Phenytoin results in increased expression of SH3YL1 mRNA CTD PMID:20345932 NCBI chr12:30,911,669...30,960,160
Ensembl chr12:30,911,668...30,960,162
JBrowse link
G Shh sonic hedgehog increases expression EXP Phenytoin results in increased expression of SHH mRNA CTD PMID:26272751 NCBI chr 5:28,456,840...28,467,101
Ensembl chr 5:28,456,815...28,467,256
JBrowse link
G Siah1a siah E3 ubiquitin protein ligase 1A increases expression ISO Phenytoin results in increased expression of SIAH1A mRNA CTD PMID:20345932 NCBI chr 8:86,720,454...86,746,006
Ensembl chr 8:86,724,007...86,745,934
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 increases expression ISO Phenytoin results in increased expression of SIPA1L1 mRNA CTD PMID:20345932 NCBI chr12:82,169,377...82,451,786
Ensembl chr12:82,169,320...82,451,786
JBrowse link
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 decreases expression ISO Phenytoin results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr17:46,432,185...46,438,477
Ensembl chr17:46,432,183...46,438,457
JBrowse link
G Slc4a3 solute carrier family 4 (anion exchanger), member 3 increases expression ISO Phenytoin results in increased expression of SLC4A3 mRNA CTD PMID:20345932 NCBI chr 1:75,546,044...75,559,431
Ensembl chr 1:75,546,266...75,562,172
JBrowse link
G Smarca1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 increases expression ISO Phenytoin results in increased expression of SMARCA1 mRNA CTD PMID:20345932 NCBI chr  X:47,809,370...47,892,613
Ensembl chr  X:47,809,368...47,892,974
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 increases expression ISO Phenytoin results in increased expression of SMARCA5 mRNA CTD PMID:20345932 NCBI chr 8:80,699,943...80,739,459
Ensembl chr 8:80,698,507...80,739,497
JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression ISO Phenytoin results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 4:52,439,221...52,488,365
Ensembl chr 4:52,439,243...52,488,260
JBrowse link
G Smc3 structural maintenance of chromosomes 3 increases expression ISO Phenytoin results in increased expression of SMC3 mRNA CTD PMID:14741686 NCBI chr19:53,600,396...53,645,831
Ensembl chr19:53,600,398...53,645,833
JBrowse link
G Smc5 structural maintenance of chromosomes 5 increases expression ISO Phenytoin results in increased expression of SMC5 mRNA CTD PMID:20345932 NCBI chr19:23,206,441...23,273,922
Ensembl chr19:23,206,451...23,273,897
JBrowse link
G Snx2 sorting nexin 2 increases expression ISO Phenytoin results in increased expression of SNX2 mRNA CTD PMID:20345932 NCBI chr18:53,176,292...53,220,866
Ensembl chr18:53,176,316...53,220,865
JBrowse link
G Sp3 trans-acting transcription factor 3 increases expression ISO Phenytoin results in increased expression of SP3 mRNA CTD PMID:14741686 NCBI chr 2:72,936,430...72,980,446
Ensembl chr 2:72,936,427...72,980,446
JBrowse link
G St13 suppression of tumorigenicity 13 increases expression ISO Phenytoin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr15:81,365,044...81,399,694
Ensembl chr15:81,363,669...81,400,077
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Phenytoin results in decreased expression of STAT4 mRNA CTD PMID:14741686 NCBI chr 1:51,987,106...52,107,189
Ensembl chr 1:51,987,148...52,107,189
JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 decreases expression ISO Phenytoin results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 PMID:17381134 NCBI chr 7:126,672,865...126,690,443
Ensembl chr 7:126,672,865...126,676,432
JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 decreases expression ISO Phenytoin results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr 7:13,796,246...13,837,410
Ensembl chr 7:13,796,246...13,837,409
JBrowse link
G Syn1 synapsin I decreases expression
multiple interactions
EXP Phenytoin results in decreased expression of SYN1 mRNA
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA]
CTD PMID:27413119 NCBI chr  X:20,860,511...20,920,918
Ensembl chr  X:20,860,511...20,921,004
JBrowse link
G Syp synaptophysin decreases expression
multiple interactions
EXP Phenytoin results in decreased expression of SYP mRNA
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA]
CTD PMID:27413119 NCBI chr  X:7,638,580...7,653,256
Ensembl chr  X:7,638,471...7,653,256
JBrowse link
G Sypl synaptophysin-like protein increases expression ISO Phenytoin results in increased expression of SYPL mRNA CTD PMID:20345932 NCBI chr12:32,953,855...32,979,502
Ensembl chr12:32,953,891...32,979,860
JBrowse link
G Taf9b TATA-box binding protein associated factor 9B increases expression ISO Phenytoin results in increased expression of TAF9B mRNA CTD PMID:20345932 NCBI chr  X:106,206,874...106,221,158
Ensembl chr  X:106,206,883...106,221,158
JBrowse link
G Tbx21 T-box 21 multiple interactions
decreases expression
EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA
Phenytoin results in decreased expression of TBX21 mRNA
CTD PMID:23986454 NCBI chr11:97,098,007...97,115,331
Ensembl chr11:97,098,071...97,115,331
JBrowse link
G Tceal1 transcription elongation factor A (SII)-like 1 increases expression ISO Phenytoin results in increased expression of TCEAL1 mRNA CTD PMID:20345932 NCBI chr  X:136,707,982...136,709,873
Ensembl chr  X:136,707,982...136,711,478
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Phenytoin results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 2:152,143,056...152,149,097
Ensembl chr 2:152,143,561...152,149,097
JBrowse link
G Terf1 telomeric repeat binding factor 1 increases expression ISO Phenytoin results in increased expression of TERF1 mRNA CTD PMID:20345932 NCBI chr 1:15,805,546...15,844,052
Ensembl chr 1:15,805,646...15,844,052
JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP Phenytoin results in increased expression of TGFA mRNA CTD PMID:9988880 NCBI chr 6:86,195,038...86,275,744
Ensembl chr 6:86,195,223...86,275,719
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
decreases expression
EXP Phenytoin results in increased expression of TGFB1 mRNA
Phenytoin results in decreased expression of TGFB1 mRNA
CTD PMID:7841657 PMID:9988880 PMID:16141649 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP Phenytoin results in decreased expression of TGFB2 mRNA CTD PMID:9118846 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO Phenytoin results in increased expression of TGFB3 mRNA CTD PMID:14741686 NCBI chr12:86,056,743...86,079,041
Ensembl chr12:86,056,745...86,079,041
JBrowse link
G Thoc6 THO complex 6 decreases expression ISO Phenytoin results in decreased expression of THOC6 mRNA CTD PMID:20345932 NCBI chr17:23,668,618...23,673,917
Ensembl chr17:23,668,614...23,673,882
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Phenytoin results in increased expression of TIMP1 mRNA; Phenytoin results in increased expression of TIMP1 protein CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tkt transketolase increases expression ISO Phenytoin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr14:30,549,131...30,574,724
Ensembl chr14:30,548,359...30,574,720
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
increases expression
EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA
Phenytoin results in increased expression of TLR2 mRNA
CTD PMID:23986454 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
decreases expression
EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
Phenytoin results in decreased expression of TLR4 mRNA
CTD PMID:23986454 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions
decreases expression
EXP [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA
Phenytoin results in decreased expression of TLR9 mRNA
CTD PMID:23986454 NCBI chr 9:106,222,598...106,226,876
Ensembl chr 9:106,222,598...106,226,883
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phenytoin results in increased expression of TNF mRNA CTD PMID:14741686 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA CTD PMID:21224054 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA CTD PMID:21224054 NCBI chr 8:105,258,575...105,264,594
Ensembl chr 8:105,258,286...105,264,609
JBrowse link
G Trmt10b tRNA methyltransferase 10B increases expression ISO Phenytoin results in increased expression of TRMT10B mRNA CTD PMID:20345932 NCBI chr 4:45,297,068...45,316,134
Ensembl chr 4:45,297,127...45,316,131
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Phenytoin results in increased expression of TP53 mRNA CTD PMID:11134551 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trp53bp2 transformation related protein 53 binding protein 2 increases expression ISO Phenytoin results in increased expression of TRP53BP2 mRNA CTD PMID:20345932 NCBI chr 1:182,409,167...182,462,436
Ensembl chr 1:182,409,172...182,462,432
JBrowse link
G Tut4 terminal uridylyl transferase 4 increases expression ISO Phenytoin results in increased expression of TUT4 mRNA CTD PMID:20345932 NCBI chr 4:108,459,410...108,559,415
Ensembl chr 4:108,459,426...108,559,421
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Phenytoin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Ube2d2a ubiquitin-conjugating enzyme E2D 2A increases expression ISO Phenytoin results in increased expression of UBE2D2 mRNA CTD PMID:20345932 NCBI chr18:35,771,559...35,807,172
Ensembl chr18:35,771,558...35,809,494
JBrowse link
G Ubl5 ubiquitin-like 5 decreases expression ISO Phenytoin results in decreased expression of UBL5 mRNA CTD PMID:20345932 NCBI chr 9:20,642,717...20,647,140
Ensembl chr 9:20,642,878...20,647,140
JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 increases expression ISO Phenytoin results in increased expression of UBR1 mRNA CTD PMID:20345932 NCBI chr 2:120,860,272...120,970,760
Ensembl chr 2:120,860,269...120,970,715
JBrowse link
G Ugdh UDP-glucose dehydrogenase decreases expression ISO Phenytoin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 affects expression
multiple interactions
increases activity
increases expression
ISO
EXP
Phenytoin affects the expression of UGT1A1 mRNA
Phenytoin results in increased expression of and results in increased activity of UGT1A1 protein
Phenytoin results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of UGT1A1 mRNA
Phenytoin results in increased expression of UGT1A1 mRNA; Phenytoin results in increased expression of UGT1A1 protein
CTD PMID:10421657 PMID:15849716 PMID:17381134 PMID:27413119 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO Phenytoin results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression ISO Phenytoin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr 5:86,916,639...86,926,503
Ensembl chr 5:86,916,638...86,926,530
JBrowse link
G Uncx UNC homeobox decreases expression ISO Phenytoin results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 5:139,543,865...139,548,179
Ensembl chr 5:139,543,494...139,548,179
JBrowse link
G Ung uracil DNA glycosylase multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA CTD PMID:21224054 NCBI chr 5:114,130,366...114,139,321
Ensembl chr 5:114,130,386...114,139,323
JBrowse link
G Vars2 valyl-tRNA synthetase 2, mitochondrial increases expression ISO Phenytoin results in increased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr17:35,655,634...35,667,639
Ensembl chr17:35,655,634...35,667,592
JBrowse link
G Vcan versican increases expression ISO Phenytoin results in increased expression of VCAN mRNA CTD PMID:14741686 NCBI chr13:89,655,309...89,743,027
Ensembl chr13:89,655,312...89,742,509
JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO Phenytoin results in decreased expression of VEGFB mRNA CTD PMID:14741686 NCBI chr19:6,982,472...6,987,651
Ensembl chr19:6,982,473...6,987,651
JBrowse link
G Vim vimentin increases expression ISO Phenytoin results in increased expression of VIM mRNA CTD PMID:14741686 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Wnt1 wingless-type MMTV integration site family, member 1 decreases expression EXP Phenytoin results in decreased expression of WNT1 mRNA CTD PMID:7841657 NCBI chr15:98,789,857...98,793,830
Ensembl chr15:98,789,857...98,793,837
JBrowse link
G Wnt3 wingless-type MMTV integration site family, member 3 decreases expression EXP Phenytoin results in decreased expression of WNT3 mRNA CTD PMID:26272751 NCBI chr11:103,774,175...103,818,021
Ensembl chr11:103,774,150...103,817,957
JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A increases expression ISO Phenytoin results in increased expression of WNT5A mRNA CTD PMID:31711903 NCBI chr14:28,504,543...28,527,448
Ensembl chr14:28,504,750...28,527,448
JBrowse link
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 multiple interactions EXP [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 NCBI chr13:89,848,914...90,089,608
Ensembl chr13:89,774,027...90,089,608
JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase decreases expression EXP Phenytoin results in decreased expression of ZAP70 mRNA CTD PMID:15136057 NCBI chr 1:36,761,798...36,782,821
Ensembl chr 1:36,761,798...36,782,818
JBrowse link
G Zfp131 zinc finger protein 131 increases expression ISO Phenytoin results in increased expression of ZFP131 mRNA CTD PMID:20345932 NCBI chr13:119,765,186...119,791,477
Ensembl chr13:119,765,187...119,790,889
JBrowse link
G Zfp503 zinc finger protein 503 increases expression ISO Phenytoin results in increased expression of ZFP503 mRNA CTD PMID:20345932 NCBI chr14:21,983,959...21,989,601
Ensembl chr14:21,983,959...21,989,601
JBrowse link
G Zfp638 zinc finger protein 638 increases expression ISO Phenytoin results in increased expression of ZFP638 mRNA CTD PMID:20345932 NCBI chr 6:83,867,068...83,986,871
Ensembl chr 6:83,867,109...83,989,550
JBrowse link
G Zscan21 zinc finger and SCAN domain containing 21 increases expression ISO Phenytoin results in increased expression of ZSCAN21 mRNA CTD PMID:20345932 NCBI chr 5:138,116,899...138,134,265
Ensembl chr 5:138,116,903...138,134,265
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21727
    role 21705
      biological role 21703
        aetiopathogenetic role 20852
          teratogenic agent 16455
            phenytoin 409
Path 2
Term Annotations click to browse term
  CHEBI ontology 21727
    subatomic particle 21713
      composite particle 21713
        hadron 21713
          baryon 21713
            nucleon 21713
              atomic nucleus 21713
                atom 21713
                  main group element atom 21629
                    p-block element atom 21629
                      carbon group element atom 21434
                        carbon atom 21334
                          organic molecular entity 21334
                            organic molecule 21228
                              organic cyclic compound 20811
                                organic heterocyclic compound 19779
                                  organic heteromonocyclic compound 17520
                                    diazolidine 599
                                      imidazolidines 590
                                        imidazolidinone 492
                                          imidazolidine-2,4-dione 470
                                            hydantoin 414
                                              phenytoin 409
paths to the root