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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenytoin
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Accession:CHEBI:8107 term browser browse the term
Definition:A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Synonyms:related_synonym: 5,5-Diphenyl-imidazolidine-2,4-dione;   5,5-diphenylimidazolidine-2,4-dione;   5,5-diphenyltetrahydro-1H-2,4-imidazoledione;   DILANTIN;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19);   InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N;   PHENTYTOIN;   SMILES=O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1;   fenitoina;   phenytoine;   phenytoinum
 alt_id: CHEBI:100921
 xref: Beilstein:384532;   CAS:57-41-0;   DrugBank:DB00252;   Drug_Central:2152;   HMDB:HMDB0014397;   KEGG:C07443;   KEGG:D00512;   LINCS:LSM-5663
 xref_mesh: MESH:D010672
 xref: PMID:10698828;   PMID:12952753;   PMID:15246836;   PMID:15744730;   PMID:16303054;   PMID:7105825;   PMID:7602118;   PMID:9186244;   Patent:WO2012174723;   Reaxys:384532;   Wikipedia:Phenytoin


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phenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AAAS aladin WD repeat nucleoporin decreases expression ISO Phenytoin results in decreased expression of AAAS mRNA CTD PMID:20345932 NCBI chr12:53,307,456...53,321,610
Ensembl chr12:53,307,456...53,324,864
JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 decreases expression ISO Phenytoin results in decreased expression of ABCA1 mRNA CTD PMID:15136057 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
multiple interactions
increases expression
increases transport
affects abundance
decreases activity
increases metabolic processing
EXP
ISO
ABCB1 protein affects the susceptibility to Phenytoin
Amino Acids, Peptides, and Proteins inhibits the reaction [Phenytoin results in increased expression of ABCB1 protein]; Phenytoin results in increased expression of and results in increased activity of ABCB1A protein
ABCB1A protein results in increased transport of Phenytoin
ABCB1 protein affects the abundance of Phenytoin
Phenytoin results in decreased activity of ABCB1 protein
ABCB1 protein results in increased metabolism of Phenytoin
CTD PMID:8001500 PMID:10580886 PMID:14749549 PMID:15569486 PMID:16220110 PMID:17045309 PMID:17376120 PMID:17529887 PMID:18408562 PMID:18440557 PMID:18473823 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions
increases expression
ISO KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein] CTD PMID:18473823 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases expression
affects response to substance
ISO
EXP
ABCC2 protein affects the transport of Phenytoin
KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]
ABCC2 protein affects the susceptibility to Phenytoin
CTD PMID:12663688 PMID:14636316 PMID:17376120 PMID:18473823 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO Phenytoin results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 decreases expression ISO Phenytoin results in decreased expression of ABCG1 mRNA CTD PMID:15136057 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G ABHD5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase increases expression ISO Phenytoin results in increased expression of ABHD5 mRNA CTD PMID:20345932 NCBI chr 3:43,690,870...43,734,371
Ensembl chr 3:43,690,108...43,734,371
JBrowse link
G ABLIM1 actin binding LIM protein 1 decreases expression ISO Phenytoin results in decreased expression of ABLIM1 mRNA CTD PMID:15136057 NCBI chr10:114,431,110...114,821,643
Ensembl chr10:114,431,113...114,768,061
JBrowse link
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Phenytoin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,561,033...15,602,148
Ensembl chr  X:15,561,033...15,602,148
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) increases activity ISO Phenytoin results in increased activity of ACHE protein CTD PMID:16946593 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 decreases expression EXP Phenytoin results in decreased expression of ADAM8 mRNA CTD PMID:14741686 NCBI chr10:133,262,422...133,276,891
Ensembl chr10:133,262,420...133,276,868
JBrowse link
G ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 increases expression ISO Phenytoin results in increased expression of ADAMTS9 mRNA CTD PMID:20345932 NCBI chr 3:64,515,654...64,688,000
Ensembl chr 3:64,515,654...64,688,000
JBrowse link
G ADGRB3 adhesion G protein-coupled receptor B3 increases expression ISO Phenytoin results in increased expression of ADGRB3 mRNA CTD PMID:20345932 NCBI chr 6:68,635,282...69,389,506
Ensembl chr 6:68,635,282...69,389,506
JBrowse link
G ADRB3 adrenoceptor beta 3 decreases expression ISO Phenytoin results in decreased expression of ADRB3 mRNA CTD PMID:20345932 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G AFP alpha fetoprotein decreases expression EXP
ISO
Phenytoin results in decreased expression of AFP mRNA CTD PMID:14741686 PMID:26272751 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 decreases expression ISO Phenytoin results in decreased expression of AGAP3 mRNA CTD PMID:20345932 NCBI chr 7:151,085,867...151,144,435
Ensembl chr 7:151,085,831...151,144,436
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
increases expression
ISO CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]
CTD PMID:17505019 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKAP10 A-kinase anchoring protein 10 increases expression ISO Phenytoin results in increased expression of AKAP10 mRNA CTD PMID:20345932 NCBI chr17:19,904,302...19,977,828
Ensembl chr17:19,904,302...19,978,343
JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 decreases expression
increases expression
ISO Phenytoin results in decreased expression of AKR7A3 mRNA
Phenytoin results in increased expression of AKR7A3 mRNA
CTD PMID:17381134 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO Phenytoin results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 decreases expression EXP Phenytoin results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866
JBrowse link
G AMN1 antagonist of mitotic exit network 1 homolog increases expression ISO Phenytoin results in increased expression of AMN1 mRNA CTD PMID:20345932 NCBI chr12:31,671,137...31,729,174
Ensembl chr12:31,671,142...31,729,121
JBrowse link
G ANXA4 annexin A4 increases expression EXP Phenytoin results in increased expression of ANXA4 mRNA CTD PMID:14741686 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112
JBrowse link
G ANXA5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 4:121,667,946...121,696,994
Ensembl chr 4:121,667,946...121,696,995
JBrowse link
G APOA1 apolipoprotein A1 increases expression ISO Phenytoin results in increased expression of APOA1 mRNA CTD PMID:15136057 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA4 apolipoprotein A4 increases expression ISO Phenytoin results in increased expression of APOA4 mRNA CTD PMID:15136057 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G APOE apolipoprotein E increases expression ISO Phenytoin results in increased expression of APOE mRNA CTD PMID:15136057 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G AR androgen receptor multiple interactions
increases expression
increases activity
ISO [Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Phenytoin results in increased expression of AR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Phenytoin results in increased expression of AR mRNA; Phenytoin results in increased expression of AR protein
Phenytoin results in increased activity of AR protein
CTD PMID:19226368 PMID:19490052 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARFIP1 ADP ribosylation factor interacting protein 1 increases expression ISO Phenytoin results in increased expression of ARFIP1 mRNA CTD PMID:20345932 NCBI chr 4:152,779,954...152,912,357
Ensembl chr 4:152,779,937...152,918,463
JBrowse link
G ARHGAP39 Rho GTPase activating protein 39 increases expression ISO Phenytoin results in increased expression of ARHGAP39 mRNA CTD PMID:20345932 NCBI chr 8:144,529,179...144,700,520
Ensembl chr 8:144,529,179...144,605,816
JBrowse link
G ARMC8 armadillo repeat containing 8 increases expression ISO Phenytoin results in increased expression of ARMC8 mRNA CTD PMID:20345932 NCBI chr 3:138,187,248...138,298,389
Ensembl chr 3:138,187,248...138,298,384
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein CTD PMID:21224054 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression ISO Phenytoin results in decreased expression of ATPAF1 mRNA CTD PMID:20345932 NCBI chr 1:46,632,737...46,668,443
Ensembl chr 1:46,632,737...46,673,867
JBrowse link
G B4GALT7 beta-1,4-galactosyltransferase 7 decreases expression ISO Phenytoin results in decreased expression of B4GALT7 mRNA CTD PMID:20345932 NCBI chr 5:177,600,102...177,610,330
Ensembl chr 5:177,600,132...177,610,330
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA CTD PMID:21224054 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
EXP
ISO
Phenytoin results in increased expression of and affects the localization of BCL2 protein
Phenytoin results in decreased expression of BCL2 mRNA
CTD PMID:9118846 PMID:10695937 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA CTD PMID:21224054 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BMP1 bone morphogenetic protein 1 decreases expression EXP Phenytoin results in decreased expression of BMP1 mRNA CTD PMID:14741686 NCBI chr 8:22,165,372...22,212,326
Ensembl chr 8:22,165,140...22,212,326
JBrowse link
G BMP4 bone morphogenetic protein 4 increases expression ISO Phenytoin results in increased expression of BMP4 mRNA CTD PMID:16141649 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G C2 complement C2 decreases expression ISO Phenytoin results in decreased expression of C2 mRNA CTD PMID:20345932 NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,672
JBrowse link
G CA6 carbonic anhydrase 6 increases expression ISO Phenytoin results in increased expression of CAR6 mRNA CTD PMID:20345932 NCBI chr 1:8,945,868...8,975,092
Ensembl chr 1:8,945,867...8,975,092
JBrowse link
G CACYBP calcyclin binding protein increases expression ISO Phenytoin results in increased expression of CACYBP mRNA CTD PMID:20345932 NCBI chr 1:174,999,435...175,012,027
Ensembl chr 1:174,999,163...175,012,027
JBrowse link
G CALCA calcitonin related polypeptide alpha decreases expression ISO Phenytoin results in decreased expression of CALCA protein CTD PMID:2470235 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CALM2 calmodulin 2 decreases expression EXP Phenytoin results in decreased expression of CALM2 mRNA CTD PMID:14741686 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,083...47,176,921
JBrowse link
G CAPN5 calpain 5 decreases expression EXP Phenytoin results in decreased expression of CAPN5 mRNA CTD PMID:14741686 NCBI chr11:77,066,971...77,126,155
Ensembl chr11:77,066,961...77,126,155
JBrowse link
G CASKIN1 CASK interacting protein 1 affects expression ISO Phenytoin affects the expression of CASKIN1 mRNA CTD PMID:20345932 NCBI chr16:2,177,180...2,196,605
Ensembl chr16:2,177,180...2,196,605
JBrowse link
G CASP10 caspase 10 increases expression EXP Phenytoin results in increased expression of CASP10 mRNA CTD PMID:14741686 NCBI chr 2:201,182,885...201,229,406
Ensembl chr 2:201,182,898...201,229,406
Ensembl chr 2:201,182,898...201,229,406
JBrowse link
G CAT catalase decreases response to substance EXP CAT protein results in decreased susceptibility to Phenytoin CTD PMID:21252394 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CBLL1 Cbl proto-oncogene like 1 increases expression ISO Phenytoin results in increased expression of CBLL1 mRNA CTD PMID:20345932 NCBI chr 7:107,743,836...107,764,997
Ensembl chr 7:107,743,949...107,761,667
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Phenytoin results in increased expression of CCL2 protein CTD PMID:14578793 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCNC cyclin C increases expression ISO Phenytoin results in increased expression of CCNC mRNA CTD PMID:20345932 NCBI chr 6:99,542,387...99,568,814
Ensembl chr 6:99,542,387...99,568,825
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA
Phenytoin results in decreased expression of CCND1 mRNA
CTD PMID:14741686 PMID:21224054 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNG1 cyclin G1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr 5:163,437,571...163,448,199
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CD47 CD47 molecule decreases expression ISO Phenytoin results in decreased expression of CD47 mRNA CTD PMID:17381134 NCBI chr 3:108,043,091...108,094,200
Ensembl chr 3:108,043,091...108,091,862
JBrowse link
G CDH2 cadherin 2 decreases expression ISO Phenytoin results in decreased expression of CDH2 mRNA CTD PMID:9118846 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression ISO Phenytoin results in decreased expression of CDK1 mRNA CTD PMID:26272751 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression
multiple interactions
EXP
ISO
Phenytoin results in decreased expression of CDKN1A mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein
CTD PMID:14741686 PMID:21224054 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDX2 caudal type homeobox 2 increases expression ISO Phenytoin results in increased expression of CDX2 mRNA CTD PMID:20345932 NCBI chr13:27,960,918...27,969,337
Ensembl chr13:27,960,918...27,969,315
JBrowse link
G CELA2A chymotrypsin like elastase 2A decreases expression EXP Phenytoin results in decreased expression of CELA2A mRNA CTD PMID:14741686 NCBI chr 1:15,456,732...15,472,091
Ensembl chr 1:15,456,728...15,472,091
JBrowse link
G CEP57 centrosomal protein 57 increases expression ISO Phenytoin results in increased expression of CEP57 mRNA CTD PMID:20345932 NCBI chr11:95,790,471...95,832,693
Ensembl chr11:95,789,965...95,832,693
JBrowse link
G CER1 cerberus 1, DAN family BMP antagonist decreases expression ISO Phenytoin results in decreased expression of CER1 mRNA CTD PMID:26272751 NCBI chr 9:14,715,082...14,724,308
Ensembl chr 9:14,719,724...14,722,733
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CKM creatine kinase, M-type increases expression EXP Phenytoin results in increased expression of CKM protein CTD PMID:6682525 NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875
JBrowse link
G CLCN6 chloride voltage-gated channel 6 decreases expression ISO Phenytoin results in decreased expression of CLCN6 mRNA CTD PMID:20345932 NCBI chr 1:11,806,191...11,843,130
Ensembl chr 1:11,806,096...11,848,079
JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 increases expression ISO Phenytoin results in increased expression of CMPK1 mRNA CTD PMID:20345932 NCBI chr 1:47,333,790...47,378,839
Ensembl chr 1:47,333,797...47,378,839
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 increases expression ISO Phenytoin results in increased expression of CNOT7 mRNA CTD PMID:20345932 NCBI chr 8:17,221,981...17,246,857
Ensembl chr 8:17,224,966...17,246,878
JBrowse link
G COL11A1 collagen type XI alpha 1 chain increases expression EXP Phenytoin results in increased expression of COL11A1 mRNA CTD PMID:14741686 NCBI chr 1:102,876,473...103,108,580
Ensembl chr 1:102,876,467...103,108,872
JBrowse link
G COL18A1 collagen type XVIII alpha 1 chain decreases expression EXP Phenytoin results in decreased expression of COL18A1 mRNA CTD PMID:14741686 NCBI chr21:45,405,165...45,513,720
Ensembl chr21:45,405,165...45,513,720
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
increases expression
decreases expression
EXP Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
Phenytoin results in increased expression of COL1A1 mRNA
Phenytoin results in decreased expression of COL1A1 mRNA
CTD PMID:8971655 PMID:14741686 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain increases expression
affects expression
EXP
ISO
Phenytoin results in increased expression of COL1A2 mRNA
Phenytoin affects the expression of COL1A2 mRNA
CTD PMID:14741686 PMID:24704097 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G COL6A1 collagen type VI alpha 1 chain decreases expression
increases expression
EXP Phenytoin results in decreased expression of COL6A1 mRNA
Phenytoin results in increased expression of COL6A1 mRNA
CTD PMID:8224229 PMID:14741686 NCBI chr21:45,981,770...46,005,048
Ensembl chr21:45,981,769...46,005,050
Ensembl chr21:45,981,769...46,005,050
JBrowse link
G COL6A2 collagen type VI alpha 2 chain increases expression EXP Phenytoin results in increased expression of COL6A2 mRNA CTD PMID:8224229 NCBI chr21:46,098,071...46,132,849
Ensembl chr21:46,098,112...46,132,848
Ensembl chr21:46,098,112...46,132,848
JBrowse link
G COL6A3 collagen type VI alpha 3 chain increases expression EXP Phenytoin results in increased expression of COL6A3 mRNA CTD PMID:8224229 NCBI chr 2:237,324,018...237,434,822
Ensembl chr 2:237,324,003...237,414,207
Ensembl chr 2:237,324,003...237,414,207
JBrowse link
G CP ceruloplasmin decreases expression ISO Phenytoin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 3:149,162,410...149,222,008
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CPSF6 cleavage and polyadenylation specific factor 6 increases expression ISO Phenytoin results in increased expression of CPSF6 mRNA CTD PMID:20345932 NCBI chr12:69,239,568...69,274,358
Ensembl chr12:69,239,569...69,274,358
JBrowse link
G CRH corticotropin releasing hormone affects expression ISO Phenytoin affects the expression of CRH mRNA CTD PMID:20345932 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CRPPA CDP-L-ribitol pyrophosphorylase A increases expression ISO Phenytoin results in increased expression of CRPPA mRNA CTD PMID:20345932 NCBI chr 7:16,087,525...16,421,538
Ensembl chr 7:16,087,525...16,502,504
Ensembl chr 7:16,087,525...16,502,504
JBrowse link
G CTSB cathepsin B increases expression
decreases activity
EXP Phenytoin results in increased expression of CTSB mRNA
Phenytoin results in decreased activity of CTSB protein
CTD PMID:10914799 PMID:14741686 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CTSL cathepsin L decreases activity
increases expression
EXP Phenytoin results in decreased activity of CTSL protein
Phenytoin results in increased expression of CTSL mRNA
CTD PMID:10914799 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,726,109...87,731,469
Ensembl chr 9:87,726,109...87,731,469
JBrowse link
G CUL4A cullin 4A increases expression ISO Phenytoin results in increased expression of CUL4A mRNA CTD PMID:20345932 NCBI chr13:113,208,193...113,267,108
Ensembl chr13:113,208,193...113,267,108
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 increases expression ISO Phenytoin results in increased expression of CX3CL1 mRNA CTD PMID:20345932 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA CTD PMID:21224054 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA] CTD PMID:23986454 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity EXP Phenytoin results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO
EXP
Phenytoin results in increased expression of CYP1A1 mRNA CTD PMID:9860486 PMID:17381134 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA CTD PMID:21224054 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
decreases expression
increases expression
increases activity
EXP
ISO
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein; pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]
Phenytoin results in decreased expression of CYP2B10 protein
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
Phenytoin results in increased expression of CYP2B6 mRNA; Phenytoin results in increased expression of CYP2B6 protein
Phenytoin results in increased activity of CYP2B6 protein
CTD PMID:12571232 PMID:12695351 PMID:14977870 PMID:15123723 PMID:17041008 PMID:17954527 PMID:18206661 PMID:18332078 PMID:19226368 PMID:21224054 PMID:21924250 PMID:23850985 PMID:28289823 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases hydroxylation
increases metabolic processing
multiple interactions
decreases metabolic processing
increases hydroxylation
affects metabolic processing
EXP
ISO
CYP2C19 gene polymorphism results in decreased hydroxylation of Phenytoin
CYP2C19 protein results in increased metabolism of Phenytoin
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CYP2C19 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C19 protein results in increased hydroxylation of Phenytoin
CYP2C19 protein affects the metabolism of Phenytoin
CTD PMID:9146858 PMID:9333104 PMID:9579299 PMID:9860067 PMID:15569425 PMID:15855726 PMID:16220110 PMID:16789993 PMID:18511451 PMID:23397584 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 affects expression
multiple interactions
increases expression
ISO Phenytoin affects the expression of CYP2C29 mRNA
[Phenytoin results in decreased activity of CYP2C29 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]
Phenytoin results in increased expression of CYP2C protein; Phenytoin results in increased expression of CYP2C29 mRNA; Phenytoin results in increased expression of CYP2C29 protein
CTD PMID:12051692 PMID:15155833 PMID:19136022 PMID:19903449 PMID:21766881 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
increases metabolic processing
increases activity
increases hydroxylation
decreases metabolic processing
decreases hydroxylation
increases expression
increases response to substance
affects metabolic processing
EXP [Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]
CYP2C9 protein results in increased metabolism of Phenytoin
Phenytoin results in increased activity of CYP2C9 protein
CYP2C9 protein results in increased hydroxylation of Phenytoin
CYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin; CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin
CYP2C9 gene polymorphism results in increased susceptibility to Phenytoin
CYP2C9 protein affects the metabolism of Phenytoin; CYP2C9 protein alternative form affects the metabolism of Phenytoin
CTD PMID:2025243 PMID:9110362 PMID:9860067 PMID:10208645 PMID:10510154 PMID:10850388 PMID:11234294 PMID:11434505 PMID:11503012 PMID:11668218 PMID:11740344 PMID:14600250 PMID:14659971 PMID:15855726 PMID:16220110 PMID:16873909 PMID:17961958 PMID:19082874 PMID:19202563 PMID:19715737 PMID:20405111 PMID:23397584 PMID:27163851 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
decreases expression
increases expression
EXP
ISO
NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]
Phenytoin results in decreased expression of CYP2E1 mRNA
Phenytoin results in increased expression of CYP2E1 mRNA; Phenytoin results in increased expression of CYP2E1 protein
CTD PMID:17381134 PMID:18206661 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases activity
increases expression
EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased activity of CYP3A4 protein
Phenytoin results in increased expression of CYP3A4 mRNA; Phenytoin results in increased expression of CYP3A4 protein
CTD PMID:9512926 PMID:10219967 PMID:12065438 PMID:12505310 PMID:12673034 PMID:12695340 PMID:14977870 PMID:15466163 PMID:16207822 PMID:16837568 PMID:17954527 PMID:18206661 PMID:18332078 PMID:21402137 PMID:21742782 PMID:23397584 PMID:28289823 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases expression EXP
ISO
Phenytoin results in increased expression of CYP3A5 mRNA
Phenytoin results in increased expression of CYP3A13 mRNA
CTD PMID:12673034 PMID:19903449 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 increases expression EXP Phenytoin results in increased expression of CYP3A7 mRNA CTD PMID:12673034 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 decreases expression ISO Phenytoin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 1:47,137,441...47,149,738
Ensembl chr 1:47,137,435...47,149,735
JBrowse link
G CYP4Z1 cytochrome P450 family 4 subfamily Z member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA CTD PMID:21224054 NCBI chr 1:47,055,525...47,118,320
Ensembl chr 1:47,067,231...47,118,318
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA CTD PMID:21224054 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 increases expression ISO Phenytoin results in increased expression of CYP7B1 mRNA CTD PMID:20345932 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737
JBrowse link
G DAP3 death associated protein 3 increases expression EXP Phenytoin results in increased expression of DAP3 mRNA CTD PMID:14741686 NCBI chr 1:155,687,902...155,739,010
Ensembl chr 1:155,687,960...155,739,010
JBrowse link
G DAPK2 death associated protein kinase 2 decreases expression EXP Phenytoin results in decreased expression of DAPK2 mRNA CTD PMID:14741686 NCBI chr15:63,907,036...64,046,485
Ensembl chr15:63,907,036...64,072,033
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA CTD PMID:21224054 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DHX9 DExH-box helicase 9 increases expression ISO Phenytoin results in increased expression of DHX9 mRNA CTD PMID:20345932 NCBI chr 1:182,839,347...182,887,982
Ensembl chr 1:182,839,347...182,887,982
JBrowse link
G DMTN dematin actin binding protein decreases expression ISO Phenytoin results in decreased expression of DMTN mRNA CTD PMID:20345932 NCBI chr 8:22,048,931...22,082,525
Ensembl chr 8:22,048,995...22,082,527
JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907
JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA CTD PMID:21224054 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EBPL EBP like increases expression ISO Phenytoin results in increased expression of EBPL mRNA CTD PMID:20345932 NCBI chr13:49,660,674...49,691,487
Ensembl chr13:49,660,674...49,691,486
JBrowse link
G EGR1 early growth response 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA CTD PMID:21224054 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EGR3 early growth response 3 increases expression ISO Phenytoin results in increased expression of EGR3 mRNA CTD PMID:20345932 NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480
JBrowse link
G EMX2 empty spiracles homeobox 2 decreases expression ISO Phenytoin results in decreased expression of EMX2 mRNA CTD PMID:9118846 NCBI chr10:117,542,746...117,549,546
Ensembl chr10:117,542,445...117,549,546
JBrowse link
G ENPEP glutamyl aminopeptidase decreases expression
increases expression
ISO Phenytoin results in decreased expression of ENPEP mRNA
Phenytoin results in increased expression of ENPEP mRNA
CTD PMID:17381134 NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285
JBrowse link
G EOMES eomesodermin increases expression EXP Phenytoin results in increased expression of EOMES mRNA CTD PMID:14741686 NCBI chr 3:27,715,953...27,722,713
Ensembl chr 3:27,715,949...27,722,711
JBrowse link
G EPHX1 epoxide hydrolase 1 affects response to substance
increases expression
EXP
ISO
EPHX1 gene polymorphism affects the susceptibility to Phenytoin
Phenytoin results in increased expression of EPHX1 mRNA
CTD PMID:17381134 PMID:19952982 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G EPHX2 epoxide hydrolase 2 decreases expression ISO Phenytoin results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G ESR1 estrogen receptor 1 increases expression ISO Phenytoin results in increased expression of ESR1 mRNA; Phenytoin results in increased expression of ESR1 protein CTD PMID:19490052 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 decreases expression EXP Phenytoin results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 8:71,197,433...71,548,104
Ensembl chr 8:71,197,433...71,592,025
JBrowse link
G F10 coagulation factor X decreases expression ISO Phenytoin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FASLG Fas ligand multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA
Phenytoin results in decreased expression of FASL mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FBXL3 F-box and leucine rich repeat protein 3 increases expression ISO Phenytoin results in increased expression of FBXL3 mRNA CTD PMID:20345932 NCBI chr13:76,992,597...77,027,164
Ensembl chr13:76,992,598...77,027,195
JBrowse link
G FBXO30 F-box protein 30 increases expression ISO Phenytoin results in increased expression of FBXO30 mRNA CTD PMID:20345932 NCBI chr 6:145,793,502...145,864,409
Ensembl chr 6:145,793,502...145,814,795
JBrowse link
G FGF12 fibroblast growth factor 12 increases expression ISO Phenytoin results in increased expression of FGF12 mRNA CTD PMID:20345932 NCBI chr 3:192,139,390...192,727,541
Ensembl chr 3:192,139,395...192,767,764
Ensembl chr 3:192,139,395...192,767,764
JBrowse link
G FGF5 fibroblast growth factor 5 increases expression EXP Phenytoin results in increased expression of FGF5 mRNA CTD PMID:14741686 NCBI chr 4:80,266,588...80,291,017
Ensembl chr 4:80,266,599...80,336,680
JBrowse link
G FGF8 fibroblast growth factor 8 increases expression EXP Phenytoin results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,130...101,780,369
JBrowse link
G FGF9 fibroblast growth factor 9 increases expression EXP Phenytoin results in increased expression of FGF9 mRNA CTD PMID:14741686 NCBI chr13:21,671,073...21,704,501
Ensembl chr13:21,671,073...21,704,498
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 increases expression EXP Phenytoin results in increased expression of FGFR2 mRNA; Phenytoin results in increased expression of FGFR2 protein CTD PMID:11352631 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,334...121,598,458
Ensembl chr10:121,478,334...121,598,458
JBrowse link
G FLRT2 fibronectin leucine rich transmembrane protein 2 increases expression EXP Phenytoin results in increased expression of FLRT2 mRNA CTD PMID:14741686 NCBI chr14:85,527,372...85,654,428
Ensembl chr14:85,530,144...85,654,428
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA CTD PMID:21224054 NCBI chr 1:171,248,473...171,285,978
Ensembl chr 1:171,248,471...171,285,978
JBrowse link
G FMO4 flavin containing dimethylaniline monoxygenase 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA CTD PMID:21224054 NCBI chr 1:171,314,131...171,342,084
Ensembl chr 1:171,314,183...171,342,084
JBrowse link
G FMOD fibromodulin decreases expression EXP Phenytoin results in decreased expression of FMOD mRNA CTD PMID:14741686 NCBI chr 1:203,340,628...203,351,122
Ensembl chr 1:203,340,628...203,351,758
JBrowse link
G FMR1 FMRP translational regulator 1 increases expression ISO Phenytoin results in increased expression of FMR1 mRNA CTD PMID:20345932 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,951...147,951,125
Ensembl chr  X:147,911,951...147,951,125
JBrowse link
G FN1 fibronectin 1 increases expression EXP Phenytoin results in increased expression of FN1 mRNA CTD PMID:14741686 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FNDC3A fibronectin type III domain containing 3A increases expression ISO Phenytoin results in increased expression of FNDC3A mRNA CTD PMID:20345932 NCBI chr13:48,975,241...49,209,779
Ensembl chr13:48,975,912...49,209,779
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]
Phenytoin results in decreased expression of FOS protein
CTD PMID:7789465 PMID:8758711 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOXC2 forkhead box C2 decreases expression EXP Phenytoin results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr16:86,566,829...86,569,728
Ensembl chr16:86,566,829...86,569,728
JBrowse link
G FOXP3 forkhead box P3 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
Phenytoin results in decreased expression of FOXP3 mRNA
CTD PMID:23986454 NCBI chr  X:49,250,436...49,264,932
Ensembl chr  X:49,250,438...49,270,477
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G FRS3 fibroblast growth factor receptor substrate 3 decreases expression EXP Phenytoin results in decreased expression of FRS3 mRNA CTD PMID:14741686 NCBI chr 6:41,770,176...41,779,900
Ensembl chr 6:41,770,176...41,786,542
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Phenytoin results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase affects response to substance ISO G6PDX protein affects the susceptibility to Phenytoin CTD PMID:10627286 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA CTD PMID:21224054 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GATA3 GATA binding protein 3 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Phenytoin results in decreased expression of GATA3 mRNA
CTD PMID:23986454 NCBI chr10:8,045,420...8,075,198
Ensembl chr10:8,045,378...8,075,198
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO Phenytoin results in increased expression of GCLM mRNA CTD PMID:20345932 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GLUL glutamate-ammonia ligase decreases activity ISO Phenytoin results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,381,704...182,392,206
Ensembl chr 1:182,381,704...182,392,206
JBrowse link
G GNL2 G protein nucleolar 2 increases expression ISO Phenytoin results in increased expression of GNL2 mRNA CTD PMID:20345932 NCBI chr 1:37,566,816...37,595,937
Ensembl chr 1:37,566,816...37,595,937
JBrowse link
G GNPDA2 glucosamine-6-phosphate deaminase 2 increases expression ISO Phenytoin results in increased expression of GNPDA2 mRNA CTD PMID:20345932 NCBI chr 4:44,701,795...44,726,634
Ensembl chr 4:44,682,200...44,726,588
JBrowse link
G GPM6A glycoprotein M6A increases expression ISO Phenytoin results in increased expression of GPM6A mRNA CTD PMID:20345932 NCBI chr 4:175,632,937...176,002,691
Ensembl chr 4:175,632,934...176,002,664
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA CTD PMID:21224054 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,905
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 increases expression ISO Phenytoin results in increased expression of GRIN1 mRNA CTD PMID:20345932 NCBI chr 9:137,139,092...137,168,759
Ensembl chr 9:137,139,154...137,168,756
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 increases expression EXP Phenytoin results in increased expression of GSTA1 mRNA CTD PMID:11134551 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression
decreases expression
ISO Phenytoin results in increased expression of GSTA2 mRNA
Phenytoin results in decreased expression of GSTA2 mRNA
CTD PMID:17381134 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP Phenytoin results in decreased expression of GSTK1 mRNA CTD PMID:14741686 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression
multiple interactions
ISO Phenytoin results in increased expression of GSTM1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein
CTD PMID:17381134 PMID:21224054 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM2 glutathione S-transferase mu 2 increases expression ISO Phenytoin results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTM3 glutathione S-transferase mu 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA CTD PMID:21224054 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Phenytoin results in decreased expression of GSTO1 mRNA CTD PMID:14741686 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
JBrowse link
G GUSB glucuronidase beta multiple interactions
decreases activity
ISO Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]
Phenytoin results in decreased activity of GUSB protein
CTD PMID:6696821 NCBI chr 7:65,960,684...65,982,230
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G HDAC7 histone deacetylase 7 increases expression ISO Phenytoin results in increased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr12:47,782,722...47,820,612
Ensembl chr12:47,782,722...47,833,132
JBrowse link
G HELZ helicase with zinc finger increases expression ISO Phenytoin results in increased expression of HELZ mRNA CTD PMID:20345932 NCBI chr17:67,070,444...67,245,989
Ensembl chr17:67,070,444...67,245,989
JBrowse link
G HEXIM1 HEXIM P-TEFb complex subunit 1 increases expression ISO Phenytoin results in increased expression of HEXIM1 mRNA CTD PMID:20345932 NCBI chr17:45,148,475...45,152,099
Ensembl chr17:45,148,502...45,152,101
Ensembl chr17:45,148,502...45,152,101
JBrowse link
G HLA-B major histocompatibility complex, class I, B affects response to substance EXP HLA-B gene polymorphism affects the susceptibility to Phenytoin CTD PMID:20235791 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,269,491...31,357,188
Ensembl chr 6:31,269,491...31,357,188
JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein CTD PMID:23986454 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Phenytoin results in increased expression of HMOX1 mRNA
CTD PMID:17381134 PMID:21224054 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression ISO Phenytoin results in increased expression of HNRNPA2B1 mRNA CTD PMID:20345932 NCBI chr 7:26,189,920...26,200,775
Ensembl chr 7:26,173,057...26,201,529
Ensembl chr 7:26,173,057...26,201,529
JBrowse link
G HOOK3 hook microtubule tethering protein 3 increases expression ISO Phenytoin results in increased expression of HOOK3 mRNA CTD PMID:20345932 NCBI chr 8:42,896,978...43,030,535
Ensembl chr 8:42,896,946...43,030,535
JBrowse link
G HOXA2 homeobox A2 decreases expression ISO Phenytoin results in decreased expression of HOXA2 mRNA; Phenytoin results in decreased expression of HOXA2 protein CTD PMID:10789828 NCBI chr 7:27,100,354...27,102,683
Ensembl chr 7:27,100,354...27,102,686
JBrowse link
G HOXB7 homeobox B7 increases expression EXP Phenytoin results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr17:48,607,232...48,611,017
Ensembl chr17:48,607,232...48,633,572
JBrowse link
G HOXB9 homeobox B9 increases expression EXP Phenytoin results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr17:48,621,156...48,626,358
Ensembl chr17:48,621,156...48,626,358
JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA CTD PMID:21224054 NCBI chr 6:31,809,619...31,815,283
Ensembl chr 6:31,809,619...31,815,283
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA CTD PMID:21224054 NCBI chr11:123,057,489...123,062,366
Ensembl chr11:123,057,489...123,063,230
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA CTD PMID:21224054 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA CTD PMID:21224054 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G HSPE1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA CTD PMID:21224054 NCBI chr 2:197,500,379...197,503,449
Ensembl chr 2:197,500,140...197,503,449
JBrowse link
G IFNG interferon gamma decreases expression ISO Phenytoin results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IFNGR1 interferon gamma receptor 1 increases expression EXP Phenytoin results in increased expression of IFNGR1 mRNA CTD PMID:14741686 NCBI chr 6:137,197,484...137,220,351
Ensembl chr 6:137,197,484...137,219,449
Ensembl chr 6:137,197,484...137,219,449
JBrowse link
G IFNGR2 interferon gamma receptor 2 increases expression EXP Phenytoin results in increased expression of IFNGR2 mRNA CTD PMID:14741686 NCBI chr21:33,402,882...33,437,516
Ensembl chr21:33,403,413...33,479,348
Ensembl chr21:33,403,413...33,479,348
JBrowse link
G IGF1 insulin like growth factor 1 decreases expression ISO Phenytoin results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF2 insulin like growth factor 2 increases expression ISO Phenytoin results in increased expression of IGF2 mRNA CTD PMID:9988880 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,141,238
JBrowse link
G IHH Indian hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of IHH mRNA CTD PMID:16141649 NCBI chr 2:219,054,424...219,060,921
Ensembl chr 2:219,054,424...219,060,921
JBrowse link
G IL17A interleukin 17A multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL18 interleukin 18 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein
CTD PMID:8971655 PMID:21224054 PMID:23986454 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL23A interleukin 23 subunit alpha multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr12:56,334,159...56,340,410
Ensembl chr12:56,334,174...56,340,410
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA
Phenytoin results in increased expression of IL6 mRNA
CTD PMID:21224054 PMID:23986454 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6R interleukin 6 receptor decreases expression ISO Phenytoin results in decreased expression of IL6RA mRNA CTD PMID:15136057 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G INPP5F inositol polyphosphate-5-phosphatase F increases expression ISO Phenytoin results in increased expression of INPP5F mRNA CTD PMID:20345932 NCBI chr10:119,704,395...119,830,482
Ensembl chr10:119,726,042...119,829,147
JBrowse link
G INSR insulin receptor increases expression EXP Phenytoin results in increased expression of INSR mRNA CTD PMID:14741686 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G IPP intracisternal A particle-promoted polypeptide increases expression ISO Phenytoin results in increased expression of IPP mRNA CTD PMID:20345932 NCBI chr 1:45,694,324...45,750,805
Ensembl chr 1:45,694,324...45,750,653
JBrowse link
G IRF9 interferon regulatory factor 9 increases expression ISO Phenytoin results in increased expression of IRF9 mRNA CTD PMID:20345932 NCBI chr14:24,161,265...24,166,565
Ensembl chr14:24,161,265...24,166,565
JBrowse link
G ITGA2 integrin subunit alpha 2 decreases expression EXP Phenytoin results in decreased expression of ITGA2 protein CTD PMID:15948689 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779
JBrowse link
G ITGA8 integrin subunit alpha 8 increases expression EXP Phenytoin results in increased expression of ITGA8 mRNA CTD PMID:14741686 NCBI chr10:15,513,954...15,720,329
Ensembl chr10:15,513,954...15,719,922
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Phenytoin results in decreased expression of ITGB1 protein CTD PMID:15948689 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G ITGB3BP integrin subunit beta 3 binding protein increases expression ISO Phenytoin results in increased expression of ITGB3BP mRNA CTD PMID:20345932 NCBI chr 1:63,440,770...63,529,395
Ensembl chr 1:63,440,770...63,593,721
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenytoin results in decreased expression of JUN mRNA CTD PMID:9118846 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KCND2 potassium voltage-gated channel subfamily D member 2 increases expression ISO Phenytoin results in increased expression of KCND2 mRNA CTD PMID:20345932 NCBI chr 7:120,273,175...120,750,337
Ensembl chr 7:120,273,175...120,750,337
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Phenytoin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCTD3 potassium channel tetramerization domain containing 3 increases expression ISO Phenytoin results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr 1:215,567,304...215,621,807
Ensembl chr 1:215,567,304...215,621,807
JBrowse link
G KDR kinase insert domain receptor increases expression ISO Phenytoin results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KHDRBS2 KH RNA binding domain containing, signal transduction associated 2 increases expression ISO Phenytoin results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 6:61,542,670...62,286,225
Ensembl chr 6:61,679,961...62,286,225
JBrowse link
G KLF2 Kruppel like factor 2 increases expression ISO Phenytoin results in increased expression of KLF2 mRNA CTD PMID:20345932 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,817...16,327,874
Ensembl chr19:16,324,817...16,327,874
JBrowse link
G KLHL2 kelch like family member 2 increases expression ISO Phenytoin results in increased expression of KLHL2 mRNA CTD PMID:20345932 NCBI chr 4:165,207,561...165,323,156
Ensembl chr 4:165,207,561...165,323,156
JBrowse link
G KLHL7 kelch like family member 7 increases expression ISO Phenytoin results in increased expression of KLHL7 mRNA CTD PMID:20345932 NCBI chr 7:23,105,785...23,177,914
Ensembl chr 7:23,105,758...23,177,914
JBrowse link
G KRIT1 KRIT1 ankyrin repeat containing increases expression ISO Phenytoin results in increased expression of KRIT1 mRNA CTD PMID:20345932 NCBI chr 7:92,198,969...92,246,100
Ensembl chr 7:92,131,774...92,245,924
Ensembl chr 7:92,131,774...92,245,924
JBrowse link
G KRT2 keratin 2 increases expression EXP Phenytoin results in increased expression of KRT2 mRNA CTD PMID:14741686 NCBI chr12:52,644,558...52,652,211
Ensembl chr12:52,644,558...52,652,211
JBrowse link
G KYAT1 kynurenine aminotransferase 1 increases activity ISO Phenytoin results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,819,663...128,881,931
Ensembl chr 9:128,819,663...128,881,931
JBrowse link
G LAMA2 laminin subunit alpha 2 increases expression ISO Phenytoin results in increased expression of LAMA2 mRNA CTD PMID:20345932 NCBI chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566
JBrowse link
G LAP3 leucine aminopeptidase 3 affects expression ISO Phenytoin affects the expression of LAP3 mRNA CTD PMID:20345932 NCBI chr 4:17,577,198...17,607,970
Ensembl chr 4:17,577,192...17,607,972
Ensembl chr 4:17,577,192...17,607,972
JBrowse link
G LCAT lecithin-cholesterol acyltransferase increases expression ISO Phenytoin results in increased expression of LCAT mRNA CTD PMID:15136057 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
JBrowse link
G LDB2 LIM domain binding 2 increases expression ISO Phenytoin results in increased expression of LDB2 mRNA CTD PMID:20345932 NCBI chr 4:16,501,541...16,898,787
Ensembl chr 4:16,501,541...16,898,678
JBrowse link
G LPIN1 lipin 1 increases expression EXP Phenytoin results in increased expression of LPIN1 mRNA CTD PMID:14741686 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409
JBrowse link
G LRBA LPS responsive beige-like anchor protein increases expression ISO Phenytoin results in increased expression of LRBA mRNA CTD PMID:20345932 NCBI chr 4:150,264,435...151,015,727
Ensembl chr 4:150,264,435...151,015,727
JBrowse link
G LSM1 LSM1 homolog, mRNA degradation associated decreases expression ISO Phenytoin results in decreased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr 8:38,163,321...38,176,730
Ensembl chr 8:38,163,335...38,176,730
JBrowse link
G LTBP4 latent transforming growth factor beta binding protein 4 increases expression ISO Phenytoin results in increased expression of LTBP4 mRNA CTD PMID:20345932 NCBI chr19:40,593,166...40,629,820
Ensembl chr19:40,592,883...40,629,818
JBrowse link
G LYPLA1 lysophospholipase 1 increases expression ISO Phenytoin results in increased expression of LYPLA1 mRNA CTD PMID:20345932 NCBI chr 8:54,046,367...54,101,997
Ensembl chr 8:54,046,367...54,102,017
JBrowse link
G MAP1B microtubule associated protein 1B increases expression EXP Phenytoin results in increased expression of MAP1B mRNA CTD PMID:14741686 NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565
JBrowse link
G MAP3K4 mitogen-activated protein kinase kinase kinase 4 increases expression ISO Phenytoin results in increased expression of MAP3K4 mRNA CTD PMID:20345932 NCBI chr 6:160,991,521...161,117,385
Ensembl chr 6:160,991,727...161,117,385
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP Phenytoin results in decreased phosphorylation of MAPK1 protein CTD PMID:15948689 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP Phenytoin results in decreased phosphorylation of MAPK3 protein CTD PMID:15948689 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPRE3 microtubule associated protein RP/EB family member 3 increases expression ISO Phenytoin results in increased expression of MAPRE3 mRNA CTD PMID:20345932 NCBI chr 2:26,970,637...27,027,219
Ensembl chr 2:26,970,637...27,027,219
JBrowse link
G MBL1P mannose binding lectin 1, pseudogene decreases expression ISO Phenytoin results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr10:79,920,178...79,923,119
Ensembl chr10:79,920,178...79,923,119
JBrowse link
G MDK midkine increases expression EXP Phenytoin results in increased expression of MDK mRNA CTD PMID:14741686 NCBI chr11:46,380,784...46,383,837
Ensembl chr11:46,380,756...46,383,837
JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G ME1 malic enzyme 1 increases expression ISO Phenytoin results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MEOX1 mesenchyme homeobox 1 decreases expression EXP Phenytoin results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr17:43,640,389...43,661,977
Ensembl chr17:43,640,389...43,661,922
JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 increases expression ISO Phenytoin results in increased expression of MESP1 mRNA CTD PMID:26272751 NCBI chr15:89,734,772...89,751,309
Ensembl chr15:89,748,661...89,751,310
JBrowse link
G MEX3D mex-3 RNA binding family member D increases expression ISO Phenytoin results in increased expression of MEX3D mRNA CTD PMID:20345932 NCBI chr19:1,554,672...1,568,325
Ensembl chr19:1,554,669...1,568,058
JBrowse link
G MGAT2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression ISO Phenytoin results in increased expression of MGAT2 mRNA CTD PMID:20345932 NCBI chr14:49,620,799...49,623,481
Ensembl chr14:49,620,799...49,623,481
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase increases methylation EXP Phenytoin results in increased methylation of MGMT promoter CTD PMID:15949900 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein CTD PMID:21224054 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MMP1 matrix metallopeptidase 1 decreases expression
increases expression
EXP Phenytoin results in decreased expression of MMP1 mRNA
Phenytoin results in increased expression of MMP1 mRNA
CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression EXP Phenytoin results in decreased expression of MMP2 mRNA CTD PMID:15948689 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 decreases expression EXP Phenytoin results in decreased expression of MMP3 mRNA CTD PMID:15948689 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MRPS18C mitochondrial ribosomal protein S18C increases expression ISO Phenytoin results in increased expression of MRPS18C mRNA CTD PMID:20345932 NCBI chr 4:83,456,058...83,462,298
Ensembl chr 4:83,455,932...83,469,735
JBrowse link
G MTF2 metal response element binding transcription factor 2 increases expression ISO Phenytoin results in increased expression of MTF2 mRNA CTD PMID:20345932 NCBI chr 1:93,079,283...93,139,076
Ensembl chr 1:93,079,235...93,139,079
JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like increases expression ISO Phenytoin results in increased expression of MTHFD1L mRNA CTD PMID:20345932 NCBI chr 6:150,865,684...151,101,887
Ensembl chr 6:150,865,549...151,101,887
Ensembl chr 6:150,865,549...151,101,887
JBrowse link
G MTX2 metaxin 2 increases expression ISO Phenytoin results in increased expression of MTX2 mRNA CTD PMID:20345932 NCBI chr 2:176,269,423...176,338,025
Ensembl chr 2:176,269,395...176,338,025
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
EXP
ISO
Phenytoin results in increased expression of MYC protein
Phenytoin results in decreased expression of MYC mRNA
CTD PMID:10695937 PMID:26272751 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYO1E myosin IE increases expression ISO Phenytoin results in increased expression of MYO1E mRNA CTD PMID:26272751 NCBI chr15:59,132,434...59,372,871
Ensembl chr15:59,132,434...59,372,871
JBrowse link
G NAP1L2 nucleosome assembly protein 1 like 2 affects expression ISO Phenytoin affects the expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:73,212,299...73,214,851
Ensembl chr  X:73,212,299...73,214,851
JBrowse link
G NCAN neurocan increases expression EXP Phenytoin results in increased expression of NCAN mRNA CTD PMID:14741686 NCBI chr19:19,211,958...19,252,233
Ensembl chr19:19,211,958...19,252,233
JBrowse link
G NCL nucleolin decreases expression ISO Phenytoin results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 2:231,453,531...231,464,484
Ensembl chr 2:231,453,531...231,483,641
JBrowse link
G NCOA1 nuclear receptor coactivator 1 multiple interactions EXP Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] CTD PMID:21924250 NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,914...24,770,702
JBrowse link
G NELFA negative elongation factor complex member A decreases expression ISO Phenytoin results in decreased expression of NELFA mRNA CTD PMID:20345932 NCBI chr 4:1,982,717...2,041,914
Ensembl chr 4:1,982,717...2,041,903
JBrowse link
G NES nestin decreases expression ISO Phenytoin results in decreased expression of NES mRNA CTD PMID:26272751 NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407
JBrowse link
G NEUROG2 neurogenin 2 increases expression EXP Phenytoin results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 4:112,513,516...112,516,180
Ensembl chr 4:112,513,516...112,516,180
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
EXP Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein]
Phenytoin results in increased expression of NFKB1 mRNA
CTD PMID:10700573 PMID:14741686 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha decreases degradation EXP Phenytoin results in decreased degradation of NFKBIA protein CTD PMID:15948689 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NGLY1 N-glycanase 1 increases expression ISO Phenytoin results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr 3:25,718,944...25,790,039
Ensembl chr 3:25,718,944...25,790,039
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA CTD PMID:23986454 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA CTD PMID:21224054 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPAS2 neuronal PAS domain protein 2 increases expression ISO Phenytoin results in increased expression of NPAS2 mRNA CTD PMID:20345932 NCBI chr 2:100,820,139...100,996,829
Ensembl chr 2:100,820,139...100,996,829
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Phenytoin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
affects activity
increases expression
increases activity
EXP
ISO
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin binds to and results in increased activity of NR1I2 protein; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin affects the activity of NR1I2 protein
Phenytoin results in increased expression of NR1I2 protein
Phenytoin results in increased activity of NR1I2 protein
CTD PMID:12065438 PMID:12695340 PMID:12695351 PMID:14600250 PMID:14977870 PMID:15039302 PMID:18473823 PMID:21402137 PMID:23611293 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions
increases expression
increases activity
increases localization
EXP
ISO
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Phenytoin results in increased expression of NR1I3 protein
NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]
Phenytoin results in increased localization of NR1I3 protein
CTD PMID:15123723 PMID:15155833 PMID:15849716 PMID:16936065 PMID:17041008 PMID:18473823 PMID:21924250 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 increases expression ISO Phenytoin results in increased expression of NR2F1 mRNA CTD PMID:20345932 NCBI chr 5:93,583,222...93,594,613
Ensembl chr 5:93,583,222...93,594,611
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions
increases expression
EXP
ISO
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased expression of NR3C1 mRNA
CTD PMID:10219967 PMID:12695351 PMID:20345932 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NRCAM neuronal cell adhesion molecule decreases expression ISO Phenytoin results in decreased expression of NRCAM mRNA CTD PMID:26272751 NCBI chr 7:108,147,649...108,456,720
Ensembl chr 7:108,147,623...108,456,717
JBrowse link
G NSMCE3 NSE3 homolog, SMC5-SMC6 complex component increases expression ISO Phenytoin results in increased expression of NSMCE3 mRNA CTD PMID:20345932 NCBI chr15:29,264,989...29,269,822
Ensembl chr15:29,264,989...29,269,822
JBrowse link
G NT5DC1 5'-nucleotidase domain containing 1 increases expression ISO Phenytoin results in increased expression of NT5DC1 mRNA CTD PMID:20345932 NCBI chr 6:116,100,833...116,249,497
Ensembl chr 6:116,100,851...116,249,497
JBrowse link
G NTF3 neurotrophin 3 decreases expression ISO Phenytoin results in decreased expression of NTF3 mRNA CTD PMID:7841657 NCBI chr12:5,432,108...5,495,299
Ensembl chr12:5,432,108...5,521,536
JBrowse link
G NUP153 nucleoporin 153 increases expression ISO Phenytoin results in increased expression of NUP153 mRNA CTD PMID:20345932 NCBI chr 6:17,615,036...17,706,925
Ensembl chr 6:17,615,035...17,706,834
Ensembl chr 6:17,615,035...17,706,834
JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 increases expression EXP Phenytoin results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions ISO [cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin CTD PMID:7870991 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B1 mRNA CTD PMID:15136057 NCBI chr17:2,593,210...2,685,617
Ensembl chr17:2,593,210...2,685,615
JBrowse link
G PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B2 mRNA CTD PMID:15136057 NCBI chr11:117,144,287...117,178,173
Ensembl chr11:117,144,284...117,176,894
JBrowse link
G PARD6G par-6 family cell polarity regulator gamma increases expression ISO Phenytoin results in increased expression of PARD6G mRNA CTD PMID:20345932 NCBI chr18:80,157,232...80,247,514
Ensembl chr18:80,157,232...80,247,514
JBrowse link
G PARG poly(ADP-ribose) glycohydrolase increases expression ISO Phenytoin results in increased expression of PARG mRNA CTD PMID:20345932 NCBI chr10:49,818,279...49,942,027
Ensembl chr10:49,818,279...49,970,203
JBrowse link
G PAX3 paired box 3 decreases expression ISO
EXP
Phenytoin results in decreased expression of PAX3 mRNA CTD PMID:9118846 PMID:31711903 NCBI chr 2:222,199,887...222,298,998
Ensembl chr 2:222,199,888...222,298,996
Ensembl chr 2:222,199,888...222,298,996
JBrowse link
G PAX6 paired box 6 increases expression EXP Phenytoin results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
G PBX1 PBX homeobox 1 increases expression ISO Phenytoin results in increased expression of PBX1 mRNA CTD PMID:20345932 NCBI chr 1:164,559,184...164,886,047
Ensembl chr 1:164,555,584...164,899,296
JBrowse link
G PCYOX1 prenylcysteine oxidase 1 increases expression ISO Phenytoin results in increased expression of PCYOX1 mRNA CTD PMID:20345932 NCBI chr 2:70,258,137...70,281,185
Ensembl chr 2:70,257,386...70,281,185
JBrowse link
G PDGFA platelet derived growth factor subunit A increases expression EXP Phenytoin results in increased expression of PDGFA mRNA CTD PMID:14741686 NCBI chr 7:497,245...520,668
Ensembl chr 7:497,258...520,296
JBrowse link
G PDGFB platelet derived growth factor subunit B increases expression ISO
EXP
Phenytoin results in increased expression of PDGFB mRNA; Phenytoin results in increased expression of PDGFB protein CTD PMID:8463938 PMID:9029455 PMID:14741686 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PGRMC1 progesterone receptor membrane component 1 increases expression ISO Phenytoin results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:119,236,285...119,244,466
Ensembl chr  X:119,236,245...119,244,466
JBrowse link
G PHF14 PHD finger protein 14 increases expression ISO Phenytoin results in increased expression of PHF14 mRNA CTD PMID:20345932 NCBI chr 7:10,973,872...11,169,618
Ensembl chr 7:10,973,336...11,169,623
Ensembl chr 7:10,973,336...11,169,623
JBrowse link
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha increases expression EXP Phenytoin results in increased expression of PIP4K2A mRNA CTD PMID:14741686 NCBI chr10:22,534,854...22,714,578
Ensembl chr10:22,534,854...22,714,578
JBrowse link
G PLAUR plasminogen activator, urokinase receptor decreases expression EXP Phenytoin results in decreased expression of PLAUR mRNA CTD PMID:14741686 NCBI chr19:43,646,095...43,670,197
Ensembl chr19:43,646,095...43,670,547
JBrowse link
G PLCL1 phospholipase C like 1 (inactive) increases expression ISO Phenytoin results in increased expression of PLCL1 mRNA CTD PMID:20345932 NCBI chr 2:197,804,593...198,149,873
Ensembl chr 2:197,804,593...198,572,581
JBrowse link
G PLEC plectin increases expression ISO Phenytoin results in increased expression of PLEC mRNA CTD PMID:20345932 NCBI chr 8:143,915,153...143,976,800
Ensembl chr 8:143,915,147...143,976,734
Ensembl chr 8:143,915,147...143,976,734
JBrowse link
G PLTP phospholipid transfer protein increases expression ISO Phenytoin results in increased expression of PLTP mRNA CTD PMID:15136057 NCBI chr20:45,898,620...45,912,155
Ensembl chr20:45,898,621...45,912,155
JBrowse link
G PLXNB2 plexin B2 decreases expression EXP Phenytoin results in decreased expression of PLXNB2 mRNA CTD PMID:14741686 NCBI chr22:50,274,979...50,307,646
Ensembl chr22:50,274,979...50,307,646
JBrowse link
G PNN pinin, desmosome associated protein increases expression ISO Phenytoin results in increased expression of PNN mRNA CTD PMID:20345932 NCBI chr14:39,175,254...39,183,220
Ensembl chr14:39,175,183...39,183,220
JBrowse link
G PON1 paraoxonase 1 decreases expression
affects activity
ISO
EXP
Phenytoin results in decreased expression of PON1 mRNA
Phenytoin affects the activity of PON1 protein
CTD PMID:15136057 PMID:28032682 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G POR cytochrome p450 oxidoreductase increases activity ISO Phenytoin results in increased activity of POR protein CTD PMID:12051692 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G POU3F1 POU class 3 homeobox 1 increases expression ISO Phenytoin results in increased expression of POU3F1 protein CTD PMID:12781989 NCBI chr 1:38,043,829...38,046,793
Ensembl chr 1:38,043,829...38,046,793
JBrowse link
G PPIL4 peptidylprolyl isomerase like 4 increases expression ISO Phenytoin results in increased expression of PPIL4 mRNA CTD PMID:20345932 NCBI chr 6:149,504,495...149,546,043
Ensembl chr 6:149,504,495...149,546,043
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline] CTD PMID:21224054 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G PRL prolactin decreases expression ISO Phenytoin results in decreased expression of PRL mRNA; Phenytoin results in decreased expression of PRL protein CTD PMID:3734668 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PRMT3 protein arginine methyltransferase 3 increases expression ISO Phenytoin results in increased expression of PRMT3 mRNA CTD PMID:20345932 NCBI chr11:20,387,563...20,510,861
Ensembl chr11:20,387,558...20,509,338
JBrowse link
G PRSS12 serine protease 12 increases expression EXP Phenytoin results in increased expression of PRSS12 mRNA CTD PMID:14741686 NCBI chr 4:118,280,038...118,353,042
Ensembl chr 4:118,280,038...118,353,003
JBrowse link
G PSIP1 PC4 and SFRS1 interacting protein 1 increases expression ISO Phenytoin results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 9:15,464,066...15,511,004
Ensembl chr 9:15,464,066...15,510,995
JBrowse link
G PSMC6 proteasome 26S subunit, ATPase 6 increases expression ISO Phenytoin results in increased expression of PSMC6 mRNA CTD PMID:20345932 NCBI chr14:52,707,163...52,728,590
Ensembl chr14:52,707,178...52,728,590
JBrowse link
G PSMD12 proteasome 26S subunit, non-ATPase 12 increases expression ISO Phenytoin results in increased expression of PSMD12 mRNA CTD PMID:20345932 NCBI chr17:67,337,916...67,366,598
Ensembl chr17:67,337,916...67,366,605
JBrowse link
G PTBP2 polypyrimidine tract binding protein 2 increases expression ISO Phenytoin results in increased expression of PTBP2 mRNA CTD PMID:20345932 NCBI chr 1:96,721,766...96,823,739
Ensembl chr 1:96,721,665...96,823,738
JBrowse link
G PTCH1 patched 1 increases expression ISO Phenytoin results in increased expression of PTCH1 mRNA CTD PMID:16141649 NCBI chr 9:95,442,980...95,516,971
Ensembl chr 9:95,442,980...95,517,057
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression ISO Phenytoin results in increased expression of PTGS2 mRNA CTD PMID:20345932 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTH parathyroid hormone increases expression EXP Phenytoin results in increased expression of PTH protein CTD PMID:20683115 NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181
JBrowse link
G RAD50 RAD50 double strand break repair protein multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA CTD PMID:21224054 NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349
JBrowse link
G RAI1 retinoic acid induced 1 increases expression ISO Phenytoin results in increased expression of RAI1 mRNA CTD PMID:20345932 NCBI chr17:17,681,376...17,811,453
Ensembl chr17:17,681,458...17,811,453
JBrowse link
G RANBP6 RAN binding protein 6 increases expression ISO Phenytoin results in increased expression of RANBP6 mRNA CTD PMID:20345932 NCBI chr 9:6,011,025...6,015,660
Ensembl chr 9:6,011,025...6,015,625
JBrowse link
G RAPGEF4 Rap guanine nucleotide exchange factor 4 increases expression ISO Phenytoin results in increased expression of RAPGEF4 mRNA CTD PMID:20345932 NCBI chr 2:172,735,282...173,052,893
Ensembl chr 2:172,735,274...173,052,893
JBrowse link
G RARA retinoic acid receptor alpha increases expression
decreases expression
ISO Phenytoin results in increased expression of RARA mRNA
Phenytoin results in decreased expression of RARA mRNA
CTD PMID:9118846 PMID:9988880 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G RARB retinoic acid receptor beta increases expression ISO Phenytoin results in increased expression of RARB mRNA CTD PMID:9988880 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:25,174,332...25,597,932
JBrowse link
G RARG retinoic acid receptor gamma increases expression ISO Phenytoin results in increased expression of RARG mRNA CTD PMID:9988880 NCBI chr12:53,210,569...53,232,231
Ensembl chr12:53,210,567...53,232,980
JBrowse link
G RBM12 RNA binding motif protein 12 increases expression ISO Phenytoin results in increased expression of RBM12 mRNA CTD PMID:20345932 NCBI chr20:35,648,925...35,664,900
Ensembl chr20:35,648,925...35,664,956
JBrowse link
G RBM3 RNA binding motif protein 3 increases expression ISO Phenytoin results in increased expression of RBM3 mRNA CTD PMID:20345932 NCBI chr  X:48,574,484...48,581,162
Ensembl chr  X:48,574,449...48,581,162
JBrowse link
G RBM34 RNA binding motif protein 34 increases expression ISO Phenytoin results in increased expression of RBM34 mRNA CTD PMID:20345932 NCBI chr 1:235,131,183...235,161,280
Ensembl chr 1:235,131,183...235,161,283
JBrowse link
G RBP2 retinol binding protein 2 increases expression ISO Phenytoin results in increased expression of RBP2 mRNA CTD PMID:9118846 NCBI chr 3:139,452,884...139,476,516
Ensembl chr 3:139,452,884...139,480,747
JBrowse link
G RDH14 retinol dehydrogenase 14 increases expression ISO Phenytoin results in increased expression of RDH14 mRNA CTD PMID:20345932 NCBI chr 2:18,554,723...18,560,653
Ensembl chr 2:18,554,723...18,560,679
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
EXP
ISO
Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
Phenytoin results in increased activity of RELA protein
CTD PMID:10700573 PMID:15322231 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RHOA ras homolog family member A decreases expression ISO Phenytoin results in decreased expression of RHOA mRNA CTD PMID:15136057 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G RIOK2 RIO kinase 2 increases expression ISO Phenytoin results in increased expression of RIOK2 mRNA CTD PMID:20345932 NCBI chr 5:97,160,867...97,183,247
Ensembl chr 5:97,160,867...97,183,247
JBrowse link
G RNASEH1 ribonuclease H1 decreases expression ISO Phenytoin results in decreased expression of RNASEH1 mRNA CTD PMID:20345932 NCBI chr 2:3,531,813...3,558,367
Ensembl chr 2:3,541,430...3,558,333
JBrowse link
G RND1 Rho family GTPase 1 increases expression ISO Phenytoin results in increased expression of RND1 mRNA CTD PMID:20345932 NCBI chr12:48,857,145...48,865,870
Ensembl chr12:48,857,145...48,865,870
JBrowse link
G RNF115 ring finger protein 115 increases expression ISO Phenytoin results in increased expression of RNF115 mRNA CTD PMID:20345932 NCBI chr 1:145,738,868...145,824,095
Ensembl chr 1:145,738,868...145,824,095
JBrowse link
G RPE ribulose-5-phosphate-3-epimerase increases expression ISO Phenytoin results in increased expression of RPE mRNA CTD PMID:20345932 NCBI chr 2:210,002,628...210,023,363
Ensembl chr 2:210,002,565...210,022,260
JBrowse link
G RPL28 ribosomal protein L28 increases expression EXP Phenytoin results in increased expression of RPL28 mRNA CTD PMID:14741686 NCBI chr19:55,385,932...55,403,342
Ensembl chr19:55,385,345...55,403,250
Ensembl chr19:55,385,345...55,403,250
JBrowse link
G RPS6KA3 ribosomal protein S6 kinase A3 increases expression ISO Phenytoin results in increased expression of RPS6KA3 mRNA CTD PMID:20345932 NCBI chr  X:20,149,911...20,267,514
Ensembl chr  X:20,149,911...20,267,519
JBrowse link
G RPSA ribosomal protein SA increases expression EXP Phenytoin results in increased expression of RPSA mRNA CTD PMID:14741686 NCBI chr 3:39,406,720...39,412,542
Ensembl chr 3:39,406,716...39,412,542
JBrowse link
G RSRC1 arginine and serine rich coiled-coil 1 decreases expression ISO Phenytoin results in decreased expression of RSRC1 mRNA CTD PMID:20345932 NCBI chr 3:158,110,052...158,545,730
Ensembl chr 3:158,105,855...158,545,730
JBrowse link
G RYR2 ryanodine receptor 2 increases expression ISO Phenytoin results in increased expression of RYR2 mRNA CTD PMID:20345932 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G S100A10 S100 calcium binding protein A10 increases expression EXP Phenytoin results in increased expression of S100A10 mRNA CTD PMID:14741686 NCBI chr 1:151,982,915...151,993,859
Ensembl chr 1:151,982,915...151,993,859
JBrowse link
G S100A4 S100 calcium binding protein A4 increases expression EXP Phenytoin results in increased expression of S100A4 mRNA CTD PMID:14741686 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G S100A8 S100 calcium binding protein A8 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA CTD PMID:23986454 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073
JBrowse link
G S100A9 S100 calcium binding protein A9 multiple interactions
increases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA
Phenytoin results in increased expression of S100A9 mRNA
CTD PMID:23986454 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
JBrowse link
G SART3 spliceosome associated factor 3, U4/U6 recycling protein increases expression ISO Phenytoin results in increased expression of SART3 mRNA CTD PMID:20345932 NCBI chr12:108,522,214...108,561,173
Ensembl chr12:108,522,214...108,561,400
JBrowse link
G SC5D sterol-C5-desaturase increases expression EXP Phenytoin results in increased expression of SC5D mRNA CTD PMID:14741686 NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410
JBrowse link
G SCAF1 SR-related CTD associated factor 1 increases expression ISO Phenytoin results in increased expression of SCAF1 mRNA CTD PMID:20345932 NCBI chr19:49,640,481...49,658,642
Ensembl chr19:49,642,209...49,658,642
JBrowse link
G SCARB1 scavenger receptor class B member 1 decreases expression ISO Phenytoin results in decreased expression of SCARB1 mRNA CTD PMID:15136057 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 affects response to substance EXP SCN1A gene polymorphism affects the susceptibility to Phenytoin; SCN1A protein affects the susceptibility to Phenytoin CTD PMID:15805193 PMID:17001291 NCBI chr 2:165,984,641...166,149,161
Ensembl chr 2:165,984,641...166,149,214
JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 affects binding
decreases response to substance
multiple interactions
EXP Phenytoin binds to [SCN1B protein binds to SCN3A protein]
SCN1B protein mutant form results in decreased susceptibility to Phenytoin
Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449
JBrowse link
G SCN2A sodium voltage-gated channel alpha subunit 2 decreases activity EXP Phenytoin results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 2:165,208,056...165,392,310
Ensembl chr 2:165,194,993...165,392,310
JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 multiple interactions
affects binding
EXP Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
Phenytoin binds to [SCN1B protein binds to SCN3A protein]
CTD PMID:15922564 NCBI chr 2:165,087,526...165,204,295
Ensembl chr 2:165,087,526...165,204,050
Ensembl chr 2:165,087,526...165,204,050
JBrowse link
G SDC4 syndecan 4 decreases expression ISO Phenytoin results in decreased expression of SDC4 mRNA CTD PMID:15136057 NCBI chr20:45,325,288...45,348,424
Ensembl chr20:45,325,288...45,348,424
JBrowse link
G SELE selectin E multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SENP7 SUMO specific peptidase 7 increases expression ISO Phenytoin results in increased expression of SENP7 mRNA CTD PMID:20345932 NCBI chr 3:101,324,205...101,513,883
Ensembl chr 3:101,324,205...101,513,241
JBrowse link
G SERPINC1 serpin family C member 1 multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 1:173,903,800...173,917,327
Ensembl chr 1:173,903,804...173,917,378
Ensembl chr 1:173,903,804...173,917,378
Ensembl chr 1:173,903,804...173,917,378
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA CTD PMID:21224054 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SH3YL1 SH3 and SYLF domain containing 1 increases expression ISO Phenytoin results in increased expression of SH3YL1 mRNA CTD PMID:20345932 NCBI chr 2:218,136...264,824
Ensembl chr 2:217,730...266,398
JBrowse link
G SHH sonic hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of SHH mRNA CTD PMID:26272751 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463
JBrowse link
G SIAH1 siah E3 ubiquitin protein ligase 1 increases expression ISO Phenytoin results in increased expression of SIAH1A mRNA CTD PMID:20345932 NCBI chr16:48,354,581...48,448,435
Ensembl chr16:48,356,364...48,448,402
JBrowse link
G SIPA1L1 signal induced proliferation associated 1 like 1 increases expression ISO Phenytoin results in increased expression of SIPA1L1 mRNA CTD PMID:20345932 NCBI chr14:71,320,418...71,741,209
Ensembl chr14:71,320,449...71,741,229
JBrowse link
G SLC22A7 solute carrier family 22 member 7 decreases expression ISO Phenytoin results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 6:43,295,710...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link
G SLC4A3 solute carrier family 4 member 3 increases expression ISO Phenytoin results in increased expression of SLC4A3 mRNA CTD PMID:20345932 NCBI chr 2:219,627,630...219,641,980
Ensembl chr 2:219,627,394...219,641,980
JBrowse link
G SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 increases expression ISO Phenytoin results in increased expression of SMARCA1 mRNA CTD PMID:20345932 NCBI chr  X:129,446,501...129,523,520
Ensembl chr  X:129,446,501...129,523,500
JBrowse link
G SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 increases expression ISO Phenytoin results in increased expression of SMARCA5 mRNA CTD PMID:20345932 NCBI chr 4:143,513,501...143,557,486
Ensembl chr 4:143,513,702...143,557,486
JBrowse link
G SMC2 structural maintenance of chromosomes 2 increases expression ISO Phenytoin results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 9:104,093,760...104,141,419
Ensembl chr 9:104,094,260...104,141,419
JBrowse link
G SMC3 structural maintenance of chromosomes 3 increases expression EXP Phenytoin results in increased expression of SMC3 mRNA CTD PMID:14741686 NCBI chr10:110,567,695...110,606,048
Ensembl chr10:110,567,691...110,604,636
Ensembl chr10:110,567,691...110,604,636
JBrowse link
G SMC5 structural maintenance of chromosomes 5 increases expression ISO Phenytoin results in increased expression of SMC5 mRNA CTD PMID:20345932 NCBI chr 9:70,258,962...70,354,873
Ensembl chr 9:70,258,978...70,354,873
JBrowse link
G SNX2 sorting nexin 2 increases expression ISO Phenytoin results in increased expression of SNX2 mRNA CTD PMID:20345932 NCBI chr 5:122,774,996...122,834,543
Ensembl chr 5:122,775,079...122,834,543
JBrowse link
G SP3 Sp3 transcription factor increases expression EXP Phenytoin results in increased expression of SP3 mRNA CTD PMID:14741686 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,702
JBrowse link
G ST13 ST13 Hsp70 interacting protein increases expression ISO Phenytoin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639
JBrowse link
G STAT4 signal transducer and activator of transcription 4 decreases expression EXP Phenytoin results in decreased expression of STAT4 mRNA CTD PMID:14741686 NCBI chr 2:191,029,576...191,172,684
Ensembl chr 2:191,029,576...191,151,596
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases expression ISO Phenytoin results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 PMID:17381134 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
Ensembl chr16:28,605,196...28,623,625
JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 decreases expression ISO Phenytoin results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
JBrowse link
G SYN1 synapsin I decreases expression
multiple interactions
ISO Phenytoin results in decreased expression of SYN1 mRNA
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA]
CTD PMID:27413119 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857
JBrowse link
G SYP synaptophysin decreases expression
multiple interactions
ISO Phenytoin results in decreased expression of SYP mRNA
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA]
CTD PMID:27413119 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,815...49,200,199
Ensembl chr  X:49,187,815...49,200,199
JBrowse link
G SYPL1 synaptophysin like 1 increases expression ISO Phenytoin results in increased expression of SYPL mRNA CTD PMID:20345932 NCBI chr 7:106,090,505...106,112,576
Ensembl chr 7:106,090,503...106,112,576
Ensembl chr 7:106,090,503...106,112,576
JBrowse link
G TAF9B TATA-box binding protein associated factor 9b increases expression ISO Phenytoin results in increased expression of TAF9B mRNA CTD PMID:20345932 NCBI chr  X:78,129,748...78,139,650
Ensembl chr  X:78,129,748...78,139,650
JBrowse link
G TBX21 T-box transcription factor 21 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA
Phenytoin results in decreased expression of TBX21 mRNA
CTD PMID:23986454 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
JBrowse link
G TCEAL1 transcription elongation factor A like 1 increases expression ISO Phenytoin results in increased expression of TCEAL1 mRNA CTD PMID:20345932 NCBI chr  X:103,628,716...103,630,953
Ensembl chr  X:103,628,704...103,630,953
JBrowse link
G TCF15 transcription factor 15 decreases expression EXP Phenytoin results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr20:604,257...610,309
Ensembl chr20:603,797...610,398
JBrowse link
G TERF1 telomeric repeat binding factor 1 increases expression ISO Phenytoin results in increased expression of TERF1 mRNA CTD PMID:20345932 NCBI chr 8:73,008,856...73,048,123
Ensembl chr 8:73,008,864...73,048,123
Ensembl chr 8:73,008,864...73,048,123
JBrowse link
G TGFA transforming growth factor alpha increases expression ISO Phenytoin results in increased expression of TGFA mRNA CTD PMID:9988880 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
decreases expression
ISO Phenytoin results in increased expression of TGFB1 mRNA
Phenytoin results in decreased expression of TGFB1 mRNA
CTD PMID:7841657 PMID:9988880 PMID:16141649 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB2 transforming growth factor beta 2 decreases expression ISO Phenytoin results in decreased expression of TGFB2 mRNA CTD PMID:9118846 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFB3 transforming growth factor beta 3 increases expression EXP Phenytoin results in increased expression of TGFB3 mRNA CTD PMID:14741686 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link
G THOC6 THO complex 6 decreases expression ISO Phenytoin results in decreased expression of THOC6 mRNA CTD PMID:20345932 NCBI chr16:3,024,035...3,027,750
Ensembl chr16:3,024,027...3,027,755
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP Phenytoin results in increased expression of TIMP1 mRNA; Phenytoin results in increased expression of TIMP1 protein CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TKT transketolase increases expression ISO Phenytoin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr 3:53,224,712...53,256,052
Ensembl chr 3:53,224,712...53,256,052
JBrowse link
G TLR2 toll like receptor 2 multiple interactions
increases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA
Phenytoin results in increased expression of TLR2 mRNA
CTD PMID:23986454 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR4 toll like receptor 4 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
Phenytoin results in decreased expression of TLR4 mRNA
CTD PMID:23986454 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TLR9 toll like receptor 9 multiple interactions
decreases expression
ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA
Phenytoin results in decreased expression of TLR9 mRNA
CTD PMID:23986454 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,226,163
Ensembl chr 3:52,221,080...52,226,163
JBrowse link
G TNF tumor necrosis factor increases expression EXP Phenytoin results in increased expression of TNF mRNA CTD PMID:14741686 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA CTD PMID:21224054 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TP53 tumor protein p53 increases expression EXP Phenytoin results in increased expression of TP53 mRNA CTD PMID:11134551 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP53BP2 tumor protein p53 binding protein 2 increases expression ISO Phenytoin results in increased expression of TRP53BP2 mRNA CTD PMID:20345932 NCBI chr 1:223,779,893...223,845,954
Ensembl chr 1:223,779,893...223,845,954
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA CTD PMID:21224054 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909
JBrowse link
G TRMT10B tRNA methyltransferase 10B increases expression ISO Phenytoin results in increased expression of TRMT10B mRNA CTD PMID:20345932 NCBI chr 9:37,753,204...37,780,459
Ensembl chr 9:37,753,803...37,778,972
JBrowse link
G TUT4 terminal uridylyl transferase 4 increases expression ISO Phenytoin results in increased expression of TUT4 mRNA CTD PMID:20345932 NCBI chr 1:52,423,275...52,553,463
Ensembl chr 1:52,408,282...52,553,487
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression ISO Phenytoin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UBE2D2 ubiquitin conjugating enzyme E2 D2 increases expression ISO Phenytoin results in increased expression of UBE2D2 mRNA CTD PMID:20345932 NCBI chr 5:139,561,286...139,628,434
Ensembl chr 5:139,526,431...139,628,434
JBrowse link
G UBL5 ubiquitin like 5 decreases expression ISO Phenytoin results in decreased expression of UBL5 mRNA CTD PMID:20345932 NCBI chr19:9,827,918...9,830,115
Ensembl chr19:9,827,892...9,830,115
JBrowse link
G UBR1 ubiquitin protein ligase E3 component n-recognin 1 increases expression ISO Phenytoin results in increased expression of UBR1 mRNA CTD PMID:20345932 NCBI chr15:42,942,897...43,106,038
Ensembl chr15:42,942,897...43,106,113
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase decreases expression ISO Phenytoin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 affects expression
increases activity
multiple interactions
increases expression
EXP
ISO
Phenytoin affects the expression of UGT1A1 mRNA
Phenytoin results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of and results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of UGT1A1 mRNA
Phenytoin results in increased expression of UGT1A1 mRNA; Phenytoin results in increased expression of UGT1A1 protein
CTD PMID:10421657 PMID:15849716 PMID:17381134 PMID:27413119 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Phenytoin results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases expression ISO Phenytoin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,184...68,568,527
JBrowse link
G UNCX UNC homeobox decreases expression EXP Phenytoin results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 7:1,232,872...1,237,326
Ensembl chr 7:1,232,872...1,237,326
JBrowse link
G UNG uracil DNA glycosylase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA CTD PMID:21224054 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,574...109,110,992
Ensembl chr12:109,097,574...109,110,992
JBrowse link
G VARS2 valyl-tRNA synthetase 2, mitochondrial increases expression ISO Phenytoin results in increased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr 6:30,914,238...30,926,459
Ensembl chr 6:30,914,205...30,926,459
JBrowse link
G VCAN versican increases expression EXP Phenytoin results in increased expression of VCAN mRNA CTD PMID:14741686 NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303
JBrowse link
G VEGFB vascular endothelial growth factor B decreases expression EXP Phenytoin results in decreased expression of VEGFB mRNA CTD PMID:14741686 NCBI chr11:64,234,584...64,239,264
Ensembl chr11:64,234,538...64,238,793
Ensembl chr11:64,234,538...64,238,793
JBrowse link
G VIM vimentin increases expression EXP Phenytoin results in increased expression of VIM mRNA CTD PMID:14741686 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G WNT1 Wnt family member 1 decreases expression ISO Phenytoin results in decreased expression of WNT1 mRNA CTD PMID:7841657 NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620
JBrowse link
G WNT3 Wnt family member 3 decreases expression ISO Phenytoin results in decreased expression of WNT3 mRNA CTD PMID:26272751 NCBI chr17:46,762,506...46,818,692
Ensembl chr17:46,762,506...46,833,154
JBrowse link
G WNT5A Wnt family member 5A increases expression EXP Phenytoin results in increased expression of WNT5A mRNA CTD PMID:31711903 NCBI chr 3:55,465,715...55,505,261
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
G XRCC4 X-ray repair cross complementing 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 NCBI chr 5:83,077,534...83,370,333
Ensembl chr 5:83,077,498...83,353,787
JBrowse link
G YME1L1 YME1 like 1 ATPase increases expression ISO Phenytoin results in increased expression of YME1L1 mRNA CTD PMID:20345932 NCBI chr10:27,110,111...27,155,051
Ensembl chr10:27,110,111...27,155,266
Ensembl chr10:27,110,111...27,155,266
JBrowse link
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 decreases expression ISO Phenytoin results in decreased expression of ZAP70 mRNA CTD PMID:15136057 NCBI chr 2:97,712,030...97,744,327
Ensembl chr 2:97,713,576...97,739,862
Ensembl chr 2:97,713,576...97,739,862
JBrowse link
G ZNF131 zinc finger protein 131 increases expression ISO Phenytoin results in increased expression of ZFP131 mRNA CTD PMID:20345932 NCBI chr 5:43,120,914...43,176,324
Ensembl chr 5:43,065,176...43,192,021
JBrowse link
G ZNF503 zinc finger protein 503 increases expression ISO Phenytoin results in increased expression of ZFP503 mRNA CTD PMID:20345932 NCBI chr10:75,279,725...75,401,916
Ensembl chr10:75,397,830...75,401,764
JBrowse link
G ZNF638 zinc finger protein 638 increases expression ISO Phenytoin results in increased expression of ZFP638 mRNA CTD PMID:20345932 NCBI chr 2:71,331,782...71,435,061
Ensembl chr 2:71,276,561...71,435,069
JBrowse link
G ZSCAN21 zinc finger and SCAN domain containing 21 increases expression ISO Phenytoin results in increased expression of ZSCAN21 mRNA CTD PMID:20345932 NCBI chr 7:100,049,774...100,065,041
Ensembl chr 7:100,049,774...100,065,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24487
    role 24398
      biological role 24365
        aetiopathogenetic role 23204
          teratogenic agent 17749
            phenytoin 406
Path 2
Term Annotations click to browse term
  CHEBI ontology 24487
    subatomic particle 24444
      composite particle 24444
        hadron 24444
          baryon 24444
            nucleon 24444
              atomic nucleus 24444
                atom 24444
                  main group element atom 24301
                    p-block element atom 24301
                      carbon group element atom 24085
                        carbon atom 24046
                          organic molecular entity 24046
                            organic molecule 23928
                              organic cyclic compound 23125
                                organic heterocyclic compound 21323
                                  organic heteromonocyclic compound 17979
                                    diazolidine 591
                                      imidazolidines 581
                                        imidazolidinone 483
                                          imidazolidine-2,4-dione 461
                                            hydantoin 412
                                              phenytoin 406
paths to the root