Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenytoin
go back to main search page
Accession:CHEBI:8107 term browser browse the term
Definition:A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Synonyms:related_synonym: 5,5-Diphenyl-imidazolidine-2,4-dione;   5,5-diphenylimidazolidine-2,4-dione;   5,5-diphenyltetrahydro-1H-2,4-imidazoledione;   DILANTIN;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19);   InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N;   PHENTYTOIN;   SMILES=O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1;   fenitoina;   phenytoine;   phenytoinum
 alt_id: CHEBI:100921
 xref: Beilstein:384532;   CAS:57-41-0;   DrugBank:DB00252;   Drug_Central:2152;   HMDB:HMDB0014397;   KEGG:C07443;   KEGG:D00512;   LINCS:LSM-5663
 xref_mesh: MESH:D010672
 xref: PMID:10698828;   PMID:12952753;   PMID:15246836;   PMID:15744730;   PMID:16303054;   PMID:7105825;   PMID:7602118;   PMID:9186244;   Patent:WO2012174723;   Reaxys:384532;   Wikipedia:Phenytoin


show annotations for term's descendants           Sort by:
phenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AAAS aladin WD repeat nucleoporin decreases expression ISO Phenytoin results in decreased expression of AAAS mRNA CTD PMID:20345932 NCBI chr12:53,307,460...53,321,610
Ensembl chr12:53,307,456...53,324,864 		JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 decreases expression ISO Phenytoin results in decreased expression of ABCA1 mRNA CTD PMID:15136057 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
multiple interactions
increases expression
increases transport
affects abundance
decreases activity
increases metabolic processing		 EXP
ISO		 ABCB1 protein affects the susceptibility to Phenytoin
Amino Acids, Peptides, and Proteins inhibits the reaction [Phenytoin results in increased expression of ABCB1 protein]; Phenytoin results in increased expression of and results in increased activity of ABCB1A protein
ABCB1A protein results in increased transport of Phenytoin
ABCB1 protein affects the abundance of Phenytoin
Phenytoin results in decreased activity of ABCB1 protein
ABCB1 protein results in increased metabolism of Phenytoin		 CTD PMID:8001500 PMID:10580886 PMID:14749549 PMID:15569486 PMID:16220110 More... NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) multiple interactions
increases expression		 ISO KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein] CTD PMID:18473823 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases expression
affects response to substance		 ISO
EXP		 ABCC2 protein affects the transport of Phenytoin
KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]
ABCC2 protein affects the susceptibility to Phenytoin		 CTD PMID:12663688 PMID:14636316 PMID:17376120 PMID:18473823 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO Phenytoin results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 decreases expression ISO Phenytoin results in decreased expression of ABCG1 mRNA CTD PMID:15136057 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G ABHD5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase increases expression ISO Phenytoin results in increased expression of ABHD5 mRNA CTD PMID:20345932 NCBI chr 3:43,690,870...43,734,371
Ensembl chr 3:43,690,108...43,734,371 		JBrowse link
G ABLIM1 actin binding LIM protein 1 decreases expression ISO Phenytoin results in decreased expression of ABLIM1 mRNA CTD PMID:15136057 NCBI chr10:114,431,110...114,801,373
Ensembl chr10:114,431,112...114,768,061 		JBrowse link
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Phenytoin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) increases activity ISO Phenytoin results in increased activity of ACHE protein CTD PMID:16946593 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 decreases expression EXP Phenytoin results in decreased expression of ADAM8 mRNA CTD PMID:14741686 NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868 		JBrowse link
G ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 increases expression ISO Phenytoin results in increased expression of ADAMTS9 mRNA CTD PMID:20345932 NCBI chr 3:64,515,654...64,688,000
Ensembl chr 3:64,515,654...64,688,000 		JBrowse link
G ADGRB3 adhesion G protein-coupled receptor B3 increases expression ISO Phenytoin results in increased expression of ADGRB3 mRNA CTD PMID:20345932 NCBI chr 6:68,635,282...69,389,506
Ensembl chr 6:68,635,282...69,390,571 		JBrowse link
G ADRB3 adrenoceptor beta 3 decreases expression ISO Phenytoin results in decreased expression of ADRB3 mRNA CTD PMID:20345932 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599 		JBrowse link
G AFP alpha fetoprotein decreases expression EXP
ISO		 Phenytoin results in decreased expression of AFP mRNA CTD PMID:14741686 PMID:26272751 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 decreases expression ISO Phenytoin results in decreased expression of AGAP3 mRNA CTD PMID:20345932 NCBI chr 7:151,085,867...151,144,434
Ensembl chr 7:151,085,831...151,144,436 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
increases expression		 ISO CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]		 CTD PMID:17505019 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKAP10 A-kinase anchoring protein 10 increases expression ISO Phenytoin results in increased expression of AKAP10 mRNA CTD PMID:20345932 NCBI chr17:19,904,302...19,977,828
Ensembl chr17:19,904,302...19,978,343 		JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 decreases expression
increases expression		 ISO Phenytoin results in decreased expression of AKR7A3 mRNA
Phenytoin results in increased expression of AKR7A3 mRNA		 CTD PMID:17381134 NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO Phenytoin results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 decreases expression EXP Phenytoin results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G AMN1 antagonist of mitotic exit network 1 homolog increases expression ISO Phenytoin results in increased expression of AMN1 mRNA CTD PMID:20345932 NCBI chr12:31,671,137...31,729,174
Ensembl chr12:31,671,142...31,729,121 		JBrowse link
G ANXA4 annexin A4 increases expression EXP Phenytoin results in increased expression of ANXA4 mRNA CTD PMID:14741686 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112 		JBrowse link
G ANXA5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 4:121,667,946...121,696,980
Ensembl chr 4:121,667,946...121,696,995 		JBrowse link
G APOA1 apolipoprotein A1 increases expression ISO Phenytoin results in increased expression of APOA1 mRNA CTD PMID:15136057 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622 		JBrowse link
G APOA4 apolipoprotein A4 increases expression ISO Phenytoin results in increased expression of APOA4 mRNA CTD PMID:15136057 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304 		JBrowse link
G APOE apolipoprotein E increases expression ISO Phenytoin results in increased expression of APOE mRNA CTD PMID:15136057 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G AR androgen receptor multiple interactions
increases expression
increases activity		 ISO [Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Phenytoin results in increased expression of AR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Phenytoin results in increased expression of AR mRNA; Phenytoin results in increased expression of AR protein
Phenytoin results in increased activity of AR protein		 CTD PMID:19226368 PMID:19490052 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARFIP1 ADP ribosylation factor interacting protein 1 increases expression ISO Phenytoin results in increased expression of ARFIP1 mRNA CTD PMID:20345932 NCBI chr 4:152,779,954...152,912,357
Ensembl chr 4:152,779,937...152,918,463 		JBrowse link
G ARHGAP39 Rho GTPase activating protein 39 increases expression ISO Phenytoin results in increased expression of ARHGAP39 mRNA CTD PMID:20345932 NCBI chr 8:144,529,179...144,700,362
Ensembl chr 8:144,529,179...144,685,846 		JBrowse link
G ARMC8 armadillo repeat containing 8 increases expression ISO Phenytoin results in increased expression of ARMC8 mRNA CTD PMID:20345932 NCBI chr 3:138,187,248...138,298,389
Ensembl chr 3:138,187,248...138,298,384 		JBrowse link
G ATM ATM serine/threonine kinase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein CTD PMID:21224054 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102 		JBrowse link
G ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression ISO Phenytoin results in decreased expression of ATPAF1 mRNA CTD PMID:20345932 NCBI chr 1:46,632,737...46,668,557
Ensembl chr 1:46,632,737...46,673,867 		JBrowse link
G B4GALT7 beta-1,4-galactosyltransferase 7 decreases expression ISO Phenytoin results in decreased expression of B4GALT7 mRNA CTD PMID:20345932 NCBI chr 5:177,600,132...177,610,330
Ensembl chr 5:177,600,132...177,610,330 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA CTD PMID:21224054 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 Phenytoin results in increased expression of and affects the localization of BCL2 protein
Phenytoin results in decreased expression of BCL2 mRNA		 CTD PMID:9118846 PMID:10695937 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA CTD PMID:21224054 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BMP1 bone morphogenetic protein 1 decreases expression EXP Phenytoin results in decreased expression of BMP1 mRNA CTD PMID:14741686 NCBI chr 8:22,165,372...22,212,326
Ensembl chr 8:22,165,140...22,212,326 		JBrowse link
G BMP4 bone morphogenetic protein 4 increases expression ISO Phenytoin results in increased expression of BMP4 mRNA CTD PMID:16141649 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G C2 complement C2 decreases expression ISO Phenytoin results in decreased expression of C2 mRNA CTD PMID:20345932 NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,673 		JBrowse link
G CA6 carbonic anhydrase 6 increases expression ISO Phenytoin results in increased expression of CAR6 mRNA CTD PMID:20345932 NCBI chr 1:8,945,868...8,975,092
Ensembl chr 1:8,945,867...8,975,092 		JBrowse link
G CACYBP calcyclin binding protein increases expression ISO Phenytoin results in increased expression of CACYBP mRNA CTD PMID:20345932 NCBI chr 1:174,999,435...175,012,027
Ensembl chr 1:174,999,163...175,012,027 		JBrowse link
G CALCA calcitonin related polypeptide alpha decreases expression ISO Phenytoin results in decreased expression of CALCA protein CTD PMID:2470235 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CALM2 calmodulin 2 decreases expression EXP Phenytoin results in decreased expression of CALM2 mRNA CTD PMID:14741686 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,084...47,176,921 		JBrowse link
G CAPN5 calpain 5 decreases expression EXP Phenytoin results in decreased expression of CAPN5 mRNA CTD PMID:14741686 NCBI chr11:77,066,971...77,126,155
Ensembl chr11:77,066,961...77,126,155 		JBrowse link
G CASKIN1 CASK interacting protein 1 affects expression ISO Phenytoin affects the expression of CASKIN1 mRNA CTD PMID:20345932 NCBI chr16:2,177,180...2,196,605
Ensembl chr16:2,177,180...2,196,605 		JBrowse link
G CASP10 caspase 10 increases expression EXP Phenytoin results in increased expression of CASP10 mRNA CTD PMID:14741686 NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428 		JBrowse link
G CAT catalase decreases response to substance EXP CAT protein results in decreased susceptibility to Phenytoin CTD PMID:21252394 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CBLL1 Cbl proto-oncogene like 1 increases expression ISO Phenytoin results in increased expression of CBLL1 mRNA CTD PMID:20345932 NCBI chr 7:107,744,142...107,761,667
Ensembl chr 7:107,743,073...107,761,667 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Phenytoin results in increased expression of CCL2 protein CTD PMID:14578793 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCNC cyclin C increases expression ISO Phenytoin results in increased expression of CCNC mRNA CTD PMID:20345932 NCBI chr 6:99,542,387...99,568,814
Ensembl chr 6:99,542,387...99,568,825 		JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression		 ISO
EXP		 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA
Phenytoin results in decreased expression of CCND1 mRNA		 CTD PMID:14741686 PMID:21224054 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNG1 cyclin G1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,446,151 		JBrowse link
G CD47 CD47 molecule decreases expression ISO Phenytoin results in decreased expression of CD47 mRNA CTD PMID:17381134 NCBI chr 3:108,043,091...108,091,031
Ensembl chr 3:108,043,091...108,091,862 		JBrowse link
G CDH2 cadherin 2 decreases expression ISO Phenytoin results in decreased expression of CDH2 mRNA CTD PMID:9118846 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression ISO Phenytoin results in decreased expression of CDK1 mRNA CTD PMID:26272751 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression
multiple interactions		 EXP
ISO		 Phenytoin results in decreased expression of CDKN1A mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein		 CTD PMID:14741686 PMID:21224054 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDX2 caudal type homeobox 2 increases expression ISO Phenytoin results in increased expression of CDX2 mRNA CTD PMID:20345932 NCBI chr13:27,960,918...27,969,315
Ensembl chr13:27,960,918...27,969,315 		JBrowse link
G CELA2A chymotrypsin like elastase 2A decreases expression EXP Phenytoin results in decreased expression of CELA2A mRNA CTD PMID:14741686 NCBI chr 1:15,456,732...15,472,091
Ensembl chr 1:15,456,728...15,472,091 		JBrowse link
G CEP57 centrosomal protein 57 increases expression ISO Phenytoin results in increased expression of CEP57 mRNA CTD PMID:20345932 NCBI chr11:95,790,498...95,832,693
Ensembl chr11:95,789,965...95,832,693 		JBrowse link
G CER1 cerberus 1, DAN family BMP antagonist decreases expression ISO Phenytoin results in decreased expression of CER1 mRNA CTD PMID:26272751 NCBI chr 9:14,717,326...14,722,733
Ensembl chr 9:14,719,724...14,722,733 		JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CKM creatine kinase, M-type increases expression EXP Phenytoin results in increased expression of CKM protein CTD PMID:6682525 NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875 		JBrowse link
G CLCN6 chloride voltage-gated channel 6 decreases expression ISO Phenytoin results in decreased expression of CLCN6 mRNA CTD PMID:20345932 NCBI chr 1:11,806,191...11,843,130
Ensembl chr 1:11,806,096...11,848,079 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 increases expression ISO Phenytoin results in increased expression of CMPK1 mRNA CTD PMID:20345932 NCBI chr 1:47,333,790...47,378,839
Ensembl chr 1:47,333,790...47,394,866 		JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 increases expression ISO Phenytoin results in increased expression of CNOT7 mRNA CTD PMID:20345932 NCBI chr 8:17,224,966...17,246,857
Ensembl chr 8:17,224,966...17,246,878 		JBrowse link
G COL11A1 collagen type XI alpha 1 chain increases expression EXP Phenytoin results in increased expression of COL11A1 mRNA CTD PMID:14741686 NCBI chr 1:102,876,473...103,108,522
Ensembl chr 1:102,876,467...103,108,872 		JBrowse link
G COL18A1 collagen type XVIII alpha 1 chain decreases expression EXP Phenytoin results in decreased expression of COL18A1 mRNA CTD PMID:14741686 NCBI chr21:45,405,165...45,513,720
Ensembl chr21:45,405,165...45,513,720 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
increases expression
decreases expression		 EXP Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
Phenytoin results in increased expression of COL1A1 mRNA
Phenytoin results in decreased expression of COL1A1 mRNA		 CTD PMID:8971655 PMID:14741686 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL1A2 collagen type I alpha 2 chain increases expression
affects expression		 EXP
ISO		 Phenytoin results in increased expression of COL1A2 mRNA
Phenytoin affects the expression of COL1A2 mRNA		 CTD PMID:14741686 PMID:24704097 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G COL6A1 collagen type VI alpha 1 chain decreases expression
increases expression		 EXP Phenytoin results in decreased expression of COL6A1 mRNA
Phenytoin results in increased expression of COL6A1 mRNA		 CTD PMID:8224229 PMID:14741686 NCBI chr21:45,981,770...46,005,048
Ensembl chr21:45,981,770...46,005,050 		JBrowse link
G COL6A2 collagen type VI alpha 2 chain increases expression EXP Phenytoin results in increased expression of COL6A2 mRNA CTD PMID:8224229 NCBI chr21:46,098,112...46,132,848
Ensembl chr21:46,098,112...46,132,848 		JBrowse link
G COL6A3 collagen type VI alpha 3 chain increases expression EXP Phenytoin results in increased expression of COL6A3 mRNA CTD PMID:8224229 NCBI chr 2:237,324,018...237,414,164
Ensembl chr 2:237,324,003...237,414,328 		JBrowse link
G CP ceruloplasmin decreases expression ISO Phenytoin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829 		JBrowse link
G CPSF6 cleavage and polyadenylation specific factor 6 increases expression ISO Phenytoin results in increased expression of CPSF6 mRNA CTD PMID:20345932 NCBI chr12:69,239,569...69,274,358
Ensembl chr12:69,239,569...69,274,358 		JBrowse link
G CRH corticotropin releasing hormone affects expression ISO Phenytoin affects the expression of CRH mRNA CTD PMID:20345932 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G CRPPA CDP-L-ribitol pyrophosphorylase A increases expression ISO Phenytoin results in increased expression of CRPPA mRNA CTD PMID:20345932 NCBI chr 7:16,087,525...16,421,538
Ensembl chr 7:16,087,525...16,502,504 		JBrowse link
G CTSB cathepsin B increases expression
decreases activity		 EXP Phenytoin results in increased expression of CTSB mRNA
Phenytoin results in decreased activity of CTSB protein		 CTD PMID:10914799 PMID:14741686 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533 		JBrowse link
G CTSL cathepsin L decreases activity
increases expression		 EXP Phenytoin results in decreased activity of CTSL protein
Phenytoin results in increased expression of CTSL mRNA		 CTD PMID:10914799 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469 		JBrowse link
G CUL4A cullin 4A increases expression ISO Phenytoin results in increased expression of CUL4A mRNA CTD PMID:20345932 NCBI chr13:113,208,193...113,267,108
Ensembl chr13:113,208,193...113,267,108 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 increases expression ISO Phenytoin results in increased expression of CX3CL1 mRNA CTD PMID:20345932 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA CTD PMID:21224054 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA] CTD PMID:23986454 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity EXP Phenytoin results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO
EXP		 Phenytoin results in increased expression of CYP1A1 mRNA CTD PMID:9860486 PMID:17381134 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA CTD PMID:21224054 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
decreases expression
increases expression
increases activity		 EXP
ISO		 [Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein; pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]
Phenytoin results in decreased expression of CYP2B10 protein
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
Phenytoin results in increased expression of CYP2B6 mRNA; Phenytoin results in increased expression of CYP2B6 protein
Phenytoin results in increased activity of CYP2B6 protein		 CTD PMID:12571232 PMID:12695351 PMID:14977870 PMID:15123723 PMID:17041008 More... NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases hydroxylation
increases metabolic processing
multiple interactions
decreases metabolic processing
increases hydroxylation
affects metabolic processing		 EXP
ISO		 CYP2C19 gene polymorphism results in decreased hydroxylation of Phenytoin
CYP2C19 protein results in increased metabolism of Phenytoin
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CYP2C19 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C19 protein results in increased hydroxylation of Phenytoin
CYP2C19 protein affects the metabolism of Phenytoin		 CTD PMID:9146858 PMID:9333104 PMID:9579299 PMID:9860067 PMID:15569425 More... NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 affects expression
multiple interactions
increases expression		 ISO Phenytoin affects the expression of CYP2C29 mRNA
[Phenytoin results in decreased activity of CYP2C29 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]
Phenytoin results in increased expression of CYP2C protein; Phenytoin results in increased expression of CYP2C29 mRNA; Phenytoin results in increased expression of CYP2C29 protein		 CTD PMID:12051692 PMID:15155833 PMID:19136022 PMID:19903449 PMID:21766881 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
increases metabolic processing
increases activity
increases hydroxylation
decreases metabolic processing
decreases hydroxylation
increases expression
increases response to substance
affects metabolic processing		 EXP [Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; [CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin; Miconazole inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin]; Miconazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Phenytoin]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]
CYP2C9 protein results in increased metabolism of Phenytoin
Phenytoin results in increased activity of CYP2C9 protein
CYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin; CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin
CYP2C9 gene polymorphism results in increased susceptibility to Phenytoin
CYP2C9 protein affects the metabolism of Phenytoin; CYP2C9 protein alternative form affects the metabolism of Phenytoin		 CTD PMID:2025243 PMID:9110362 PMID:9860067 PMID:10208645 PMID:10510154 More... NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]
Phenytoin results in decreased expression of CYP2E1 mRNA
Phenytoin results in increased expression of CYP2E1 mRNA; Phenytoin results in increased expression of CYP2E1 protein		 CTD PMID:17381134 PMID:18206661 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases expression
increases activity		 EXP
ISO		 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased expression of CYP3A2 mRNA; Phenytoin results in increased expression of CYP3A2 protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
Phenytoin results in increased activity of CYP3A4 protein
Phenytoin results in increased expression of CYP3A4 mRNA; Phenytoin results in increased expression of CYP3A4 protein		 CTD PMID:9512926 PMID:10219967 PMID:12065438 PMID:12505310 PMID:12673034 More... NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases expression EXP
ISO		 Phenytoin results in increased expression of CYP3A5 mRNA
Phenytoin results in increased expression of CYP3A13 mRNA		 CTD PMID:12673034 PMID:19903449 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 increases expression EXP
ISO		 Phenytoin results in increased expression of CYP3A7 mRNA
Phenytoin results in increased expression of CYP3A13 mRNA		 CTD PMID:12673034 PMID:19903449 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 decreases expression ISO Phenytoin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA CTD PMID:21224054 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 increases expression ISO Phenytoin results in increased expression of CYP7B1 mRNA CTD PMID:20345932 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G DAP3 death associated protein 3 increases expression EXP Phenytoin results in increased expression of DAP3 mRNA CTD PMID:14741686 NCBI chr 1:155,687,948...155,739,010
Ensembl chr 1:155,687,960...155,739,010 		JBrowse link
G DAPK2 death associated protein kinase 2 decreases expression EXP Phenytoin results in decreased expression of DAPK2 mRNA CTD PMID:14741686 NCBI chr15:63,907,036...64,046,485
Ensembl chr15:63,907,036...64,072,033 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA CTD PMID:21224054 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DHX9 DExH-box helicase 9 increases expression ISO Phenytoin results in increased expression of DHX9 mRNA CTD PMID:20345932 NCBI chr 1:182,839,347...182,887,982
Ensembl chr 1:182,839,347...182,887,982 		JBrowse link
G DMTN dematin actin binding protein decreases expression ISO Phenytoin results in decreased expression of DMTN mRNA CTD PMID:20345932 NCBI chr 8:22,048,931...22,082,525
Ensembl chr 8:22,048,995...22,082,527 		JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907 		JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA CTD PMID:21224054 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G EBPL EBP like increases expression ISO Phenytoin results in increased expression of EBPL mRNA CTD PMID:20345932 NCBI chr13:49,660,674...49,691,487
Ensembl chr13:49,660,674...49,691,486 		JBrowse link
G EGR1 early growth response 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA CTD PMID:21224054 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G EGR3 early growth response 3 increases expression ISO Phenytoin results in increased expression of EGR3 mRNA CTD PMID:20345932 NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480 		JBrowse link
G EMX2 empty spiracles homeobox 2 decreases expression ISO Phenytoin results in decreased expression of EMX2 mRNA CTD PMID:9118846 NCBI chr10:117,542,746...117,549,546
Ensembl chr10:117,542,445...117,549,546 		JBrowse link
G ENPEP glutamyl aminopeptidase decreases expression
increases expression		 ISO Phenytoin results in decreased expression of ENPEP mRNA
Phenytoin results in increased expression of ENPEP mRNA		 CTD PMID:17381134 NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285 		JBrowse link
G EOMES eomesodermin increases expression EXP Phenytoin results in increased expression of EOMES mRNA CTD PMID:14741686 NCBI chr 3:27,715,953...27,722,713
Ensembl chr 3:27,715,949...27,722,711 		JBrowse link
G EPHX1 epoxide hydrolase 1 affects response to substance
increases expression		 EXP
ISO		 EPHX1 gene polymorphism affects the susceptibility to Phenytoin
Phenytoin results in increased expression of EPHX1 mRNA		 CTD PMID:17381134 PMID:19952982 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G EPHX2 epoxide hydrolase 2 decreases expression ISO Phenytoin results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564 		JBrowse link
G ESR1 estrogen receptor 1 increases expression ISO Phenytoin results in increased expression of ESR1 mRNA; Phenytoin results in increased expression of ESR1 protein CTD PMID:19490052 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 decreases expression EXP Phenytoin results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 8:71,197,433...71,548,094
Ensembl chr 8:71,197,433...71,592,025 		JBrowse link
G F10 coagulation factor X decreases expression ISO Phenytoin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G FASLG Fas ligand multiple interactions
decreases expression		 ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA
Phenytoin results in decreased expression of FASL mRNA		 CTD PMID:21224054 PMID:23986454 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FBXL3 F-box and leucine rich repeat protein 3 increases expression ISO Phenytoin results in increased expression of FBXL3 mRNA CTD PMID:20345932 NCBI chr13:77,005,260...77,027,159
Ensembl chr13:76,992,598...77,027,195 		JBrowse link
G FBXO30 F-box protein 30 increases expression ISO Phenytoin results in increased expression of FBXO30 mRNA CTD PMID:20345932 NCBI chr 6:145,793,502...145,814,795
Ensembl chr 6:145,793,502...145,814,795 		JBrowse link
G FGF12 fibroblast growth factor 12 increases expression ISO Phenytoin results in increased expression of FGF12 mRNA CTD PMID:20345932 NCBI chr 3:192,139,390...192,727,541
Ensembl chr 3:192,139,390...192,767,764 		JBrowse link
G FGF5 fibroblast growth factor 5 increases expression EXP Phenytoin results in increased expression of FGF5 mRNA CTD PMID:14741686 NCBI chr 4:80,266,588...80,291,017
Ensembl chr 4:80,266,639...80,336,680 		JBrowse link
G FGF8 fibroblast growth factor 8 increases expression EXP Phenytoin results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,109...101,780,371 		JBrowse link
G FGF9 fibroblast growth factor 9 increases expression EXP Phenytoin results in increased expression of FGF9 mRNA CTD PMID:14741686 NCBI chr13:21,671,073...21,704,498
Ensembl chr13:21,671,073...21,704,498 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 increases expression EXP Phenytoin results in increased expression of FGFR2 mRNA; Phenytoin results in increased expression of FGFR2 protein CTD PMID:11352631 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G FLRT2 fibronectin leucine rich transmembrane protein 2 increases expression EXP Phenytoin results in increased expression of FLRT2 mRNA CTD PMID:14741686 NCBI chr14:85,530,144...85,654,428
Ensembl chr14:85,530,144...85,654,428 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA CTD PMID:21224054 NCBI chr 1:171,248,494...171,285,978
Ensembl chr 1:171,248,471...171,285,978 		JBrowse link
G FMO4 flavin containing dimethylaniline monoxygenase 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA CTD PMID:21224054 NCBI chr 1:171,314,183...171,342,084
Ensembl chr 1:171,314,183...171,342,084 		JBrowse link
G FMOD fibromodulin decreases expression EXP Phenytoin results in decreased expression of FMOD mRNA CTD PMID:14741686 NCBI chr 1:203,340,628...203,351,122
Ensembl chr 1:203,340,628...203,351,758 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 increases expression ISO Phenytoin results in increased expression of FMR1 mRNA CTD PMID:20345932 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125 		JBrowse link
G FN1 fibronectin 1 increases expression EXP Phenytoin results in increased expression of FN1 mRNA CTD PMID:14741686 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FNDC3A fibronectin type III domain containing 3A increases expression ISO Phenytoin results in increased expression of FNDC3A mRNA CTD PMID:20345932 NCBI chr13:48,975,291...49,209,779
Ensembl chr13:48,975,912...49,209,779 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]
Phenytoin results in decreased expression of FOS protein		 CTD PMID:7789465 PMID:8758711 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOXC2 forkhead box C2 decreases expression EXP Phenytoin results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr16:86,566,829...86,569,728
Ensembl chr16:86,566,829...86,569,728 		JBrowse link
G FOXP3 forkhead box P3 multiple interactions
decreases expression		 ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
Phenytoin results in decreased expression of FOXP3 mRNA		 CTD PMID:23986454 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G FRS3 fibroblast growth factor receptor substrate 3 decreases expression EXP Phenytoin results in decreased expression of FRS3 mRNA CTD PMID:14741686 NCBI chr 6:41,770,176...41,779,900
Ensembl chr 6:41,770,176...41,786,542 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Phenytoin results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase affects response to substance ISO G6PDX protein affects the susceptibility to Phenytoin CTD PMID:10627286 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA CTD PMID:21224054 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GATA3 GATA binding protein 3 multiple interactions
decreases expression		 ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Phenytoin results in decreased expression of GATA3 mRNA		 CTD PMID:23986454 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO Phenytoin results in increased expression of GCLM mRNA CTD PMID:20345932 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GLUL glutamate-ammonia ligase decreases activity ISO Phenytoin results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206 		JBrowse link
G GNL2 G protein nucleolar 2 increases expression ISO Phenytoin results in increased expression of GNL2 mRNA CTD PMID:20345932 NCBI chr 1:37,566,816...37,595,937
Ensembl chr 1:37,566,816...37,595,937 		JBrowse link
G GNPDA2 glucosamine-6-phosphate deaminase 2 increases expression ISO Phenytoin results in increased expression of GNPDA2 mRNA CTD PMID:20345932 NCBI chr 4:44,701,795...44,726,556
Ensembl chr 4:44,682,200...44,726,588 		JBrowse link
G GPM6A glycoprotein M6A increases expression ISO Phenytoin results in increased expression of GPM6A mRNA CTD PMID:20345932 NCBI chr 4:175,632,937...176,002,691
Ensembl chr 4:175,632,934...176,002,664 		JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA CTD PMID:21224054 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 increases expression ISO Phenytoin results in increased expression of GRIN1 mRNA CTD PMID:20345932 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 increases expression EXP Phenytoin results in increased expression of GSTA1 mRNA CTD PMID:11134551 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860 		JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression
decreases expression		 ISO Phenytoin results in increased expression of GSTA2 mRNA
Phenytoin results in decreased expression of GSTA2 mRNA		 CTD PMID:17381134 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475 		JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP Phenytoin results in decreased expression of GSTK1 mRNA CTD PMID:14741686 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression
multiple interactions		 ISO Phenytoin results in increased expression of GSTM1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein		 CTD PMID:17381134 PMID:21224054 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 increases expression ISO Phenytoin results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G GSTM3 glutathione S-transferase mu 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA CTD PMID:21224054 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Phenytoin results in decreased expression of GSTO1 mRNA CTD PMID:14741686 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459 		JBrowse link
G GUSB glucuronidase beta multiple interactions
decreases activity		 ISO Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]
Phenytoin results in decreased activity of GUSB protein		 CTD PMID:6696821 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G HDAC7 histone deacetylase 7 increases expression ISO Phenytoin results in increased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr12:47,782,722...47,821,344
Ensembl chr12:47,782,722...47,833,132 		JBrowse link
G HELZ helicase with zinc finger increases expression ISO Phenytoin results in increased expression of HELZ mRNA CTD PMID:20345932 NCBI chr17:67,070,444...67,245,989
Ensembl chr17:67,070,444...67,245,989 		JBrowse link
G HEXIM1 HEXIM P-TEFb complex subunit 1 increases expression ISO Phenytoin results in increased expression of HEXIM1 mRNA CTD PMID:20345932 NCBI chr17:45,148,475...45,152,099
Ensembl chr17:45,148,475...45,152,099 		JBrowse link
G HLA-B major histocompatibility complex, class I, B affects response to substance EXP HLA-B gene polymorphism affects the susceptibility to Phenytoin CTD PMID:20235791 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein CTD PMID:23986454 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Phenytoin results in increased expression of HMOX1 mRNA		 CTD PMID:17381134 PMID:21224054 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression ISO Phenytoin results in increased expression of HNRNPA2B1 mRNA CTD PMID:20345932 NCBI chr 7:26,189,927...26,200,746
Ensembl chr 7:26,171,151...26,201,529 		JBrowse link
G HOOK3 hook microtubule tethering protein 3 increases expression ISO Phenytoin results in increased expression of HOOK3 mRNA CTD PMID:20345932 NCBI chr 8:42,896,978...43,030,535
Ensembl chr 8:42,896,946...43,030,535 		JBrowse link
G HOXA2 homeobox A2 decreases expression ISO Phenytoin results in decreased expression of HOXA2 mRNA; Phenytoin results in decreased expression of HOXA2 protein CTD PMID:10789828 NCBI chr 7:27,100,354...27,102,683
Ensembl chr 7:27,100,354...27,102,686 		JBrowse link
G HOXB7 homeobox B7 increases expression EXP Phenytoin results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr17:48,607,232...48,611,017
Ensembl chr17:48,607,232...48,633,572 		JBrowse link
G HOXB9 homeobox B9 increases expression EXP Phenytoin results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr17:48,621,156...48,626,358
Ensembl chr17:48,621,156...48,626,358 		JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA CTD PMID:21224054 NCBI chr 6:31,809,619...31,815,283
Ensembl chr 6:31,809,619...31,815,283 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA CTD PMID:21224054 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA CTD PMID:21224054 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA CTD PMID:21224054 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737 		JBrowse link
G HSPE1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA CTD PMID:21224054 NCBI chr 2:197,500,379...197,503,449
Ensembl chr 2:197,500,140...197,503,449 		JBrowse link
G IFNG interferon gamma decreases expression ISO Phenytoin results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IFNGR1 interferon gamma receptor 1 increases expression EXP Phenytoin results in increased expression of IFNGR1 mRNA CTD PMID:14741686 NCBI chr 6:137,197,484...137,219,385
Ensembl chr 6:137,197,483...137,219,449 		JBrowse link
G IFNGR2 interferon gamma receptor 2 increases expression EXP Phenytoin results in increased expression of IFNGR2 mRNA CTD PMID:14741686 NCBI chr21:33,402,882...33,437,516
Ensembl chr21:33,403,413...33,479,348 		JBrowse link
G IGF1 insulin like growth factor 1 decreases expression ISO Phenytoin results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF2 insulin like growth factor 2 increases expression ISO Phenytoin results in increased expression of IGF2 mRNA CTD PMID:9988880 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G IHH Indian hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of IHH mRNA CTD PMID:16141649 NCBI chr 2:219,054,424...219,060,921
Ensembl chr 2:219,054,424...219,060,921 		JBrowse link
G IL17A interleukin 17A multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL18 interleukin 18 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO		 Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein		 CTD PMID:8971655 PMID:21224054 PMID:23986454 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL23A interleukin 23 subunit alpha multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression		 ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA
Phenytoin results in increased expression of IL6 mRNA		 CTD PMID:21224054 PMID:23986454 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6R interleukin 6 receptor decreases expression ISO Phenytoin results in decreased expression of IL6RA mRNA CTD PMID:15136057 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G INPP5F inositol polyphosphate-5-phosphatase F increases expression ISO Phenytoin results in increased expression of INPP5F mRNA CTD PMID:20345932 NCBI chr10:119,726,050...119,829,147
Ensembl chr10:119,726,042...119,829,147 		JBrowse link
G INSR insulin receptor increases expression EXP Phenytoin results in increased expression of INSR mRNA CTD PMID:14741686 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IPP intracisternal A particle-promoted polypeptide increases expression ISO Phenytoin results in increased expression of IPP mRNA CTD PMID:20345932 NCBI chr 1:45,694,324...45,750,653
Ensembl chr 1:45,694,324...45,750,653 		JBrowse link
G IRF9 interferon regulatory factor 9 increases expression ISO Phenytoin results in increased expression of IRF9 mRNA CTD PMID:20345932 NCBI chr14:24,161,265...24,166,565
Ensembl chr14:24,161,234...24,168,043 		JBrowse link
G ITGA2 integrin subunit alpha 2 decreases expression EXP Phenytoin results in decreased expression of ITGA2 protein CTD PMID:15948689 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G ITGA8 integrin subunit alpha 8 increases expression EXP Phenytoin results in increased expression of ITGA8 mRNA CTD PMID:14741686 NCBI chr10:15,513,954...15,719,922
Ensembl chr10:15,513,954...15,719,922 		JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Phenytoin results in decreased expression of ITGB1 protein CTD PMID:15948689 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G ITGB3BP integrin subunit beta 3 binding protein increases expression ISO Phenytoin results in increased expression of ITGB3BP mRNA CTD PMID:20345932 NCBI chr 1:63,440,770...63,529,187
Ensembl chr 1:63,440,770...63,593,721 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenytoin results in decreased expression of JUN mRNA CTD PMID:9118846 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KCND2 potassium voltage-gated channel subfamily D member 2 increases expression ISO Phenytoin results in increased expression of KCND2 mRNA CTD PMID:20345932 NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Phenytoin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KCTD3 potassium channel tetramerization domain containing 3 increases expression ISO Phenytoin results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr 1:215,567,304...215,621,807
Ensembl chr 1:215,567,304...215,621,807 		JBrowse link
G KDR kinase insert domain receptor increases expression ISO Phenytoin results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G KHDRBS2 KH RNA binding domain containing, signal transduction associated 2 increases expression ISO Phenytoin results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 6:61,542,670...62,286,225
Ensembl chr 6:61,679,961...62,286,225 		JBrowse link
G KLF2 KLF transcription factor 2 increases expression ISO Phenytoin results in increased expression of KLF2 mRNA CTD PMID:20345932 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685 		JBrowse link
G KLHL2 kelch like family member 2 increases expression ISO Phenytoin results in increased expression of KLHL2 mRNA CTD PMID:20345932 NCBI chr 4:165,207,561...165,323,156
Ensembl chr 4:165,207,561...165,323,156 		JBrowse link
G KLHL7 kelch like family member 7 increases expression ISO Phenytoin results in increased expression of KLHL7 mRNA CTD PMID:20345932 NCBI chr 7:23,105,785...23,177,914
Ensembl chr 7:23,105,758...23,177,914 		JBrowse link
G KRIT1 KRIT1 ankyrin repeat containing increases expression ISO Phenytoin results in increased expression of KRIT1 mRNA CTD PMID:20345932 NCBI chr 7:92,198,969...92,246,100
Ensembl chr 7:92,197,498...92,246,166 		JBrowse link
G KRT2 keratin 2 increases expression EXP Phenytoin results in increased expression of KRT2 mRNA CTD PMID:14741686 NCBI chr12:52,644,558...52,652,211
Ensembl chr12:52,644,558...52,652,211 		JBrowse link
G KYAT1 kynurenine aminotransferase 1 increases activity ISO Phenytoin results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,832,942...128,882,494
Ensembl chr 9:128,832,942...128,882,494 		JBrowse link
G LAMA2 laminin subunit alpha 2 increases expression ISO Phenytoin results in increased expression of LAMA2 mRNA CTD PMID:20345932 NCBI chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566 		JBrowse link
G LAP3 leucine aminopeptidase 3 affects expression ISO Phenytoin affects the expression of LAP3 mRNA CTD PMID:20345932 NCBI chr 4:17,577,198...17,607,970
Ensembl chr 4:17,577,198...17,607,972 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase increases expression ISO Phenytoin results in increased expression of LCAT mRNA CTD PMID:15136057 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131 		JBrowse link
G LDB2 LIM domain binding 2 increases expression ISO Phenytoin results in increased expression of LDB2 mRNA CTD PMID:20345932 NCBI chr 4:16,501,541...16,898,645
Ensembl chr 4:16,501,541...16,898,678 		JBrowse link
G LPIN1 lipin 1 increases expression EXP Phenytoin results in increased expression of LPIN1 mRNA CTD PMID:14741686 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409 		JBrowse link
G LRBA LPS responsive beige-like anchor protein increases expression ISO Phenytoin results in increased expression of LRBA mRNA CTD PMID:20345932 NCBI chr 4:150,264,435...151,015,727
Ensembl chr 4:150,264,435...151,015,727 		JBrowse link
G LSM1 LSM1 homolog, mRNA degradation associated decreases expression ISO Phenytoin results in decreased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr 8:38,163,321...38,176,730
Ensembl chr 8:38,163,335...38,176,730 		JBrowse link
G LTBP4 latent transforming growth factor beta binding protein 4 increases expression ISO Phenytoin results in increased expression of LTBP4 mRNA CTD PMID:20345932 NCBI chr19:40,593,166...40,629,820
Ensembl chr19:40,592,883...40,629,818 		JBrowse link
G LYPLA1 lysophospholipase 1 increases expression ISO Phenytoin results in increased expression of LYPLA1 mRNA CTD PMID:20345932 NCBI chr 8:54,046,367...54,101,947
Ensembl chr 8:54,046,367...54,102,017 		JBrowse link
G MAP1B microtubule associated protein 1B increases expression EXP Phenytoin results in increased expression of MAP1B mRNA CTD PMID:14741686 NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565 		JBrowse link
G MAP3K4 mitogen-activated protein kinase kinase kinase 4 increases expression ISO Phenytoin results in increased expression of MAP3K4 mRNA CTD PMID:20345932 NCBI chr 6:160,991,769...161,117,380
Ensembl chr 6:160,991,727...161,117,385 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP Phenytoin results in decreased phosphorylation of MAPK1 protein CTD PMID:15948689 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP Phenytoin results in decreased phosphorylation of MAPK3 protein CTD PMID:15948689 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPRE3 microtubule associated protein RP/EB family member 3 increases expression ISO Phenytoin results in increased expression of MAPRE3 mRNA CTD PMID:20345932 NCBI chr 2:26,970,637...27,027,219
Ensembl chr 2:26,970,637...27,027,219 		JBrowse link
G MBL1P mannose binding lectin 1, pseudogene decreases expression ISO Phenytoin results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr10:79,920,178...79,923,119
Ensembl chr10:79,920,327...79,923,032
Ensembl chr10:79,920,327...79,923,032 		JBrowse link
G MDK midkine increases expression EXP Phenytoin results in increased expression of MDK mRNA CTD PMID:14741686 NCBI chr11:46,380,784...46,383,837
Ensembl chr11:46,380,756...46,383,837 		JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G ME1 malic enzyme 1 increases expression ISO Phenytoin results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051 		JBrowse link
G MEOX1 mesenchyme homeobox 1 decreases expression EXP Phenytoin results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr17:43,640,389...43,661,922
Ensembl chr17:43,640,389...43,661,922 		JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 increases expression ISO Phenytoin results in increased expression of MESP1 mRNA CTD PMID:26272751 NCBI chr15:89,732,446...89,751,249
Ensembl chr15:89,749,875...89,751,249 		JBrowse link
G MEX3D mex-3 RNA binding family member D increases expression ISO Phenytoin results in increased expression of MEX3D mRNA CTD PMID:20345932 NCBI chr19:1,554,672...1,568,325
Ensembl chr19:1,554,672...1,568,325 		JBrowse link
G MGAT2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression ISO Phenytoin results in increased expression of MGAT2 mRNA CTD PMID:20345932 NCBI chr14:49,620,799...49,623,481
Ensembl chr14:49,620,799...49,623,481 		JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase increases methylation EXP Phenytoin results in increased methylation of MGMT promoter CTD PMID:15949900 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983 		JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein CTD PMID:21224054 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MMP1 matrix metallopeptidase 1 decreases expression
increases expression		 EXP Phenytoin results in decreased expression of MMP1 mRNA
Phenytoin results in increased expression of MMP1 mRNA		 CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression EXP Phenytoin results in decreased expression of MMP2 mRNA CTD PMID:15948689 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP3 matrix metallopeptidase 3 decreases expression EXP Phenytoin results in decreased expression of MMP3 mRNA CTD PMID:15948689 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MRPS18C mitochondrial ribosomal protein S18C increases expression ISO Phenytoin results in increased expression of MRPS18C mRNA CTD PMID:20345932 NCBI chr 4:83,456,058...83,462,298
Ensembl chr 4:83,455,932...83,469,735 		JBrowse link
G MTF2 metal response element binding transcription factor 2 increases expression ISO Phenytoin results in increased expression of MTF2 mRNA CTD PMID:20345932 NCBI chr 1:93,079,283...93,139,076
Ensembl chr 1:93,079,235...93,139,079 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like increases expression ISO Phenytoin results in increased expression of MTHFD1L mRNA CTD PMID:20345932 NCBI chr 6:150,865,702...151,101,887
Ensembl chr 6:150,865,679...151,101,887 		JBrowse link
G MTX2 metaxin 2 increases expression ISO Phenytoin results in increased expression of MTX2 mRNA CTD PMID:20345932 NCBI chr 2:176,269,442...176,338,025
Ensembl chr 2:176,269,395...176,338,025 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression		 EXP
ISO		 Phenytoin results in increased expression of MYC protein
Phenytoin results in decreased expression of MYC mRNA		 CTD PMID:10695937 PMID:26272751 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G MYO1E myosin IE increases expression ISO Phenytoin results in increased expression of MYO1E mRNA CTD PMID:26272751 NCBI chr15:59,132,434...59,372,871
Ensembl chr15:59,132,434...59,372,871 		JBrowse link
G NAP1L2 nucleosome assembly protein 1 like 2 affects expression ISO Phenytoin affects the expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:73,212,299...73,214,851
Ensembl chr  X:73,212,299...73,214,851 		JBrowse link
G NCAN neurocan increases expression EXP Phenytoin results in increased expression of NCAN mRNA CTD PMID:14741686 NCBI chr19:19,211,958...19,252,233
Ensembl chr19:19,211,958...19,252,233 		JBrowse link
G NCL nucleolin decreases expression ISO Phenytoin results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 2:231,453,531...231,464,484
Ensembl chr 2:231,453,531...231,483,641 		JBrowse link
G NCOA1 nuclear receptor coactivator 1 multiple interactions EXP Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] CTD PMID:21924250 NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702 		JBrowse link
G NELFA negative elongation factor complex member A decreases expression ISO Phenytoin results in decreased expression of NELFA mRNA CTD PMID:20345932 NCBI chr 4:1,982,723...2,008,974
Ensembl chr 4:1,982,717...2,041,903 		JBrowse link
G NES nestin decreases expression ISO Phenytoin results in decreased expression of NES mRNA CTD PMID:26272751 NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407 		JBrowse link
G NEUROG2 neurogenin 2 increases expression EXP Phenytoin results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 4:112,513,516...112,516,180
Ensembl chr 4:112,513,516...112,516,180 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 EXP Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein]
Phenytoin results in increased expression of NFKB1 mRNA		 CTD PMID:10700573 PMID:14741686 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha decreases degradation EXP Phenytoin results in decreased degradation of NFKBIA protein CTD PMID:15948689 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NGLY1 N-glycanase 1 increases expression ISO Phenytoin results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr 3:25,718,944...25,790,039
Ensembl chr 3:25,718,944...25,790,039 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA CTD PMID:23986454 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA CTD PMID:21224054 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPAS2 neuronal PAS domain protein 2 increases expression ISO Phenytoin results in increased expression of NPAS2 mRNA CTD PMID:20345932 NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Phenytoin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
affects activity
increases expression
increases activity		 EXP
ISO		 Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin binds to and results in increased activity of NR1I2 protein; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin affects the activity of NR1I2 protein
Phenytoin results in increased expression of NR1I2 protein
Phenytoin results in increased activity of NR1I2 protein		 CTD PMID:12065438 PMID:12695340 PMID:12695351 PMID:14600250 PMID:14977870 More... NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions
increases expression
increases activity
increases localization		 EXP
ISO		 [Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Phenytoin results in increased expression of NR1I3 protein
NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]
Phenytoin results in increased localization of NR1I3 protein		 CTD PMID:15123723 PMID:15155833 PMID:15849716 PMID:16936065 PMID:17041008 More... NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 increases expression ISO Phenytoin results in increased expression of NR2F1 mRNA CTD PMID:20345932 NCBI chr 5:93,583,222...93,594,611
Ensembl chr 5:93,583,222...93,594,611 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions
increases expression		 EXP
ISO		 Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased expression of NR3C1 mRNA		 CTD PMID:10219967 PMID:12695351 PMID:20345932 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NRCAM neuronal cell adhesion molecule decreases expression ISO Phenytoin results in decreased expression of NRCAM mRNA CTD PMID:26272751 NCBI chr 7:108,147,649...108,456,720
Ensembl chr 7:108,147,623...108,456,717 		JBrowse link
G NSMCE3 NSE3 homolog, SMC5-SMC6 complex component increases expression ISO Phenytoin results in increased expression of NSMCE3 mRNA CTD PMID:20345932 NCBI chr15:29,264,989...29,269,822
Ensembl chr15:29,264,989...29,269,822 		JBrowse link
G NT5DC1 5'-nucleotidase domain containing 1 increases expression ISO Phenytoin results in increased expression of NT5DC1 mRNA CTD PMID:20345932 NCBI chr 6:116,100,853...116,249,497
Ensembl chr 6:116,100,851...116,249,497 		JBrowse link
G NTF3 neurotrophin 3 decreases expression ISO Phenytoin results in decreased expression of NTF3 mRNA CTD PMID:7841657 NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536 		JBrowse link
G NUP153 nucleoporin 153 increases expression ISO Phenytoin results in increased expression of NUP153 mRNA CTD PMID:20345932 NCBI chr 6:17,615,037...17,706,925
Ensembl chr 6:17,615,035...17,706,925 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 increases expression EXP Phenytoin results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394 		JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions ISO [cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin CTD PMID:7870991 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B1 mRNA CTD PMID:15136057 NCBI chr17:2,593,183...2,685,615
Ensembl chr17:2,593,210...2,685,615 		JBrowse link
G PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 decreases expression ISO Phenytoin results in decreased expression of PAFAH1B2 mRNA CTD PMID:15136057 NCBI chr11:117,144,287...117,178,173
Ensembl chr11:117,144,284...117,176,894 		JBrowse link
G PARD6G par-6 family cell polarity regulator gamma increases expression ISO Phenytoin results in increased expression of PARD6G mRNA CTD PMID:20345932 NCBI chr18:80,157,232...80,247,514
Ensembl chr18:80,157,232...80,247,514 		JBrowse link
G PARG poly(ADP-ribose) glycohydrolase increases expression ISO Phenytoin results in increased expression of PARG mRNA CTD PMID:20345932 NCBI chr10:49,818,279...49,942,027
Ensembl chr10:49,818,279...49,970,203 		JBrowse link
G PAX3 paired box 3 decreases expression ISO
EXP		 Phenytoin results in decreased expression of PAX3 mRNA CTD PMID:9118846 PMID:31711903 NCBI chr 2:222,199,887...222,298,998
Ensembl chr 2:222,199,887...222,298,998 		JBrowse link
G PAX6 paired box 6 increases expression EXP Phenytoin results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961 		JBrowse link
G PBX1 PBX homeobox 1 increases expression ISO Phenytoin results in increased expression of PBX1 mRNA CTD PMID:20345932 NCBI chr 1:164,559,184...164,886,047
Ensembl chr 1:164,555,584...164,899,296 		JBrowse link
G PCYOX1 prenylcysteine oxidase 1 increases expression ISO Phenytoin results in increased expression of PCYOX1 mRNA CTD PMID:20345932 NCBI chr 2:70,257,915...70,281,185
Ensembl chr 2:70,257,386...70,281,185 		JBrowse link
G PDGFA platelet derived growth factor subunit A increases expression EXP Phenytoin results in increased expression of PDGFA mRNA CTD PMID:14741686 NCBI chr 7:497,258...520,700
Ensembl chr 7:497,258...520,296 		JBrowse link
G PDGFB platelet derived growth factor subunit B increases expression ISO
EXP		 Phenytoin results in increased expression of PDGFB mRNA; Phenytoin results in increased expression of PDGFB protein CTD PMID:8463938 PMID:9029455 PMID:14741686 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982 		JBrowse link
G PGRMC1 progesterone receptor membrane component 1 increases expression ISO Phenytoin results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:119,236,285...119,244,466
Ensembl chr  X:119,236,245...119,244,466 		JBrowse link
G PHF14 PHD finger protein 14 increases expression ISO Phenytoin results in increased expression of PHF14 mRNA CTD PMID:20345932 NCBI chr 7:10,973,872...11,169,618
Ensembl chr 7:10,973,336...11,169,623 		JBrowse link
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha increases expression EXP Phenytoin results in increased expression of PIP4K2A mRNA CTD PMID:14741686 NCBI chr10:22,534,854...22,714,578
Ensembl chr10:22,534,854...22,714,578 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor decreases expression EXP Phenytoin results in decreased expression of PLAUR mRNA CTD PMID:14741686 NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547 		JBrowse link
G PLCL1 phospholipase C like 1 (inactive) increases expression ISO Phenytoin results in increased expression of PLCL1 mRNA CTD PMID:20345932 NCBI chr 2:197,804,593...198,149,863
Ensembl chr 2:197,804,593...198,572,581 		JBrowse link
G PLEC plectin increases expression ISO Phenytoin results in increased expression of PLEC mRNA CTD PMID:20345932 NCBI chr 8:143,915,153...143,976,745
Ensembl chr 8:143,915,153...143,976,734 		JBrowse link
G PLTP phospholipid transfer protein increases expression ISO Phenytoin results in increased expression of PLTP mRNA CTD PMID:15136057 NCBI chr20:45,898,620...45,912,155
Ensembl chr20:45,898,621...45,912,155 		JBrowse link
G PLXNB2 plexin B2 decreases expression EXP Phenytoin results in decreased expression of PLXNB2 mRNA CTD PMID:14741686 NCBI chr22:50,274,979...50,307,646
Ensembl chr22:50,274,979...50,307,646 		JBrowse link
G PNN pinin, desmosome associated protein increases expression ISO Phenytoin results in increased expression of PNN mRNA CTD PMID:20345932 NCBI chr14:39,175,254...39,183,220
Ensembl chr14:39,175,183...39,183,220 		JBrowse link
G PON1 paraoxonase 1 decreases expression
affects activity		 ISO
EXP		 Phenytoin results in decreased expression of PON1 mRNA
Phenytoin affects the activity of PON1 protein		 CTD PMID:15136057 PMID:28032682 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G POR cytochrome p450 oxidoreductase increases activity ISO Phenytoin results in increased activity of POR protein CTD PMID:12051692 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G POU3F1 POU class 3 homeobox 1 increases expression ISO Phenytoin results in increased expression of POU3F1 protein CTD PMID:12781989 NCBI chr 1:38,043,829...38,046,793
Ensembl chr 1:38,043,829...38,046,793 		JBrowse link
G PPIL4 peptidylprolyl isomerase like 4 increases expression ISO Phenytoin results in increased expression of PPIL4 mRNA CTD PMID:20345932 NCBI chr 6:149,504,495...149,546,043
Ensembl chr 6:149,504,495...149,546,043 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline] CTD PMID:21224054 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178 		JBrowse link
G PRL prolactin decreases expression ISO Phenytoin results in decreased expression of PRL mRNA; Phenytoin results in decreased expression of PRL protein CTD PMID:3734668 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 increases expression ISO Phenytoin results in increased expression of PRMT3 mRNA CTD PMID:20345932 NCBI chr11:20,387,716...20,509,338
Ensembl chr11:20,387,558...20,509,338 		JBrowse link
G PRSS12 serine protease 12 increases expression EXP Phenytoin results in increased expression of PRSS12 mRNA CTD PMID:14741686 NCBI chr 4:118,280,038...118,353,003
Ensembl chr 4:118,280,038...118,353,003 		JBrowse link
G PSIP1 PC4 and SRSF1 interacting protein 1 increases expression ISO Phenytoin results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 9:15,464,066...15,510,970
Ensembl chr 9:15,464,066...15,510,995 		JBrowse link
G PSMC6 proteasome 26S subunit, ATPase 6 increases expression ISO Phenytoin results in increased expression of PSMC6 mRNA CTD PMID:20345932 NCBI chr14:52,707,200...52,728,590
Ensembl chr14:52,707,178...52,728,590 		JBrowse link
G PSMD12 proteasome 26S subunit, non-ATPase 12 increases expression ISO Phenytoin results in increased expression of PSMD12 mRNA CTD PMID:20345932 NCBI chr17:67,337,916...67,366,577
Ensembl chr17:67,337,916...67,366,605 		JBrowse link
G PTBP2 polypyrimidine tract binding protein 2 increases expression ISO Phenytoin results in increased expression of PTBP2 mRNA CTD PMID:20345932 NCBI chr 1:96,721,784...96,823,739
Ensembl chr 1:96,721,665...96,823,738 		JBrowse link
G PTCH1 patched 1 increases expression ISO Phenytoin results in increased expression of PTCH1 mRNA CTD PMID:16141649 NCBI chr 9:95,442,980...95,516,971
Ensembl chr 9:95,442,980...95,517,057 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression ISO Phenytoin results in increased expression of PTGS2 mRNA CTD PMID:20345932 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTH parathyroid hormone increases expression EXP Phenytoin results in increased expression of PTH protein CTD PMID:20683115 NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181 		JBrowse link
G RAD50 RAD50 double strand break repair protein multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA CTD PMID:21224054 NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349 		JBrowse link
G RAI1 retinoic acid induced 1 increases expression ISO Phenytoin results in increased expression of RAI1 mRNA CTD PMID:20345932 NCBI chr17:17,681,458...17,811,453
Ensembl chr17:17,681,458...17,811,453 		JBrowse link
G RANBP6 RAN binding protein 6 increases expression ISO Phenytoin results in increased expression of RANBP6 mRNA CTD PMID:20345932 NCBI chr 9:6,011,025...6,015,624
Ensembl chr 9:6,011,025...6,015,625 		JBrowse link
G RAPGEF4 Rap guanine nucleotide exchange factor 4 increases expression ISO Phenytoin results in increased expression of RAPGEF4 mRNA CTD PMID:20345932 NCBI chr 2:172,735,318...173,052,893
Ensembl chr 2:172,735,274...173,052,893 		JBrowse link
G RARA retinoic acid receptor alpha increases expression
decreases expression		 ISO Phenytoin results in increased expression of RARA mRNA
Phenytoin results in decreased expression of RARA mRNA		 CTD PMID:9118846 PMID:9988880 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G RARB retinoic acid receptor beta increases expression ISO Phenytoin results in increased expression of RARB mRNA CTD PMID:9988880 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932 		JBrowse link
G RARG retinoic acid receptor gamma increases expression ISO Phenytoin results in increased expression of RARG mRNA CTD PMID:9988880 NCBI chr12:53,210,569...53,232,209
Ensembl chr12:53,210,567...53,232,980 		JBrowse link
G RBM12 RNA binding motif protein 12 increases expression ISO Phenytoin results in increased expression of RBM12 mRNA CTD PMID:20345932 NCBI chr20:35,648,925...35,664,900
Ensembl chr20:35,648,925...35,664,956 		JBrowse link
G RBM3 RNA binding motif protein 3 increases expression ISO Phenytoin results in increased expression of RBM3 mRNA CTD PMID:20345932 NCBI chr  X:48,574,484...48,581,162
Ensembl chr  X:48,574,449...48,581,162 		JBrowse link
G RBM34 RNA binding motif protein 34 increases expression ISO Phenytoin results in increased expression of RBM34 mRNA CTD PMID:20345932 NCBI chr 1:235,131,183...235,161,250
Ensembl chr 1:235,131,183...235,161,283 		JBrowse link
G RBP2 retinol binding protein 2 increases expression ISO Phenytoin results in increased expression of RBP2 mRNA CTD PMID:9118846 NCBI chr 3:139,452,884...139,476,516
Ensembl chr 3:139,452,884...139,480,747 		JBrowse link
G RDH14 retinol dehydrogenase 14 increases expression ISO Phenytoin results in increased expression of RDH14 mRNA CTD PMID:20345932 NCBI chr 2:18,554,723...18,560,653
Ensembl chr 2:18,554,723...18,560,679 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity		 EXP
ISO		 Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
Phenytoin results in increased activity of RELA protein		 CTD PMID:10700573 PMID:15322231 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RHOA ras homolog family member A decreases expression ISO Phenytoin results in decreased expression of RHOA mRNA CTD PMID:15136057 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G RIOK2 RIO kinase 2 increases expression ISO Phenytoin results in increased expression of RIOK2 mRNA CTD PMID:20345932 NCBI chr 5:97,160,867...97,183,247
Ensembl chr 5:97,160,867...97,183,247 		JBrowse link
G RNASEH1 ribonuclease H1 decreases expression ISO Phenytoin results in decreased expression of RNASEH1 mRNA CTD PMID:20345932 NCBI chr 2:3,531,813...3,558,333
Ensembl chr 2:3,541,430...3,558,333 		JBrowse link
G RND1 Rho family GTPase 1 increases expression ISO Phenytoin results in increased expression of RND1 mRNA CTD PMID:20345932 NCBI chr12:48,857,145...48,865,870
Ensembl chr12:48,857,145...48,865,870 		JBrowse link
G RNF115 ring finger protein 115 increases expression ISO Phenytoin results in increased expression of RNF115 mRNA CTD PMID:20345932 NCBI chr 1:145,738,868...145,824,095
Ensembl chr 1:145,738,868...145,824,095 		JBrowse link
G RPE ribulose-5-phosphate-3-epimerase increases expression ISO Phenytoin results in increased expression of RPE mRNA CTD PMID:20345932 NCBI chr 2:210,002,638...210,022,260
Ensembl chr 2:210,002,565...210,022,260 		JBrowse link
G RPL28 ribosomal protein L28 increases expression EXP Phenytoin results in increased expression of RPL28 mRNA CTD PMID:14741686 NCBI chr19:55,385,932...55,403,342
Ensembl chr19:55,385,932...55,403,250 		JBrowse link
G RPS6KA3 ribosomal protein S6 kinase A3 increases expression ISO Phenytoin results in increased expression of RPS6KA3 mRNA CTD PMID:20345932 NCBI chr  X:20,149,911...20,267,097
Ensembl chr  X:20,149,911...20,267,519 		JBrowse link
G RPSA ribosomal protein SA increases expression EXP Phenytoin results in increased expression of RPSA mRNA CTD PMID:14741686 NCBI chr 3:39,406,720...39,412,542
Ensembl chr 3:39,406,716...39,426,255 		JBrowse link
G RSRC1 arginine and serine rich coiled-coil 1 decreases expression ISO Phenytoin results in decreased expression of RSRC1 mRNA CTD PMID:20345932 NCBI chr 3:158,110,089...158,545,730
Ensembl chr 3:158,105,855...158,545,730 		JBrowse link
G RYR2 ryanodine receptor 2 increases expression ISO Phenytoin results in increased expression of RYR2 mRNA CTD PMID:20345932 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988 		JBrowse link
G S100A10 S100 calcium binding protein A10 increases expression EXP Phenytoin results in increased expression of S100A10 mRNA CTD PMID:14741686 NCBI chr 1:151,982,915...151,993,859
Ensembl chr 1:151,982,915...151,993,859 		JBrowse link
G S100A4 S100 calcium binding protein A4 increases expression EXP Phenytoin results in increased expression of S100A4 mRNA CTD PMID:14741686 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136 		JBrowse link
G S100A8 S100 calcium binding protein A8 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA CTD PMID:23986454 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073 		JBrowse link
G S100A9 S100 calcium binding protein A9 multiple interactions
increases expression		 ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA
Phenytoin results in increased expression of S100A9 mRNA		 CTD PMID:23986454 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023 		JBrowse link
G SART3 spliceosome associated factor 3, U4/U6 recycling protein increases expression ISO Phenytoin results in increased expression of SART3 mRNA CTD PMID:20345932 NCBI chr12:108,522,214...108,561,173
Ensembl chr12:108,522,214...108,561,400 		JBrowse link
G SC5D sterol-C5-desaturase increases expression EXP Phenytoin results in increased expression of SC5D mRNA CTD PMID:14741686 NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410 		JBrowse link
G SCAF1 SR-related CTD associated factor 1 increases expression ISO Phenytoin results in increased expression of SCAF1 mRNA CTD PMID:20345932 NCBI chr19:49,640,465...49,658,642
Ensembl chr19:49,642,209...49,658,642 		JBrowse link
G SCARB1 scavenger receptor class B member 1 decreases expression ISO Phenytoin results in decreased expression of SCARB1 mRNA CTD PMID:15136057 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668 		JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 affects response to substance EXP SCN1A gene polymorphism affects the susceptibility to Phenytoin; SCN1A protein affects the susceptibility to Phenytoin CTD PMID:15805193 PMID:17001291 NCBI chr 2:165,984,641...166,149,161
Ensembl chr 2:165,984,641...166,149,214 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 affects binding
decreases response to substance
multiple interactions		 EXP Phenytoin binds to [SCN1B protein binds to SCN3A protein]
SCN1B protein mutant form results in decreased susceptibility to Phenytoin
Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]		 CTD PMID:15922564 NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449 		JBrowse link
G SCN2A sodium voltage-gated channel alpha subunit 2 decreases activity EXP Phenytoin results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 2:165,239,414...165,392,304
Ensembl chr 2:165,194,993...165,392,310 		JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 multiple interactions
affects binding		 EXP Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
Phenytoin binds to [SCN1B protein binds to SCN3A protein]		 CTD PMID:15922564 NCBI chr 2:165,087,526...165,204,050
Ensembl chr 2:165,087,526...165,204,050 		JBrowse link
G SDC4 syndecan 4 decreases expression ISO Phenytoin results in decreased expression of SDC4 mRNA CTD PMID:15136057 NCBI chr20:45,325,288...45,348,424
Ensembl chr20:45,325,288...45,348,424 		JBrowse link
G SELE selectin E multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SENP7 SUMO specific peptidase 7 increases expression ISO Phenytoin results in increased expression of SENP7 mRNA CTD PMID:20345932 NCBI chr 3:101,324,205...101,513,212
Ensembl chr 3:101,324,205...101,513,241 		JBrowse link
G SERPINC1 serpin family C member 1 multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 1:173,903,800...173,917,327
Ensembl chr 1:173,903,800...173,917,327 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA CTD PMID:21224054 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SH3YL1 SH3 and SYLF domain containing 1 increases expression ISO Phenytoin results in increased expression of SH3YL1 mRNA CTD PMID:20345932 NCBI chr 2:218,136...264,824
Ensembl chr 2:217,730...266,398 		JBrowse link
G SHH sonic hedgehog signaling molecule increases expression ISO Phenytoin results in increased expression of SHH mRNA CTD PMID:26272751 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G SIAH1 siah E3 ubiquitin protein ligase 1 increases expression ISO Phenytoin results in increased expression of SIAH1A mRNA CTD PMID:20345932 NCBI chr16:48,360,531...48,387,246
Ensembl chr16:48,356,364...48,448,402 		JBrowse link
G SIPA1L1 signal induced proliferation associated 1 like 1 increases expression ISO Phenytoin results in increased expression of SIPA1L1 mRNA CTD PMID:20345932 NCBI chr14:71,320,476...71,741,209
Ensembl chr14:71,320,449...71,741,229 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 decreases expression ISO Phenytoin results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G SLC4A3 solute carrier family 4 member 3 increases expression ISO Phenytoin results in increased expression of SLC4A3 mRNA CTD PMID:20345932 NCBI chr 2:219,627,630...219,641,971
Ensembl chr 2:219,627,394...219,641,980 		JBrowse link
G SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 increases expression ISO Phenytoin results in increased expression of SMARCA1 mRNA CTD PMID:20345932 NCBI chr  X:129,446,506...129,523,490
Ensembl chr  X:129,446,501...129,523,500 		JBrowse link
G SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 increases expression ISO Phenytoin results in increased expression of SMARCA5 mRNA CTD PMID:20345932 NCBI chr 4:143,513,702...143,557,486
Ensembl chr 4:143,513,702...143,557,486 		JBrowse link
G SMC2 structural maintenance of chromosomes 2 increases expression ISO Phenytoin results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 9:104,088,263...104,141,419
Ensembl chr 9:104,094,260...104,141,419 		JBrowse link
G SMC3 structural maintenance of chromosomes 3 increases expression EXP Phenytoin results in increased expression of SMC3 mRNA CTD PMID:14741686 NCBI chr10:110,567,695...110,606,048
Ensembl chr10:110,567,684...110,606,048 		JBrowse link
G SMC5 structural maintenance of chromosomes 5 increases expression ISO Phenytoin results in increased expression of SMC5 mRNA CTD PMID:20345932 NCBI chr 9:70,258,978...70,354,873
Ensembl chr 9:70,258,978...70,354,873 		JBrowse link
G SNX2 sorting nexin 2 increases expression ISO Phenytoin results in increased expression of SNX2 mRNA CTD PMID:20345932 NCBI chr 5:122,774,996...122,834,543
Ensembl chr 5:122,775,079...122,834,543 		JBrowse link
G SP3 Sp3 transcription factor increases expression EXP Phenytoin results in increased expression of SP3 mRNA CTD PMID:14741686 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373 		JBrowse link
G ST13 ST13 Hsp70 interacting protein increases expression ISO Phenytoin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 decreases expression EXP Phenytoin results in decreased expression of STAT4 mRNA CTD PMID:14741686 NCBI chr 2:191,029,576...191,151,596
Ensembl chr 2:191,029,576...191,151,596 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases expression ISO Phenytoin results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 PMID:17381134 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 decreases expression ISO Phenytoin results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G SYN1 synapsin I decreases expression
multiple interactions		 ISO Phenytoin results in decreased expression of SYN1 mRNA
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA]		 CTD PMID:27413119 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857 		JBrowse link
G SYP synaptophysin decreases expression
multiple interactions		 ISO Phenytoin results in decreased expression of SYP mRNA
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA]		 CTD PMID:27413119 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,815...49,200,218 		JBrowse link
G SYPL1 synaptophysin like 1 increases expression ISO Phenytoin results in increased expression of SYPL1 mRNA CTD PMID:20345932 NCBI chr 7:106,090,505...106,112,576
Ensembl chr 7:106,090,505...106,112,589 		JBrowse link
G TAF9B TATA-box binding protein associated factor 9b increases expression ISO Phenytoin results in increased expression of TAF9B mRNA CTD PMID:20345932 NCBI chr  X:78,129,748...78,139,650
Ensembl chr  X:78,129,748...78,139,650 		JBrowse link
G TBX21 T-box transcription factor 21 multiple interactions
decreases expression		 ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA
Phenytoin results in decreased expression of TBX21 mRNA		 CTD PMID:23986454 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G TCEAL1 transcription elongation factor A like 1 increases expression ISO Phenytoin results in increased expression of TCEAL1 mRNA CTD PMID:20345932 NCBI chr  X:103,628,716...103,630,953
Ensembl chr  X:103,628,704...103,630,953 		JBrowse link
G TCF15 transcription factor 15 decreases expression EXP Phenytoin results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr20:604,257...610,309
Ensembl chr20:604,257...610,309 		JBrowse link
G TERF1 telomeric repeat binding factor 1 increases expression ISO Phenytoin results in increased expression of TERF1 mRNA CTD PMID:20345932 NCBI chr 8:73,008,864...73,048,123
Ensembl chr 8:73,008,856...73,048,123 		JBrowse link
G TGFA transforming growth factor alpha increases expression ISO Phenytoin results in increased expression of TGFA mRNA CTD PMID:9988880 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
decreases expression		 ISO Phenytoin results in increased expression of TGFB1 mRNA
Phenytoin results in decreased expression of TGFB1 mRNA		 CTD PMID:7841657 PMID:9988880 PMID:16141649 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 decreases expression ISO Phenytoin results in decreased expression of TGFB2 mRNA CTD PMID:9118846 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TGFB3 transforming growth factor beta 3 increases expression EXP Phenytoin results in increased expression of TGFB3 mRNA CTD PMID:14741686 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G THOC6 THO complex subunit 6 decreases expression ISO Phenytoin results in decreased expression of THOC6 mRNA CTD PMID:20345932 NCBI chr16:3,024,035...3,027,750
Ensembl chr16:3,024,027...3,027,755 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP Phenytoin results in increased expression of TIMP1 mRNA; Phenytoin results in increased expression of TIMP1 protein CTD PMID:10914799 PMID:14741686 PMID:15948689 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TKT transketolase increases expression ISO Phenytoin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr 3:53,224,712...53,256,022
Ensembl chr 3:53,224,712...53,256,052 		JBrowse link
G TLR2 toll like receptor 2 multiple interactions
increases expression		 ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA
Phenytoin results in increased expression of TLR2 mRNA		 CTD PMID:23986454 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions
decreases expression		 ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
Phenytoin results in decreased expression of TLR4 mRNA		 CTD PMID:23986454 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TLR9 toll like receptor 9 multiple interactions
decreases expression		 ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA
Phenytoin results in decreased expression of TLR9 mRNA		 CTD PMID:23986454 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645 		JBrowse link
G TNF tumor necrosis factor increases expression EXP Phenytoin results in increased expression of TNF mRNA CTD PMID:14741686 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA CTD PMID:21224054 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TP53 tumor protein p53 increases expression EXP Phenytoin results in increased expression of TP53 mRNA CTD PMID:11134551 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TP53BP2 tumor protein p53 binding protein 2 increases expression ISO Phenytoin results in increased expression of TRP53BP2 mRNA CTD PMID:20345932 NCBI chr 1:223,779,893...223,845,947
Ensembl chr 1:223,779,893...223,845,954 		JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA CTD PMID:21224054 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909 		JBrowse link
G TRMT10B tRNA methyltransferase 10B increases expression ISO Phenytoin results in increased expression of TRMT10B mRNA CTD PMID:20345932 NCBI chr 9:37,752,901...37,778,972
Ensembl chr 9:37,753,803...37,778,972 		JBrowse link
G TUT4 terminal uridylyl transferase 4 increases expression ISO Phenytoin results in increased expression of TUT4 mRNA CTD PMID:20345932 NCBI chr 1:52,423,275...52,553,463
Ensembl chr 1:52,408,282...52,553,487 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression ISO Phenytoin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
G UBE2D2 ubiquitin conjugating enzyme E2 D2 increases expression ISO Phenytoin results in increased expression of UBE2D2 mRNA CTD PMID:20345932 NCBI chr 5:139,526,240...139,628,434
Ensembl chr 5:139,526,431...139,628,434 		JBrowse link
G UBL5 ubiquitin like 5 decreases expression ISO Phenytoin results in decreased expression of UBL5 mRNA CTD PMID:20345932 NCBI chr19:9,827,918...9,830,115
Ensembl chr19:9,827,892...9,830,115 		JBrowse link
G UBR1 ubiquitin protein ligase E3 component n-recognin 1 increases expression ISO Phenytoin results in increased expression of UBR1 mRNA CTD PMID:20345932 NCBI chr15:42,942,897...43,106,038
Ensembl chr15:42,942,897...43,106,113 		JBrowse link
G UGDH UDP-glucose 6-dehydrogenase decreases expression ISO Phenytoin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 affects expression
increases activity
multiple interactions
increases expression		 EXP
ISO		 Phenytoin affects the expression of UGT1A1 mRNA
Phenytoin results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of and results in increased activity of UGT1A1 protein
Phenytoin results in increased expression of UGT1A1 mRNA
Phenytoin results in increased expression of UGT1A1 mRNA; Phenytoin results in increased expression of UGT1A1 protein		 CTD PMID:10421657 PMID:15849716 PMID:17381134 PMID:27413119 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Phenytoin results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases expression ISO Phenytoin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
G UNCX UNC homeobox decreases expression EXP Phenytoin results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 7:1,232,872...1,237,326
Ensembl chr 7:1,232,872...1,237,326 		JBrowse link
G UNG uracil DNA glycosylase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA CTD PMID:21224054 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,126,725 		JBrowse link
G VARS2 valyl-tRNA synthetase 2, mitochondrial increases expression ISO Phenytoin results in increased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr 6:30,914,238...30,926,459
Ensembl chr 6:30,914,205...30,926,459 		JBrowse link
G VCAN versican increases expression EXP Phenytoin results in increased expression of VCAN mRNA CTD PMID:14741686 NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303 		JBrowse link
G VEGFB vascular endothelial growth factor B decreases expression EXP Phenytoin results in decreased expression of VEGFB mRNA CTD PMID:14741686 NCBI chr11:64,234,584...64,239,264
Ensembl chr11:64,234,584...64,239,264 		JBrowse link
G VIM vimentin increases expression EXP Phenytoin results in increased expression of VIM mRNA CTD PMID:14741686 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G WNT1 Wnt family member 1 decreases expression ISO Phenytoin results in decreased expression of WNT1 mRNA CTD PMID:7841657 NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620 		JBrowse link
G WNT3 Wnt family member 3 decreases expression ISO Phenytoin results in decreased expression of WNT3 mRNA CTD PMID:26272751 NCBI chr17:46,762,506...46,818,692
Ensembl chr17:46,762,506...46,833,154 		JBrowse link
G WNT5A Wnt family member 5A increases expression EXP Phenytoin results in increased expression of WNT5A mRNA CTD PMID:31711903 NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 NCBI chr 5:83,077,547...83,374,473
Ensembl chr 5:83,077,498...83,353,787 		JBrowse link
G YME1L1 YME1 like 1 ATPase increases expression ISO Phenytoin results in increased expression of YME1L1 mRNA CTD PMID:20345932 NCBI chr10:27,110,111...27,154,384
Ensembl chr10:27,110,111...27,155,266 		JBrowse link
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 decreases expression ISO Phenytoin results in decreased expression of ZAP70 mRNA CTD PMID:15136057 NCBI chr 2:97,713,576...97,756,364
Ensembl chr 2:97,713,576...97,739,862 		JBrowse link
G ZNF131 zinc finger protein 131 increases expression ISO Phenytoin results in increased expression of ZFP131 mRNA CTD PMID:20345932 NCBI chr 5:43,120,914...43,176,324
Ensembl chr 5:43,065,176...43,192,021 		JBrowse link
G ZNF503 zinc finger protein 503 increases expression ISO Phenytoin results in increased expression of ZFP503 mRNA CTD PMID:20345932 NCBI chr10:75,279,725...75,401,916
Ensembl chr10:75,397,830...75,401,764 		JBrowse link
G ZNF638 zinc finger protein 638 increases expression ISO Phenytoin results in increased expression of ZFP638 mRNA CTD PMID:20345932 NCBI chr 2:71,331,782...71,435,061
Ensembl chr 2:71,276,561...71,435,069 		JBrowse link
G ZSCAN21 zinc finger and SCAN domain containing 21 increases expression ISO Phenytoin results in increased expression of ZSCAN21 mRNA CTD PMID:20345932 NCBI chr 7:100,049,774...100,065,040
Ensembl chr 7:100,049,774...100,065,040 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        aetiopathogenetic role 24592
          teratogenic agent 18039
            phenytoin 405
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organic heteromonocyclic compound 19212
                                    diazolidine 1017
                                      imidazolidines 1007
                                        imidazolidinone 619
                                          imidazolidine-2,4-dione 483
                                            hydantoin 412
                                              phenytoin 405
paths to the root