phenytoin - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	phenytoin	go back to main search page
Accession:	CHEBI:8107	browse the term
Definition:	A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Synonyms:	related_synonym:	5,5-Diphenyl-imidazolidine-2,4-dione; 5,5-diphenylimidazolidine-2,4-dione; 5,5-diphenyltetrahydro-1H-2,4-imidazoledione; DILANTIN; Formula=C15H12N2O2; InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19); InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N; PHENTYTOIN; SMILES=O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1; fenitoina; phenytoine; phenytoinum
	alt_id:	CHEBI:100921
	xref:	Beilstein:384532; CAS:57-41-0; DrugBank:DB00252; Drug_Central:2152; HMDB:HMDB0014397; KEGG:C07443; KEGG:D00512; LINCS:LSM-5663
	xref_mesh:	MESH:D010672
	xref:	PMID:10698828; PMID:12952753; PMID:15246836; PMID:15744730; PMID:16303054; PMID:7105825; PMID:7602118; PMID:9186244; Patent:WO2012174723; Reaxys:384532; Wikipedia:Phenytoin

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Genes (408)

phenytoin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aladin WD repeat nucleoporin

decreases expression

Phenytoin results in decreased expression of AAAS mRNA

NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961

G

ATP binding cassette subfamily A member 1

decreases expression

Phenytoin results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

affects response to substance
affects abundance
increases metabolic processing
decreases activity
increases transport
increases expression
multiple interactions

ABCB1 protein affects the susceptibility to Phenytoin
ABCB1 protein affects the abundance of Phenytoin
ABCB1 protein results in increased metabolism of Phenytoin
Phenytoin results in decreased activity of ABCB1 protein
ABCB1A protein results in increased transport of Phenytoin
Phenytoin results in increased expression of ABCB1 protein
Amino Acids, Peptides, and Proteins inhibits the reaction [Phenytoin results in increased expression of ABCB1 protein]; Phenytoin results in increased expression of and results in increased activity of ABCB1A protein

PMID:8001500 PMID:10580886 PMID:14749549 PMID:15569486 PMID:16220110 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects abundance

ABCB1B protein affects the abundance of Phenytoin

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

multiple interactions
increases expression

KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

affects transport
affects response to substance
increases expression
multiple interactions

ABCC2 protein affects the transport of Phenytoin
ABCC2 protein affects the susceptibility to Phenytoin
Phenytoin results in increased expression of ABCC2 protein
KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]

PMID:12663688 PMID:14636316 PMID:17376120 PMID:18473823

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

Phenytoin results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 1

decreases expression

Phenytoin results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase

increases expression

Phenytoin results in increased expression of ABHD5 mRNA

NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447

G

actin-binding LIM protein 1

decreases expression

Phenytoin results in decreased expression of ABLIM1 mRNA

NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969

G

angiotensin converting enzyme 2

decreases expression

Phenytoin results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

increases activity

Phenytoin results in increased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ADAM metallopeptidase domain 8

decreases expression

Phenytoin results in decreased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

ADAM metallopeptidase with thrombospondin type 1 motif, 9

increases expression

Phenytoin results in increased expression of ADAMTS9 mRNA

NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929

G

adhesion G protein-coupled receptor B3

increases expression

Phenytoin results in increased expression of ADGRB3 mRNA

NCBI chr 9:27,421,168...28,148,979
Ensembl chr 9:27,421,168...28,148,855

G

adrenoceptor beta 3

decreases expression

Phenytoin results in decreased expression of ADRB3 mRNA

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

alpha-fetoprotein

decreases expression

Phenytoin results in decreased expression of AFP mRNA

PMID:14741686 PMID:26272751

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

decreases expression

Phenytoin results in decreased expression of AGAP3 mRNA

NCBI chr 4:10,674,746...10,724,848
Ensembl chr 4:10,674,064...10,725,244

G

aryl hydrocarbon receptor

multiple interactions
increases expression

CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA]
Phenytoin results in increased expression of AHR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

A-kinase anchoring protein 10

increases expression

Phenytoin results in increased expression of AKAP10 mRNA

NCBI chr10:46,545,371...46,608,730
Ensembl chr10:46,551,532...46,608,769

G

aldo-keto reductase family 7 member A3

decreases expression
increases expression

Phenytoin results in decreased expression of AKR7A3 mRNA
Phenytoin results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Phenytoin results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A2

decreases expression

Phenytoin results in decreased expression of ALDH1A2 mRNA

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

antagonist of mitotic exit network 1 homolog

increases expression

Phenytoin results in increased expression of AMN1 mRNA

NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016

G

annexin A4

increases expression

Phenytoin results in increased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

annexin A5

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apolipoprotein A1

increases expression

Phenytoin results in increased expression of APOA1 mRNA

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A4

increases expression

Phenytoin results in increased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein E

increases expression

Phenytoin results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

androgen receptor

multiple interactions
increases activity
increases expression

[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Phenytoin results in increased activity of AR protein
Phenytoin results in increased expression of AR mRNA; Phenytoin results in increased expression of AR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]

PMID:19226368 PMID:19490052

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ADP-ribosylation factor interacting protein 1

increases expression

Phenytoin results in increased expression of ARFIP1 mRNA

NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142

G

Rho GTPase activating protein 39

increases expression

Phenytoin results in increased expression of ARHGAP39 mRNA

NCBI chr 7:108,446,280...108,538,875
Ensembl chr 7:108,446,282...108,538,831

G

armadillo repeat containing 8

increases expression

Phenytoin results in increased expression of ARMC8 mRNA

NCBI chr 8:100,036,946...100,131,544
Ensembl chr 8:100,036,946...100,131,520

G

ATM serine/threonine kinase

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATP synthase mitochondrial F1 complex assembly factor 1

decreases expression

Phenytoin results in decreased expression of ATPAF1 mRNA

NCBI chr 5:129,265,789...129,292,463
Ensembl chr 5:129,266,404...129,293,556

G

beta-1,4-galactosyltransferase 7

decreases expression

Phenytoin results in decreased expression of B4GALT7 mRNA

NCBI chr17:9,018,514...9,027,591
Ensembl chr17:9,018,935...9,027,573

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

Phenytoin results in increased expression of and affects the localization of BCL2 protein
Phenytoin results in decreased expression of BCL2 mRNA

PMID:9118846 PMID:10695937

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

bone morphogenetic protein 1

decreases expression

Phenytoin results in decreased expression of BMP1 mRNA

NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776

G

bone morphogenetic protein 4

increases expression

Phenytoin results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

complement C2

decreases expression

Phenytoin results in decreased expression of C2 mRNA

NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505

G

calcyclin binding protein

increases expression

Phenytoin results in increased expression of CACYBP mRNA

NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177

G

calcitonin-related polypeptide alpha

decreases expression

Phenytoin results in decreased expression of CALCA protein

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calmodulin 2

decreases expression

Phenytoin results in decreased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calpain 5

decreases expression

Phenytoin results in decreased expression of CAPN5 mRNA

NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923

G

carbonic anhydrase 6

increases expression

Phenytoin results in increased expression of CAR6 mRNA

NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644

G

CASK interacting protein 1

affects expression

Phenytoin affects the expression of CASKIN1 mRNA

NCBI chr10:13,512,684...13,533,380
Ensembl chr10:13,513,465...13,533,377

G

catalase

decreases response to substance

CAT protein results in decreased susceptibility to Phenytoin

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene like 1

increases expression

Phenytoin results in increased expression of CBLL1 mRNA

NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444

G

C-C motif chemokine ligand 2

increases expression

Phenytoin results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin C

increases expression

Phenytoin results in increased expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

multiple interactions
decreases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA
Phenytoin results in decreased expression of CCND1 mRNA; Phenytoin results in decreased expression of CCND1 protein
MIR4680 affects the reaction [Phenytoin results in decreased expression of CCND1 protein]

PMID:14741686 PMID:21224054 PMID:38191190

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression
multiple interactions

Phenytoin results in decreased expression of CCNE1 protein
MIR4680 affects the reaction [Phenytoin results in decreased expression of CCNE1 protein]

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin G1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

Cd47 molecule

decreases expression

Phenytoin results in decreased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

cadherin 2

decreases expression

Phenytoin results in decreased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

decreases expression

Phenytoin results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1A

decreases expression
multiple interactions

Phenytoin results in decreased expression of CDKN1A mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein

PMID:14741686 PMID:21224054

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

caudal type homeo box 2

increases expression

Phenytoin results in increased expression of CDX2 mRNA

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

G

chymotrypsin like elastase 2A

decreases expression

Phenytoin results in decreased expression of CELA2A mRNA

NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632

G

centrosomal protein 57

increases expression

Phenytoin results in increased expression of CEP57 mRNA

NCBI chr 8:10,669,588...10,689,257
Ensembl chr 8:10,669,590...10,689,249

G

cerberus 1, DAN family BMP antagonist

decreases expression

Phenytoin results in decreased expression of CER1 mRNA

NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783

G

checkpoint kinase 2

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

creatine kinase, M-type

increases expression

Phenytoin results in increased expression of CKM protein

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

chloride voltage-gated channel 6

decreases expression

Phenytoin results in decreased expression of CLCN6 mRNA

NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059

G

cytidine/uridine monophosphate kinase 1

increases expression

Phenytoin results in increased expression of CMPK1 mRNA

NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830

G

CCR4-NOT transcription complex, subunit 7

increases expression

Phenytoin results in increased expression of CNOT7 mRNA

NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576

G

collagen type XI alpha 1 chain

increases expression

Phenytoin results in increased expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type XVIII alpha 1 chain

decreases expression

Phenytoin results in decreased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 1 chain

multiple interactions
decreases expression
increases expression

Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
Phenytoin results in decreased expression of COL1A1 mRNA
Phenytoin results in increased expression of COL1A1 mRNA

PMID:8971655 PMID:14741686

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

increases expression
affects expression

Phenytoin results in increased expression of COL1A2 mRNA
Phenytoin affects the expression of COL1A2 mRNA

PMID:14741686 PMID:24704097

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type VI alpha 1 chain

decreases expression
increases expression

Phenytoin results in decreased expression of COL6A1 mRNA
Phenytoin results in increased expression of COL6A1 mRNA

PMID:8224229 PMID:14741686

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VI alpha 2 chain

increases expression

Phenytoin results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VI alpha 3 chain

increases expression

Phenytoin results in increased expression of COL6A3 mRNA

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

G

ceruloplasmin

decreases expression

Phenytoin results in decreased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cleavage and polyadenylation specific factor 6

increases expression

Phenytoin results in increased expression of CPSF6 mRNA

NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122

G

corticotropin releasing hormone

affects expression

Phenytoin affects the expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

CDP-L-ribitol pyrophosphorylase A

increases expression

Phenytoin results in increased expression of CRPPA mRNA

NCBI chr 6:53,120,264...53,397,030
Ensembl chr 6:53,121,438...53,397,028

G

cathepsin B

increases expression
decreases activity

Phenytoin results in increased expression of CTSB mRNA
Phenytoin results in decreased activity of CTSB protein

PMID:10914799 PMID:14741686

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin L

increases expression
decreases activity

Phenytoin results in increased expression of CTSL mRNA
Phenytoin results in decreased activity of CTSL protein

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cullin 4A

increases expression

Phenytoin results in increased expression of CUL4A mRNA

NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330

G

C-X3-C motif chemokine ligand 1

increases expression

Phenytoin results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 10

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 2

multiple interactions

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

Phenytoin results in decreased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Phenytoin results in increased expression of CYP1A1 mRNA

PMID:9860486 PMID:17381134

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases expression
increases expression

Phenytoin results in decreased expression of CYP2B1 mRNA
Phenytoin results in increased expression of CYP2B1 mRNA

PMID:9819145 PMID:10945841

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

Phenytoin results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases activity
increases expression
decreases expression

[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein; pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]
Phenytoin results in increased activity of CYP2B6 protein
Phenytoin results in increased expression of CYP2B6 mRNA; Phenytoin results in increased expression of CYP2B6 protein
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
Phenytoin results in decreased expression of CYP2B10 protein

PMID:12571232 PMID:12695351 PMID:14977870 PMID:15123723 PMID:17041008 More...

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases hydroxylation
increases metabolic processing
increases hydroxylation
decreases metabolic processing
affects metabolic processing
affects expression
increases expression

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CYP2C19 gene polymorphism results in decreased hydroxylation of Phenytoin
CYP2C19 protein results in increased metabolism of Phenytoin
CYP2C19 protein results in increased hydroxylation of Phenytoin
CYP2C19 gene polymorphism results in decreased metabolism of Phenytoin
CYP2C19 protein affects the metabolism of Phenytoin
Phenytoin affects the expression of CYP2C29 mRNA
Phenytoin results in increased expression of CYP2C protein; Phenytoin results in increased expression of CYP2C29 mRNA; Phenytoin results in increased expression of CYP2C29 protein
[Phenytoin results in decreased activity of CYP2C29 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]

PMID:9146858 PMID:9333104 PMID:9579299 PMID:9860067 PMID:12051692 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 7

increases metabolic processing

CYP2C9 protein results in increased metabolism of Phenytoin

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases expression
decreases expression

NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]
Phenytoin results in increased expression of CYP2E1 mRNA; Phenytoin results in increased expression of CYP2E1 protein
Phenytoin results in decreased expression of CYP2E1 mRNA

PMID:17381134 PMID:18206661

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions
increases activity

Phenytoin results in increased expression of CYP3A2 mRNA; Phenytoin results in increased expression of CYP3A2 protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
Phenytoin results in increased expression of CYP3A4 mRNA; Phenytoin results in increased expression of CYP3A4 protein
Phenytoin results in increased activity of CYP3A4 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]

PMID:9512926 PMID:10219967 PMID:12065438 PMID:12505310 PMID:12673034 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

decreases expression
increases expression

Phenytoin results in decreased expression of CYP3A23-3A1 mRNA
Phenytoin results in increased expression of CYP3A23-3A1 mRNA

PMID:10945841 PMID:17381134

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

Phenytoin results in increased expression of CYP3A5 mRNA
Phenytoin results in increased expression of CYP3A13 mRNA

PMID:12673034 PMID:19903449

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 1

decreases expression

Phenytoin results in decreased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

increases expression

Phenytoin results in increased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

death associated protein 3

increases expression

Phenytoin results in increased expression of DAP3 mRNA

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

G

death-associated protein kinase 2

decreases expression

Phenytoin results in decreased expression of DAPK2 mRNA

NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567

G

DNA-damage inducible transcript 3

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DExH-box helicase 9

increases expression

Phenytoin results in increased expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

dematin actin binding protein

decreases expression

Phenytoin results in decreased expression of DMTN mRNA

NCBI chr15:45,677,974...45,702,261
Ensembl chr15:45,677,977...45,705,601

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

E2F transcription factor 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

EBP like

increases expression

Phenytoin results in increased expression of EBPL mRNA

NCBI chr15:35,508,074...35,531,472
Ensembl chr15:35,508,074...35,531,472

G

early growth response 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 3

increases expression

Phenytoin results in increased expression of EGR3 mRNA

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 1A

increases expression

Phenytoin results in increased expression of EIF1A mRNA

NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696

G

empty spiracles homeobox 2

decreases expression

Phenytoin results in decreased expression of EMX2 mRNA

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

glutamyl aminopeptidase

decreases expression
increases expression

Phenytoin results in decreased expression of ENPEP mRNA
Phenytoin results in increased expression of ENPEP mRNA

NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947

G

eomesodermin

increases expression

Phenytoin results in increased expression of EOMES mRNA

NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316

G

epoxide hydrolase 1

affects response to substance
increases expression

EPHX1 gene polymorphism affects the susceptibility to Phenytoin
Phenytoin results in increased expression of EPHX1 mRNA

PMID:17381134 PMID:19952982

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epoxide hydrolase 2

decreases expression

Phenytoin results in decreased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

erb-b2 receptor tyrosine kinase 2

decreases expression
multiple interactions

Phenytoin results in decreased expression of ERBB2 mRNA; Phenytoin results in decreased expression of ERBB2 protein
MIR4680 affects the reaction [Phenytoin results in decreased expression of ERBB2 mRNA]; MIR4680 affects the reaction [Phenytoin results in decreased expression of ERBB2 protein]

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

estrogen receptor 1

increases expression

Phenytoin results in increased expression of ESR1 mRNA; Phenytoin results in increased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

Phenytoin results in decreased expression of EYA1 mRNA

NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483

G

coagulation factor X

decreases expression

Phenytoin results in decreased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor II, thrombin

multiple interactions

[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

Fas ligand

multiple interactions
decreases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA
Phenytoin results in decreased expression of FASL mRNA

PMID:21224054 PMID:23986454

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box and leucine-rich repeat protein 3

increases expression

Phenytoin results in increased expression of FBXL3 mRNA

NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867

G

F-box protein 30

increases expression

Phenytoin results in increased expression of FBXO30 mRNA

NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441

G

fibroblast growth factor 12

increases expression

Phenytoin results in increased expression of FGF12 mRNA

NCBI chr11:71,997,151...72,564,757
Ensembl chr11:71,997,099...72,562,607

G

fibroblast growth factor 5

increases expression

Phenytoin results in increased expression of FGF5 mRNA

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

G

fibroblast growth factor 8

increases expression

Phenytoin results in increased expression of FGF8 mRNA

NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359

G

fibroblast growth factor 9

increases expression

Phenytoin results in increased expression of FGF9 mRNA

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

fibroblast growth factor receptor 2

increases expression

Phenytoin results in increased expression of FGFR2 mRNA; Phenytoin results in increased expression of FGFR2 protein

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibronectin leucine rich transmembrane protein 2

increases expression

Phenytoin results in increased expression of FLRT2 mRNA

NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

flavin containing dimethylaniline monoxygenase 4

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA

NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874

G

fibromodulin

decreases expression

Phenytoin results in decreased expression of FMOD mRNA

NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133

G

fragile X messenger ribonucleoprotein 1

increases expression

Phenytoin results in increased expression of FMR1 mRNA

NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050

G

fibronectin 1

increases expression

Phenytoin results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 3a

increases expression

Phenytoin results in increased expression of FNDC3A mRNA

NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

[Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]
Phenytoin results in decreased expression of FOS protein

PMID:7789465 PMID:8758711

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box C2

decreases expression

Phenytoin results in decreased expression of FOXC2 mRNA

NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737

G

forkhead box P3

multiple interactions
decreases expression

[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
Phenytoin results in decreased expression of FOXP3 mRNA

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

fibroblast growth factor receptor substrate 3

decreases expression

Phenytoin results in decreased expression of FRS3 mRNA

NCBI chr 9:13,288,559...13,297,285
Ensembl chr 9:13,288,667...13,295,382

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

Phenytoin results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

affects response to substance

G6PDX protein affects the susceptibility to Phenytoin

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

GATA binding protein 3

multiple interactions
decreases expression

[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Phenytoin results in decreased expression of GATA3 mRNA

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glutamate cysteine ligase, modifier subunit

increases expression

Phenytoin results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutamate-ammonia ligase

decreases activity

Phenytoin results in decreased activity of GLUL protein

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

G protein nucleolar 2

increases expression

Phenytoin results in increased expression of GNL2 mRNA

NCBI chr 5:137,293,141...137,318,528
Ensembl chr 5:137,293,081...137,318,526

G

glucosamine-6-phosphate deaminase 2

increases expression

Phenytoin results in increased expression of GNPDA2 mRNA

NCBI chr14:38,520,663...38,538,713
Ensembl chr14:38,520,705...38,538,713

G

glycoprotein m6a

increases expression

Phenytoin results in increased expression of GPM6A mRNA

NCBI chr16:36,641,282...36,973,377
Ensembl chr16:36,641,284...36,973,475

G

glutathione peroxidase 2

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor NMDA type subunit 1

increases expression

Phenytoin results in increased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutathione S-transferase alpha 1

increases expression

Phenytoin results in increased expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

increases expression
decreases expression

Phenytoin results in increased expression of GSTA2 mRNA
Phenytoin results in decreased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase kappa 1

decreases expression

Phenytoin results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

increases expression
multiple interactions

Phenytoin results in increased expression of GSTM1 mRNA
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein

PMID:17381134 PMID:21224054

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

increases expression

Phenytoin results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase, mu 5

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase omega 1

decreases expression

Phenytoin results in decreased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glucuronidase, beta

multiple interactions
decreases activity

Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]
Phenytoin results in decreased activity of GUSB protein

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

histone deacetylase 7

increases expression

Phenytoin results in increased expression of HDAC7 mRNA

NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072

G

helicase with zinc finger

increases expression

Phenytoin results in increased expression of HELZ mRNA

NCBI chr10:92,479,403...92,645,234
Ensembl chr10:92,501,518...92,638,383

G

HEXIM P-TEFb complex subunit 1

increases expression

Phenytoin results in increased expression of HEXIM1 mRNA

NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189

G

high mobility group box 1

multiple interactions

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

multiple interactions
increases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Phenytoin results in increased expression of HMOX1 mRNA

PMID:17381134 PMID:21224054

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A2/B1

increases expression

Phenytoin results in increased expression of HNRNPA2B1 mRNA

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

hook microtubule-tethering protein 3

increases expression

Phenytoin results in increased expression of HOOK3 mRNA

NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338

G

homeobox A2

decreases expression

Phenytoin results in decreased expression of HOXA2 mRNA; Phenytoin results in decreased expression of HOXA2 protein

NCBI chr 4:81,262,668...81,266,970
Ensembl chr 4:81,262,768...81,265,044

G

homeo box B7

increases expression

Phenytoin results in increased expression of HOXB7 mRNA

NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034

G

homeo box B9

increases expression

Phenytoin results in increased expression of HOXB9 mRNA

NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 8

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

interferon gamma

decreases expression

Phenytoin results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

increases expression

Phenytoin results in increased expression of IFNGR1 mRNA

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

interferon gamma receptor 2

increases expression

Phenytoin results in increased expression of IFNGR2 mRNA

NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005

G

insulin-like growth factor 1

decreases expression

Phenytoin results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

increases expression

Phenytoin results in increased expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

Indian hedgehog signaling molecule

increases expression

Phenytoin results in increased expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

interleukin 17A

multiple interactions

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein

PMID:8971655 PMID:21224054 PMID:23986454

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 23 subunit alpha

multiple interactions

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 6

multiple interactions
increases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA
Phenytoin results in increased expression of IL6 mRNA

PMID:21224054 PMID:23986454

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

decreases expression

Phenytoin results in decreased expression of IL6RA mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

inositol polyphosphate-5-phosphatase F

increases expression

Phenytoin results in increased expression of INPP5F mRNA

NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276

G

insulin receptor

increases expression

Phenytoin results in increased expression of INSR mRNA

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

intracisternal A particle-promoted polypeptide

increases expression

Phenytoin results in increased expression of IPP mRNA

NCBI chr 5:129,962,528...130,001,237
Ensembl chr 5:129,962,643...130,001,242

G

interferon regulatory factor 9

increases expression

Phenytoin results in increased expression of IRF9 mRNA

NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236

G

integrin subunit alpha 2

decreases expression

Phenytoin results in decreased expression of ITGA2 protein

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha 8

increases expression

Phenytoin results in increased expression of ITGA8 mRNA

NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510

G

integrin subunit beta 1

decreases expression

Phenytoin results in decreased expression of ITGB1 protein

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 3 binding protein

increases expression

Phenytoin results in increased expression of ITGB3BP mRNA

NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704

G

jade family PHD finger 1

multiple interactions
decreases expression

MIR4680 affects the reaction [Phenytoin results in decreased expression of JADE1 mRNA]; MIR4680 affects the reaction [Phenytoin results in decreased expression of JADE1 protein]
Phenytoin results in decreased expression of JADE1 mRNA; Phenytoin results in decreased expression of JADE1 protein

NCBI chr 2:124,543,233...124,596,361
Ensembl chr 2:124,543,286...124,596,354

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

Phenytoin results in decreased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily D member 2

increases expression

Phenytoin results in increased expression of KCND2 mRNA

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Phenytoin results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium channel tetramerization domain containing 3

increases expression

Phenytoin results in increased expression of KCTD3 mRNA

NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718

G

kinase insert domain receptor

increases expression

Phenytoin results in increased expression of KDR mRNA

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

KH RNA binding domain containing, signal transduction associated 2

increases expression

Phenytoin results in increased expression of KHDRBS2 mRNA

NCBI chr 9:34,447,023...34,953,684
Ensembl chr 9:34,447,056...34,915,530

G

KLF transcription factor 2

increases expression

Phenytoin results in increased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

kelch-like family member 2

increases expression

Phenytoin results in increased expression of KLHL2 mRNA

NCBI chr16:24,860,744...24,973,348
Ensembl chr16:24,860,667...24,973,341

G

kelch-like family member 7

increases expression

Phenytoin results in increased expression of KLHL7 mRNA

NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541

G

KRIT1, ankyrin repeat containing

increases expression

Phenytoin results in increased expression of KRIT1 mRNA

NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359

G

keratin 2

increases expression

Phenytoin results in increased expression of KRT2 mRNA

NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963

G

kynurenine aminotransferase 1

increases activity

Phenytoin results in increased activity of KYAT1 protein

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

laminin subunit alpha 2

increases expression

Phenytoin results in increased expression of LAMA2 mRNA

NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530

G

leucine aminopeptidase 3

affects expression

Phenytoin affects the expression of LAP3 mRNA

NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359

G

lecithin cholesterol acyltransferase

increases expression

Phenytoin results in increased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LIM domain binding 2

increases expression

Phenytoin results in increased expression of LDB2 mRNA

NCBI chr14:66,277,044...66,598,071
Ensembl chr14:66,277,085...66,597,778

G

lipin 1

increases expression

Phenytoin results in increased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

LPS responsive beige-like anchor protein

increases expression

Phenytoin results in increased expression of LRBA mRNA

NCBI chr 2:171,623,668...172,202,576
Ensembl chr 2:171,621,507...172,202,724

G

LSM1 homolog, mRNA degradation associated

decreases expression

Phenytoin results in decreased expression of LSM1 mRNA

NCBI chr16:66,277,345...66,288,852
Ensembl chr16:66,277,345...66,288,852

G

latent transforming growth factor beta binding protein 4

increases expression

Phenytoin results in increased expression of LTBP4 mRNA

NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178

G

lysophospholipase 1

increases expression

Phenytoin results in increased expression of LYPLA1 mRNA

NCBI chr 5:14,679,605...14,708,774
Ensembl chr 5:14,679,606...14,708,746

G

microtubule-associated protein 1B

increases expression

Phenytoin results in increased expression of MAP1B mRNA

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

mitogen activated protein kinase kinase kinase 4

increases expression

Phenytoin results in increased expression of MAP3K4 mRNA

NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358

G

mitogen activated protein kinase 1

decreases phosphorylation

Phenytoin results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation

Phenytoin results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein, RP/EB family, member 3

increases expression

Phenytoin results in increased expression of MAPRE3 mRNA

NCBI chr 6:25,513,800...25,558,876
Ensembl chr 6:25,513,800...25,558,881

G

mannose binding lectin 1

decreases expression

Phenytoin results in decreased expression of MBL1 mRNA

NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174

G

midkine

increases expression

Phenytoin results in increased expression of MDK mRNA

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

MDM2 proto-oncogene

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 1

increases expression

Phenytoin results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

mesenchyme homeobox 1

decreases expression

Phenytoin results in decreased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

mesoderm posterior bHLH transcription factor 1

increases expression

Phenytoin results in increased expression of MESP1 mRNA

NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875

G

mex-3 RNA binding family member D

increases expression

Phenytoin results in increased expression of MEX3D mRNA

NCBI chr 7:9,325,575...9,332,705
Ensembl chr 7:9,325,488...9,332,096

G

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

increases expression

Phenytoin results in increased expression of MGAT2 mRNA

NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177

G

O-6-methylguanine-DNA methyltransferase

increases methylation

Phenytoin results in increased methylation of MGMT promoter

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 1

decreases expression
increases expression

Phenytoin results in decreased expression of MMP1 mRNA
Phenytoin results in increased expression of MMP1 mRNA

PMID:10914799 PMID:14741686 PMID:15948689

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

decreases expression

Phenytoin results in decreased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

decreases expression

Phenytoin results in decreased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

mitochondrial ribosomal protein S18C

increases expression

Phenytoin results in increased expression of MRPS18C mRNA

NCBI chr14:8,812,301...8,818,538
Ensembl chr14:8,791,330...8,818,516

G

metal response element binding transcription factor 2

increases expression

Phenytoin results in increased expression of MTF2 mRNA

NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

increases expression

Phenytoin results in increased expression of MTHFD1L mRNA

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

G

metaxin 2

increases expression

Phenytoin results in increased expression of MTX2 mRNA

NCBI chr 3:59,730,206...59,792,202
Ensembl chr 3:59,730,197...59,792,201

G

MYC proto-oncogene, bHLH transcription factor

increases expression
decreases expression

Phenytoin results in increased expression of MYC protein
Phenytoin results in decreased expression of MYC mRNA

PMID:10695937 PMID:26272751

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin IE

increases expression

Phenytoin results in increased expression of MYO1E mRNA

NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169

G

nucleosome assembly protein 1-like 2

affects expression

Phenytoin affects the expression of NAP1L2 mRNA

NCBI chr X:68,174,051...68,176,449
Ensembl chr X:68,173,987...68,176,666

G

neurocan

increases expression

Phenytoin results in increased expression of NCAN mRNA

NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436

G

nucleolin

decreases expression

Phenytoin results in decreased expression of NCL mRNA

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

nuclear receptor coactivator 1

multiple interactions

Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

negative elongation factor complex member A

decreases expression

Phenytoin results in decreased expression of NELFA mRNA

NCBI chr14:76,808,920...76,832,998
Ensembl chr14:76,808,870...76,832,994

G

nestin

decreases expression

Phenytoin results in decreased expression of NES mRNA

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

G

neurogenin 2

increases expression

Phenytoin results in increased expression of NEUROG2 mRNA

NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein]
Phenytoin results in increased expression of NFKB1 mRNA

PMID:10700573 PMID:14741686

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

decreases degradation

Phenytoin results in decreased degradation of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

N-glycanase 1

increases expression

Phenytoin results in increased expression of NGLY1 mRNA

NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630

G

NLR family, pyrin domain containing 3

multiple interactions

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuronal PAS domain protein 2

increases expression

Phenytoin results in increased expression of NPAS2 mRNA

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

NAD(P)H quinone dehydrogenase 1

increases expression

Phenytoin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity
increases expression
affects activity

Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin binds to and results in increased activity of NR1I2 protein; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased activity of NR1I2 protein
Phenytoin results in increased expression of NR1I2 protein
Phenytoin affects the activity of NR1I2 protein

PMID:12065438 PMID:12695340 PMID:12695351 PMID:14600250 PMID:14977870 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
increases localization
increases activity
increases expression

[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Phenytoin results in increased localization of NR1I3 protein
NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]
Phenytoin results in increased expression of NR1I3 protein

PMID:15123723 PMID:15155833 PMID:15849716 PMID:16936065 PMID:17041008 More...

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 2, group F, member 1

increases expression

Phenytoin results in increased expression of NR2F1 mRNA

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions
increases expression

Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]
Phenytoin results in increased expression of NR3C1 mRNA

PMID:10219967 PMID:12695351 PMID:20345932

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neuronal cell adhesion molecule

decreases expression

Phenytoin results in decreased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

NSE3 homolog, SMC5-SMC6 complex component

increases expression

Phenytoin results in increased expression of NSMCE3 mRNA

NCBI chr 1:118,401,302...118,402,629

G

5'-nucleotidase domain containing 1

increases expression

Phenytoin results in increased expression of NT5DC1 mRNA

NCBI chr20:38,105,677...38,208,613
Ensembl chr20:38,105,678...38,208,591

G

neurotrophin 3

decreases expression

Phenytoin results in decreased expression of NTF3 mRNA

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

nucleoporin 153

increases expression

Phenytoin results in increased expression of NUP153 mRNA

NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876

G

oligodendrocyte transcription factor 3

increases expression

Phenytoin results in increased expression of OLIG3 mRNA

NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149

G

opioid receptor, mu 1

multiple interactions

[cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

decreases expression

Phenytoin results in decreased expression of PAFAH1B1 mRNA

NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808

G

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2

decreases expression

Phenytoin results in decreased expression of PAFAH1B2 mRNA

NCBI chr 8:46,260,069...46,312,073
Ensembl chr 8:46,261,064...46,279,833

G

par-6 family cell polarity regulator gamma

increases expression

Phenytoin results in increased expression of PARD6G mRNA

NCBI chr18:73,497,992...73,565,048
Ensembl chr18:73,498,021...73,565,029

G

poly (ADP-ribose) glycohydrolase

increases expression

Phenytoin results in increased expression of PARG mRNA

NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273

G

paired box 3

decreases expression

Phenytoin results in decreased expression of PAX3 mRNA

PMID:9118846 PMID:31711903

NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042

G

paired box 6

increases expression

Phenytoin results in increased expression of PAX6 mRNA

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

PBX homeobox 1

increases expression

Phenytoin results in increased expression of PBX1 mRNA

NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594

G

prenylcysteine oxidase 1

increases expression

Phenytoin results in increased expression of PCYOX1 mRNA

NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951

G

platelet derived growth factor subunit A

increases expression

Phenytoin results in increased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

increases expression

Phenytoin results in increased expression of PDGFB mRNA; Phenytoin results in increased expression of PDGFB protein

PMID:8463938 PMID:9029455 PMID:14741686

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

progesterone receptor membrane component 1

increases expression

Phenytoin results in increased expression of PGRMC1 mRNA

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

PHD finger protein 14

increases expression

Phenytoin results in increased expression of PHF14 mRNA

NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885

G

phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

increases expression

Phenytoin results in increased expression of PIP4K2A mRNA

NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029

G

plasminogen activator, urokinase receptor

decreases expression

Phenytoin results in decreased expression of PLAUR mRNA

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

phospholipase C-like 1

increases expression

Phenytoin results in increased expression of PLCL1 mRNA

NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782

G

plectin

increases expression

Phenytoin results in increased expression of PLEC mRNA

NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467

G

phospholipid transfer protein

increases expression

Phenytoin results in increased expression of PLTP mRNA

NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647

G

plexin B2

decreases expression

Phenytoin results in decreased expression of PLXNB2 mRNA

NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330

G

pinin, desmosome associated protein

increases expression

Phenytoin results in increased expression of PNN mRNA

NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889

G

paraoxonase 1

decreases expression
affects activity

Phenytoin results in decreased expression of PON1 mRNA
Phenytoin affects the activity of PON1 protein

PMID:15136057 PMID:28032682

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

cytochrome p450 oxidoreductase

increases activity

Phenytoin results in increased activity of POR protein

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

POU class 3 homeobox 1

increases expression

Phenytoin results in increased expression of POU3F1 protein

NCBI chr 5:136,910,391...136,913,371
Ensembl chr 5:136,910,391...136,913,371

G

peptidylprolyl isomerase like 4

increases expression

Phenytoin results in increased expression of PPIL4 mRNA

NCBI chr 1:2,273,582...2,305,639
Ensembl chr 1:2,273,609...2,305,632

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline]

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

prolactin

decreases expression

Phenytoin results in decreased expression of PRL mRNA; Phenytoin results in decreased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

protein arginine methyltransferase 3

increases expression

Phenytoin results in increased expression of PRMT3 mRNA

NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435

G

serine protease 12

increases expression

Phenytoin results in increased expression of PRSS12 mRNA

NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126

G

PC4 and SRSF1 interacting protein 1

increases expression

Phenytoin results in increased expression of PSIP1 mRNA

NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257

G

proteasome 26S subunit, ATPase 6

increases expression

Phenytoin results in increased expression of PSMC6 mRNA

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

proteasome 26S subunit, non-ATPase 12

increases expression

Phenytoin results in increased expression of PSMD12 mRNA

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287

G

polypyrimidine tract binding protein 2

increases expression

Phenytoin results in increased expression of PTBP2 mRNA

NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506

G

patched 1

increases expression

Phenytoin results in increased expression of PTCH1 mRNA

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

prostaglandin-endoperoxide synthase 2

increases expression

Phenytoin results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

increases expression

Phenytoin results in increased expression of PTH protein

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

RAD50 double strand break repair protein

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

G

retinoic acid induced 1

increases expression

Phenytoin results in increased expression of RAI1 mRNA

NCBI chr10:44,913,231...45,008,232
Ensembl chr10:44,947,909...45,008,232

G

RAN binding protein 6

increases expression

Phenytoin results in increased expression of RANBP6 mRNA

NCBI chr 1:227,572,394...227,576,915
Ensembl chr 1:227,572,105...227,576,942

G

Rap guanine nucleotide exchange factor 4

increases expression

Phenytoin results in increased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

retinoic acid receptor, alpha

increases expression
decreases expression

Phenytoin results in increased expression of RARA mRNA
Phenytoin results in decreased expression of RARA mRNA

PMID:9118846 PMID:9988880

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

increases expression

Phenytoin results in increased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

retinoic acid receptor, gamma

increases expression

Phenytoin results in increased expression of RARG mRNA

NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177

G

RNA binding motif protein 12

increases expression

Phenytoin results in increased expression of RBM12 mRNA

NCBI chr 3:144,609,661...144,629,911
Ensembl chr 3:144,611,623...144,629,915
Ensembl chr 3:144,611,623...144,629,915

G

RNA binding motif protein 3

increases expression

Phenytoin results in increased expression of RBM3 mRNA

NCBI chr X:14,348,909...14,352,387
Ensembl chr X:14,348,910...14,353,580

G

RNA binding motif protein 34

increases expression

Phenytoin results in increased expression of RBM34 mRNA

NCBI chr19:54,936,516...54,956,810
Ensembl chr19:54,936,531...54,956,715

G

retinol binding protein 2

increases expression

Phenytoin results in increased expression of RBP2 mRNA

NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473

G

retinol dehydrogenase 14

increases expression

Phenytoin results in increased expression of RDH14 mRNA

NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity

Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
Phenytoin results in increased activity of RELA protein

PMID:10700573 PMID:15322231

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

decreases expression

Phenytoin results in decreased expression of RHOA mRNA

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

RIO kinase 2

increases expression

Phenytoin results in increased expression of RIOK2 mRNA

NCBI chr 1:58,103,132...58,119,397
Ensembl chr 1:58,103,084...58,120,512

G

ribonuclease H1

decreases expression

Phenytoin results in decreased expression of RNASEH1 mRNA

NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236

G

Rho family GTPase 1

increases expression

Phenytoin results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

ring finger protein 115

increases expression

Phenytoin results in increased expression of RNF115 mRNA

NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823

G

ribulose-5-phosphate-3-epimerase

increases expression

Phenytoin results in increased expression of RPE mRNA

NCBI chr 9:68,191,027...68,211,295
Ensembl chr 9:68,191,292...68,211,591

G

ribosomal protein L28

increases expression

Phenytoin results in increased expression of RPL28 mRNA

NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032

G

ribosomal protein S6 kinase A3

increases expression

Phenytoin results in increased expression of RPS6KA3 mRNA

NCBI chr X:35,517,306...35,623,296
Ensembl chr X:35,517,306...35,623,207

G

ribosomal protein SA

increases expression

Phenytoin results in increased expression of RPSA mRNA

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

arginine and serine rich coiled-coil 1

decreases expression

Phenytoin results in decreased expression of RSRC1 mRNA

NCBI chr 2:151,226,821...151,632,771
Ensembl chr 2:151,231,156...151,632,765

G

ryanodine receptor 2

increases expression

Phenytoin results in increased expression of RYR2 mRNA

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

S100 calcium binding protein A10

increases expression

Phenytoin results in increased expression of S100A10 mRNA

NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661

G

S100 calcium-binding protein A4

increases expression

Phenytoin results in increased expression of S100A4 mRNA

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

S100 calcium binding protein A8

multiple interactions

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

multiple interactions
increases expression

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA
Phenytoin results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

spliceosome associated factor 3, U4/U6 recycling protein

increases expression

Phenytoin results in increased expression of SART3 mRNA

NCBI chr12:42,859,026...42,887,041
Ensembl chr12:42,859,305...42,887,038

G

sterol-C5-desaturase

increases expression

Phenytoin results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

SR-related CTD-associated factor 1

increases expression

Phenytoin results in increased expression of SCAF1 mRNA

NCBI chr 1:95,485,448...95,499,389
Ensembl chr 1:95,485,448...95,496,029

G

scavenger receptor class B, member 1

decreases expression

Phenytoin results in decreased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

sodium voltage-gated channel alpha subunit 1

affects response to substance

SCN1A gene polymorphism affects the susceptibility to Phenytoin; SCN1A protein affects the susceptibility to Phenytoin

PMID:15805193 PMID:17001291

NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699

G

sodium voltage-gated channel beta subunit 1

affects binding
multiple interactions
decreases response to substance

Phenytoin binds to [SCN1B protein binds to SCN3A protein]
Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
SCN1B protein mutant form results in decreased susceptibility to Phenytoin

NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739

G

sodium voltage-gated channel alpha subunit 2

decreases activity

Phenytoin results in decreased activity of SCN2A protein

NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214

G

sodium voltage-gated channel alpha subunit 3

multiple interactions
affects binding

Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]
Phenytoin binds to [SCN1B protein binds to SCN3A protein]

NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119

G

syndecan 4

decreases expression

Phenytoin results in decreased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

selectin E

multiple interactions

[clobazam co-treated with Phenytoin] results in increased expression of SELE protein

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

SUMO specific peptidase 7

increases expression

Phenytoin results in increased expression of SENP7 mRNA

NCBI chr11:44,423,733...44,584,129
Ensembl chr11:44,423,735...44,564,711

G

serpin family C member 1

multiple interactions

[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family E member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

SH3 and SYLF domain containing 1

increases expression

Phenytoin results in increased expression of SH3YL1 mRNA

NCBI chr 6:47,522,098...47,565,858
Ensembl chr 6:47,522,091...47,565,858

G

sonic hedgehog signaling molecule

increases expression

Phenytoin results in increased expression of SHH mRNA

NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170

G

siah E3 ubiquitin protein ligase 1

increases expression

Phenytoin results in increased expression of SIAH1A mRNA

NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808

G

signal-induced proliferation-associated 1 like 1

increases expression

Phenytoin results in increased expression of SIPA1L1 mRNA

NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950

G

solute carrier family 22 member 7

decreases expression

Phenytoin results in decreased expression of SLC22A7 mRNA

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 4 member 3

increases expression

Phenytoin results in increased expression of SLC4A3 mRNA

NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:77,037,016...77,049,105

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

increases expression

Phenytoin results in increased expression of SMARCA1 mRNA

NCBI chr X:126,980,201...127,066,385
Ensembl chr X:126,994,947...127,066,347

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

increases expression

Phenytoin results in increased expression of SMARCA5 mRNA

NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594

G

structural maintenance of chromosomes 2

increases expression

Phenytoin results in increased expression of SMC2 mRNA

NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242

G

structural maintenance of chromosomes 3

increases expression

Phenytoin results in increased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

structural maintenance of chromosomes 5

increases expression

Phenytoin results in increased expression of SMC5 mRNA

NCBI chr 1:220,769,366...220,839,138
Ensembl chr 1:220,769,366...220,839,096

G

sorting nexin 2

increases expression

Phenytoin results in increased expression of SNX2 mRNA

NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865

G

Sp3 transcription factor

increases expression

Phenytoin results in increased expression of SP3 mRNA

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

ST13, Hsp70 interacting protein

increases expression

Phenytoin results in increased expression of ST13 mRNA

NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945

G

signal transducer and activator of transcription 4

decreases expression

Phenytoin results in decreased expression of STAT4 mRNA

NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540

G

sulfotransferase family 1A member 1

decreases expression

Phenytoin results in decreased expression of SULT1A1 mRNA

PMID:9566755 PMID:17381134

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 2A member 1

decreases expression

Phenytoin results in decreased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

synapsin I

multiple interactions
decreases expression

Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA]

NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396

G

synaptophysin

multiple interactions
decreases expression

Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA]

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

synaptophysin-like 1

increases expression

Phenytoin results in increased expression of SYPL1 mRNA

NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330

G

TATA-box binding protein associated factor 9b

increases expression

Phenytoin results in increased expression of TAF9B mRNA

NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604

G

T-box transcription factor 21

multiple interactions
decreases expression

[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA
Phenytoin results in decreased expression of TBX21 mRNA

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

G

transcription elongation factor A like 1

increases expression

Phenytoin results in increased expression of TCEAL1 mRNA

NCBI chr X:100,058,485...100,060,439
Ensembl chr X:100,058,132...100,060,551

G

transcription factor 15

decreases expression

Phenytoin results in decreased expression of TCF15 mRNA

NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766

G

telomeric repeat binding factor 1

increases expression

Phenytoin results in increased expression of TERF1 mRNA

NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340

G

transforming growth factor alpha

increases expression

Phenytoin results in increased expression of TGFA mRNA

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

increases expression
decreases expression

Phenytoin results in increased expression of TGFB1 mRNA
Phenytoin results in decreased expression of TGFB1 mRNA

PMID:7841657 PMID:9988880 PMID:16141649

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

decreases expression

Phenytoin results in decreased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

increases expression

Phenytoin results in increased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

THO complex subunit 6

decreases expression

Phenytoin results in decreased expression of THOC6 mRNA

NCBI chr10:12,700,051...12,705,411
Ensembl chr10:12,700,051...12,706,925

G

TIMP metallopeptidase inhibitor 1

increases expression

Phenytoin results in increased expression of TIMP1 mRNA; Phenytoin results in increased expression of TIMP1 protein

PMID:10914799 PMID:14741686 PMID:15948689

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

transketolase

increases expression

Phenytoin results in increased expression of TKT mRNA

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

G

toll-like receptor 2

multiple interactions
increases expression

[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA
Phenytoin results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions
decreases expression

[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
Phenytoin results in decreased expression of TLR4 mRNA

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 9

multiple interactions
decreases expression

[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA
Phenytoin results in decreased expression of TLR9 mRNA

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

tumor necrosis factor

increases expression

Phenytoin results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

increases expression

Phenytoin results in increased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein, 2

increases expression

Phenytoin results in increased expression of TRP53BP2 mRNA

NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432

G

TNFRSF1A-associated via death domain

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

tRNA methyltransferase 10B

increases expression

Phenytoin results in increased expression of TRMT10B mRNA

NCBI chr 5:59,548,845...59,572,529
Ensembl chr 5:59,548,869...59,572,526

G

terminal uridylyl transferase 4

increases expression

Phenytoin results in increased expression of TUT4 mRNA

NCBI chr 5:123,201,723...123,306,582
Ensembl chr 5:123,203,003...123,306,465

G

thioredoxin reductase 1

increases expression

Phenytoin results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin-conjugating enzyme E2D 2

increases expression

Phenytoin results in increased expression of UBE2D2 mRNA

NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181

G

ubiquitin-like 5

decreases expression

Phenytoin results in decreased expression of UBL5 mRNA

NCBI chr 8:19,181,504...19,185,224
Ensembl chr 8:19,181,615...19,185,217

G

ubiquitin protein ligase E3 component n-recognin 1

increases expression

Phenytoin results in increased expression of UBR1 mRNA

NCBI chr 3:107,813,721...107,921,701
Ensembl chr 3:107,811,392...107,922,204

G

UDP-glucose 6-dehydrogenase

decreases expression

Phenytoin results in decreased expression of UGDH mRNA

NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354

G

UDP glucuronosyltransferase family 1 member A1

affects expression
increases expression
multiple interactions
increases activity

Phenytoin affects the expression of UGT1A1 mRNA
Phenytoin results in increased expression of UGT1A1 mRNA; Phenytoin results in increased expression of UGT1A1 protein
Phenytoin results in increased expression of and results in increased activity of UGT1A1 protein
Phenytoin results in increased activity of UGT1A1 protein

PMID:10421657 PMID:15849716 PMID:17381134 PMID:27413119

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

increases expression

Phenytoin results in increased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

Phenytoin results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UNC homeobox

decreases expression

Phenytoin results in decreased expression of UNCX mRNA

NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300

G

uracil-DNA glycosylase

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

valyl-tRNA synthetase 2, mitochondrial

increases expression

Phenytoin results in increased expression of VARS2 mRNA

NCBI chr20:3,077,132...3,087,994
Ensembl chr20:3,077,132...3,087,994

G

versican

increases expression

Phenytoin results in increased expression of VCAN mRNA

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

vascular endothelial growth factor B

decreases expression

Phenytoin results in decreased expression of VEGFB mRNA

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

vimentin

increases expression

Phenytoin results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

Wnt family member 1

decreases expression

Phenytoin results in decreased expression of WNT1 mRNA

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

G

Wnt family member 3

decreases expression

Phenytoin results in decreased expression of WNT3 mRNA

NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099

G

Wnt family member 5A

increases expression

Phenytoin results in increased expression of WNT5A mRNA

NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234

G

X-ray repair cross complementing 4

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA

NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808

G

YME1-like 1 ATPase

increases expression

Phenytoin results in increased expression of YME1L1 mRNA

NCBI chr17:85,287,607...85,326,068
Ensembl chr17:85,287,554...85,326,335

G

zeta chain of T cell receptor associated protein kinase 70

decreases expression

Phenytoin results in decreased expression of ZAP70 mRNA

NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700

G

zinc finger protein 131

increases expression

Phenytoin results in increased expression of ZFP131 mRNA

NCBI chr 2:51,722,774...51,753,662
Ensembl chr 2:51,725,541...51,753,639

G

zinc finger protein 503

increases expression

Phenytoin results in increased expression of ZFP503 mRNA

NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848

G

zinc finger protein 638

increases expression

Phenytoin results in increased expression of ZFP638 mRNA

NCBI chr 4:116,355,934...116,475,051
Ensembl chr 4:116,402,428...116,479,845

G

zinc finger and SCAN domain containing 21

increases expression

Phenytoin results in increased expression of ZSCAN21 mRNA

NCBI chr12:16,998,496...17,024,167
Ensembl chr12:16,998,538...17,013,506

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19911
role	19854
biological role	19852
aetiopathogenetic role	19250
teratogenic agent	16157
phenytoin	408
Path 2
Term	Annotations
CHEBI ontology	19911
subatomic particle	19909
composite particle	19909
hadron	19880
baryon	19880
nucleon	19909
atomic nucleus	19880
atom	19909
main group element atom	19849
p-block element atom	19849
carbon group element atom	19766
carbon atom	19785
organic molecular entity	19785
organic molecule	19737
organic cyclic compound	19526
organic heterocyclic compound	18870
organic heteromonocyclic compound	17791
diazolidine	1033
imidazolidines	1024
imidazolidinone	618
imidazolidine-2,4-dione	483
hydantoin	414
phenytoin	408

paths to the root