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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3beta-hydroxycholest-5-en-26-oic acid
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Accession:CHEBI:81014 term browser browse the term
Definition:A steroid acid resulting from the oxidation of one of the terminal methyl groups of cholesterol to the corresponding aldehyde.
Synonyms:related_synonym: 3-HCOA;   3-Hydroxy-5-cholesten-26-oic acid;   3-Hydroxy-5-cholestenoic acid;   3beta-Hydroxy-5-cholestenoic acid;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21+,22-,23+,24+,26+,27-/m1/s1;   InChIKey=WVXOMPRLWLXFAP-AMQKJUDNSA-N;   SMILES=C[C@H](CCCC(C)C(O)=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
 xref: CAS:6561-58-6;   HMDB:HMDB0012453;   KEGG:C17333
 xref_mesh: MESH:C029435
 xref: PMID:20843794;   Reaxys:3170242
 cyclic_relationship: is_conjugate_acid_of CHEBI:84146


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3beta-hydroxycholest-5-en-26-oic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases chemical synthesis
multiple interactions
ISO CYP27A1 protein results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid
[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid
CTD PMID:8078928, PMID:9215552, PMID:9660774, PMID:14622972 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein] CTD PMID:11089551 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein]; 3-hydroxy-5-cholestenoic acid binds to and results in increased activity of NR1H3 protein CTD PMID:11089551 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            prokaryotic metabolite 18357
              bacterial metabolite 18357
                3beta-hydroxycholest-5-en-26-oic acid 3
                  (25R)-3beta-hydroxycholest-5-en-26-oic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic polycyclic compound 16384
                                  steroid 12788
                                    hydroxy steroid 12371
                                      3-hydroxy steroid 9999
                                        3beta-hydroxy steroid 1988
                                          3beta-hydroxy-Delta(5)-steroid 1834
                                            cholesterol 317
                                              3beta-hydroxycholest-5-en-26-oic acid 3
                                                (25R)-3beta-hydroxycholest-5-en-26-oic acid 0
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