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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3beta-hydroxycholest-5-en-26-oic acid
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Accession:CHEBI:81014 term browser browse the term
Definition:A steroid acid resulting from the oxidation of one of the terminal methyl groups of cholesterol to the corresponding aldehyde.
Synonyms:related_synonym: 3-HCOA;   3-Hydroxy-5-cholesten-26-oic acid;   3-Hydroxy-5-cholestenoic acid;   3beta-Hydroxy-5-cholestenoic acid;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21+,22-,23+,24+,26+,27-/m1/s1;   InChIKey=WVXOMPRLWLXFAP-AMQKJUDNSA-N;   SMILES=C[C@H](CCCC(C)C(O)=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
 xref: CAS:6561-58-6;   HMDB:HMDB0012453;   KEGG:C17333
 xref_mesh: MESH:C029435
 xref: PMID:20843794;   Reaxys:3170242
 cyclic_relationship: is_conjugate_acid_of CHEBI:84146



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3beta-hydroxycholest-5-en-26-oic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases chemical synthesis
multiple interactions
ISO CYP27A1 protein results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid
[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid
CTD PMID:8078928 PMID:9215552 PMID:9660774 PMID:14622972 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein] CTD PMID:11089551 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein]; 3-hydroxy-5-cholestenoic acid binds to and results in increased activity of NR1H3 protein CTD PMID:11089551 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            prokaryotic metabolite 18616
              bacterial metabolite 18616
                3beta-hydroxycholest-5-en-26-oic acid 3
                  (25R)-3beta-hydroxycholest-5-en-26-oic acid 0
                  (25S)-cholestenoic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic polycyclic compound 17279
                                  steroid 14707
                                    hydroxy steroid 14451
                                      3-hydroxy steroid 12787
                                        3beta-hydroxy steroid 2533
                                          3beta-hydroxy-Delta(5)-steroid 2365
                                            cholesterol 346
                                              3beta-hydroxycholest-5-en-26-oic acid 3
                                                (25R)-3beta-hydroxycholest-5-en-26-oic acid 0
                                                (25S)-cholestenoic acid + 0
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