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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3beta-hydroxycholest-5-en-26-oic acid
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Accession:CHEBI:81014 term browser browse the term
Definition:A steroid acid resulting from the oxidation of one of the terminal methyl groups of cholesterol to the corresponding aldehyde.
Synonyms:related_synonym: 3-HCOA;   3-Hydroxy-5-cholesten-26-oic acid;   3-Hydroxy-5-cholestenoic acid;   3beta-Hydroxy-5-cholestenoic acid;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21+,22-,23+,24+,26+,27-/m1/s1;   InChIKey=WVXOMPRLWLXFAP-AMQKJUDNSA-N;   SMILES=C[C@H](CCCC(C)C(O)=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
 xref: CAS:6561-58-6;   HMDB:HMDB0012453;   KEGG:C17333
 xref_mesh: MESH:C029435
 xref: PMID:20843794;   Reaxys:3170242
 cyclic_relationship: is_conjugate_acid_of CHEBI:84146


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3beta-hydroxycholest-5-en-26-oic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases chemical synthesis
multiple interactions
ISO CYP27A1 protein results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid
[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid
CTD PMID:8078928 PMID:9215552 PMID:9660774 PMID:14622972 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein] CTD PMID:11089551 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein]; 3-hydroxy-5-cholestenoic acid binds to and results in increased activity of NR1H3 protein CTD PMID:11089551 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            prokaryotic metabolite 18420
              bacterial metabolite 18420
                3beta-hydroxycholest-5-en-26-oic acid 3
                  (25R)-3beta-hydroxycholest-5-en-26-oic acid 0
                  (25S)-cholestenoic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic polycyclic compound 16535
                                  steroid 13057
                                    hydroxy steroid 12657
                                      3-hydroxy steroid 10367
                                        3beta-hydroxy steroid 2014
                                          3beta-hydroxy-Delta(5)-steroid 1849
                                            cholesterol 333
                                              3beta-hydroxycholest-5-en-26-oic acid 3
                                                (25R)-3beta-hydroxycholest-5-en-26-oic acid 0
                                                (25S)-cholestenoic acid + 0
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