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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenylephrine
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Accession:CHEBI:8093 term browser browse the term
Definition:A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Synonyms:exact_synonym: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
 related_synonym: (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;   Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-;   Benzyl alcohol, m-hydroxy-alpha-((methylamino)methyl)-, (-)-;   Formula=C9H13NO2;   InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1;   InChIKey=SONNWYBIRXJNDC-VIFPVBQESA-N;   R(-)-Phenylephrine;   SMILES=CNC[C@H](O)c1cccc(O)c1;   fenilefrina;   l-(3-Hydroxyphenyl)-N-methylethanolamine;   phenylephrinum
 xref: CAS:59-42-7;   DrugBank:DB00388;   Drug_Central:2146;   HMDB:HMDB0002182;   KEGG:C07441;   KEGG:D08365;   LINCS:LSM-15380
 xref_mesh: MESH:D010656
 xref: PMID:10100801;   PMID:11064374;   PMID:11528305;   PMID:12172708;   PMID:15492464;   PMID:15522277;   PMID:15686119;   PMID:19372348;   PMID:19427353;   PMID:24588024;   PMID:25719378;   PMID:25902390;   PMID:26143019;   PMID:26428281;   PMID:26513673;   PMID:26597497;   PMID:26709790;   PMID:26873547;   PMID:26928367;   PMID:26991619;   PMID:26992790;   PMID:27020488;   PMID:27117950;   PMID:27164015;   PMID:27249899;   PMID:27288620;   PMID:28166217;   PMID:7516005;   PMID:7879981;   PMID:8763311;   PMID:8853328;   Patent:US1932347;   Patent:US1954389;   Reaxys:3198815;   Wikipedia:Phenylephrine
 cyclic_relationship: is_conjugate_base_of CHEBI:132294


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phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression EXP Phenylephrine results in decreased expression of ABCC9 mRNA CTD PMID:18158353 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Phenylephrine results in increased expression of ABHD2 mRNA CTD PMID:18158353 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
affects response to substance
increases phosphorylation
EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
ABL1 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased phosphorylation of ABL1 protein
CTD PMID:17615370 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
decreases expression
EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA] CTD PMID:19699196 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ACAT2 mRNA CTD PMID:18158353 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Ace angiotensin I converting enzyme affects response to substance ISO ACE protein affects the susceptibility to Phenylephrine CTD PMID:18431347 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Phenylephrine results in increased expression of ACOT2 mRNA CTD PMID:18158353 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions
increases expression
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]
CTD PMID:10642269, PMID:10710348, PMID:11230109, PMID:11499749, PMID:11513749, PMID:12435817, PMID:15201137, PMID:15652358, PMID:15795322, PMID:16513848, PMID:16517124, PMID:16556869, PMID:17592507, PMID:18502941, PMID:18701451, PMID:19540241 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
EXP MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA] CTD PMID:16556869, PMID:18158353 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actr3 actin related protein 3 increases expression EXP Phenylephrine results in increased expression of ACTR3 mRNA CTD PMID:18158353 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions EXP ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein] CTD PMID:16760267 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Phenylephrine CTD PMID:12869393 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression EXP Phenylephrine results in decreased expression of ADHFE1 mRNA CTD PMID:18158353 NCBI chr 5:9,403,194...9,429,783
Ensembl chr 5:9,403,196...9,429,859
JBrowse link
G Adm adrenomedullin multiple interactions
increases expression
decreases secretion
decreases expression
decreases response to substance
EXP
ISO
[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in decreased expression of ADM mRNA
ADM protein results in decreased susceptibility to Phenylephrine
CTD PMID:11470465, PMID:15370692, PMID:17250927 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
increases expression
EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein
CTD PMID:19966059 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions
increases expression
EXP 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein
CTD PMID:19966059 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora3 adenosine A3 receptor multiple interactions
increases expression
EXP 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein
CTD PMID:19966059 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 increases expression EXP Phenylephrine results in increased expression of ADPRHL1 mRNA CTD PMID:18158353 NCBI chr16:81,616,098...81,648,133
Ensembl chr16:81,616,604...81,632,030
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
increases activity
affects activity
increases response to substance
affects binding
affects response to substance
ISO
EXP
5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein affects the susceptibility to Phenylephrine
CTD PMID:8183249, PMID:11709419, PMID:12935885, PMID:15306222, PMID:15365637, PMID:15550506, PMID:15603588, PMID:15672411, PMID:16498073, PMID:16545797, PMID:18257748, PMID:19133277, PMID:19419905, PMID:19566752, PMID:20217639 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B affects response to substance
multiple interactions
increases activity
decreases expression
increases response to substance
ISO
EXP
ADRA1B protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
ADRA1B protein results in increased susceptibility to Phenylephrine
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein
CTD PMID:10801782, PMID:11499749, PMID:11693201, PMID:15306222, PMID:16498073, PMID:18257748, PMID:18480251 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D affects response to substance
increases activity
affects binding
multiple interactions
increases response to substance
ISO
EXP
ADRA1D protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of ADRA1D protein
Phenylephrine binds to ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
ADRA1D affects the susceptibility to Phenylephrine
CTD PMID:8183249, PMID:11901185, PMID:15306222, PMID:15493479, PMID:16371063, PMID:18257748, PMID:19566752 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] CTD PMID:10742289 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B affects response to substance
multiple interactions
ISO ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]
CTD PMID:16815979 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine] CTD PMID:16474418 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases response to substance
ISO amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine] CTD PMID:16022967 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Agt angiotensinogen affects response to substance
increases response to substance
multiple interactions
increases expression
EXP
ISO
AGT protein affects the susceptibility to Phenylephrine
AGT protein modified form results in increased susceptibility to Phenylephrine
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]
CTD PMID:2298476, PMID:7900855, PMID:16251426, PMID:16794485, PMID:27094369 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
affects response to substance
EXP
ISO
[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine
CTD PMID:11714657, PMID:19151255 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Phenylephrine results in increased expression of AIFM1 protein CTD PMID:31605733 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Ak4 adenylate kinase 4 increases expression EXP Phenylephrine results in increased expression of AK4 mRNA CTD PMID:18158353 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation
ISO
EXP
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the phosphorylation of AKT1 protein
CTD PMID:10679475, PMID:18084315, PMID:28759639 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression EXP Phenylephrine results in increased expression of ALDH18A1 mRNA CTD PMID:18158353 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Angpt1 angiopoietin 1 multiple interactions
increases expression
ISO ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine results in increased expression of ANGPT1 mRNA; Phenylephrine results in increased expression of ANGPT1 protein
CTD PMID:18502941 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Phenylephrine results in decreased expression of ANGPTL4 mRNA CTD PMID:18158353 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE protein affects the susceptibility to Phenylephrine CTD PMID:17899169 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Areg amphiregulin increases expression EXP Phenylephrine results in increased expression of AREG mRNA CTD PMID:18158353 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 decreases expression EXP Phenylephrine results in decreased expression of ARHGEF12 mRNA CTD PMID:18158353 NCBI chr 8:47,259,377...47,393,042
Ensembl chr 8:47,259,404...47,393,503
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression EXP Phenylephrine results in decreased expression of ARRDC3 mRNA CTD PMID:18158353 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Asb18 ankyrin repeat and SOCS box-containing 18 decreases expression EXP Phenylephrine results in decreased expression of ASB18 mRNA CTD PMID:18158353 NCBI chr 9:97,085,234...97,151,832
Ensembl chr 9:97,085,234...97,151,832
JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 increases expression EXP Phenylephrine results in increased expression of ASB4 mRNA CTD PMID:18158353 NCBI chr 4:30,461,673...30,501,340
Ensembl chr 4:30,313,102...30,501,329
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Phenylephrine results in increased expression of ASNS mRNA CTD PMID:18158353 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP Phenylephrine results in increased expression of ATF5 mRNA CTD PMID:18158353 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Phenylephrine results in increased expression of ATP1B1 mRNA CTD PMID:11204457 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
decreases expression
affects response to substance
increases expression
decreases activity
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein
Phenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]
ATP2A2 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of ATP2A2 mRNA
Phenylephrine results in decreased activity of ATP2A2 protein
CTD PMID:11499749, PMID:11577024, PMID:15795322, PMID:16236312, PMID:17287366, PMID:17592507, PMID:19244478, PMID:21952229, PMID:23939492 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 increases response to substance ISO ATP2B4 protein results in increased susceptibility to Phenylephrine CTD PMID:12933703 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) increases expression EXP Phenylephrine results in increased expression of ATP9A mRNA CTD PMID:18158353 NCBI chr 3:165,405,588...165,511,104
Ensembl chr 3:165,412,803...165,477,771
JBrowse link
G Auts2 activator of transcription and developmental regulator AUTS2 decreases expression EXP Phenylephrine results in decreased expression of AUTS2 mRNA CTD PMID:18158353 NCBI chr12:27,155,362...28,252,752
Ensembl chr12:28,212,333...28,251,816
JBrowse link
G Avp arginine vasopressin multiple interactions
increases secretion
EXP Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dexamethasone inhibits the reaction [Phenylephrine results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:2271928, PMID:11102496 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Avpi1 arginine vasopressin-induced 1 increases expression EXP Phenylephrine results in increased expression of AVPI1 mRNA CTD PMID:18158353 NCBI chr 1:261,365,590...261,371,519
Ensembl chr 1:261,365,590...261,371,508
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Phenylephrine results in increased expression of BAD protein CTD PMID:31605733 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression EXP Phenylephrine results in increased expression of BAMBI mRNA CTD PMID:18158353 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Phenylephrine results in decreased expression of BAX protein
Phenylephrine results in increased expression of BAX protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]
CTD PMID:19910689, PMID:31605733 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions
increases phosphorylation
EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha decreases expression EXP Phenylephrine results in decreased expression of BCKDHA mRNA CTD PMID:18158353 NCBI chr 1:82,423,291...82,452,094
Ensembl chr 1:82,423,277...82,452,281
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
EXP
ISO
BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]
Phenylephrine results in decreased expression of BCL2 protein
Phenylephrine results in increased expression of BCL2 mRNA; Phenylephrine results in increased expression of BCL2 protein
CTD PMID:11042672, PMID:19910689, PMID:31605733 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
EXP
ISO
Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 protein]
Phenylephrine results in decreased expression of BCL2L1 protein
CTD PMID:11042672, PMID:31605733 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 increases expression EXP Phenylephrine results in increased expression of BDH1 mRNA CTD PMID:18158353 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 decreases expression EXP Phenylephrine results in decreased expression of BDH2 mRNA CTD PMID:18158353 NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance
increases expression
ISO
EXP
BDKRB2 affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of BDKRB2 mRNA
CTD PMID:10614985, PMID:18158353 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Phenylephrine results in increased expression of BDNF mRNA CTD PMID:18158353 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bmp7 bone morphogenetic protein 7 decreases expression EXP Phenylephrine results in decreased expression of BMP7 mRNA CTD PMID:18158353 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Phenylephrine results in increased expression of BNIP3L mRNA CTD PMID:16291751 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Boll boule homolog, RNA binding protein decreases expression EXP Phenylephrine results in decreased expression of BOLL mRNA CTD PMID:18158353 NCBI chr 9:61,836,517...61,975,640
Ensembl chr 9:64,480,031...64,573,660
Ensembl chr 9:64,480,031...64,573,660
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions
increases expression
EXP Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]
Phenylephrine results in increased expression of BRD4 protein
CTD PMID:23939492 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Btbd11 BTB domain containing 11 decreases expression EXP Phenylephrine results in decreased expression of BTBD11 mRNA CTD PMID:18158353 NCBI chr 7:24,041,194...24,314,418
Ensembl chr 7:24,043,126...24,313,885
JBrowse link
G Btg3 BTG anti-proliferation factor 3 increases expression EXP Phenylephrine results in increased expression of BTG3 mRNA CTD PMID:18158353 NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201
JBrowse link
G Ca4 carbonic anhydrase 4 increases expression EXP Phenylephrine results in increased expression of CA4 protein CTD PMID:17124262 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067
JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions EXP CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein] CTD PMID:10655507, PMID:17060317 NCBI chr20:13,836,032...13,963,003
Ensembl chr20:13,836,030...13,963,003
JBrowse link
G Cadps calcium dependent secretion activator decreases expression EXP Phenylephrine results in decreased expression of CADPS mRNA CTD PMID:18158353 NCBI chr15:15,275,489...15,690,575
Ensembl chr15:15,275,541...15,667,778
JBrowse link
G Calca calcitonin-related polypeptide alpha affects response to substance ISO
EXP
CALCA protein affects the susceptibility to Phenylephrine CTD PMID:11728430, PMID:18055875 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA CTD PMID:17250927 NCBI chr 3:71,747,938...71,845,487
Ensembl chr 3:71,747,956...71,845,232
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression EXP Phenylephrine results in decreased expression of CAMK2A mRNA CTD PMID:18158353 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta multiple interactions EXP CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylephrine results in decreased activity of CA1 protein CTD PMID:28800181 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity
EXP
ISO
Phenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 protein
Phenylephrine results in decreased activity of CA2 protein
CTD PMID:17124262, PMID:28800181 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp2 caspase 2 affects activity ISO Phenylephrine affects the activity of CASP2 protein CTD PMID:31605733 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
Phenylephrine inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Phenylephrine results in increased activity of CASP3 protein
CTD PMID:11042672, PMID:31605733 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 affects activity ISO Phenylephrine affects the activity of CASP8 protein CTD PMID:31605733 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Phenylephrine results in increased activity of CASP9 protein CTD PMID:31605733 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] CTD PMID:11071898 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cat catalase multiple interactions
decreases expression
EXP CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in decreased expression of CAT protein
CTD PMID:16513848, PMID:18171680, PMID:20886221 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Sodium, Dietary affects the reaction [CAV1 protein results in increased susceptibility to Phenylephrine] CTD PMID:18178722 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cav3 caveolin 3 multiple interactions
decreases response to substance
affects localization
ISO
EXP
CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CAV3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of CAV3 protein
CTD PMID:12847114, PMID:19299911 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
Phenylephrine results in increased expression of CCL2 mRNA; Phenylephrine results in increased expression of CCL2 protein
CTD PMID:15721863, PMID:15728586 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression EXP Phenylephrine results in increased expression of CCL27 mRNA CTD PMID:18158353 NCBI chr 5:58,159,066...58,166,182
Ensembl chr 5:58,159,066...58,163,584
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; calphostin C inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]
Phenylephrine results in increased expression of CCN1 mRNA; Phenylephrine results in increased expression of CCN1 protein
CTD PMID:15117851 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Phenylephrine results in increased expression of CCN2 mRNA; Phenylephrine results in increased expression of CCN2 protein CTD PMID:15276029 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND1 protein] CTD PMID:12163013, PMID:15603588 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression EXP Phenylephrine results in increased expression of CCND2 protein CTD PMID:12163013 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein] CTD PMID:12163013 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccnt1 cyclin T1 multiple interactions EXP Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein] CTD PMID:17459355 NCBI chr 7:140,215,052...140,245,958
Ensembl chr 7:140,219,551...140,245,723
JBrowse link
G Cd200 Cd200 molecule decreases expression EXP Phenylephrine results in decreased expression of CD200 mRNA CTD PMID:18158353 NCBI chr11:60,371,617...60,398,450
Ensembl chr11:60,371,684...60,403,196
JBrowse link
G Cdh2 cadherin 2 increases expression EXP Phenylephrine results in increased expression of CDH2 protein CTD PMID:17526999 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Phenylephrine results in increased expression of CDK2 protein CTD PMID:15603588 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Phenylephrine results in increased expression of CDK4 protein CTD PMID:15603588 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
increases stability
ISO
EXP
Phenylephrine results in increased expression of CDKN1A mRNA; Phenylephrine results in increased expression of CDKN1A protein
Phenylephrine results in increased stability of CDKN1A mRNA
CTD PMID:10766810, PMID:15603588 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Phenylephrine results in increased expression of CDKN1B CTD PMID:15603588 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP Phenylephrine results in decreased expression of CEBPA mRNA CTD PMID:19443575 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP [Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein; [Phenylephrine co-treated with 6-hydroxy-10-chlorobenzo(c)quinolizinium] results in increased activity of CFTR protein; Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein] CTD PMID:17596272 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP Phenylephrine results in increased expression of CHCHD6 mRNA CTD PMID:18158353 NCBI chr 4:121,340,952...121,565,222
Ensembl chr 4:121,340,952...121,565,212
JBrowse link
G Clic2 chloride intracellular channel 2 decreases expression EXP Phenylephrine results in decreased expression of CLIC2 mRNA CTD PMID:18158353 NCBI chr20:295,338...310,363
Ensembl chr20:295,250...310,380
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression EXP Phenylephrine results in increased expression of CLIC4 mRNA CTD PMID:18158353 NCBI chr 5:153,568,937...153,625,669
Ensembl chr 5:153,568,745...153,625,869
JBrowse link
G Clu clusterin increases expression EXP Phenylephrine results in increased expression of CLU mRNA; Phenylephrine results in increased expression of CLU protein CTD PMID:19443575 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cnn1 calponin 1 increases expression EXP Phenylephrine results in increased expression of CNN1 mRNA CTD PMID:18158353 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression EXP Phenylephrine results in decreased expression of COL18A1 mRNA CTD PMID:18158353 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Colec12 collectin sub-family member 12 decreases expression EXP Phenylephrine results in decreased expression of COLEC12 mRNA CTD PMID:18158353 NCBI chr18:867,048...1,054,047
Ensembl chr18:867,048...1,052,606
JBrowse link
G Corin corin, serine peptidase increases expression EXP Phenylephrine results in increased expression of CORIN mRNA CTD PMID:15191894 NCBI chr14:38,247,379...38,474,931
Ensembl chr14:38,247,791...38,473,648
JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of COX11 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]
CTD PMID:23818984, PMID:25107896 NCBI chr10:78,168,691...78,173,845
NCBI chr10:78,102,620...78,174,584
Ensembl chr10:78,111,050...78,174,584
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 multiple interactions
decreases expression
EXP Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein] CTD PMID:23818984, PMID:25107896 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of COX4I1 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]
CTD PMID:23818984 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
decreases expression
increases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]
Phenylephrine results in decreased expression of CPT1B mRNA; Phenylephrine results in decreased expression of CPT1B protein
Phenylephrine results in increased expression of CPT1B mRNA
CTD PMID:11879187, PMID:15721863, PMID:19699196 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] CTD PMID:14741741, PMID:15522277 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions
increases response to substance
EXP [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of CREBBP protein; Phenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein
CREBBP protein results in increased susceptibility to Phenylephrine
CTD PMID:11705990, PMID:12477714, PMID:15006641, PMID:15522277, PMID:19966502 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Phenylephrine results in increased expression of CREM mRNA CTD PMID:12791704, PMID:18158353 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Phenylephrine results in decreased expression of CSNK2A1 mRNA CTD PMID:18158353 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 increases expression EXP Phenylephrine results in increased expression of CSPG4 mRNA CTD PMID:18158353 NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Phenylephrine results in increased expression of CSRP2 mRNA CTD PMID:18158353 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases localization EXP Phenylephrine results in increased localization of CSRP3 protein CTD PMID:19376126 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
JBrowse link
G Cth cystathionine gamma-lyase increases activity EXP Phenylephrine results in increased activity of CTH protein CTD PMID:18184479 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter] CTD PMID:19799869 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsc cathepsin C decreases expression EXP Phenylephrine results in decreased expression of CTSC mRNA CTD PMID:18158353 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Phenylephrine results in decreased expression of CXCL1 mRNA CTD PMID:18158353 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Phenylephrine results in decreased expression of CXCL10 mRNA CTD PMID:18158353 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression EXP Phenylephrine results in decreased expression of CXCL11 mRNA CTD PMID:18158353 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression EXP Phenylephrine results in decreased expression of CXCL5 mRNA CTD PMID:18158353 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cxxc4 CXXC finger protein 4 decreases expression EXP Phenylephrine results in decreased expression of CXXC4 mRNA CTD PMID:18158353 NCBI chr 2:239,414,882...239,439,640
Ensembl chr 2:239,415,046...239,439,568
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Phenylephrine results in increased expression of CYP11B2 mRNA CTD PMID:19966502 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]] CTD PMID:16510159 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 increases expression EXP Phenylephrine results in increased expression of CYP26B1 mRNA CTD PMID:18158353 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases response to substance
affects response to substance
EXP 20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]; DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine] CTD PMID:11124159, PMID:12388396 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Phenylephrine results in increased expression of CYP51 mRNA CTD PMID:18158353 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression EXP Phenylephrine results in decreased expression of DAPK1 mRNA CTD PMID:18158353 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dgke diacylglycerol kinase epsilon multiple interactions ISO DGKE protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein] CTD PMID:18487437 NCBI chr10:76,375,981...76,408,224
Ensembl chr10:76,386,471...76,407,989
JBrowse link
G Dgkz diacylglycerol kinase zeta multiple interactions ISO DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16380548 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP Phenylephrine results in increased expression of DHCR7 mRNA CTD PMID:18158353 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
increases expression
EXP Phenylephrine results in increased activity of DIO2 protein
Phenylephrine results in increased expression of DIO2 mRNA
CTD PMID:15345674 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dnah12 dynein, axonemal, heavy chain 12 decreases expression EXP Phenylephrine results in decreased expression of DNAH12 mRNA CTD PMID:18158353 NCBI chr16:2,377,218...2,534,130
Ensembl chr16:2,379,480...2,534,131
JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 increases expression EXP Phenylephrine results in increased expression of DNAJB5 mRNA CTD PMID:18158353 NCBI chr 5:58,393,197...58,402,162
Ensembl chr 5:58,393,233...58,401,870
JBrowse link
G Dnm1l dynamin 1-like increases expression
multiple interactions
EXP Phenylephrine results in increased expression of DNM1L protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]
CTD PMID:20886221 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Dpt dermatopontin decreases expression EXP Phenylephrine results in decreased expression of DPT mRNA CTD PMID:18158353 NCBI chr13:83,073,307...83,102,404
Ensembl chr13:83,073,544...83,102,401
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Phenylephrine results in increased expression of DUSP1 mRNA CTD PMID:18158353 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions EXP DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:15757502 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G E2f3 E2F transcription factor 3 increases expression EXP Phenylephrine results in increased expression of E2F3 protein CTD PMID:12682052 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G E2f4 E2F transcription factor 4 increases expression EXP Phenylephrine results in increased expression of E2F4 protein CTD PMID:12682052 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G E2f5 E2F transcription factor 5 increases expression EXP Phenylephrine results in increased expression of E2F5 protein CTD PMID:12682052 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP Phenylephrine results in increased expression of ECE1 mRNA CTD PMID:15007106 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Ecm1 extracellular matrix protein 1 increases expression EXP Phenylephrine results in increased expression of ECM1 mRNA CTD PMID:18158353 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
increases expression
affects response to substance
EXP MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
Phenylephrine results in increased expression of MBF1
MBF1 protein affects the susceptibility to Phenylephrine
CTD PMID:12729799 NCBI chr 3:2,781,169...2,785,474
Ensembl chr 3:2,781,169...2,785,474
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases response to substance
increases expression
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EDN1 mRNA; Phenylephrine results in increased expression of EDN1 protein
CTD PMID:10788492, PMID:11739382, PMID:12724418, PMID:15007106, PMID:15220332, PMID:20977430 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Phenylephrine results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein CTD PMID:16760267 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO
EXP
Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]; Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein
Phenylephrine results in increased phosphorylation of EGFR protein
[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:14676212, PMID:16760267, PMID:18360054 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Phenylephrine results in increased expression of EGLN3 mRNA CTD PMID:18158353 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO
EXP
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]
Phenylephrine results in increased expression of EGR1; Phenylephrine results in increased expression of EGR1 mRNA
Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]
CTD PMID:7905536, PMID:10710348, PMID:10779383, PMID:15621046 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
increases phosphorylation
EXP CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein] CTD PMID:15757502 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
increases phosphorylation
EXP 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397, PMID:12720544, PMID:12935885, PMID:15757502 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases expression
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]
Phenylephrine results in increased phosphorylation of ELK1 protein
CTD PMID:10900171 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression EXP Phenylephrine results in increased expression of ELOVL5 mRNA CTD PMID:18158353 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Eno2 enolase 2 increases expression EXP Phenylephrine results in increased expression of ENO2 mRNA CTD PMID:18158353 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Eno3 enolase 3 increases expression EXP Phenylephrine results in increased expression of ENO3 mRNA CTD PMID:18158353 NCBI chr10:57,278,271...57,283,661
Ensembl chr10:57,278,307...57,283,653
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
increases expression
increases response to substance
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EP300 mRNA; Phenylephrine results in increased expression of EP300 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]
EP300 protein results in increased susceptibility to Phenylephrine
CTD PMID:11705990, PMID:12477714, PMID:12724418, PMID:15006641, PMID:15220332, PMID:15593114, PMID:23297412, PMID:27094368 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression EXP Phenylephrine results in decreased expression of EPAS1 mRNA CTD PMID:18158353 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Epb41l4b erythrocyte membrane protein band 4.1 like 4B increases expression EXP Phenylephrine results in increased expression of EPB41L4B mRNA CTD PMID:18158353 NCBI chr 5:74,030,950...74,192,275
Ensembl chr 5:74,030,882...74,191,167
JBrowse link
G Epha4 Eph receptor A4 decreases expression EXP Phenylephrine results in decreased expression of EPHA4 mRNA CTD PMID:18158353 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Phenylephrine results in decreased expression of EPHX2 mRNA CTD PMID:18158353 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine] CTD PMID:17158209 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 multiple interactions EXP EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:17327491 NCBI chr 3:162,285,275...162,470,642
Ensembl chr 3:162,346,490...162,470,065
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression EXP Phenylephrine results in decreased expression of FABP4 mRNA CTD PMID:18158353 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fads3 fatty acid desaturase 3 increases expression EXP Phenylephrine results in increased expression of FADS3 mRNA CTD PMID:18158353 NCBI chr 1:226,091,774...226,108,332
Ensembl chr 1:226,091,774...226,108,332
JBrowse link
G Fam110b family with sequence similarity 110, member B decreases expression EXP Phenylephrine results in decreased expression of FAM110B mRNA CTD PMID:18158353 NCBI chr 5:18,762,488...18,903,818
Ensembl chr 5:18,901,039...18,902,672
JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]; FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]; FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine] CTD PMID:17641673 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fdx1 ferredoxin 1 increases expression EXP Phenylephrine results in increased expression of FDX1 mRNA CTD PMID:18158353 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233
JBrowse link
G Fgf12 fibroblast growth factor 12 increases expression EXP Phenylephrine results in increased expression of FGF12 mRNA CTD PMID:18158353 NCBI chr11:75,606,360...76,171,078
Ensembl chr11:75,905,443...76,168,989
JBrowse link
G Fgf18 fibroblast growth factor 18 increases expression EXP Phenylephrine results in increased expression of FGF18 mRNA CTD PMID:18158353 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter] CTD PMID:10779383 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Phenylephrine results in increased expression of FHL1 mRNA CTD PMID:18158353 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Fhl2 four and a half LIM domains 2 decreases response to substance EXP FHL2 gene mutant form results in decreased susceptibility to Phenylephrine CTD PMID:25358972 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression
multiple interactions
EXP Phenylephrine results in increased expression of FIS1 protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]
CTD PMID:20886221 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases expression
EXP FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of FLT1 protein
CTD PMID:19542178, PMID:24903162 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Phenylephrine results in increased expression of FN1 protein CTD PMID:11821714 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
affects response to substance
increases expression
ISO
EXP
[Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; U 0126 inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]
Phenylephrine affects the expression of FOS protein
FOS protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of FOS; Phenylephrine results in increased expression of FOS mRNA; Phenylephrine results in increased expression of FOS protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; Troglitazone inhibits the reaction [Phenylephrine results in increased expression of FOS protein]
CTD PMID:7844257, PMID:7900855, PMID:7905536, PMID:8750937, PMID:8809800, PMID:8949925, PMID:9412514, PMID:10422649, PMID:10710348, PMID:10861511, PMID:10900171, PMID:11854500, PMID:12717712, PMID:12729908, PMID:14764439, PMID:15059776, PMID:15452191, PMID:16690042, PMID:18158353, PMID:19225867, PMID:19463813, PMID:27094369 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases activity
increases expression
EXP Phenylephrine results in increased activity of FOSB protein
Phenylephrine results in increased expression of FOSB
CTD PMID:7905536, PMID:15949472 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Phenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 protein CTD PMID:16020479 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fstl3 follistatin like 3 affects expression EXP Phenylephrine affects the expression of FSTL3 mRNA CTD PMID:18158353 NCBI chr 7:12,806,031...12,810,556
Ensembl chr 7:12,804,919...12,810,570
JBrowse link
G Fxyd5 FXYD domain-containing ion transport regulator 5 increases expression EXP Phenylephrine results in increased expression of FXYD5 mRNA CTD PMID:18158353 NCBI chr 1:89,464,853...89,474,450
Ensembl chr 1:89,464,860...89,474,252
JBrowse link
G Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 decreases expression EXP Phenylephrine results in decreased expression of GALNT13 mRNA CTD PMID:18158353 NCBI chr 3:39,967,056...40,625,144
Ensembl chr 3:40,038,336...40,624,530
JBrowse link
G Gamt guanidinoacetate N-methyltransferase decreases expression EXP Phenylephrine results in decreased expression of GAMT mRNA CTD PMID:18158353 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases activity
increases expression
increases acetylation
affects response to substance
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of GATA4 protein
Phenylephrine results in increased acetylation of GATA4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of GATA4 protein; Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]
GATA4 protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA
CTD PMID:10710348, PMID:10788492, PMID:11739382, PMID:12724418, PMID:15220332, PMID:18252717, PMID:19966502, PMID:20067472 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gdf15 growth differentiation factor 15 affects expression ISO Phenylephrine affects the expression of GDF15 mRNA CTD PMID:19505289 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein] CTD PMID:12628311 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
affects response to substance
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]
Phenylephrine results in increased expression of GJA1 mRNA; Phenylephrine results in increased expression of GJA1 protein
GJA1 protein affects the susceptibility to Phenylephrine
CTD PMID:16352648, PMID:18445782, PMID:18593691 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression EXP Phenylephrine results in decreased expression of GJA5 mRNA CTD PMID:18158353 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gla galactosidase, alpha affects response to substance ISO GLA protein affects the susceptibility to Phenylephrine CTD PMID:18565198 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Glrx3 glutaredoxin 3 affects response to substance
increases expression
multiple interactions
EXP GLRX3 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of GLRX3 mRNA
GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]
CTD PMID:16809552 NCBI chr 1:209,768,696...209,799,912
Ensembl chr 1:209,768,696...209,799,903
JBrowse link
G Gmfg glia maturation factor, gamma increases expression EXP Phenylephrine results in increased expression of GMFG mRNA CTD PMID:18158353 NCBI chr 1:85,312,473...85,322,860
Ensembl chr 1:85,312,528...85,317,968
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]] CTD PMID:14676212 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnas GNAS complex locus affects response to substance EXP GNAS protein affects the susceptibility to Phenylephrine CTD PMID:10696522 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions
increases secretion
decreases secretion
EXP alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein]; Testosterone affects the reaction [Phenylephrine affects the secretion of GNRH1 protein] CTD PMID:1975657 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gpm6a glycoprotein m6a decreases expression EXP Phenylephrine results in decreased expression of GPM6A mRNA CTD PMID:18158353 NCBI chr16:39,367,697...39,719,292
Ensembl chr16:39,367,692...39,719,187
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions
increases expression
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein
Phenylephrine results in increased expression of GRK2 protein
GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]
CTD PMID:11499749, PMID:28759639 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
EXP GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein] CTD PMID:15795328, PMID:28759639 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression EXP Phenylephrine results in decreased expression of GSTK1 mRNA CTD PMID:18158353 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Phenylephrine results in decreased expression of GSTM3 mRNA CTD PMID:18158353 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gys2 glycogen synthase 2 decreases activity EXP Phenylephrine results in decreased activity of GYS2 protein CTD PMID:747652 NCBI chr 4:176,638,632...176,679,805
Ensembl chr 4:176,638,629...176,679,815
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP Phenylephrine results in decreased expression of HAMP mRNA CTD PMID:18158353 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression EXP Phenylephrine results in increased expression of DTR mRNA CTD PMID:18158353 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO [Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein CTD PMID:19124542 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hdgfl2 HDGF like 2 decreases expression EXP Phenylephrine results in decreased expression of HDGFL2 mRNA CTD PMID:18158353 NCBI chr 9:10,972,342...10,991,938
Ensembl chr 9:10,972,351...10,991,927
JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 increases expression EXP Phenylephrine results in increased expression of HERC3 mRNA CTD PMID:18158353 NCBI chr 4:89,078,670...89,169,150
Ensembl chr 4:89,078,711...89,169,146
JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 multiple interactions EXP Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein] CTD PMID:17459355 NCBI chr10:91,200,874...91,202,986
Ensembl chr10:91,200,874...91,202,984
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions
decreases expression
decreases response to substance
ISO HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in decreased expression of HEY2 mRNA
HEY2 protein results in decreased susceptibility to Phenylephrine
CTD PMID:16603706, PMID:20001863 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Phenylephrine results in increased expression of HIGD1A mRNA CTD PMID:18158353 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Phenylephrine results in increased expression of HMGCS1 mRNA CTD PMID:18158353 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Phenylephrine results in increased expression of HOMER1 mRNA alternative form CTD PMID:16786172 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hspb3 heat shock protein family B (small) member 3 increases expression EXP Phenylephrine results in increased expression of HSPB3 mRNA CTD PMID:18158353 NCBI chr 2:45,517,788...45,518,502
Ensembl chr 2:45,517,789...45,518,502
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression EXP Phenylephrine results in increased expression of ID1 mRNA CTD PMID:18158353 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id4 inhibitor of DNA binding 4, HLH protein increases expression EXP Phenylephrine results in increased expression of ID4 mRNA CTD PMID:18158353 NCBI chr17:16,692,557...16,695,126
Ensembl chr17:16,692,557...16,695,126
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Phenylephrine results in increased expression of IDI1 mRNA CTD PMID:18158353 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ier3 immediate early response 3 decreases response to substance
affects localization
ISO IER3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of IER3 protein
CTD PMID:11934837 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Igf1 insulin-like growth factor 1 affects response to substance EXP IGF1 protein affects the susceptibility to Phenylephrine CTD PMID:11159833 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 affects response to substance EXP IGFBP4 protein affects the susceptibility to Phenylephrine CTD PMID:11159833 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression EXP Phenylephrine results in decreased expression of IGFBP5 mRNA CTD PMID:18158353 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases activity
multiple interactions
EXP Phenylephrine results in increased activity of IKBKB protein
IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:11381115 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
affects response to substance
EXP Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]
IL1B protein results in decreased susceptibility to Phenylephrine
CTD PMID:11506125, PMID:13679239 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
EXP Phenylephrine results in increased expression of IL6 mRNA
[resveratrol co-treated with Phenylephrine] results in increased expression of IL6 mRNA
Phenylephrine results in decreased expression of IL6 mRNA
CTD PMID:11406463, PMID:12423672, PMID:22748497 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilk integrin-linked kinase multiple interactions
affects localization
ISO
EXP
Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine affects the localization of ILK protein
ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:16170337, PMID:18502941 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Inha inhibin subunit alpha increases expression EXP Phenylephrine results in increased expression of INHA mRNA CTD PMID:18158353 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP Phenylephrine results in decreased expression of IRF7 mRNA CTD PMID:18158353 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression EXP Phenylephrine results in decreased expression of ISG15 mRNA CTD PMID:18158353 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Itga9 integrin subunit alpha 9 increases expression EXP Phenylephrine results in increased expression of ITGA9 mRNA CTD PMID:18158353 NCBI chr 8:127,271,029...127,576,709
Ensembl chr 8:127,271,289...127,572,988
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein increases expression EXP Phenylephrine results in increased expression of ITGB3BP mRNA CTD PMID:18158353 NCBI chr 5:118,476,410...118,541,928
Ensembl chr 5:118,476,430...118,673,780
JBrowse link
G Itgb8 integrin subunit beta 8 increases expression EXP Phenylephrine results in increased expression of ITGB8 mRNA CTD PMID:18158353 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases activity
multiple interactions
ISO Phenylephrine results in increased activity of ITPR2 protein
[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA
CTD PMID:15201137 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
increases expression
increases activity
affects response to substance
ISO
EXP
[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]
Phenylephrine results in increased phosphorylation of JUN protein
Phenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN protein
Phenylephrine results in increased activity of JUN protein
JUN protein affects the susceptibility to Phenylephrine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
CTD PMID:7905536, PMID:10710348, PMID:11799083, PMID:12169099, PMID:12574153, PMID:14764439, PMID:15949472, PMID:16690042, PMID:19002563, PMID:19225867, PMID:19443575, PMID:20067472 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
increases activity
EXP Phenylephrine results in increased expression of JUNB
Phenylephrine results in increased activity of JUNB protein
CTD PMID:7905536, PMID:15949472 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of JUND mRNA
CTD PMID:16690042 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 multiple interactions
decreases expression
decreases response to substance
EXP CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of KCND2 mRNA; Phenylephrine results in decreased expression of KCND2 protein
KCND2 protein results in decreased susceptibility to Phenylephrine
CTD PMID:12403671, PMID:16385079, PMID:17060317 NCBI chr 4:48,309,283...48,816,804 JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 multiple interactions
decreases expression
ISO
EXP
[KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]
Phenylephrine results in decreased expression of KCND3 mRNA; Phenylephrine results in decreased expression of KCND3 protein
CTD PMID:11249870, PMID:11709419, PMID:16385079, PMID:17060317 NCBI chr 2:207,923,775...208,140,727
Ensembl chr 2:207,923,775...208,140,727
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:19419905 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 multiple interactions
decreases expression
EXP MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]
Phenylephrine results in decreased expression of KCNIP2 mRNA; Phenylephrine results in decreased expression of KCNIP2 mRNA alternative form; Phenylephrine results in decreased expression of KCNIP2 protein
CTD PMID:16385079, PMID:17060317, PMID:18158353 NCBI chr 1:265,549,610...265,573,393
Ensembl chr 1:265,549,593...265,573,409
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP Phenylephrine results in increased expression of KDELR3 mRNA CTD PMID:18158353 NCBI chr 7:120,749,680...120,760,163
Ensembl chr 7:120,749,752...120,760,160
JBrowse link
G Kdr kinase insert domain receptor decreases expression
multiple interactions
increases expression
EXP Phenylephrine results in decreased expression of KDR mRNA
Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]
CTD PMID:18158353, PMID:24903162 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kif5b kinesin family member 5B decreases expression EXP Phenylephrine results in decreased expression of KIF5B mRNA CTD PMID:18158353 NCBI chr17:54,181,416...54,219,048
Ensembl chr17:54,181,419...54,212,096
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
decreases expression
EXP Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]
Phenylephrine results in decreased expression of KLF4 mRNA; Phenylephrine results in decreased expression of KLF4 protein
CTD PMID:19729022 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klhl24 kelch-like family member 24 decreases expression EXP Phenylephrine results in decreased expression of KLHL24 mRNA CTD PMID:18158353 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Kmt2e lysine methyltransferase 2E decreases expression EXP Phenylephrine results in decreased expression of KMT2E mRNA CTD PMID:18158353 NCBI chr 4:8,187,751...8,255,578
Ensembl chr 4:8,187,751...8,255,514
JBrowse link
G Lamc1 laminin subunit gamma 1 increases expression EXP Phenylephrine results in increased expression of LAMC1 mRNA CTD PMID:18158353 NCBI chr13:70,656,727...70,783,515
Ensembl chr13:70,658,707...70,783,515
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Phenylephrine results in increased expression of LAMC2 mRNA CTD PMID:18158353 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Ldlr low density lipoprotein receptor increases expression EXP Phenylephrine results in increased expression of LDLR mRNA CTD PMID:18158353 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression EXP Phenylephrine results in decreased expression of LGALS3BP mRNA CTD PMID:18158353 NCBI chr10:107,415,334...107,424,672
Ensembl chr10:107,415,326...107,424,710
JBrowse link
G Lims1 LIM zinc finger domain containing 1 affects localization EXP Phenylephrine affects the localization of LIMS1 protein CTD PMID:16170337 NCBI chr20:27,895,981...28,004,767
Ensembl chr20:27,954,433...28,002,082
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Phenylephrine results in increased expression of LMCD1 mRNA CTD PMID:18158353 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Lpl lipoprotein lipase affects response to substance ISO LPL protein affects the susceptibility to Phenylephrine CTD PMID:11786490 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrrc27 leucine rich repeat containing 27 decreases expression EXP Phenylephrine results in decreased expression of LRRC27 mRNA CTD PMID:18158353 NCBI chr 1:211,543,751...211,575,823
Ensembl chr 1:211,543,751...211,575,820
JBrowse link
G Lyl1 LYL1, basic helix-loop-helix family member increases expression EXP Phenylephrine results in increased expression of LYL1 mRNA CTD PMID:18158353 NCBI chr19:25,815,207...25,818,074
Ensembl chr19:25,815,207...25,818,074
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression EXP Phenylephrine results in increased expression of MAFK mRNA CTD PMID:18158353 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 decreases expression EXP Phenylephrine results in decreased expression of MAN1A mRNA CTD PMID:18158353 NCBI chr20:35,257,688...35,450,132
Ensembl chr20:35,257,985...35,450,513
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine CTD PMID:11834493 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO [MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine CTD PMID:11834493 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:10888249 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions EXP MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:10727428 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions
increases activity
EXP CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]; KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation
ISO
EXP
[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Phenylephrine results in increased expression of MAPK1 protein modified form
Phenylephrine results in increased activity of MAPK1 protein
Phenylephrine affects the phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
CTD PMID:10422649, PMID:10660688, PMID:10727428, PMID:10788492, PMID:10888249, PMID:10900171, PMID:11195782, PMID:11693273, PMID:11705990, PMID:11739382, PMID:11804996, PMID:11854500, PMID:12094073, PMID:12213976, PMID:12513686, PMID:12720544, PMID:12729908, PMID:12847114, PMID:14676212, PMID:14975926, PMID:15007106, PMID:15258898, PMID:15306222, PMID:15452191, PMID:15757502, PMID:16513848, PMID:16517124, PMID:16760267, PMID:16809552, PMID:16877402, PMID:17306214, PMID:18084315, PMID:18360054, PMID:18445782, PMID:18977218, PMID:19002563, PMID:19002953, PMID:19540241 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine] CTD PMID:16949803 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation EXP Phenylephrine results in increased phosphorylation of MAPK14 protein CTD PMID:15757502 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation
ISO
EXP
[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of MAPK3 protein modified form
Phenylephrine results in increased activity of MAPK3 protein
Phenylephrine affects the phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:10422649, PMID:10660688, PMID:10727428, PMID:10788492, PMID:10888249, PMID:10900171, PMID:11195782, PMID:11693273, PMID:11705990, PMID:11739382, PMID:11804996, PMID:11854500, PMID:12094073, PMID:12213976, PMID:12513686, PMID:12720544, PMID:12729908, PMID:12847114, PMID:14676212, PMID:14975926, PMID:15007106, PMID:15258898, PMID:15306222, PMID:15452191, PMID:15757502, PMID:16513848, PMID:16517124, PMID:16760267, PMID:16809552, PMID:16877402, PMID:17306214, PMID:18084315, PMID:18360054, PMID:18445782, PMID:18977218, PMID:19002563, PMID:19002953, PMID:19540241 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions EXP Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein] CTD PMID:12574153 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
Phenylephrine results in increased phosphorylation of MAPK8 protein
CTD PMID:10727428, PMID:16385079, PMID:16517124, PMID:16809552 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 affects response to substance
multiple interactions
EXP MAPK8IP1 protein affects the susceptibility to Phenylephrine
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:11513749 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
affects response to substance
ISO
EXP
MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]
Phenylephrine results in increased phosphorylation of MAPK9 protein
CTD PMID:10727428, PMID:16949803 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Masp1 mannan-binding lectin serine peptidase 1 decreases expression EXP Phenylephrine results in decreased expression of MASP1 mRNA CTD PMID:18158353 NCBI chr11:80,736,424...80,806,278
Ensembl chr11:80,736,576...80,803,382
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions
increases expression
increases activity
ISO
EXP
Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]
Phenylephrine results in increased expression of MEF2C mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]
CTD PMID:10737771, PMID:19124542 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mfap4 microfibril associated protein 4 decreases expression EXP Phenylephrine results in decreased expression of MFAP4 mRNA CTD PMID:18158353 NCBI chr10:47,765,463...47,768,484
Ensembl chr10:47,765,432...47,768,483
JBrowse link
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 decreases expression EXP Phenylephrine results in decreased expression of MFHAS1 mRNA CTD PMID:18158353 NCBI chr16:60,120,457...60,208,550
Ensembl chr16:60,128,201...60,208,462
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of MFN2 mRNA; Phenylephrine results in decreased expression of MFN2 protein
CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]
CTD PMID:17499311, PMID:20886221 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mgll monoglyceride lipase decreases expression EXP Phenylephrine results in decreased expression of MGLL mRNA CTD PMID:18158353 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mir21 microRNA 21 increases expression EXP Phenylephrine results in increased expression of MIR21 mRNA CTD PMID:17525252 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO Phenylephrine results in increased expression of MLKL protein CTD PMID:31605733 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor increases expression EXP Phenylephrine results in increased expression of MLLT11 mRNA CTD PMID:18158353 NCBI chr 2:196,392,936...196,402,106
Ensembl chr 2:196,392,938...196,402,106
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO
EXP
MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
CTD PMID:16251426, PMID:16980344 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Phenylephrine results in increased expression of MMP9 mRNA CTD PMID:16574429 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mov10l1 Mov10 like RISC complex RNA helicase 1 multiple interactions ISO
EXP
MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
CTD PMID:11854500, PMID:12754203 NCBI chr 7:129,973,391...130,039,306
Ensembl chr 7:129,973,480...130,037,344
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP Phenylephrine results in increased expression of MSMO1 mRNA CTD PMID:18158353 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Msn moesin increases expression EXP Phenylephrine results in increased expression of MSN mRNA CTD PMID:18158353 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression EXP Phenylephrine results in increased expression of MTHFD1L mRNA CTD PMID:18158353 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein] CTD PMID:12935885 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mustn1 musculoskeletal, embryonic nuclear protein 1 increases expression EXP Phenylephrine results in increased expression of MUSTN1 mRNA CTD PMID:18158353 NCBI chr16:6,962,737...6,964,987
Ensembl chr16:6,962,722...6,964,989
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression EXP Phenylephrine results in increased expression of MYBL1 mRNA CTD PMID:18158353 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Mybpc3 myosin binding protein C3 multiple interactions ISO MYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
MYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
CTD PMID:22076249 NCBI chr 3:79,940,509...79,958,731
Ensembl chr 3:79,940,561...79,958,730
JBrowse link
G Myh14 myosin heavy chain 14 decreases expression EXP Phenylephrine results in decreased expression of MYH14 mRNA CTD PMID:18158353 NCBI chr 1:100,608,975...100,671,086
Ensembl chr 1:100,608,966...100,671,074
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
decreases expression
EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]; THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024, PMID:15578571, PMID:15795322, PMID:17592507 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
increases expression
ISO
EXP
CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]
Phenylephrine results in increased expression of MYH7 mRNA
Phenylephrine results in increased expression of MYH7 mRNA; Phenylephrine results in increased expression of MYH7 protein
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; spiruchostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
[Phenylephrine co-treated with Isoproterenol] results in increased expression of MYH7 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
CTD PMID:10642269, PMID:10710348, PMID:11249870, PMID:11513749, PMID:11577024, PMID:11739382, PMID:12435817, PMID:12847114, PMID:15220332, PMID:15578571, PMID:15593114, PMID:15652358, PMID:15795322, PMID:16603706, PMID:17327491, PMID:17592507, PMID:18252717, PMID:18487437, PMID:18502941, PMID:18851973, PMID:19729022, PMID:27094368, PMID:28759639 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Phenylephrine results in increased expression of MYL1 mRNA CTD PMID:18158353 NCBI chr 9:73,937,820...73,958,480
Ensembl chr 9:73,937,823...73,958,480
JBrowse link
G Myl2 myosin light chain 2 multiple interactions
increases phosphorylation
increases expression
EXP ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]
Phenylephrine results in increased phosphorylation of MYL2 protein
CTD PMID:11470465, PMID:11513749, PMID:14676212, PMID:15007106, PMID:18202317 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
JBrowse link
G Myl7 myosin light chain 7 multiple interactions
increases phosphorylation
ISO ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein] CTD PMID:15621049 NCBI chr14:86,144,770...86,147,075
Ensembl chr14:86,143,862...86,147,553
JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation EXP Phenylephrine results in increased phosphorylation of MYL9 protein CTD PMID:18835913 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Mylk3 myosin light chain kinase 3 increases phosphorylation ISO Phenylephrine results in increased phosphorylation of MYLK3 protein CTD PMID:18202317 NCBI chr19:27,388,163...27,442,451
Ensembl chr19:27,404,712...27,441,536
JBrowse link
G Myocd myocardin multiple interactions
increases expression
EXP MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]
Phenylephrine results in increased expression of MYOCD mRNA; Phenylephrine results in increased expression of MYOCD protein
CTD PMID:14676212, PMID:16556869 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Myoz2 myozenin 2 multiple interactions
decreases response to substance
ISO MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
MYOZ2 protein results in decreased susceptibility to Phenylephrine
CTD PMID:18025526 NCBI chr 2:227,180,887...227,207,629
Ensembl chr 2:227,180,886...227,207,635
JBrowse link
G Nab1 Ngfi-A binding protein 1 multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNA CTD PMID:10710348 NCBI chr 9:53,906,073...53,945,474
Ensembl chr 9:53,906,073...53,945,473
JBrowse link
G Nab2 Ngfi-A binding protein 2 multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA] CTD PMID:10710348 NCBI chr 7:70,963,580...70,971,471
Ensembl chr 7:70,961,575...70,969,905
JBrowse link
G Ncald neurocalcin delta increases expression EXP Phenylephrine results in increased expression of NCALD mRNA CTD PMID:18158353 NCBI chr 7:76,199,305...76,632,847
Ensembl chr 7:76,199,306...76,488,216
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases phosphorylation
increases expression
EXP
ISO
Phenylephrine results in increased phosphorylation of NCF1 protein
Phenylephrine results in increased expression of NCF1 mRNA
CTD PMID:14656924, PMID:15936005 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions EXP Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein CTD PMID:12403671, PMID:19349967 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 increases localization
multiple interactions
ISO Phenylephrine results in increased localization of NFATC3 protein
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]
CTD PMID:15939815 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions
increases localization
affects localization
ISO
EXP
Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
Phenylephrine affects the localization of NFATC4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
CTD PMID:11044444, PMID:16055480 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions ISO U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA] CTD PMID:12729908 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
decreases expression
EXP 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in decreased expression of NFKBIA protein]; KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11381115, PMID:15629441, PMID:16421291 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nid2 nidogen 2 increases expression EXP Phenylephrine results in increased expression of NID2 mRNA CTD PMID:18158353 NCBI chr15:4,893,999...4,951,893
Ensembl chr15:4,894,213...4,951,917
JBrowse link
G Nkx2-5 NK2 homeobox 5 multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA CTD PMID:10710348 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
G Nodal nodal growth differentiation factor affects expression EXP Phenylephrine affects the expression of NODAL mRNA; Phenylephrine affects the expression of NODAL protein CTD PMID:11029149 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Nol3 nucleolar protein 3 decreases phosphorylation EXP Phenylephrine results in decreased phosphorylation of NOL3 protein CTD PMID:18171680 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases activity
decreases response to substance
affects response to substance
ISO
EXP
NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Calcimycin]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Nitroprusside]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]
Phenylephrine results in increased activity of NOS2 protein
NOS2 protein results in decreased susceptibility to Phenylephrine
NOS2 protein affects the susceptibility to Phenylephrine
CTD PMID:11498454, PMID:15753950, PMID:15902277 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 affects response to substance
decreases response to substance
multiple interactions
increases expression
ISO
EXP
NOS3 protein affects the susceptibility to Phenylephrine
NOS3 protein results in decreased susceptibility to Phenylephrine
NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]
Phenylephrine results in increased expression of NOS3 mRNA; Phenylephrine results in increased expression of NOS3 protein
CTD PMID:10954898, PMID:11504159, PMID:15381055, PMID:15753950, PMID:17403420 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A increases secretion
increases expression
multiple interactions
decreases response to substance
ISO
EXP
Phenylephrine results in increased secretion of NPPA protein
Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 8-(4-sulfophenyl)theophylline inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; kenpaullone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; U 0126 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
NPPA protein results in decreased susceptibility to Phenylephrine
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:2847676, PMID:8188982, PMID:10642269, PMID:10655507, PMID:10679475, PMID:10710348, PMID:10727428, PMID:10843871, PMID:10888249, PMID:11042672, PMID:11230109, PMID:11299230, PMID:11381115, PMID:11470465, PMID:11499749, PMID:11513749, PMID:11705990, PMID:11739382, PMID:11754973, PMID:11799083, PMID:11799084, PMID:11804996, PMID:11836006, PMID:11854500, PMID:12403671, PMID:12435817, PMID:12477714, PMID:12513686, PMID:12682052, PMID:12729799, PMID:12754203, PMID:14676212, PMID:14718400, PMID:15007106, PMID:15191894, PMID:15201137, PMID:15220332, PMID:15258898, PMID:15452191, PMID:15522277, PMID:15721863, PMID:15795322, PMID:15939815, PMID:16170337, PMID:16380548, PMID:16421291, PMID:16513848, PMID:16517124, PMID:16533503, PMID:16556869, PMID:16603706, PMID:16690042, PMID:16787574, PMID:16809552, PMID:17124262, PMID:17204550, PMID:17266992, PMID:17287366, PMID:17327491, PMID:17499311, PMID:17592507, PMID:18252717, PMID:18378355, PMID:18487437, PMID:18502941, PMID:18701451, PMID:18790048, PMID:18851973, PMID:19111554, PMID:19540241, PMID:19729022, PMID:19799869, PMID:19966059, PMID:19966502, PMID:20067472, PMID:20886221, PMID:21565836, PMID:23297412, PMID:23939492, PMID:25341891, PMID:25358972, PMID:25449040, PMID:27094368, PMID:27094369, PMID:28759639, PMID:28822817 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
increases secretion
ISO
EXP
ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in increased expression of NPPB mRNA; Phenylephrine results in increased expression of NPPB protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
CTD PMID:10642269, PMID:11754973, PMID:11799083, PMID:11804996, PMID:11854500, PMID:12435817, PMID:16556869, PMID:16603706, PMID:18502941, PMID:18701451, PMID:18790048, PMID:20067472, PMID:23939492, PMID:25358972, PMID:27094368, PMID:27094369, PMID:28759639, PMID:28822817 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nppc natriuretic peptide C affects response to substance
multiple interactions
EXP NPPC protein affects the susceptibility to Phenylephrine
SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]
CTD PMID:17026587 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Npr1 natriuretic peptide receptor 1 multiple interactions ISO [NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein] CTD PMID:15939815 NCBI chr 2:189,840,403...189,857,032
Ensembl chr 2:189,840,403...189,856,090
JBrowse link
G Npy neuropeptide Y multiple interactions ISO [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]] CTD PMID:10660688, PMID:11499749 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy5r neuropeptide Y receptor Y5 multiple interactions ISO NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]] CTD PMID:10660688 NCBI chr16:24,796,685...24,805,730
Ensembl chr16:24,797,124...24,805,079
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance ISO NR1I2 protein affects the susceptibility to Phenylephrine CTD PMID:17159084 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Phenylephrine results in increased expression of NR3C1 mRNA CTD PMID:16533503 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
increases expression
EXP Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of NR3C2 protein; Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
Phenylephrine results in increased expression of NR3C2 mRNA
CTD PMID:16533503, PMID:19966502 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Phenylephrine results in increased expression of NR4A3 mRNA CTD PMID:18158353 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP Phenylephrine results in decreased expression of NREP mRNA CTD PMID:18158353 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Nrg1 neuregulin 1 decreases expression EXP Phenylephrine results in decreased expression of NRG1 mRNA; Phenylephrine results in decreased expression of NRG1 protein CTD PMID:16698793 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nts neurotensin decreases response to substance EXP NTS protein results in decreased susceptibility to Phenylephrine CTD PMID:2326505 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Nup62 nucleoporin 62 multiple interactions
decreases expression
EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; trichostatin A inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein] CTD PMID:25341891 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Ogn osteoglycin decreases expression EXP Phenylephrine results in decreased expression of OGN mRNA CTD PMID:18158353 NCBI chr17:14,607,442...14,628,274
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions
increases secretion
EXP Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein] CTD PMID:11102496, PMID:15149956 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G P2rx5 purinergic receptor P2X 5 increases expression EXP Phenylephrine results in increased expression of P2RX5 mRNA CTD PMID:18158353 NCBI chr10:59,725,438...59,737,126
Ensembl chr10:59,725,398...59,737,126
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 increases expression EXP Phenylephrine results in increased expression of P4HA1 mRNA CTD PMID:18158353 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G Pacc1 proton activated chloride channel 1 decreases expression EXP Phenylephrine results in decreased expression of PACC1 mRNA CTD PMID:18158353 NCBI chr13:110,006,975...110,032,790
Ensembl chr13:110,007,010...110,031,895
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein] CTD PMID:11042672 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parva parvin, alpha affects localization EXP Phenylephrine affects the localization of PARVA protein CTD PMID:16170337 NCBI chr 1:177,249,302...177,408,160
Ensembl chr 1:177,249,226...177,408,205
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Phenylephrine results in increased expression of PCNA protein CTD PMID:15603588 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression EXP Phenylephrine results in decreased expression of PCP4 mRNA CTD PMID:18158353 NCBI chr11:36,851,035...36,912,272
Ensembl chr11:36,851,038...36,912,229
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 increases expression EXP Phenylephrine results in increased expression of PCSK6 mRNA CTD PMID:18158353 NCBI chr 1:126,749,508...126,947,392
Ensembl chr 1:126,749,508...126,947,392
JBrowse link
G Pde1a phosphodiesterase 1A multiple interactions EXP PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein] CTD PMID:19797176 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094
JBrowse link
G Pde4b phosphodiesterase 4B increases expression EXP Phenylephrine results in increased expression of PDE4B mRNA CTD PMID:18158353 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:18790048 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP Phenylephrine results in decreased expression of PDK2 mRNA CTD PMID:18158353 NCBI chr10:82,838,270...82,852,758
Ensembl chr10:82,839,153...82,852,660
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions
decreases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15721863, PMID:15728586 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdlim3 PDZ and LIM domain 3 increases expression EXP Phenylephrine results in increased expression of PDLIM3 mRNA CTD PMID:18158353 NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression EXP Phenylephrine results in increased expression of PEA15 mRNA CTD PMID:18158353 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466
JBrowse link
G Per1 period circadian regulator 1 multiple interactions ISO U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA] CTD PMID:12729908 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Per2 period circadian regulator 2 multiple interactions ISO U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA] CTD PMID:12729908 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha decreases expression EXP Phenylephrine results in decreased expression of PEX11A mRNA CTD PMID:18158353 NCBI chr 1:141,474,189...141,481,270
Ensembl chr 1:141,474,180...141,481,315
JBrowse link
G Pfkl phosphofructokinase, liver type increases expression EXP Phenylephrine results in increased expression of PFKL mRNA CTD PMID:18158353 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Phenylephrine results in increased expression of PHGDH mRNA CTD PMID:18158353 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression EXP Phenylephrine results in increased expression of PHLDA1 mRNA CTD PMID:18158353 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting affects response to substance ISO PKD1 protein affects the susceptibility to Phenylephrine CTD PMID:18679710 NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions
decreases activity
EXP Calcium inhibits the reaction [Phenylephrine results in decreased activity of PKLR protein] CTD PMID:747652 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pkp4 plakophilin 4 decreases expression EXP Phenylephrine results in decreased expression of PKP4 mRNA CTD PMID:18158353 NCBI chr 3:45,211,097...45,414,524
Ensembl chr 3:45,277,348...45,414,613
JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression EXP Phenylephrine results in decreased expression of PLA2G2A mRNA CTD PMID:18158353 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g6 phospholipase A2 group VI affects response to substance EXP PLA2G6 protein affects the susceptibility to Phenylephrine CTD PMID:17885217 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Plaat1 phospholipase A and acyltransferase 1 increases expression EXP Phenylephrine results in increased expression of PLAAT1 mRNA CTD PMID:18158353 NCBI chr11:75,125,951...75,145,868
Ensembl chr11:75,125,952...75,144,903
JBrowse link
G Plcb1 phospholipase C beta 1 increases expression EXP Phenylephrine results in increased expression of PLCB1 mRNA CTD PMID:16714034 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb3 phospholipase C beta 3 increases expression EXP Phenylephrine results in increased expression of PLCB3 mRNA CTD PMID:16714034 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression EXP Phenylephrine results in increased expression of PLCD1 mRNA CTD PMID:16714034 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression EXP Phenylephrine results in increased expression of PLCG1 mRNA CTD PMID:16714034 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases response to substance
increases secretion
EXP
ISO
Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]
POMC protein results in increased susceptibility to Phenylephrine
CTD PMID:2822310, PMID:3015460, PMID:10898105 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein]
Phenylephrine results in decreased expression of PPARA mRNA; Phenylephrine results in decreased expression of PPARA protein
CTD PMID:18701451, PMID:19699196 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:15721863, PMID:18701451 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions
increases phosphorylation
EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein] CTD PMID:24449418, PMID:25449040 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions
increases phosphorylation
EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein] CTD PMID:24449418 NCBI chr 1:87,224,683...87,232,842
Ensembl chr 1:87,224,677...87,232,848
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta increases expression
increases activity
multiple interactions
ISO
EXP
Phenylephrine results in increased expression of PPP3CB mRNA
Phenylephrine results in increased expression of PPP3CB mRNA; Phenylephrine results in increased expression of PPP3CB protein
Phenylephrine results in increased activity of PPP3CB protein
CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]
CTD PMID:10655507, PMID:16024800 NCBI chr15:4,209,702...4,236,895
Ensembl chr15:4,209,703...4,236,895
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases expression
increases activity
increases localization
ISO
EXP
DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]
Phenylephrine results in increased expression of PRKCA protein modified form
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein
Phenylephrine results in increased activity of PRKCA protein
CTD PMID:12435817, PMID:16809552, PMID:18487437, PMID:21565836 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases expression
EXP Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein] CTD PMID:17121852 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta increases expression
affects localization
EXP Phenylephrine results in increased expression of PRKCD protein
Phenylephrine affects the localization of PRKCD protein
CTD PMID:12720544 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
increases expression
affects localization
increases localization
ISO
EXP
DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]
Phenylephrine results in increased expression of PRKCE protein
Phenylephrine affects the localization of PRKCE protein
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein
CTD PMID:12003851, PMID:12700091, PMID:12720544, PMID:16809552, PMID:18487437 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkcz protein kinase C, zeta affects localization
increases phosphorylation
decreases activity
multiple interactions
EXP Phenylephrine affects the localization of PRKCZ protein
Phenylephrine results in increased phosphorylation of PRKCZ protein
Phenylephrine results in decreased activity of PRKCZ protein
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]
CTD PMID:14736339, PMID:16809552, PMID:27094369 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Prkd1 protein kinase D1 affects localization
multiple interactions
increases activity
ISO Phenylephrine affects the localization of PRKD1 protein
[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein
CTD PMID:19124542 NCBI chr 6:71,035,017...71,349,531
Ensembl chr 6:71,035,332...71,349,249
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases expression
increases activity
decreases activity
EXP [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]; PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]; VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of PRKG1 protein
CTD PMID:11799084, PMID:16378109, PMID:19542178, PMID:19797176, PMID:26168186 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Procr protein C receptor increases expression EXP Phenylephrine results in increased expression of PROCR mRNA CTD PMID:18158353 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Psph phosphoserine phosphatase increases expression EXP Phenylephrine results in increased expression of PSPH mRNA CTD PMID:18158353 NCBI chr12:30,514,128...30,526,551
Ensembl chr12:30,514,112...30,526,557
JBrowse link
G Ptgis prostaglandin I2 synthase increases expression EXP Phenylephrine results in increased expression of PTGIS mRNA CTD PMID:18158353 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
affects response to substance
ISO FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine] CTD PMID:17641673 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein] CTD PMID:17244722, PMID:18701451 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression
multiple interactions
EXP Phenylephrine results in increased expression of PTHLH mRNA; Phenylephrine results in increased expression of PTHLH protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
CTD PMID:19910689 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression EXP Phenylephrine results in decreased expression of PTPRF mRNA CTD PMID:18158353 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression EXP Phenylephrine results in decreased expression of PTPRK mRNA CTD PMID:18158353 NCBI chr 1:17,445,052...18,058,266
Ensembl chr 1:17,446,417...18,058,055
JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Phenylephrine results in increased expression of PVR mRNA CTD PMID:18158353 NCBI chr 1:80,820,306...80,835,712
Ensembl chr 1:80,820,050...80,835,701
JBrowse link
G Pycard PYD and CARD domain containing decreases expression EXP Phenylephrine results in decreased expression of PYCARD mRNA CTD PMID:18158353 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Pygl glycogen phosphorylase L multiple interactions
increases expression
EXP [Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein; Glucose inhibits the reaction [[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein]
Phenylephrine results in increased expression of PYGL mRNA
CTD PMID:747652, PMID:18158353 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rab3b RAB3B, member RAS oncogene family decreases expression EXP Phenylephrine results in decreased expression of RAB3B mRNA CTD PMID:18158353 NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity EXP Phenylephrine results in increased activity of RAC1 protein CTD PMID:11158304 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
increases phosphorylation
EXP Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of RAF1 protein] CTD PMID:15258898 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rai14 retinoic acid induced 14 increases expression EXP Phenylephrine results in increased expression of RAI14 mRNA CTD PMID:18158353 NCBI chr 2:60,546,083...60,684,365
Ensembl chr 2:60,546,091...60,683,451
JBrowse link
G Ramp1 receptor activity modifying protein 1 affects expression EXP Phenylephrine affects the expression of RAMP1 mRNA CTD PMID:17250927 NCBI chr 9:98,313,632...98,364,206
Ensembl chr 9:98,313,632...98,364,205
JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions
increases expression
decreases expression
EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of RAMP2 mRNA
Phenylephrine results in increased expression of RAMP2 mRNA
Phenylephrine results in decreased expression of RAMP2 mRNA
CTD PMID:12899678, PMID:17250927 NCBI chr10:89,166,170...89,168,962
Ensembl chr10:89,166,890...89,168,965
JBrowse link
G Ramp3 receptor activity modifying protein 3 increases expression EXP Phenylephrine results in increased expression of RAMP3 mRNA CTD PMID:18158353 NCBI chr14:86,922,223...86,939,722
Ensembl chr14:86,922,223...86,939,719
JBrowse link
G Ranbp1 RAN binding protein 1 multiple interactions EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; Phenylephrine affects the localization of and affects the expression of RANBP1 protein; trichostatin A inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein] CTD PMID:25341891 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Phenylephrine results in increased expression of RAPGEF4 mRNA CTD PMID:18158353 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rapsn receptor-associated protein of the synapse decreases expression EXP Phenylephrine results in decreased expression of RAPSN mRNA CTD PMID:18158353 NCBI chr 3:79,859,815...79,869,486
Ensembl chr 3:79,860,179...79,869,524
JBrowse link
G Rasd2 RASD family, member 2 decreases expression EXP Phenylephrine results in decreased expression of RASD2 mRNA CTD PMID:18158353 NCBI chr19:14,653,198...14,663,914
Ensembl chr19:14,653,198...14,663,914
JBrowse link
G Rassf1 Ras association domain family member 1 decreases response to substance ISO
EXP
RASSF1 protein results in decreased susceptibility to Phenylephrine CTD PMID:19652091 NCBI chr 8:116,307,149...116,318,289
Ensembl chr 8:116,307,141...116,318,289
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
affects phosphorylation
EXP Phenylephrine results in increased expression of RB1 protein
Phenylephrine affects the phosphorylation of RB1 protein
CTD PMID:15603588, PMID:18084315 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 multiple interactions
affects response to substance
EXP Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; Phenylephrine results in increased phosphorylation of and results in increased expression of RBCK1 protein; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]
RBCK1 protein affects the susceptibility to Phenylephrine
CTD PMID:17121852 NCBI chr 3:147,793,014...147,809,941
Ensembl chr 3:147,793,017...147,809,919
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression
multiple interactions
ISO
EXP
Phenylephrine results in increased expression of RCAN1 protein
Phenylephrine results in increased expression of RCAN1 mRNA
MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
CTD PMID:18025526, PMID:25358972 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
affects localization
EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]
Phenylephrine affects the localization of RELA protein
CTD PMID:11381115, PMID:18701451 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin decreases activity
affects response to substance
ISO Phenylephrine results in decreased activity of REN protein
REN1 protein affects the susceptibility to Phenylephrine
CTD PMID:2847676, PMID:17679040 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit decreases expression EXP Phenylephrine results in decreased expression of REV3L mRNA CTD PMID:18158353 NCBI chr20:44,803,664...44,961,362
Ensembl chr20:44,803,666...44,961,382
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
increases expression
affects response to substance
EXP
ISO
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
RGS2 protein affects the susceptibility to Phenylephrine
CTD PMID:15452191, PMID:16517124, PMID:17644703, PMID:18158353 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases activity
EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; monomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein] CTD PMID:10843871, PMID:15081308, PMID:21708234, PMID:24449418, PMID:25449040 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO Phenylephrine results in increased expression of RIPK1 protein CTD PMID:31605733 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO Phenylephrine results in increased expression of RIPK3 protein CTD PMID:31605733 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Phenylephrine results in increased expression of RND1 mRNA CTD PMID:18158353 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G Rnf39 ring finger protein 39 increases expression EXP Phenylephrine results in increased expression of RNF39 mRNA CTD PMID:18158353 NCBI chr20:2,098,375...2,103,864
Ensembl chr20:2,098,375...2,103,864
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression EXP Phenylephrine results in increased expression of ROCK2 mRNA CTD PMID:18158353 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein] CTD PMID:15522277, PMID:19002563 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
EXP 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] CTD PMID:12411397, PMID:12720544, PMID:12935885, PMID:15757502, PMID:15795328, PMID:18562309 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein] CTD PMID:12720544 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator decreases expression EXP Phenylephrine results in decreased expression of RRAD protein CTD PMID:18056528 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression EXP Phenylephrine results in decreased expression of RUNX1T1 mRNA CTD PMID:18158353 NCBI chr 5:27,284,921...27,440,802
Ensembl chr 5:27,312,928...27,442,841
JBrowse link
G S100a6 S100 calcium binding protein A6 multiple interactions EXP S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA] CTD PMID:15652358 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G S100b S100 calcium binding protein B increases expression
multiple interactions
EXP Phenylephrine results in increased expression of S100B mRNA
S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
CTD PMID:15652358 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Phenylephrine results in increased expression of SC5D mRNA CTD PMID:18158353 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression EXP Phenylephrine results in increased expression of SCD2 mRNA CTD PMID:18158353 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression EXP Phenylephrine results in decreased expression of SELENBP1 mRNA CTD PMID:18158353 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Sema6d semaphorin 6D decreases expression EXP Phenylephrine results in decreased expression of SEMA6D mRNA CTD PMID:18158353 NCBI chr 3:116,899,906...116,958,059
Ensembl chr 3:116,899,878...116,958,050
JBrowse link
G Septin5 septin 5 increases expression EXP Phenylephrine results in increased expression of SEPTIN5 mRNA CTD PMID:18158353 NCBI chr11:86,516,377...86,522,169
Ensembl chr11:86,512,797...86,522,168
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO
EXP
Phenylephrine results in increased expression of SERPINE1 mRNA CTD PMID:15808835, PMID:15850565 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases phosphorylation
multiple interactions
EXP Phenylephrine results in increased phosphorylation of SGK1 protein
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]
CTD PMID:15795328, PMID:16533503 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sik1 salt-inducible kinase 1 increases expression EXP Phenylephrine results in increased expression of SIK1 mRNA CTD PMID:18158353 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Sirt6 sirtuin 6 multiple interactions EXP [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine results in decreased expression of and results in decreased activity of SIRT6 protein; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:27094368 NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of SLC12A2 protein]; Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium] CTD PMID:14630635 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP Phenylephrine results in decreased expression of SLC16A10 mRNA CTD PMID:18158353 NCBI chr20:45,138,433...45,260,155
Ensembl chr20:45,143,453...45,260,119
JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression EXP Phenylephrine results in increased expression of SLC16A3 mRNA CTD PMID:18158353 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc16a7 solute carrier family 16 member 7 decreases expression EXP Phenylephrine results in decreased expression of SLC16A7 mRNA CTD PMID:18158353 NCBI chr 7:68,438,341...68,606,312
Ensembl chr 7:68,446,193...68,549,763
JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression EXP Phenylephrine results in increased expression of SLC1A3 mRNA CTD PMID:18158353 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions EXP [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc26a6 solute carrier family 26 member 6 decreases activity
increases expression
EXP Phenylephrine results in decreased activity of SLC26A6 protein
Phenylephrine results in increased expression of SLC26A6 protein
CTD PMID:17124262 NCBI chr 8:117,648,792...117,659,376
Ensembl chr 8:117,648,745...117,659,804
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases expression EXP Phenylephrine results in increased expression of SLC29A1 mRNA CTD PMID:19966059 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Phenylephrine results in increased expression of SLC2A1 mRNA CTD PMID:15808844 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression EXP Phenylephrine results in decreased expression of SLC4A1AP mRNA CTD PMID:18158353 NCBI chr 6:26,214,083...26,241,337
Ensembl chr 6:26,214,335...26,241,337
JBrowse link
G Slc4a3 solute carrier family 4 member 3 increases activity EXP Phenylephrine results in increased activity of SLC4A3 protein CTD PMID:17124262 NCBI chr 9:82,742,207...82,755,119
Ensembl chr 9:82,741,920...82,755,153
JBrowse link
G Slc7a1 solute carrier family 7 member 1 increases expression EXP Phenylephrine results in increased expression of SLC7A1 mRNA CTD PMID:18158353 NCBI chr12:8,032,775...8,108,972
Ensembl chr12:8,032,809...8,108,972
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions
increases expression
decreases expression
ISO
EXP
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]
Phenylephrine results in increased expression of SLC8A1 mRNA
Phenylephrine results in decreased expression of SLC8A1 protein
CTD PMID:11179087, PMID:15621046, PMID:19244478 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions
increases expression
increases activity
EXP 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of SLC9A1 mRNA; Phenylephrine results in increased expression of SLC9A1 protein
CTD PMID:15452191, PMID:16236312, PMID:16513848, PMID:16517124 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein CTD PMID:19443575 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 decreases expression EXP Phenylephrine results in decreased expression of SMOC2 mRNA CTD PMID:18158353 NCBI chr 1:56,242,289...56,374,106
Ensembl chr 1:56,242,346...56,374,120
JBrowse link
G Smr3b submaxillary gland androgen regulated protein 3B multiple interactions EXP SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine] CTD PMID:17026587 NCBI chr14:21,490,216...21,709,077
Ensembl chr14:21,490,217...21,709,084
JBrowse link
G Sord sorbitol dehydrogenase decreases expression EXP Phenylephrine results in decreased expression of SORD mRNA CTD PMID:18158353 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Sox6 SRY-box transcription factor 6 decreases expression EXP Phenylephrine results in decreased expression of SOX6 mRNA CTD PMID:18158353 NCBI chr 1:185,631,702...186,186,192
Ensembl chr 1:185,673,177...186,182,829
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] CTD PMID:10710348 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Phenylephrine results in increased expression of SPP1 protein CTD PMID:10406839 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 increases expression EXP Phenylephrine results in increased expression of SPRY1 mRNA CTD PMID:18158353 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 decreases expression EXP Phenylephrine results in decreased expression of SPTA1 mRNA CTD PMID:18158353 NCBI chr13:92,264,231...92,340,091
Ensembl chr13:92,264,231...92,340,083
JBrowse link
G Sqle squalene epoxidase increases expression EXP Phenylephrine results in increased expression of SQLE mRNA CTD PMID:18158353 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP Phenylephrine results in decreased expression of SQSTM1 mRNA CTD PMID:18158353 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ST3GAL2 mRNA CTD PMID:18158353 NCBI chr19:43,273,251...43,324,265
Ensembl chr19:43,274,493...43,290,363
JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 increases expression EXP Phenylephrine results in increased expression of ST3GAL4 mRNA CTD PMID:18158353 NCBI chr 8:36,264,741...36,314,811
Ensembl chr 8:36,264,750...36,314,811
JBrowse link
G St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 increases expression EXP Phenylephrine results in increased expression of ST8SIA5 mRNA CTD PMID:18158353 NCBI chr18:73,564,010...73,630,256
Ensembl chr18:73,564,247...73,625,137
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression EXP Phenylephrine results in decreased expression of STAT1 mRNA CTD PMID:18158353 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization
increases expression
multiple interactions
EXP Phenylephrine affects the localization of STAT3 protein
Phenylephrine results in increased expression of STAT3
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein; Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]
CTD PMID:19299911, PMID:27094369 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stc1 stanniocalcin 1 affects expression EXP Phenylephrine affects the expression of STC1 mRNA CTD PMID:18158353 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP Phenylephrine results in decreased expression of STMN1 mRNA CTD PMID:18158353 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Stx11 syntaxin 11 affects expression EXP Phenylephrine affects the expression of STX11 mRNA CTD PMID:18158353 NCBI chr 1:7,039,160...7,064,870
Ensembl chr 1:7,039,162...7,064,870
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases secretion
affects response to substance
EXP alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein]
TAC1 protein affects the susceptibility to Phenylephrine
CTD PMID:11270094, PMID:17240043 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 increases response to substance EXP TACR1 protein results in increased susceptibility to Phenylephrine CTD PMID:16982039 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 increases expression EXP Phenylephrine results in increased expression of TAF1 mRNA CTD PMID:15808844 NCBI chr  X:71,412,291...71,486,456
Ensembl chr  X:71,412,289...71,485,085
JBrowse link
G Tcte1 t-complex-associated testis expressed 1 decreases expression EXP Phenylephrine results in decreased expression of TCTE1 mRNA CTD PMID:18158353 NCBI chr 9:17,847,866...17,867,276
Ensembl chr 9:17,846,364...17,866,927
JBrowse link
G Tfdp1 transcription factor Dp-1 increases expression EXP Phenylephrine results in increased expression of TFDP1 protein CTD PMID:12682052 NCBI chr16:81,088,642...81,127,244
Ensembl chr16:81,089,292...81,127,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO
EXP
Phenylephrine results in increased expression of TGFB1 mRNA
Phenylephrine results in increased expression of TGFB1 mRNA; Phenylephrine results in increased expression of TGFB1 protein
CTD PMID:10406839, PMID:11821714, PMID:19443575 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression
multiple interactions
EXP Phenylephrine results in increased expression of TGFB1I1 protein
[Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
CTD PMID:19540241 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Phenylephrine results in increased expression of TGFB2 mRNA CTD PMID:19443575 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression EXP Phenylephrine results in increased expression of TGFB3 mRNA CTD PMID:18158353 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP Phenylephrine results in increased expression of TGFBR1 mRNA CTD PMID:19443575 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP Phenylephrine results in increased expression of TGFBR2 mRNA CTD PMID:19443575 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
decreases activity
increases expression
EXP ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; Ethanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]
Phenylephrine results in increased expression of TGM2 mRNA
CTD PMID:10801782, PMID:18158353 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
increases expression
EXP THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]
Phenylephrine results in increased expression of THRA protein
CTD PMID:11577024, PMID:17389455 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression
increases expression
multiple interactions
EXP Phenylephrine results in decreased expression of THRB mRNA; Phenylephrine results in decreased expression of THRB protein
Phenylephrine results in increased expression of THRB protein
THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]
CTD PMID:11577024, PMID:17389455 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
EXP BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
Phenylephrine results in increased expression of TIMP1 mRNA; Phenylephrine results in increased expression of TIMP1 protein
CTD PMID:18158353, PMID:19910689 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmem140 transmembrane protein 140 decreases expression EXP Phenylephrine results in decreased expression of TMEM140 mRNA CTD PMID:18158353 NCBI chr 4:62,380,914...62,391,913
Ensembl chr 4:62,380,914...62,391,912
JBrowse link
G Tmem176b transmembrane protein 176B decreases expression EXP Phenylephrine results in decreased expression of TMEM176B mRNA CTD PMID:18158353 NCBI chr 4:78,450,724...78,458,600
Ensembl chr 4:78,450,724...78,458,179
JBrowse link
G Tmem43 transmembrane protein 43 increases expression EXP Phenylephrine results in increased expression of TMEM43 mRNA CTD PMID:18158353 NCBI chr 4:123,118,468...123,133,610
Ensembl chr 4:123,118,468...123,133,609
JBrowse link
G Tmsb15b2 thymosin beta 15B2 increases expression EXP Phenylephrine results in increased expression of TMSB15B2 mRNA CTD PMID:18158353 NCBI chr  X:107,612,518...107,614,632
Ensembl chr  X:107,612,518...107,614,632
JBrowse link
G Tnf tumor necrosis factor decreases secretion
decreases response to substance
increases expression
multiple interactions
EXP Phenylephrine results in decreased secretion of TNF protein
TNF protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in increased expression of TNF mRNA; Phenylephrine results in increased expression of TNF protein
Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]
CTD PMID:12423672, PMID:13679239, PMID:16020479, PMID:17872965, PMID:18701451 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Phenylephrine results in increased expression of TNFAIP3 protein CTD PMID:12900338 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Phenylephrine results in increased expression of TNFRSF12A mRNA CTD PMID:18158353 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression
multiple interactions
ISO Phenylephrine results in increased expression of TNFSF11 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]
CTD PMID:17306214 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tox thymocyte selection-associated high mobility group box decreases expression EXP Phenylephrine results in decreased expression of TOX mRNA CTD PMID:18158353 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
G Tpm2 tropomyosin 2 increases expression EXP Phenylephrine results in increased expression of TPM2 mRNA CTD PMID:18158353 NCBI chr 5:59,016,616...59,025,971
Ensembl chr 5:59,016,622...59,025,631
JBrowse link
G Trdn triadin decreases expression EXP Phenylephrine results in decreased expression of TRDN mRNA CTD PMID:18158353 NCBI chr 1:25,403,390...25,787,664
Ensembl chr 1:25,403,390...25,839,345
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP Phenylephrine results in increased expression of TRIB3 mRNA CTD PMID:18158353 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression EXP Phenylephrine results in decreased expression of TRIM2 mRNA CTD PMID:18158353 NCBI chr 2:183,145,096...183,223,819
Ensembl chr 2:183,145,089...183,213,228
JBrowse link
G Trim25 tripartite motif-containing 25 decreases expression EXP Phenylephrine results in decreased expression of TRIM25 mRNA CTD PMID:18158353 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145
JBrowse link
G Trim34 tripartite motif-containing 34 decreases expression EXP Phenylephrine results in decreased expression of TRIM34 mRNA CTD PMID:18158353 NCBI chr 1:169,433,539...169,445,041
Ensembl chr 1:169,433,539...169,445,041
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP Phenylephrine results in increased expression of TRPC1 protein CTD PMID:17174323 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 multiple interactions
increases expression
EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]; [Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium; TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]
Phenylephrine results in increased expression of TRPC3 mRNA; Phenylephrine results in increased expression of TRPC3 protein
CTD PMID:15672411, PMID:19244478 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions EXP TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium] CTD PMID:15672411 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 multiple interactions EXP 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenylephrine binds to and results in increased activity of TRPM8 protein CTD PMID:19363131 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with calcitonin gene-related peptide (8-37)]; TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with capsazepine] CTD PMID:17082722 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
increases phosphorylation
EXP SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein] CTD PMID:15757502, PMID:15795328 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Phenylephrine results in increased expression of TUBB6 mRNA CTD PMID:18158353 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Tyr tyrosinase multiple interactions
increases activity
EXP Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ubn1 ubinuclein 1 decreases expression EXP Phenylephrine results in decreased expression of UBN1 mRNA CTD PMID:18158353 NCBI chr10:10,690,224...10,725,655
Ensembl chr10:10,690,224...10,725,655
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression EXP Phenylephrine results in increased expression of UCHL1 mRNA CTD PMID:18158353 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
G Ucn urocortin affects response to substance EXP UCN protein affects the susceptibility to Phenylephrine CTD PMID:17885217 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Phenylephrine results in decreased expression of VCAM1 mRNA CTD PMID:18158353 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vcan versican increases expression EXP Phenylephrine results in increased expression of VCAN mRNA CTD PMID:18158353 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP VEGFA protein inhibits the reaction [Phenylephrine results in decreased abundance of Copper]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein] CTD PMID:25107896 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin increases expression
multiple interactions
EXP Phenylephrine results in increased expression of VIM protein
VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
CTD PMID:26168186 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vip vasoactive intestinal peptide affects response to substance ISO VIP protein affects the susceptibility to Phenylephrine CTD PMID:11728430 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
G Wasl WASP like actin nucleation promoting factor multiple interactions EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]] CTD PMID:17615370 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
G Wfdc1 WAP four-disulfide core domain 1 increases expression EXP Phenylephrine results in increased expression of WFDC1 mRNA CTD PMID:18158353 NCBI chr19:52,313,771...52,332,721
Ensembl chr19:52,313,795...52,332,697
JBrowse link
G Wif1 Wnt inhibitory factor 1 increases expression EXP Phenylephrine results in increased expression of WIF1 mRNA CTD PMID:18158353 NCBI chr 7:63,094,955...63,165,158
Ensembl chr 7:63,094,911...63,165,159
JBrowse link
G Xpr1 xenotropic and polytropic retrovirus receptor 1 increases expression EXP Phenylephrine results in increased expression of XPR1 mRNA CTD PMID:18158353 NCBI chr13:72,918,552...73,056,785
Ensembl chr13:72,918,490...73,056,875
JBrowse link
G Zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ZDHHC2 mRNA CTD PMID:18158353 NCBI chr16:54,932,546...55,002,322
Ensembl chr16:54,934,056...55,002,322
JBrowse link
G Zfp46 zinc finger protein 46 decreases expression EXP Phenylephrine results in decreased expression of ZFP46 mRNA CTD PMID:18158353 NCBI chr 5:154,644,099...154,655,132
Ensembl chr 5:154,650,632...154,655,132
JBrowse link
G Zfp503 zinc finger protein 503 decreases expression EXP Phenylephrine results in decreased expression of ZFP503 mRNA CTD PMID:18158353 NCBI chr15:2,374,582...2,378,370
Ensembl chr15:2,374,582...2,378,370
JBrowse link
G Zfpm2 zinc finger protein, multitype 2 decreases response to substance
multiple interactions
ISO
EXP
ZFPM2 protein results in decreased susceptibility to Phenylephrine
ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:15220332 NCBI chr 7:79,471,277...79,964,405
Ensembl chr 7:79,638,046...79,964,405
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            protective agent 16345
              phenylephrine 516
Path 2
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  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        amino alcohol 882
                                          ethanolamines 769
                                            phenylethanolamines 586
                                              phenylephrine 516
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.