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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenylephrine
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Accession:CHEBI:8093 term browser browse the term
Definition:A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Synonyms:exact_synonym: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
 related_synonym: (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;   Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-;   Benzyl alcohol, m-hydroxy-alpha-((methylamino)methyl)-, (-)-;   Formula=C9H13NO2;   InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1;   InChIKey=SONNWYBIRXJNDC-VIFPVBQESA-N;   R(-)-Phenylephrine;   SMILES=CNC[C@H](O)c1cccc(O)c1;   fenilefrina;   l-(3-Hydroxyphenyl)-N-methylethanolamine;   phenylephrinum
 xref: CAS:59-42-7;   DrugBank:DB00388;   Drug_Central:2146;   HMDB:HMDB0002182;   KEGG:C07441;   KEGG:D08365;   LINCS:LSM-15380
 xref_mesh: MESH:D010656
 xref: PMID:10100801;   PMID:11064374;   PMID:11528305;   PMID:12172708;   PMID:15492464;   PMID:15522277;   PMID:15686119;   PMID:19372348;   PMID:19427353;   PMID:24588024;   PMID:25719378;   PMID:25902390;   PMID:26143019;   PMID:26428281;   PMID:26513673;   PMID:26597497;   PMID:26709790;   PMID:26873547;   PMID:26928367;   PMID:26991619;   PMID:26992790;   PMID:27020488;   PMID:27117950;   PMID:27164015;   PMID:27249899;   PMID:27288620;   PMID:28166217;   PMID:7516005;   PMID:7879981;   PMID:8763311;   PMID:8853328;   Patent:US1932347;   Patent:US1954389;   Reaxys:3198815;   Wikipedia:Phenylephrine
 cyclic_relationship: is_conjugate_base_of CHEBI:132294


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phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression EXP Phenylephrine results in decreased expression of ABCC9 mRNA CTD PMID:18158353 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Phenylephrine results in increased expression of ABHD2 mRNA CTD PMID:18158353 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
affects response to substance
increases phosphorylation
EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
ABL1 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased phosphorylation of ABL1 protein
CTD PMID:17615370 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
decreases expression
EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA] CTD PMID:19699196 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ACAT2 mRNA CTD PMID:18158353 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Ace angiotensin I converting enzyme affects response to substance ISO ACE protein affects the susceptibility to Phenylephrine CTD PMID:18431347 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Phenylephrine results in increased expression of ACOT2 mRNA CTD PMID:18158353 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions
increases expression
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]
CTD PMID:10642269 PMID:10710348 PMID:11230109 PMID:11499749 PMID:11513749 More... NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
EXP MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA] CTD PMID:16556869 PMID:18158353 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actr3 actin related protein 3 increases expression EXP Phenylephrine results in increased expression of ACTR3 mRNA CTD PMID:18158353 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions EXP ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein] CTD PMID:16760267 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Phenylephrine CTD PMID:12869393 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression EXP Phenylephrine results in decreased expression of ADHFE1 mRNA CTD PMID:18158353 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
JBrowse link
G Adm adrenomedullin multiple interactions
increases expression
decreases secretion
decreases expression
decreases response to substance
EXP
ISO
[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in decreased expression of ADM mRNA
ADM protein results in decreased susceptibility to Phenylephrine
CTD PMID:11470465 PMID:15370692 PMID:17250927 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
increases expression
EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein
CTD PMID:19966059 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions
increases expression
EXP 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein
CTD PMID:19966059 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adora3 adenosine A3 receptor multiple interactions
increases expression
EXP 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein
CTD PMID:19966059
G Adprhl1 ADP-ribosylhydrolase like 1 increases expression EXP Phenylephrine results in increased expression of ADPRHL1 mRNA CTD PMID:18158353 NCBI chr16:76,283,199...76,298,614 JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
increases activity
affects activity
increases response to substance
affects binding
affects response to substance
ISO
EXP
5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein affects the susceptibility to Phenylephrine
CTD PMID:8183249 PMID:11709419 PMID:12935885 PMID:15306222 PMID:15365637 More... NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B affects response to substance
multiple interactions
increases activity
decreases expression
increases response to substance
ISO
EXP
ADRA1B protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
ADRA1B protein results in increased susceptibility to Phenylephrine
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein
CTD PMID:10801782 PMID:11499749 PMID:11693201 PMID:15306222 PMID:16498073 More... NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D affects response to substance
increases activity
affects binding
multiple interactions
increases response to substance
ISO
EXP
ADRA1D protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of ADRA1D protein
Phenylephrine binds to ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
ADRA1D affects the susceptibility to Phenylephrine
CTD PMID:8183249 PMID:11901185 PMID:15306222 PMID:15493479 PMID:16371063 More... NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] CTD PMID:10742289 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2b adrenoceptor alpha 2B affects response to substance
multiple interactions
ISO ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]
CTD PMID:16815979 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine] CTD PMID:16474418 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases response to substance
ISO amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine] CTD PMID:16022967 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Agt angiotensinogen affects response to substance
increases response to substance
multiple interactions
increases expression
EXP
ISO
AGT protein affects the susceptibility to Phenylephrine
AGT protein modified form results in increased susceptibility to Phenylephrine
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]
CTD PMID:2298476 PMID:7900855 PMID:16251426 PMID:16794485 PMID:27094369 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
affects response to substance
EXP
ISO
[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine
CTD PMID:11714657 PMID:19151255 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Phenylephrine results in increased expression of AIFM1 protein CTD PMID:31605733 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ak4 adenylate kinase 4 increases expression EXP Phenylephrine results in increased expression of AK4 mRNA CTD PMID:18158353 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation
ISO
EXP
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the phosphorylation of AKT1 protein
CTD PMID:10679475 PMID:18084315 PMID:28759639 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression EXP Phenylephrine results in increased expression of ALDH18A1 mRNA CTD PMID:18158353 NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
JBrowse link
G Angpt1 angiopoietin 1 multiple interactions
increases expression
ISO ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine results in increased expression of ANGPT1 mRNA; Phenylephrine results in increased expression of ANGPT1 protein
CTD PMID:18502941 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Phenylephrine results in decreased expression of ANGPTL4 mRNA CTD PMID:18158353 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE protein affects the susceptibility to Phenylephrine CTD PMID:17899169 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Areg amphiregulin increases expression EXP Phenylephrine results in increased expression of AREG mRNA CTD PMID:18158353 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 decreases expression EXP Phenylephrine results in decreased expression of ARHGEF12 mRNA CTD PMID:18158353 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression EXP Phenylephrine results in decreased expression of ARRDC3 mRNA CTD PMID:18158353 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Asb18 ankyrin repeat and SOCS box-containing 18 decreases expression EXP Phenylephrine results in decreased expression of ASB18 mRNA CTD PMID:18158353 NCBI chr 9:90,531,350...90,595,953
Ensembl chr 9:90,531,596...90,595,848
JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 increases expression EXP Phenylephrine results in increased expression of ASB4 mRNA CTD PMID:18158353 NCBI chr 4:33,506,992...33,544,630
Ensembl chr 4:33,506,992...33,544,630
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Phenylephrine results in increased expression of ASNS mRNA CTD PMID:18158353 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP Phenylephrine results in increased expression of ATF5 mRNA CTD PMID:18158353 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Phenylephrine results in increased expression of ATP1B1 mRNA CTD PMID:11204457 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
decreases expression
affects response to substance
increases expression
decreases activity
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein
Phenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]
ATP2A2 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of ATP2A2 mRNA
Phenylephrine results in decreased activity of ATP2A2 protein
CTD PMID:11499749 PMID:11577024 PMID:15795322 PMID:16236312 PMID:17287366 More... NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 increases response to substance ISO ATP2B4 protein results in increased susceptibility to Phenylephrine CTD PMID:12933703 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) increases expression EXP Phenylephrine results in increased expression of ATP9A mRNA CTD PMID:18158353 NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818
JBrowse link
G Atxn1 ataxin 1 multiple interactions EXP Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]] CTD PMID:32278511 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Auts2 activator of transcription and developmental regulator AUTS2 decreases expression EXP Phenylephrine results in decreased expression of AUTS2 mRNA CTD PMID:18158353
G Avp arginine vasopressin multiple interactions
increases secretion
EXP Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dexamethasone inhibits the reaction [Phenylephrine results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:2271928 PMID:11102496 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpi1 arginine vasopressin-induced 1 increases expression EXP Phenylephrine results in increased expression of AVPI1 mRNA CTD PMID:18158353 NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Phenylephrine results in increased expression of BAD protein CTD PMID:31605733 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression EXP Phenylephrine results in increased expression of BAMBI mRNA CTD PMID:18158353 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Phenylephrine results in decreased expression of BAX protein
Phenylephrine results in increased expression of BAX protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]
CTD PMID:19910689 PMID:31605733 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions
increases phosphorylation
EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha decreases expression EXP Phenylephrine results in decreased expression of BCKDHA mRNA CTD PMID:18158353 NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
EXP
ISO
BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]
Phenylephrine results in decreased expression of BCL2 protein
Phenylephrine results in increased expression of BCL2 mRNA; Phenylephrine results in increased expression of BCL2 protein
CTD PMID:11042672 PMID:19910689 PMID:31605733 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
EXP
ISO
Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 protein]
Phenylephrine results in decreased expression of BCL2L1 protein
CTD PMID:11042672 PMID:31605733 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 increases expression EXP Phenylephrine results in increased expression of BDH1 mRNA CTD PMID:18158353 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 decreases expression EXP Phenylephrine results in decreased expression of BDH2 mRNA CTD PMID:18158353 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance
increases expression
ISO
EXP
BDKRB2 affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of BDKRB2 mRNA
CTD PMID:10614985 PMID:18158353 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Phenylephrine results in increased expression of BDNF mRNA CTD PMID:18158353 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bmp7 bone morphogenetic protein 7 decreases expression EXP Phenylephrine results in decreased expression of BMP7 mRNA CTD PMID:18158353 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Phenylephrine results in increased expression of BNIP3L mRNA CTD PMID:16291751 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Boll boule homolog, RNA binding protein decreases expression EXP Phenylephrine results in decreased expression of BOLL mRNA CTD PMID:18158353 NCBI chr 9:56,734,890...56,859,917
Ensembl chr 9:56,733,584...56,859,916
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions
increases expression
EXP Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]
Phenylephrine results in increased expression of BRD4 protein
CTD PMID:23939492 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Btbd11 BTB domain containing 11 decreases expression EXP Phenylephrine results in decreased expression of BTBD11 mRNA CTD PMID:18158353 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834
JBrowse link
G Btg3 BTG anti-proliferation factor 3 increases expression EXP Phenylephrine results in increased expression of BTG3 mRNA CTD PMID:18158353 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
JBrowse link
G Ca4 carbonic anhydrase 4 increases expression EXP Phenylephrine results in increased expression of CA4 protein CTD PMID:17124262 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions EXP CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein] CTD PMID:10655507 PMID:17060317 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357
JBrowse link
G Cadps calcium dependent secretion activator decreases expression EXP Phenylephrine results in decreased expression of CADPS mRNA CTD PMID:18158353 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
JBrowse link
G Calca calcitonin-related polypeptide alpha affects response to substance ISO
EXP
CALCA protein affects the susceptibility to Phenylephrine CTD PMID:11728430 PMID:18055875 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA CTD PMID:17250927 NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression EXP Phenylephrine results in decreased expression of CAMK2A mRNA CTD PMID:18158353 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta multiple interactions EXP CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylephrine results in decreased activity of CA1 protein CTD PMID:28800181 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity
EXP
ISO
Phenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 protein
Phenylephrine results in decreased activity of CA2 protein
CTD PMID:17124262 PMID:28800181 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp2 caspase 2 affects activity ISO Phenylephrine affects the activity of CASP2 protein CTD PMID:31605733 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
Phenylephrine inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Phenylephrine results in increased activity of CASP3 protein
CTD PMID:11042672 PMID:31605733 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 affects activity ISO Phenylephrine affects the activity of CASP8 protein CTD PMID:31605733 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Phenylephrine results in increased activity of CASP9 protein CTD PMID:31605733 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] CTD PMID:11071898 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cat catalase multiple interactions
decreases expression
EXP CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in decreased expression of CAT protein
CTD PMID:16513848 PMID:18171680 PMID:20886221 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Sodium, Dietary affects the reaction [CAV1 protein results in increased susceptibility to Phenylephrine] CTD PMID:18178722 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cav3 caveolin 3 multiple interactions
decreases response to substance
affects localization
ISO
EXP
CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CAV3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of CAV3 protein
CTD PMID:12847114 PMID:19299911 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
Phenylephrine results in increased expression of CCL2 mRNA; Phenylephrine results in increased expression of CCL2 protein
CTD PMID:15721863 PMID:15728586 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression EXP Phenylephrine results in increased expression of CCL27 mRNA CTD PMID:18158353 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; calphostin C inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]
Phenylephrine results in increased expression of CCN1 mRNA; Phenylephrine results in increased expression of CCN1 protein
CTD PMID:15117851 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Phenylephrine results in increased expression of CCN2 mRNA; Phenylephrine results in increased expression of CCN2 protein CTD PMID:15276029 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND1 protein] CTD PMID:12163013 PMID:15603588 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 increases expression EXP Phenylephrine results in increased expression of CCND2 protein CTD PMID:12163013 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein] CTD PMID:12163013 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccnt1 cyclin T1 multiple interactions EXP Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein] CTD PMID:17459355 NCBI chr 7:129,687,146...129,718,082
Ensembl chr 7:129,691,209...129,717,871
JBrowse link
G Cd200 Cd200 molecule decreases expression EXP Phenylephrine results in decreased expression of CD200 mRNA CTD PMID:18158353 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
JBrowse link
G Cdh2 cadherin 2 increases expression EXP Phenylephrine results in increased expression of CDH2 protein CTD PMID:17526999 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Phenylephrine results in increased expression of CDK2 protein CTD PMID:15603588 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Phenylephrine results in increased expression of CDK4 protein CTD PMID:15603588 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
increases stability
ISO
EXP
Phenylephrine results in increased expression of CDKN1A mRNA; Phenylephrine results in increased expression of CDKN1A protein
Phenylephrine results in increased stability of CDKN1A mRNA
CTD PMID:10766810 PMID:15603588 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Phenylephrine results in increased expression of CDKN1B CTD PMID:15603588 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP Phenylephrine results in decreased expression of CEBPA mRNA CTD PMID:19443575 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP [Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein; [Phenylephrine co-treated with 6-hydroxy-10-chlorobenzo(c)quinolizinium] results in increased activity of CFTR protein; Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein] CTD PMID:17596272 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP Phenylephrine results in increased expression of CHCHD6 mRNA CTD PMID:18158353 NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
JBrowse link
G Clic2 chloride intracellular channel 2 decreases expression EXP Phenylephrine results in decreased expression of CLIC2 mRNA CTD PMID:18158353 NCBI chr20:149,337...164,375
Ensembl chr20:148,907...164,355
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression EXP Phenylephrine results in increased expression of CLIC4 mRNA CTD PMID:18158353 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
JBrowse link
G Clu clusterin increases expression EXP Phenylephrine results in increased expression of CLU mRNA; Phenylephrine results in increased expression of CLU protein CTD PMID:19443575 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cnn1 calponin 1 increases expression EXP Phenylephrine results in increased expression of CNN1 mRNA CTD PMID:18158353 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression EXP Phenylephrine results in decreased expression of COL18A1 mRNA CTD PMID:18158353 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Colec12 collectin sub-family member 12 decreases expression EXP Phenylephrine results in decreased expression of COLEC12 mRNA CTD PMID:18158353 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
JBrowse link
G Corin corin, serine peptidase increases expression EXP Phenylephrine results in increased expression of CORIN mRNA CTD PMID:15191894 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of COX11 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]
CTD PMID:23818984 PMID:25107896 NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 multiple interactions
decreases expression
EXP Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein] CTD PMID:23818984 PMID:25107896 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of COX4I1 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]
CTD PMID:23818984 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
decreases expression
increases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]
Phenylephrine results in decreased expression of CPT1B mRNA; Phenylephrine results in decreased expression of CPT1B protein
Phenylephrine results in increased expression of CPT1B mRNA
CTD PMID:11879187 PMID:15721863 PMID:19699196 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] CTD PMID:14741741 PMID:15522277 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions
increases response to substance
EXP [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of CREBBP protein; Phenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein
CREBBP protein results in increased susceptibility to Phenylephrine
CTD PMID:11705990 PMID:12477714 PMID:15006641 PMID:15522277 PMID:19966502 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Phenylephrine results in increased expression of CREM mRNA CTD PMID:12791704 PMID:18158353 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Phenylephrine results in decreased expression of CSNK2A1 mRNA CTD PMID:18158353 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 increases expression EXP Phenylephrine results in increased expression of CSPG4 mRNA CTD PMID:18158353 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Phenylephrine results in increased expression of CSRP2 mRNA CTD PMID:18158353 NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases localization EXP Phenylephrine results in increased localization of CSRP3 protein CTD PMID:19376126 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
JBrowse link
G Cth cystathionine gamma-lyase increases activity EXP Phenylephrine results in increased activity of CTH protein CTD PMID:18184479 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter] CTD PMID:19799869 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsc cathepsin C decreases expression EXP Phenylephrine results in decreased expression of CTSC mRNA CTD PMID:18158353 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Phenylephrine results in decreased expression of CXCL1 mRNA CTD PMID:18158353 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Phenylephrine results in decreased expression of CXCL10 mRNA CTD PMID:18158353 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression EXP Phenylephrine results in decreased expression of CXCL11 mRNA CTD PMID:18158353 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression EXP Phenylephrine results in decreased expression of CXCL5 mRNA CTD PMID:18158353 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxxc4 CXXC finger protein 4 decreases expression EXP Phenylephrine results in decreased expression of CXXC4 mRNA CTD PMID:18158353 NCBI chr 2:222,664,148...222,689,365
Ensembl chr 2:222,664,771...222,689,365
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Phenylephrine results in increased expression of CYP11B2 mRNA CTD PMID:19966502 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 increases expression EXP Phenylephrine results in increased expression of CYP26B1 mRNA CTD PMID:18158353 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases response to substance
affects response to substance
EXP 20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]; DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine] CTD PMID:11124159 PMID:12388396 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Phenylephrine results in increased expression of CYP51 mRNA CTD PMID:18158353 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression EXP Phenylephrine results in decreased expression of DAPK1 mRNA CTD PMID:18158353 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Dgke diacylglycerol kinase epsilon multiple interactions ISO DGKE protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein] CTD PMID:18487437 NCBI chr10:73,852,679...73,877,334
Ensembl chr10:73,855,583...73,877,100
JBrowse link
G Dgkz diacylglycerol kinase zeta multiple interactions ISO DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16380548 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP Phenylephrine results in increased expression of DHCR7 mRNA CTD PMID:18158353 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
increases expression
EXP Phenylephrine results in increased activity of DIO2 protein
Phenylephrine results in increased expression of DIO2 mRNA
CTD PMID:15345674 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dnah12 dynein, axonemal, heavy chain 12 decreases expression EXP Phenylephrine results in decreased expression of DNAH12 mRNA CTD PMID:18158353 NCBI chr16:1,936,354...2,092,663
Ensembl chr16:1,937,817...2,092,664
JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 increases expression EXP Phenylephrine results in increased expression of DNAJB5 mRNA CTD PMID:18158353 NCBI chr 5:57,176,840...57,185,492
Ensembl chr 5:57,176,845...57,185,490
JBrowse link
G Dnm1l dynamin 1-like increases expression
multiple interactions
EXP Phenylephrine results in increased expression of DNM1L protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]
CTD PMID:20886221 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dpt dermatopontin decreases expression EXP Phenylephrine results in decreased expression of DPT mRNA CTD PMID:18158353 NCBI chr13:77,122,926...77,151,646
Ensembl chr13:77,123,115...77,151,639
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Phenylephrine results in increased expression of DUSP1 mRNA CTD PMID:18158353 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions EXP DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:15757502 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G E2f3 E2F transcription factor 3 increases expression EXP Phenylephrine results in increased expression of E2F3 protein CTD PMID:12682052 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G E2f4 E2F transcription factor 4 increases expression EXP Phenylephrine results in increased expression of E2F4 protein CTD PMID:12682052 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
JBrowse link
G E2f5 E2F transcription factor 5 increases expression EXP Phenylephrine results in increased expression of E2F5 protein CTD PMID:12682052 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP Phenylephrine results in increased expression of ECE1 mRNA CTD PMID:15007106 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Ecm1 extracellular matrix protein 1 increases expression EXP Phenylephrine results in increased expression of ECM1 mRNA CTD PMID:18158353 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
increases expression
affects response to substance
EXP MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
Phenylephrine results in increased expression of MBF1
MBF1 protein affects the susceptibility to Phenylephrine
CTD PMID:12729799 NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases response to substance
increases expression
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EDN1 mRNA; Phenylephrine results in increased expression of EDN1 protein
CTD PMID:10788492 PMID:11739382 PMID:12724418 PMID:15007106 PMID:15220332 More... NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Phenylephrine results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein CTD PMID:16760267 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO
EXP
Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]; Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein
Phenylephrine results in increased phosphorylation of EGFR protein
[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:14676212 PMID:16760267 PMID:18360054 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Phenylephrine results in increased expression of EGLN3 mRNA CTD PMID:18158353 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO
EXP
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]
Phenylephrine results in increased expression of EGR1; Phenylephrine results in increased expression of EGR1 mRNA
Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]
CTD PMID:7905536 PMID:10710348 PMID:10779383 PMID:15621046 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
increases phosphorylation
EXP CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein] CTD PMID:15757502 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
increases phosphorylation
EXP 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases expression
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]
Phenylephrine results in increased phosphorylation of ELK1 protein
CTD PMID:10900171 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression EXP Phenylephrine results in increased expression of ELOVL5 mRNA CTD PMID:18158353 NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G Eno2 enolase 2 increases expression EXP Phenylephrine results in increased expression of ENO2 mRNA CTD PMID:18158353 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Eno3 enolase 3 increases expression EXP Phenylephrine results in increased expression of ENO3 mRNA CTD PMID:18158353 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
increases expression
increases response to substance
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EP300 mRNA; Phenylephrine results in increased expression of EP300 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]
EP300 protein results in increased susceptibility to Phenylephrine
CTD PMID:11705990 PMID:12477714 PMID:12724418 PMID:15006641 PMID:15220332 More... NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression EXP Phenylephrine results in decreased expression of EPAS1 mRNA CTD PMID:18158353 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epb41l4b erythrocyte membrane protein band 4.1 like 4B increases expression EXP Phenylephrine results in increased expression of EPB41L4B mRNA CTD PMID:18158353 NCBI chr 5:71,691,706...71,852,039
Ensembl chr 5:71,694,331...71,851,990
JBrowse link
G Epha4 Eph receptor A4 decreases expression EXP Phenylephrine results in decreased expression of EPHA4 mRNA CTD PMID:18158353 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Phenylephrine results in decreased expression of EPHX2 mRNA CTD PMID:18158353 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine] CTD PMID:17158209 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 multiple interactions EXP EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:17327491 NCBI chr 3:154,335,558...154,519,006
Ensembl chr 3:154,335,400...154,518,793
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression EXP Phenylephrine results in decreased expression of FABP4 mRNA CTD PMID:18158353 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fads3 fatty acid desaturase 3 increases expression EXP Phenylephrine results in increased expression of FADS3 mRNA CTD PMID:18158353 NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769
JBrowse link
G Fam110b family with sequence similarity 110, member B decreases expression EXP Phenylephrine results in decreased expression of FAM110B mRNA CTD PMID:18158353 NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828
JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]; FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]; FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine] CTD PMID:17641673 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fdx1 ferredoxin 1 increases expression EXP Phenylephrine results in increased expression of FDX1 mRNA CTD PMID:18158353 NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
JBrowse link
G Fgf12 fibroblast growth factor 12 increases expression EXP Phenylephrine results in increased expression of FGF12 mRNA CTD PMID:18158353 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607
JBrowse link
G Fgf18 fibroblast growth factor 18 increases expression EXP Phenylephrine results in increased expression of FGF18 mRNA CTD PMID:18158353 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter] CTD PMID:10779383 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Phenylephrine results in increased expression of FHL1 mRNA CTD PMID:18158353 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Fhl2 four and a half LIM domains 2 decreases response to substance EXP FHL2 gene mutant form results in decreased susceptibility to Phenylephrine CTD PMID:25358972 NCBI chr 9:45,388,979...45,462,530
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression
multiple interactions
EXP Phenylephrine results in increased expression of FIS1 protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]
CTD PMID:20886221 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases expression
EXP FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of FLT1 protein
CTD PMID:19542178 PMID:24903162 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Phenylephrine results in increased expression of FN1 protein CTD PMID:11821714 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
affects response to substance
increases expression
ISO
EXP
[Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; U 0126 inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]
Phenylephrine affects the expression of FOS protein
FOS protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of FOS; Phenylephrine results in increased expression of FOS mRNA; Phenylephrine results in increased expression of FOS protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; Troglitazone inhibits the reaction [Phenylephrine results in increased expression of FOS protein]
CTD PMID:7844257 PMID:7900855 PMID:7905536 PMID:8750937 PMID:8809800 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases activity
increases expression
EXP Phenylephrine results in increased activity of FOSB protein
Phenylephrine results in increased expression of FOSB
CTD PMID:7905536 PMID:15949472 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Phenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 protein CTD PMID:16020479 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fstl3 follistatin like 3 affects expression EXP Phenylephrine affects the expression of FSTL3 mRNA CTD PMID:18158353 NCBI chr 7:9,924,670...9,929,195
Ensembl chr 7:9,923,576...9,939,639
JBrowse link
G Fxyd5 FXYD domain-containing ion transport regulator 5 increases expression EXP Phenylephrine results in increased expression of FXYD5 mRNA CTD PMID:18158353 NCBI chr 1:86,267,937...86,277,329
Ensembl chr 1:86,267,406...86,277,519
JBrowse link
G Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 decreases expression EXP Phenylephrine results in decreased expression of GALNT13 mRNA CTD PMID:18158353 NCBI chr 3:38,903,695...39,560,683
Ensembl chr 3:38,974,490...39,558,803
JBrowse link
G Gamt guanidinoacetate N-methyltransferase decreases expression EXP Phenylephrine results in decreased expression of GAMT mRNA CTD PMID:18158353 NCBI chr 7:9,448,590...9,451,778
Ensembl chr 7:9,448,628...9,451,778
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases activity
increases expression
increases acetylation
affects response to substance
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of GATA4 protein
Phenylephrine results in increased acetylation of GATA4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of GATA4 protein; Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]
GATA4 protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA
CTD PMID:10710348 PMID:10788492 PMID:11739382 PMID:12724418 PMID:15220332 More... NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gdf15 growth differentiation factor 15 affects expression ISO Phenylephrine affects the expression of GDF15 mRNA CTD PMID:19505289 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein] CTD PMID:12628311 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
affects response to substance
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]
Phenylephrine results in increased expression of GJA1 mRNA; Phenylephrine results in increased expression of GJA1 protein
GJA1 protein affects the susceptibility to Phenylephrine
CTD PMID:16352648 PMID:18445782 PMID:18593691 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression EXP Phenylephrine results in decreased expression of GJA5 mRNA CTD PMID:18158353 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gla galactosidase, alpha affects response to substance ISO GLA protein affects the susceptibility to Phenylephrine CTD PMID:18565198 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664
JBrowse link
G Glrx3 glutaredoxin 3 affects response to substance
increases expression
multiple interactions
EXP GLRX3 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of GLRX3 mRNA
GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]
CTD PMID:16809552 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Gmfg glia maturation factor, gamma increases expression EXP Phenylephrine results in increased expression of GMFG mRNA CTD PMID:18158353 NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]] CTD PMID:14676212 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gnas GNAS complex locus affects response to substance EXP GNAS protein affects the susceptibility to Phenylephrine CTD PMID:10696522 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions
increases secretion
decreases secretion
EXP alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein]; Testosterone affects the reaction [Phenylephrine affects the secretion of GNRH1 protein] CTD PMID:1975657 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gpm6a glycoprotein m6a decreases expression EXP Phenylephrine results in decreased expression of GPM6A mRNA CTD PMID:18158353 NCBI chr16:36,641,282...36,973,477
Ensembl chr16:36,641,284...36,973,475
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions
increases expression
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein
Phenylephrine results in increased expression of GRK2 protein
GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]
CTD PMID:11499749 PMID:28759639 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
EXP GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein] CTD PMID:15795328 PMID:28759639 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression EXP Phenylephrine results in decreased expression of GSTK1 mRNA CTD PMID:18158353 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Phenylephrine results in decreased expression of GSTM3 mRNA CTD PMID:18158353 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gys2 glycogen synthase 2 decreases activity EXP Phenylephrine results in decreased activity of GYS2 protein CTD PMID:747652 NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP Phenylephrine results in decreased expression of HAMP mRNA CTD PMID:18158353 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression EXP Phenylephrine results in increased expression of DTR mRNA CTD PMID:18158353 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO [Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein CTD PMID:19124542 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdgfl2 HDGF like 2 decreases expression EXP Phenylephrine results in decreased expression of HDGFL2 mRNA CTD PMID:18158353 NCBI chr 9:909,581...929,195
Ensembl chr 9:909,614...929,186
JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 increases expression EXP Phenylephrine results in increased expression of HERC3 mRNA CTD PMID:18158353 NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 multiple interactions EXP Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein] CTD PMID:17459355 NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions
decreases expression
decreases response to substance
ISO HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in decreased expression of HEY2 mRNA
HEY2 protein results in decreased susceptibility to Phenylephrine
CTD PMID:16603706 PMID:20001863 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Phenylephrine results in increased expression of HIGD1A mRNA CTD PMID:18158353 NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Phenylephrine results in increased expression of HMGCS1 mRNA CTD PMID:18158353 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Phenylephrine results in increased expression of HOMER1 mRNA alternative form CTD PMID:16786172 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hspb3 heat shock protein family B (small) member 3 increases expression EXP Phenylephrine results in increased expression of HSPB3 mRNA CTD PMID:18158353 NCBI chr 2:45,295,285...45,295,999
Ensembl chr 2:45,295,053...45,296,145
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression EXP Phenylephrine results in increased expression of ID1 mRNA CTD PMID:18158353 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id4 inhibitor of DNA binding 4, HLH protein increases expression EXP Phenylephrine results in increased expression of ID4 mRNA CTD PMID:18158353 NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Phenylephrine results in increased expression of IDI1 mRNA CTD PMID:18158353 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ier3 immediate early response 3 decreases response to substance
affects localization
ISO IER3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of IER3 protein
CTD PMID:11934837 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Igf1 insulin-like growth factor 1 affects response to substance EXP IGF1 protein affects the susceptibility to Phenylephrine CTD PMID:11159833 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 affects response to substance EXP IGFBP4 protein affects the susceptibility to Phenylephrine CTD PMID:11159833 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression EXP Phenylephrine results in decreased expression of IGFBP5 mRNA CTD PMID:18158353 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases activity
multiple interactions
EXP Phenylephrine results in increased activity of IKBKB protein
IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:11381115 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
affects response to substance
EXP Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]
IL1B protein results in decreased susceptibility to Phenylephrine
CTD PMID:11506125 PMID:13679239 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
EXP Phenylephrine results in increased expression of IL6 mRNA
[resveratrol co-treated with Phenylephrine] results in increased expression of IL6 mRNA
Phenylephrine results in decreased expression of IL6 mRNA
CTD PMID:11406463 PMID:12423672 PMID:22748497 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ilk integrin-linked kinase multiple interactions
affects localization
ISO
EXP
Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine affects the localization of ILK protein
ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:16170337 PMID:18502941 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Inha inhibin subunit alpha increases expression EXP Phenylephrine results in increased expression of INHA mRNA CTD PMID:18158353 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP Phenylephrine results in decreased expression of IRF7 mRNA CTD PMID:18158353 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression EXP Phenylephrine results in decreased expression of ISG15 mRNA CTD PMID:18158353 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Itga9 integrin subunit alpha 9 increases expression EXP Phenylephrine results in increased expression of ITGA9 mRNA CTD PMID:18158353 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein increases expression EXP Phenylephrine results in increased expression of ITGB3BP mRNA CTD PMID:18158353 NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704
JBrowse link
G Itgb8 integrin subunit beta 8 increases expression EXP Phenylephrine results in increased expression of ITGB8 mRNA CTD PMID:18158353 NCBI chr 6:140,124,997...140,208,254
Ensembl chr 6:140,127,203...140,208,476
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases activity
multiple interactions
ISO Phenylephrine results in increased activity of ITPR2 protein
[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA
CTD PMID:15201137 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
increases expression
increases activity
affects response to substance
ISO
EXP
[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]
Phenylephrine results in increased phosphorylation of JUN protein
Phenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN protein
Phenylephrine results in increased activity of JUN protein
JUN protein affects the susceptibility to Phenylephrine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
CTD PMID:7905536 PMID:10710348 PMID:11799083 PMID:12169099 PMID:12574153 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
increases activity
EXP Phenylephrine results in increased expression of JUNB
Phenylephrine results in increased activity of JUNB protein
CTD PMID:7905536 PMID:15949472 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of JUND mRNA
CTD PMID:16690042 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 multiple interactions
decreases expression
decreases response to substance
EXP CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of KCND2 mRNA; Phenylephrine results in decreased expression of KCND2 protein
KCND2 protein results in decreased susceptibility to Phenylephrine
CTD PMID:12403671 PMID:16385079 PMID:17060317 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 multiple interactions
decreases expression
ISO
EXP
[KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]
Phenylephrine results in decreased expression of KCND3 mRNA; Phenylephrine results in decreased expression of KCND3 protein
CTD PMID:11249870 PMID:11709419 PMID:16385079 PMID:17060317 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:19419905 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 multiple interactions
decreases expression
EXP MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]
Phenylephrine results in decreased expression of KCNIP2 mRNA; Phenylephrine results in decreased expression of KCNIP2 mRNA alternative form; Phenylephrine results in decreased expression of KCNIP2 protein
CTD PMID:16385079 PMID:17060317 PMID:18158353 NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP Phenylephrine results in increased expression of KDELR3 mRNA CTD PMID:18158353 NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600
JBrowse link
G Kdr kinase insert domain receptor decreases expression
multiple interactions
increases expression
EXP Phenylephrine results in decreased expression of KDR mRNA
Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]
CTD PMID:18158353 PMID:24903162 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif5b kinesin family member 5B decreases expression EXP Phenylephrine results in decreased expression of KIF5B mRNA CTD PMID:18158353 NCBI chr17:51,489,873...51,527,508
Ensembl chr17:51,489,944...51,527,508
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
decreases expression
EXP Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]
Phenylephrine results in decreased expression of KLF4 mRNA; Phenylephrine results in decreased expression of KLF4 protein
CTD PMID:19729022 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klhl24 kelch-like family member 24 decreases expression EXP Phenylephrine results in decreased expression of KLHL24 mRNA CTD PMID:18158353 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Kmt2e lysine methyltransferase 2E decreases expression EXP Phenylephrine results in decreased expression of KMT2E mRNA CTD PMID:18158353 NCBI chr 4:11,657,811...11,727,373
Ensembl chr 4:11,658,979...11,727,373
JBrowse link
G Lamc1 laminin subunit gamma 1 increases expression EXP Phenylephrine results in increased expression of LAMC1 mRNA CTD PMID:18158353 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Phenylephrine results in increased expression of LAMC2 mRNA CTD PMID:18158353 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Ldlr low density lipoprotein receptor increases expression EXP Phenylephrine results in increased expression of LDLR mRNA CTD PMID:18158353 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression EXP Phenylephrine results in decreased expression of LGALS3BP mRNA CTD PMID:18158353 NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256
JBrowse link
G Lims1 LIM zinc finger domain containing 1 affects localization EXP Phenylephrine affects the localization of LIMS1 protein CTD PMID:16170337 NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Phenylephrine results in increased expression of LMCD1 mRNA CTD PMID:18158353 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Lpl lipoprotein lipase affects response to substance ISO LPL protein affects the susceptibility to Phenylephrine CTD PMID:11786490 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrrc27 leucine rich repeat containing 27 decreases expression EXP Phenylephrine results in decreased expression of LRRC27 mRNA CTD PMID:18158353 NCBI chr 1:194,004,967...194,035,087
Ensembl chr 1:194,005,182...194,035,084
JBrowse link
G Lyl1 LYL1, basic helix-loop-helix family member increases expression EXP Phenylephrine results in increased expression of LYL1 mRNA CTD PMID:18158353 NCBI chr19:23,452,140...23,455,007
Ensembl chr19:23,452,140...23,455,007
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression EXP Phenylephrine results in increased expression of MAFK mRNA CTD PMID:18158353 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048
JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 decreases expression EXP Phenylephrine results in decreased expression of MAN1A mRNA CTD PMID:18158353 NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine CTD PMID:11834493 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO [MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine CTD PMID:11834493 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:10888249 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions EXP MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:10727428 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions
increases activity
EXP CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]; KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation
ISO
EXP
[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Phenylephrine results in increased expression of MAPK1 protein modified form
Phenylephrine results in increased activity of MAPK1 protein
Phenylephrine affects the phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
CTD PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine] CTD PMID:16949803 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation EXP Phenylephrine results in increased phosphorylation of MAPK14 protein CTD PMID:15757502 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation
ISO
EXP
[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of MAPK3 protein modified form
Phenylephrine results in increased activity of MAPK3 protein
Phenylephrine affects the phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions EXP Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein] CTD PMID:12574153 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
Phenylephrine results in increased phosphorylation of MAPK8 protein
CTD PMID:10727428 PMID:16385079 PMID:16517124 PMID:16809552 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 affects response to substance
multiple interactions
EXP MAPK8IP1 protein affects the susceptibility to Phenylephrine
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:11513749 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
affects response to substance
ISO
EXP
MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]
Phenylephrine results in increased phosphorylation of MAPK9 protein
CTD PMID:10727428 PMID:16949803 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Masp1 MBL associated serine protease 1 decreases expression EXP Phenylephrine results in decreased expression of MASP1 mRNA CTD PMID:18158353 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions
increases expression
increases activity
ISO
EXP
Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]
Phenylephrine results in increased expression of MEF2C mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]
CTD PMID:10737771 PMID:19124542 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mfap4 microfibril associated protein 4 decreases expression EXP Phenylephrine results in decreased expression of MFAP4 mRNA CTD PMID:18158353 NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155
JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 decreases expression EXP Phenylephrine results in decreased expression of MFHAS1 mRNA CTD PMID:18158353 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of MFN2 mRNA; Phenylephrine results in decreased expression of MFN2 protein
CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]
CTD PMID:17499311 PMID:20886221 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mgll monoglyceride lipase decreases expression EXP Phenylephrine results in decreased expression of MGLL mRNA CTD PMID:18158353 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mir21 microRNA 21 increases expression EXP Phenylephrine results in increased expression of MIR21 mRNA CTD PMID:17525252 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO Phenylephrine results in increased expression of MLKL protein CTD PMID:31605733 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor increases expression EXP Phenylephrine results in increased expression of MLLT11 mRNA CTD PMID:18158353 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO
EXP
MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
CTD PMID:16251426 PMID:16980344 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Phenylephrine results in increased expression of MMP9 mRNA CTD PMID:16574429 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mov10l1 Mov10 like RISC complex RNA helicase 1 multiple interactions ISO
EXP
MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
CTD PMID:11854500 PMID:12754203 NCBI chr 7:120,070,171...120,135,406
Ensembl chr 7:120,070,135...120,134,765
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP Phenylephrine results in increased expression of MSMO1 mRNA CTD PMID:18158353 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Msn moesin increases expression EXP Phenylephrine results in increased expression of MSN mRNA CTD PMID:18158353 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression EXP Phenylephrine results in increased expression of MTHFD1L mRNA CTD PMID:18158353 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein] CTD PMID:12935885 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mustn1 musculoskeletal, embryonic nuclear protein 1 increases expression EXP Phenylephrine results in increased expression of MUSTN1 mRNA CTD PMID:18158353 NCBI chr16:6,072,908...6,075,158
Ensembl chr16:6,072,833...6,075,161
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression EXP Phenylephrine results in increased expression of MYBL1 mRNA CTD PMID:18158353 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Mybpc3 myosin binding protein C3 multiple interactions ISO MYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
MYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
CTD PMID:22076249 NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
JBrowse link
G Myh14 myosin heavy chain 14 decreases expression EXP Phenylephrine results in decreased expression of MYH14 mRNA CTD PMID:18158353 NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
decreases expression
EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]; THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024 PMID:15578571 PMID:15795322 PMID:17592507 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
increases expression
ISO
EXP
CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]
Phenylephrine results in increased expression of MYH7 mRNA
Phenylephrine results in increased expression of MYH7 mRNA; Phenylephrine results in increased expression of MYH7 protein
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; spiruchostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
[Phenylephrine co-treated with Isoproterenol] results in increased expression of MYH7 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
CTD PMID:10642269 PMID:10710348 PMID:11249870 PMID:11513749 PMID:11577024 More... NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Phenylephrine results in increased expression of MYL1 mRNA CTD PMID:18158353 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
JBrowse link
G Myl2 myosin light chain 2 multiple interactions
increases phosphorylation
increases expression
EXP ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]
Phenylephrine results in increased phosphorylation of MYL2 protein
CTD PMID:11470465 PMID:11513749 PMID:14676212 PMID:15007106 PMID:18202317 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
JBrowse link
G Myl7 myosin light chain 7 multiple interactions
increases phosphorylation
ISO ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein] CTD PMID:15621049 NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244
JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation EXP Phenylephrine results in increased phosphorylation of MYL9 protein CTD PMID:18835913 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Mylk3 myosin light chain kinase 3 increases phosphorylation ISO Phenylephrine results in increased phosphorylation of MYLK3 protein CTD PMID:18202317 NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954
JBrowse link
G Myocd myocardin multiple interactions
increases expression
EXP MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]
Phenylephrine results in increased expression of MYOCD mRNA; Phenylephrine results in increased expression of MYOCD protein
CTD PMID:14676212 PMID:16556869 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Myoz2 myozenin 2 multiple interactions
decreases response to substance
ISO MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
MYOZ2 protein results in decreased susceptibility to Phenylephrine
CTD PMID:18025526 NCBI chr 2:211,141,463...211,168,202
Ensembl chr 2:211,141,463...211,168,221
JBrowse link
G Nab1 Ngfi-A binding protein 1 multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNA CTD PMID:10710348 NCBI chr 9:49,053,579...49,093,078
Ensembl chr 9:49,053,758...49,092,098
JBrowse link
G Nab2 Ngfi-A binding protein 2 multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA] CTD PMID:10710348 NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
JBrowse link
G Ncald neurocalcin delta increases expression EXP Phenylephrine results in increased expression of NCALD mRNA CTD PMID:18158353 NCBI chr 7:68,532,671...68,964,740
Ensembl chr 7:68,534,421...68,964,496
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases phosphorylation
increases expression
EXP
ISO
Phenylephrine results in increased phosphorylation of NCF1 protein
Phenylephrine results in increased expression of NCF1 mRNA
CTD PMID:14656924 PMID:15936005 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions EXP Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein CTD PMID:12403671 PMID:19349967 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 increases localization
multiple interactions
ISO Phenylephrine results in increased localization of NFATC3 protein
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]
CTD PMID:15939815 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions
increases localization
affects localization
ISO
EXP
Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
Phenylephrine affects the localization of NFATC4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
CTD PMID:11044444 PMID:16055480 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions ISO U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA] CTD PMID:12729908 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
decreases expression
EXP 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in decreased expression of NFKBIA protein]; KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11381115 PMID:15629441 PMID:16421291 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nid2 nidogen 2 increases expression EXP Phenylephrine results in increased expression of NID2 mRNA CTD PMID:18158353 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
JBrowse link
G Nkx2-5 NK2 homeobox 5 multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA CTD PMID:10710348 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Nodal nodal growth differentiation factor affects expression EXP Phenylephrine affects the expression of NODAL mRNA; Phenylephrine affects the expression of NODAL protein CTD PMID:11029149 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837
JBrowse link
G Nol3 nucleolar protein 3 decreases phosphorylation EXP Phenylephrine results in decreased phosphorylation of NOL3 protein CTD PMID:18171680 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases activity
decreases response to substance
affects response to substance
ISO
EXP
NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Calcimycin]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Nitroprusside]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]
Phenylephrine results in increased activity of NOS2 protein
NOS2 protein results in decreased susceptibility to Phenylephrine
NOS2 protein affects the susceptibility to Phenylephrine
CTD PMID:11498454 PMID:15753950 PMID:15902277 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 affects response to substance
decreases response to substance
multiple interactions
increases expression
ISO
EXP
NOS3 protein affects the susceptibility to Phenylephrine
NOS3 protein results in decreased susceptibility to Phenylephrine
NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]
Phenylephrine results in increased expression of NOS3 mRNA; Phenylephrine results in increased expression of NOS3 protein
CTD PMID:10954898 PMID:11504159 PMID:15381055 PMID:15753950 PMID:17403420 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A increases secretion
increases expression
multiple interactions
decreases response to substance
ISO
EXP
Phenylephrine results in increased secretion of NPPA protein
Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 8-(4-sulfophenyl)theophylline inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; kenpaullone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; U 0126 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
NPPA protein results in decreased susceptibility to Phenylephrine
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:2847676 PMID:8188982 PMID:10642269 PMID:10655507 PMID:10679475 More... NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
increases secretion
ISO
EXP
ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in increased expression of NPPB mRNA; Phenylephrine results in increased expression of NPPB protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
CTD PMID:10642269 PMID:11754973 PMID:11799083 PMID:11804996 PMID:11854500 More... NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nppc natriuretic peptide C affects response to substance
multiple interactions
EXP NPPC protein affects the susceptibility to Phenylephrine
SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]
CTD PMID:17026587 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Npr1 natriuretic peptide receptor 1 multiple interactions ISO [NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein] CTD PMID:15939815 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
JBrowse link
G Npy neuropeptide Y multiple interactions ISO [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]] CTD PMID:10660688 PMID:11499749 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Npy5r neuropeptide Y receptor Y5 multiple interactions ISO NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]] CTD PMID:10660688 NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance ISO NR1I2 protein affects the susceptibility to Phenylephrine CTD PMID:17159084 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Phenylephrine results in increased expression of NR3C1 mRNA CTD PMID:16533503 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
increases expression
EXP Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of NR3C2 protein; Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
Phenylephrine results in increased expression of NR3C2 mRNA
CTD PMID:16533503 PMID:19966502 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Phenylephrine results in increased expression of NR4A3 mRNA CTD PMID:18158353 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP Phenylephrine results in decreased expression of NREP mRNA CTD PMID:18158353 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Nrg1 neuregulin 1 decreases expression EXP Phenylephrine results in decreased expression of NRG1 mRNA; Phenylephrine results in decreased expression of NRG1 protein CTD PMID:16698793 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nts neurotensin decreases response to substance EXP NTS protein results in decreased susceptibility to Phenylephrine CTD PMID:2326505 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Nup62 nucleoporin 62 multiple interactions
decreases expression
EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; trichostatin A inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein] CTD PMID:25341891 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
JBrowse link
G Ogn osteoglycin decreases expression EXP Phenylephrine results in decreased expression of OGN mRNA CTD PMID:18158353 NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions
increases secretion
EXP Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein] CTD PMID:11102496 PMID:15149956 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G P2rx5 purinergic receptor P2X 5 increases expression EXP Phenylephrine results in increased expression of P2RX5 mRNA CTD PMID:18158353 NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 increases expression EXP Phenylephrine results in increased expression of P4HA1 mRNA CTD PMID:18158353 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
JBrowse link
G Pacc1 proton activated chloride channel 1 decreases expression EXP Phenylephrine results in decreased expression of PACC1 mRNA CTD PMID:18158353 NCBI chr13:102,904,668...102,929,770
Ensembl chr13:102,894,612...102,929,770
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions EXP Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]; Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]; Phenylephrine inhibits the reaction [Iodine-131 results in decreased expression of PAFAH1B1 protein] CTD PMID:32278511 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein] CTD PMID:11042672 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parva parvin, alpha affects localization EXP Phenylephrine affects the localization of PARVA protein CTD PMID:16170337 NCBI chr 1:166,547,202...166,704,958
Ensembl chr 1:166,547,132...166,704,950
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
EXP Phenylephrine results in increased expression of PCNA protein
Phenylephrine promotes the reaction [Iodine-131 results in increased expression of PCNA protein]
CTD PMID:15603588 PMID:32278511 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression EXP Phenylephrine results in decreased expression of PCP4 mRNA CTD PMID:18158353 NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 increases expression EXP Phenylephrine results in increased expression of PCSK6 mRNA CTD PMID:18158353 NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
JBrowse link
G Pde1a phosphodiesterase 1A multiple interactions EXP PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein] CTD PMID:19797176 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
JBrowse link
G Pde4b phosphodiesterase 4B increases expression EXP Phenylephrine results in increased expression of PDE4B mRNA CTD PMID:18158353 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:18790048 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP Phenylephrine results in decreased expression of PDK2 mRNA CTD PMID:18158353 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions
decreases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15721863 PMID:15728586 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pdlim3 PDZ and LIM domain 3 increases expression EXP Phenylephrine results in increased expression of PDLIM3 mRNA CTD PMID:18158353 NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression EXP Phenylephrine results in increased expression of PEA15 mRNA CTD PMID:18158353 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
JBrowse link
G Per1 period circadian regulator 1 multiple interactions ISO U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA] CTD PMID:12729908 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per2 period circadian regulator 2 multiple interactions ISO U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA] CTD PMID:12729908 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha decreases expression EXP Phenylephrine results in decreased expression of PEX11A mRNA CTD PMID:18158353 NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
JBrowse link
G Pfkl phosphofructokinase, liver type increases expression EXP Phenylephrine results in increased expression of PFKL mRNA CTD PMID:18158353 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Phenylephrine results in increased expression of PHGDH mRNA CTD PMID:18158353 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression EXP Phenylephrine results in increased expression of PHLDA1 mRNA CTD PMID:18158353 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting affects response to substance ISO PKD1 protein affects the susceptibility to Phenylephrine CTD PMID:18679710 NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions
decreases activity
EXP Calcium inhibits the reaction [Phenylephrine results in decreased activity of PKLR protein] CTD PMID:747652 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pkp4 plakophilin 4 decreases expression EXP Phenylephrine results in decreased expression of PKP4 mRNA CTD PMID:18158353 NCBI chr 3:43,632,364...43,835,834
Ensembl chr 3:43,631,880...43,835,474
JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression EXP Phenylephrine results in decreased expression of PLA2G2A mRNA CTD PMID:18158353 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pla2g6 phospholipase A2 group VI affects response to substance EXP PLA2G6 protein affects the susceptibility to Phenylephrine CTD PMID:17885217 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Plaat1 phospholipase A and acyltransferase 1 increases expression EXP Phenylephrine results in increased expression of PLAAT1 mRNA CTD PMID:18158353 NCBI chr11:71,517,492...71,537,142
Ensembl chr11:71,517,493...71,527,020
JBrowse link
G Plcb1 phospholipase C beta 1 increases expression EXP Phenylephrine results in increased expression of PLCB1 mRNA CTD PMID:16714034 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcb3 phospholipase C beta 3 increases expression EXP Phenylephrine results in increased expression of PLCB3 mRNA CTD PMID:16714034 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228
JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression EXP Phenylephrine results in increased expression of PLCD1 mRNA CTD PMID:16714034 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression EXP Phenylephrine results in increased expression of PLCG1 mRNA CTD PMID:16714034 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases response to substance
increases secretion
EXP
ISO
Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]
POMC protein results in increased susceptibility to Phenylephrine
CTD PMID:2822310 PMID:3015460 PMID:10898105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein]
Phenylephrine results in decreased expression of PPARA mRNA; Phenylephrine results in decreased expression of PPARA protein
CTD PMID:18701451 PMID:19699196 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:15721863 PMID:18701451 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions
increases phosphorylation
EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein] CTD PMID:24449418 PMID:25449040 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions
increases phosphorylation
EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein] CTD PMID:24449418 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta increases expression
increases activity
multiple interactions
ISO
EXP
Phenylephrine results in increased expression of PPP3CB mRNA
Phenylephrine results in increased expression of PPP3CB mRNA; Phenylephrine results in increased expression of PPP3CB protein
Phenylephrine results in increased activity of PPP3CB protein
CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]
CTD PMID:10655507 PMID:16024800 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases expression
increases activity
increases localization
ISO
EXP
DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]
Phenylephrine results in increased expression of PRKCA protein modified form
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein
Phenylephrine results in increased activity of PRKCA protein
CTD PMID:12435817 PMID:16809552 PMID:18487437 PMID:21565836 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases expression
EXP Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein] CTD PMID:17121852 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta increases expression
affects localization
EXP Phenylephrine results in increased expression of PRKCD protein
Phenylephrine affects the localization of PRKCD protein
CTD PMID:12720544 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
increases expression
affects localization
increases localization
ISO
EXP
DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]
Phenylephrine results in increased expression of PRKCE protein
Phenylephrine affects the localization of PRKCE protein
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein
CTD PMID:12003851 PMID:12700091 PMID:12720544 PMID:16809552 PMID:18487437 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcz protein kinase C, zeta affects localization
increases phosphorylation
decreases activity
multiple interactions
EXP Phenylephrine affects the localization of PRKCZ protein
Phenylephrine results in increased phosphorylation of PRKCZ protein
Phenylephrine results in decreased activity of PRKCZ protein
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]
CTD PMID:14736339 PMID:16809552 PMID:27094369 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Prkd1 protein kinase D1 affects localization
multiple interactions
increases activity
ISO Phenylephrine affects the localization of PRKD1 protein
[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein
CTD PMID:19124542 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases expression
increases activity
decreases activity
EXP [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]; PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]; VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of PRKG1 protein
CTD PMID:11799084 PMID:16378109 PMID:19542178 PMID:19797176 PMID:26168186 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Procr protein C receptor increases expression EXP Phenylephrine results in increased expression of PROCR mRNA CTD PMID:18158353 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link
G Psph phosphoserine phosphatase increases expression EXP Phenylephrine results in increased expression of PSPH mRNA CTD PMID:18158353 NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074
JBrowse link
G Ptgis prostaglandin I2 synthase increases expression EXP Phenylephrine results in increased expression of PTGIS mRNA CTD PMID:18158353 NCBI chr 3:155,928,564...155,964,228 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
affects response to substance
ISO FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine] CTD PMID:17641673 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein] CTD PMID:17244722 PMID:18701451 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression
multiple interactions
EXP Phenylephrine results in increased expression of PTHLH mRNA; Phenylephrine results in increased expression of PTHLH protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
CTD PMID:19910689 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression EXP Phenylephrine results in decreased expression of PTPRF mRNA CTD PMID:18158353 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression EXP Phenylephrine results in decreased expression of PTPRK mRNA CTD PMID:18158353 NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:16,850,576...17,103,605
JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Phenylephrine results in increased expression of PVR mRNA CTD PMID:18158353 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
JBrowse link
G Pycard PYD and CARD domain containing decreases expression EXP Phenylephrine results in decreased expression of PYCARD mRNA CTD PMID:18158353 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Pygl glycogen phosphorylase L multiple interactions
increases expression
EXP [Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein; Glucose inhibits the reaction [[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein]
Phenylephrine results in increased expression of PYGL mRNA
CTD PMID:747652 PMID:18158353 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Rab3b RAB3B, member RAS oncogene family decreases expression EXP Phenylephrine results in decreased expression of RAB3B mRNA CTD PMID:18158353 NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity EXP Phenylephrine results in increased activity of RAC1 protein CTD PMID:11158304 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
increases phosphorylation
EXP Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of RAF1 protein] CTD PMID:15258898 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rai14 retinoic acid induced 14 increases expression EXP Phenylephrine results in increased expression of RAI14 mRNA CTD PMID:18158353 NCBI chr 2:59,546,284...59,682,687
Ensembl chr 2:59,546,284...59,681,971
JBrowse link
G Ramp1 receptor activity modifying protein 1 affects expression EXP Phenylephrine affects the expression of RAMP1 mRNA CTD PMID:17250927 NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions
increases expression
decreases expression
EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of RAMP2 mRNA
Phenylephrine results in increased expression of RAMP2 mRNA
Phenylephrine results in decreased expression of RAMP2 mRNA
CTD PMID:12899678 PMID:17250927 NCBI chr10:86,187,366...86,190,692 JBrowse link
G Ramp3 receptor activity modifying protein 3 increases expression EXP Phenylephrine results in increased expression of RAMP3 mRNA CTD PMID:18158353 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902
JBrowse link
G Ranbp1 RAN binding protein 1 multiple interactions EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; Phenylephrine affects the localization of and affects the expression of RANBP1 protein; trichostatin A inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein] CTD PMID:25341891 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Phenylephrine results in increased expression of RAPGEF4 mRNA CTD PMID:18158353 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rapsn receptor-associated protein of the synapse decreases expression EXP Phenylephrine results in decreased expression of RAPSN mRNA CTD PMID:18158353 NCBI chr 3:77,014,699...77,024,373
Ensembl chr 3:76,983,471...77,024,373
JBrowse link
G Rasd2 RASD family, member 2 decreases expression EXP Phenylephrine results in decreased expression of RASD2 mRNA CTD PMID:18158353 NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016
JBrowse link
G Rassf1 Ras association domain family member 1 decreases response to substance ISO
EXP
RASSF1 protein results in decreased susceptibility to Phenylephrine CTD PMID:19652091 NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
affects phosphorylation
EXP Phenylephrine results in increased expression of RB1 protein
Phenylephrine affects the phosphorylation of RB1 protein
CTD PMID:15603588 PMID:18084315 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 multiple interactions
affects response to substance
EXP Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; Phenylephrine results in increased phosphorylation of and results in increased expression of RBCK1 protein; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]
RBCK1 protein affects the susceptibility to Phenylephrine
CTD PMID:17121852 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression
multiple interactions
ISO
EXP
Phenylephrine results in increased expression of RCAN1 protein
Phenylephrine results in increased expression of RCAN1 mRNA
MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
CTD PMID:18025526 PMID:25358972 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
affects localization
EXP [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]
Phenylephrine affects the localization of RELA protein
CTD PMID:11381115 PMID:18701451 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin decreases activity
affects response to substance
ISO Phenylephrine results in decreased activity of REN protein
REN1 protein affects the susceptibility to Phenylephrine
CTD PMID:2847676 PMID:17679040 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit decreases expression EXP Phenylephrine results in decreased expression of REV3L mRNA CTD PMID:18158353 NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
increases expression
affects response to substance
EXP
ISO
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
RGS2 protein affects the susceptibility to Phenylephrine
CTD PMID:15452191 PMID:16517124 PMID:17644703 PMID:18158353 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases activity
EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; monomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein] CTD PMID:10843871 PMID:15081308 PMID:21708234 PMID:24449418 PMID:25449040 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO Phenylephrine results in increased expression of RIPK1 protein CTD PMID:31605733 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO Phenylephrine results in increased expression of RIPK3 protein CTD PMID:31605733 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Phenylephrine results in increased expression of RND1 mRNA CTD PMID:18158353 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Rnf39 ring finger protein 39 increases expression EXP Phenylephrine results in increased expression of RNF39 mRNA CTD PMID:18158353 NCBI chr20:1,604,794...1,610,283
Ensembl chr20:1,604,794...1,610,283
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression EXP Phenylephrine results in increased expression of ROCK2 mRNA CTD PMID:18158353 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein] CTD PMID:15522277 PMID:19002563 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
EXP 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] CTD PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 PMID:15795328 More... NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein] CTD PMID:12720544 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator decreases expression EXP Phenylephrine results in decreased expression of RRAD protein CTD PMID:18056528 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression EXP Phenylephrine results in decreased expression of RUNX1T1 mRNA CTD PMID:18158353 NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592
JBrowse link
G S100a6 S100 calcium binding protein A6 multiple interactions EXP S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA] CTD PMID:15652358 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G S100b S100 calcium binding protein B increases expression
multiple interactions
EXP Phenylephrine results in increased expression of S100B mRNA
S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
CTD PMID:15652358 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Phenylephrine results in increased expression of SC5D mRNA CTD PMID:18158353 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression EXP Phenylephrine results in increased expression of SCD2 mRNA CTD PMID:18158353 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression EXP Phenylephrine results in decreased expression of SELENBP1 mRNA CTD PMID:18158353
G Sema6d semaphorin 6D decreases expression EXP Phenylephrine results in decreased expression of SEMA6D mRNA CTD PMID:18158353 NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:111,883,872...111,941,094
JBrowse link
G Septin5 septin 5 increases expression EXP Phenylephrine results in increased expression of SEPTIN5 mRNA CTD PMID:18158353 NCBI chr11:82,373,601...82,379,393
Ensembl chr11:82,369,754...82,379,393
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO
EXP
Phenylephrine results in increased expression of SERPINE1 mRNA CTD PMID:15808835 PMID:15850565 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases phosphorylation
multiple interactions
EXP Phenylephrine results in increased phosphorylation of SGK1 protein
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]
CTD PMID:15795328 PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sik1 salt-inducible kinase 1 increases expression EXP Phenylephrine results in increased expression of SIK1 mRNA CTD PMID:18158353 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
JBrowse link
G Sirt6 sirtuin 6 multiple interactions EXP [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine results in decreased expression of and results in decreased activity of SIRT6 protein; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:27094368 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of SLC12A2 protein]; Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium] CTD PMID:14630635 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP Phenylephrine results in decreased expression of SLC16A10 mRNA CTD PMID:18158353 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression EXP Phenylephrine results in increased expression of SLC16A3 mRNA CTD PMID:18158353 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562
JBrowse link
G Slc16a7 solute carrier family 16 member 7 decreases expression EXP Phenylephrine results in decreased expression of SLC16A7 mRNA CTD PMID:18158353 NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994
JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression EXP Phenylephrine results in increased expression of SLC1A3 mRNA CTD PMID:18158353 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions EXP [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc26a6 solute carrier family 26 member 6 decreases activity
increases expression
EXP Phenylephrine results in decreased activity of SLC26A6 protein
Phenylephrine results in increased expression of SLC26A6 protein
CTD PMID:17124262 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases expression EXP Phenylephrine results in increased expression of SLC29A1 mRNA CTD PMID:19966059 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Phenylephrine results in increased expression of SLC2A1 mRNA CTD PMID:15808844 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression EXP Phenylephrine results in decreased expression of SLC4A1AP mRNA CTD PMID:18158353 NCBI chr 6:24,905,941...24,933,651
Ensembl chr 6:24,905,941...24,933,815
JBrowse link
G Slc4a3 solute carrier family 4 member 3 increases activity EXP Phenylephrine results in increased activity of SLC4A3 protein CTD PMID:17124262 NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:77,037,016...77,049,105
JBrowse link
G Slc7a1 solute carrier family 7 member 1 increases expression EXP Phenylephrine results in increased expression of SLC7A1 mRNA CTD PMID:18158353 NCBI chr12:6,628,214...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions
increases expression
decreases expression
ISO
EXP
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]
Phenylephrine results in increased expression of SLC8A1 mRNA
Phenylephrine results in decreased expression of SLC8A1 protein
CTD PMID:11179087 PMID:15621046 PMID:19244478 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions
increases expression
increases activity
EXP 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of SLC9A1 mRNA; Phenylephrine results in increased expression of SLC9A1 protein
CTD PMID:15452191 PMID:16236312 PMID:16513848 PMID:16517124 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein CTD PMID:19443575 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 decreases expression EXP Phenylephrine results in decreased expression of SMOC2 mRNA CTD PMID:18158353 NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
JBrowse link
G Smr3b submaxillary gland androgen regulated protein 3B multiple interactions EXP SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine] CTD PMID:17026587 NCBI chr14:19,783,815...19,788,557
Ensembl chr14:19,783,816...19,788,492
JBrowse link
G Sord sorbitol dehydrogenase decreases expression EXP Phenylephrine results in decreased expression of SORD mRNA CTD PMID:18158353 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions EXP Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]] CTD PMID:32278511 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sox6 SRY-box transcription factor 6 decreases expression EXP Phenylephrine results in decreased expression of SOX6 mRNA CTD PMID:18158353 NCBI chr 1:169,723,306...170,334,846
Ensembl chr 1:169,729,194...170,277,386
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] CTD PMID:10710348 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Phenylephrine results in increased expression of SPP1 protein CTD PMID:10406839 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 increases expression EXP Phenylephrine results in increased expression of SPRY1 mRNA CTD PMID:18158353 NCBI chr 2:120,557,276...120,561,918
Ensembl chr 2:120,556,706...120,566,189
JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 decreases expression EXP Phenylephrine results in decreased expression of SPTA1 mRNA CTD PMID:18158353 NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371
JBrowse link
G Sqle squalene epoxidase increases expression EXP Phenylephrine results in increased expression of SQLE mRNA CTD PMID:18158353 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP Phenylephrine results in decreased expression of SQSTM1 mRNA CTD PMID:18158353 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ST3GAL2 mRNA CTD PMID:18158353 NCBI chr19:38,888,851...38,939,874
Ensembl chr19:38,923,999...38,939,869
JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 increases expression EXP Phenylephrine results in increased expression of ST3GAL4 mRNA CTD PMID:18158353 NCBI chr 8:33,415,666...33,465,365
Ensembl chr 8:33,415,671...33,524,389
JBrowse link
G St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 increases expression EXP Phenylephrine results in increased expression of ST8SIA5 mRNA CTD PMID:18158353 NCBI chr18:70,736,632...70,802,537
Ensembl chr18:70,736,602...70,797,789
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression EXP Phenylephrine results in decreased expression of STAT1 mRNA CTD PMID:18158353 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization
increases expression
multiple interactions
EXP Phenylephrine affects the localization of STAT3 protein
Phenylephrine results in increased expression of STAT3
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein; Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]
CTD PMID:19299911 PMID:27094369 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stc1 stanniocalcin 1 affects expression EXP Phenylephrine affects the expression of STC1 mRNA CTD PMID:18158353 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP Phenylephrine results in decreased expression of STMN1 mRNA CTD PMID:18158353 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Stx11 syntaxin 11 affects expression EXP Phenylephrine affects the expression of STX11 mRNA CTD PMID:18158353 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases secretion
affects response to substance
EXP alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein]
TAC1 protein affects the susceptibility to Phenylephrine
CTD PMID:11270094 PMID:17240043 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 increases response to substance EXP TACR1 protein results in increased susceptibility to Phenylephrine CTD PMID:16982039 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 increases expression EXP Phenylephrine results in increased expression of TAF1 mRNA CTD PMID:15808844 NCBI chr  X:66,640,915...66,716,543
Ensembl chr  X:66,640,982...66,716,543
JBrowse link
G Tcte1 t-complex-associated testis expressed 1 decreases expression EXP Phenylephrine results in decreased expression of TCTE1 mRNA CTD PMID:18158353 NCBI chr 9:15,463,573...15,482,258
Ensembl chr 9:15,463,739...15,472,954
JBrowse link
G Tfdp1 transcription factor Dp-1 increases expression EXP Phenylephrine results in increased expression of TFDP1 protein CTD PMID:12682052 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO
EXP
Phenylephrine results in increased expression of TGFB1 mRNA
Phenylephrine results in increased expression of TGFB1 mRNA; Phenylephrine results in increased expression of TGFB1 protein
CTD PMID:10406839 PMID:11821714 PMID:19443575 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression
multiple interactions
EXP Phenylephrine results in increased expression of TGFB1I1 protein
[Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
CTD PMID:19540241 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Phenylephrine results in increased expression of TGFB2 mRNA CTD PMID:19443575 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression EXP Phenylephrine results in increased expression of TGFB3 mRNA CTD PMID:18158353 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP Phenylephrine results in increased expression of TGFBR1 mRNA CTD PMID:19443575 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP Phenylephrine results in increased expression of TGFBR2 mRNA CTD PMID:19443575 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
decreases activity
increases expression
EXP ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; Ethanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]
Phenylephrine results in increased expression of TGM2 mRNA
CTD PMID:10801782 PMID:18158353 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
increases expression
EXP THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]
Phenylephrine results in increased expression of THRA protein
CTD PMID:11577024 PMID:17389455 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression
increases expression
multiple interactions
EXP Phenylephrine results in decreased expression of THRB mRNA; Phenylephrine results in decreased expression of THRB protein
Phenylephrine results in increased expression of THRB protein
THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]
CTD PMID:11577024 PMID:17389455 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
EXP BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
Phenylephrine results in increased expression of TIMP1 mRNA; Phenylephrine results in increased expression of TIMP1 protein
CTD PMID:18158353 PMID:19910689 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmem140 transmembrane protein 140 decreases expression EXP Phenylephrine results in decreased expression of TMEM140 mRNA CTD PMID:18158353 NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455
JBrowse link
G Tmem176b transmembrane protein 176B decreases expression EXP Phenylephrine results in decreased expression of TMEM176B mRNA CTD PMID:18158353 NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384
JBrowse link
G Tmem43 transmembrane protein 43 increases expression EXP Phenylephrine results in increased expression of TMEM43 mRNA CTD PMID:18158353 NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:123,977,625...123,992,825
JBrowse link
G Tmsb15b2 thymosin beta 15B2 increases expression EXP Phenylephrine results in increased expression of TMSB15B2 mRNA CTD PMID:18158353 NCBI chr  X:100,298,705...100,300,820
Ensembl chr  X:100,298,514...100,300,886
JBrowse link
G Tnf tumor necrosis factor decreases secretion
decreases response to substance
increases expression
multiple interactions
EXP Phenylephrine results in decreased secretion of TNF protein
TNF protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in increased expression of TNF mRNA; Phenylephrine results in increased expression of TNF protein
Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]
CTD PMID:12423672 PMID:13679239 PMID:16020479 PMID:17872965 PMID:18701451 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Phenylephrine results in increased expression of TNFAIP3 protein CTD PMID:12900338 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Phenylephrine results in increased expression of TNFRSF12A mRNA CTD PMID:18158353 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression
multiple interactions
ISO Phenylephrine results in increased expression of TNFSF11 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]
CTD PMID:17306214 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tox thymocyte selection-associated high mobility group box decreases expression EXP Phenylephrine results in decreased expression of TOX mRNA CTD PMID:18158353 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
G Tpm2 tropomyosin 2 increases expression EXP Phenylephrine results in increased expression of TPM2 mRNA CTD PMID:18158353 NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
JBrowse link
G Trdn triadin decreases expression EXP Phenylephrine results in decreased expression of TRDN mRNA CTD PMID:18158353 NCBI chr 1:23,955,651...24,410,494
Ensembl chr 1:23,955,651...24,410,595
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP Phenylephrine results in increased expression of TRIB3 mRNA CTD PMID:18158353 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression EXP Phenylephrine results in decreased expression of TRIM2 mRNA CTD PMID:18158353 NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
JBrowse link
G Trim25 tripartite motif-containing 25 decreases expression EXP Phenylephrine results in decreased expression of TRIM25 mRNA CTD PMID:18158353 NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257
JBrowse link
G Trim34 tripartite motif-containing 34 decreases expression EXP Phenylephrine results in decreased expression of TRIM34 mRNA CTD PMID:18158353 NCBI chr 1:158,707,172...158,720,214
Ensembl chr 1:158,707,172...158,718,674
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP Phenylephrine results in increased expression of TRPC1 protein CTD PMID:17174323 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 multiple interactions
increases expression
EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]; [Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium; TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]
Phenylephrine results in increased expression of TRPC3 mRNA; Phenylephrine results in increased expression of TRPC3 protein
CTD PMID:15672411 PMID:19244478 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions EXP TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium] CTD PMID:15672411 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 multiple interactions EXP 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenylephrine binds to and results in increased activity of TRPM8 protein CTD PMID:19363131 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with calcitonin gene-related peptide (8-37)]; TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with capsazepine] CTD PMID:17082722 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
increases phosphorylation
EXP SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein] CTD PMID:15757502 PMID:15795328 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Phenylephrine results in increased expression of TUBB6 mRNA CTD PMID:18158353 NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
JBrowse link
G Tyr tyrosinase multiple interactions
increases activity
EXP Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Ubn1 ubinuclein 1 decreases expression EXP Phenylephrine results in decreased expression of UBN1 mRNA CTD PMID:18158353 NCBI chr10:10,496,576...10,532,010
Ensembl chr10:10,496,576...10,532,010
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression EXP Phenylephrine results in increased expression of UCHL1 mRNA CTD PMID:18158353 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Ucn urocortin affects response to substance EXP UCN protein affects the susceptibility to Phenylephrine CTD PMID:17885217 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Phenylephrine results in decreased expression of VCAM1 mRNA CTD PMID:18158353 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcan versican increases expression EXP Phenylephrine results in increased expression of VCAN mRNA CTD PMID:18158353 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP VEGFA protein inhibits the reaction [Phenylephrine results in decreased abundance of Copper]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein] CTD PMID:25107896 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin increases expression
multiple interactions
EXP Phenylephrine results in increased expression of VIM protein
VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
CTD PMID:26168186 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vip vasoactive intestinal peptide affects response to substance ISO VIP protein affects the susceptibility to Phenylephrine CTD PMID:11728430 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link
G Wasl WASP like actin nucleation promoting factor multiple interactions EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]] CTD PMID:17615370 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
JBrowse link
G Wfdc1 WAP four-disulfide core domain 1 increases expression EXP Phenylephrine results in increased expression of WFDC1 mRNA CTD PMID:18158353 NCBI chr19:47,720,191...47,739,121
Ensembl chr19:47,720,423...47,739,108
JBrowse link
G Wif1 Wnt inhibitory factor 1 increases expression EXP Phenylephrine results in increased expression of WIF1 mRNA CTD PMID:18158353 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360
JBrowse link
G Xpr1 xenotropic and polytropic retrovirus receptor 1 increases expression EXP Phenylephrine results in increased expression of XPR1 mRNA CTD PMID:18158353 NCBI chr13:67,441,205...67,585,950
Ensembl chr13:67,446,380...67,585,946
JBrowse link
G Zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ZDHHC2 mRNA CTD PMID:18158353 NCBI chr16:51,808,465...51,878,060
Ensembl chr16:51,808,468...51,878,060
JBrowse link
G Zfp46 zinc finger protein 46 decreases expression EXP Phenylephrine results in decreased expression of ZFP46 mRNA CTD PMID:18158353 NCBI chr 5:148,519,403...148,529,903
Ensembl chr 5:148,520,855...148,529,459
JBrowse link
G Zfp503 zinc finger protein 503 decreases expression EXP Phenylephrine results in decreased expression of ZFP503 mRNA CTD PMID:18158353 NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848
JBrowse link
G Zfpm2 zinc finger protein, multitype 2 decreases response to substance
multiple interactions
ISO
EXP
ZFPM2 protein results in decreased susceptibility to Phenylephrine
ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:15220332 NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            protective agent 16487
              phenylephrine 520
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        amino alcohol 1035
                                          ethanolamines 800
                                            phenylethanolamines 593
                                              phenylephrine 520
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