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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:liquiritin
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Accession:CHEBI:80845 term browser browse the term
Definition:A flavanone glycoside that is liquiritigenin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage.
Synonyms:exact_synonym: 4-[(2S)-7-hydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl]phenyl beta-D-glucopyranoside
 related_synonym: 4',7-dihydroxyflavanone 4'-(beta-D-glucopyranoside);   4'-O-beta-D-glucopyranosyl-7-hydroxyflavan-4-one;   7-hydroxyflavanone 4'-O-beta-D-glucoside;   7-hydroxyflavanone 4'-O-glucoside;   Formula=C21H22O9;   InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1;   InChIKey=DEMKZLAVQYISIA-ZRWXNEIDSA-N;   SMILES=OC[C@H]1O[C@@H](Oc2ccc(cc2)[C@@H]2CC(=O)c3ccc(O)cc3O2)[C@H](O)[C@@H](O)[C@@H]1O;   likviritin;   liquiritigenin 4'-O-beta-D-glucopyranoside;   liquiritigenin-4'-beta-D-glucoside;   liquiritoside
 xref: AGR:IND606831444;   CAS:551-15-5;   HMDB:HMDB0029520;   KEGG:C16989;   KNApSAcK:C00008193;   LIPID_MAPS_instance:LMPK12140021
 xref_mesh: MESH:C512196
 xref: MetaCyc:CPD-21623;   PMID:13829014;   PMID:25744461;   PMID:25746576;   PMID:25993793;   PMID:27892811;   PMID:29455337;   PMID:29545865;   PMID:30785275;   PMID:31083444;   PMID:31773731;   PMID:31956937;   PMID:32281178;   PMID:32322472;   PMID:32388008;   PMID:32390832;   Reaxys:61653;   Wikipedia:Liquiritin

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liquiritin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]		 CTD PMID:31589899 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein CTD PMID:21800547 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 EXP liquiritin results in increased expression of GCLC protein
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]		 CTD PMID:29908794 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]
liquiritin results in increased expression of GCLM protein		 CTD PMID:29908794 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] CTD PMID:31589899 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] CTD PMID:29908794 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] CTD PMID:29908794 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO
EXP		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]		 CTD PMID:31589899 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]		 CTD PMID:31589899 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] CTD PMID:29908794 PMID:31589899 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] CTD PMID:31589899 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases response to substance
multiple interactions		 ISO
EXP		 NFE2L2 gene mutant form results in decreased susceptibility to liquiritin
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]		 CTD PMID:29908794 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]		 CTD PMID:31589899 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA] CTD PMID:29908794 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]		 CTD PMID:31589899 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] CTD PMID:29908794 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] CTD PMID:31589899 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] CTD PMID:29908794 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] CTD PMID:29908794 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        anti-inflammatory agent 15836
          liquiritin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      monosaccharide 4298
                                        aldose 2673
                                          aldohexose 2310
                                            glucose 2273
                                              D-glucose 2273
                                                D-glucopyranose 1739
                                                  beta-D-glucose 1606
                                                    beta-D-glucoside 1413
                                                      liquiritin 19
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