(E,E)-germacrone - Ontology Report - Rat Genome Database

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	(E,E)-germacrone	go back to main search page
Accession:	CHEBI:80830	browse the term
Definition:	A germacrane sesquiterpenoid that has formula C15H22O. It is a natural product found in traditional medicinal plants of the family Zingiberaceae. The compound exhibits a range of pharmacological activities including anti-inflammatory, anticancer, antiviral, anti-androgenic, antioxidant, antimicrobial, antifungal, neuroprotective and insecticidal activities.
Synonyms:	exact_synonym:	(3E,7E)-3,7-dimethyl-10-(propan-2-ylidene)cyclodeca-3,7-dien-1-one
	related_synonym:	(3E,7E)-3,7-dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one; Formula=C15H22O; InChI=1S/C15H22O/c1-11(2)14-9-8-12(3)6-5-7-13(4)10-15(14)16/h7-8H,5-6,9-10H2,1-4H3/b12-8+,13-7-; InChIKey=CAULGCQHVOVVRN-SWZPTJTJSA-N; SMILES=CC(C)=C1C\\C=C(C)\\CC\\C=C(C)\\CC1=O; germacron; germacrone; trans,trans-3,7-dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
	xref:	AGR:IND606833661; CAS:6902-91-6; Chemspider:4940991; FooDB:FDB005347; KEGG:C16966; KNApSAcK:C00011728
	xref_mesh:	MESH:C048393
	xref:	PMID:24095670; PMID:26997613; PMID:27178541; PMID:28148897; PMID:29138518; PMID:29159692; PMID:29218943; PMID:2938786; PMID:29655913; PMID:31318092; PMID:31377407; PMID:31404973; PMID:31451221; PMID:31602228; PMID:31766701; PMID:32004654; PMID:32020876; PMID:32071920; PMID:32145743; PMID:32513194; PMID:32521813; PMID:32547235; PMID:32723267; PMID:32887356; PMID:33010370; PMID:33132314; PMID:33244453; PMID:33402180; PMID:33432733; PMID:33677207; PMID:33678144; PMID:33688362; PMID:33721752; PMID:33835632; Reaxys:2047453; Wikipedia:Germacrone

show annotations for term's descendants Sort by:
Rat (11) Mouse (12) Human (12) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (11)

(E,E)-germacrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ABCB1 protein inhibits the reaction [germacrone results in increased susceptibility to Doxorubicin]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

BCL2 associated X, apoptosis regulator

multiple interactions

[germacrone results in increased susceptibility to Doxorubicin] which results in increased expression of BAX

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[germacrone results in increased susceptibility to Doxorubicin] which results in decreased expression of BCL2

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

[germacrone results in increased susceptibility to Doxorubicin] which results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

germacrone results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
decreases activity

germacrone results in increased expression of CYP2B6 mRNA
germacrone results in decreased activity of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1

decreases activity

germacrone results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

germacrone results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
increases expression

germacrone results in decreased activity of CYP3A4 protein
germacrone results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008

G

nuclear receptor subfamily 1, group I, member 2

increases activity

germacrone results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity

germacrone results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19812
role	19784
chemical role	19418
antioxidant	15723
(E,E)-germacrone	11
Path 2
Term	Annotations
CHEBI ontology	19812
subatomic particle	19810
composite particle	19810
hadron	19810
baryon	19810
nucleon	19810
atomic nucleus	19810
atom	19810
main group element atom	19755
main group molecular entity	19755
s-block molecular entity	19605
hydrogen molecular entity	19595
hydrides	19072
organic hydride	18667
organic fundamental parent	18667
hydrocarbon	18414
terpene	13728
terpenoid	13407
sesquiterpenoid	3236
germacrane sesquiterpenoid	11
(E,E)-germacrone	11

paths to the root