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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Gastrodin
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Accession:CHEBI:80828 term browser browse the term
Definition:A glycoside that has formula C13H18O7.
Synonyms:related_synonym: 4-(Hydroxymethyl)phenyl-beta-D-glucopyranoside;   Formula=C13H18O7;   InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1;   InChIKey=PUQSUZTXKPLAPR-UJPOAAIJSA-N;   SMILES=OC[C@H]1O[C@@H](Oc2ccc(CO)cc2)[C@H](O)[C@@H](O)[C@@H]1O
 xref: CAS:62499-27-8;   KEGG:C16964
 xref_mesh: MESH:C045345



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Gastrodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] CTD PMID:26634892 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:26634892 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in increased expression of ACSL4 protein] CTD PMID:31698019 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO gastrodin promotes the reaction [RELA protein binds to BCL2 promoter]
gastrodin results in increased expression of BCL2 mRNA
CTD PMID:23578476 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO gastrodin results in increased expression of BCL2L1 mRNA CTD PMID:23578476 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 affects activity
multiple interactions
ISO
EXP
gastrodin affects the activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]
CTD PMID:23578476 PMID:33645131 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 affects activity ISO gastrodin affects the activity of CASP9 protein CTD PMID:23578476 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:26634892 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:26634892 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP gastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 mRNA]; gastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 protein]; gastrodin inhibits the reaction [Rotenone results in increased phosphorylation of GJA1 protein] CTD PMID:23783886 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 protein] CTD PMID:31698019 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of HMGB1 protein] CTD PMID:31468582 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
gastrodin results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]; gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in decreased expression of HMOX1 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]
[gastrodin co-treated with Oleic Acid] results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[gastrodin co-treated with Oleic Acid] results in increased expression of HMOX1 protein]
[gastrodin co-treated with Dietary Fats] results in increased expression of HMOX1 protein; gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of HMOX1 protein]
CTD PMID:26634892 PMID:31468582 PMID:31698019 PMID:33645131 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma affects expression ISO gastrodin affects the expression of IFNG protein CTD PMID:23578476 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of IL1B protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein] CTD PMID:30790395 PMID:31468582 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 affects expression
multiple interactions
increases expression
ISO gastrodin affects the expression of IL2 protein
gastrodin promotes the reaction [RELA protein binds to IL2 promoter]
gastrodin results in increased expression of IL2 mRNA
CTD PMID:23578476 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 affects expression ISO gastrodin affects the expression of IL4 protein CTD PMID:23578476 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
gastrodin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of IL6 protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]
CTD PMID:26634892 PMID:30790395 PMID:31468582 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein] CTD PMID:30790395 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of MYD88 protein] CTD PMID:30790395 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO
EXP
[gastrodin co-treated with Dietary Fats] results in increased phosphorylation of NFE2L2 protein; gastrodin affects the reaction [Glutamic Acid affects the localization of NFE2L2 protein]
gastrodin results in increased expression of NFE2L2 protein
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in decreased expression of NFE2L2 protein]
[gastrodin co-treated with Oleic Acid] results in increased phosphorylation of and affects the localization of NFE2L2 protein; dorsomorphin inhibits the reaction [[gastrodin co-treated with Oleic Acid] results in increased phosphorylation of and affects the localization of NFE2L2 protein]; gastrodin results in increased phosphorylation of and affects the localization of NFE2L2 protein
CTD PMID:26634892 PMID:31468582 PMID:31698019 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased phosphorylation of NFKBIA protein] CTD PMID:31468582 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]] CTD PMID:33645131 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 protein]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of PTGS2 mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of PTGS2 mRNA]
CTD PMID:26634892 PMID:31698019 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
gastrodin promotes the reaction [RELA protein binds to BCL2 promoter]; gastrodin promotes the reaction [RELA protein binds to IL2 promoter]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased phosphorylation of RELA protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]
CTD PMID:23578476 PMID:30790395 PMID:31468582 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of SLC40A1 protein] CTD PMID:31698019 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of SOD1 mRNA]
gastrodin inhibits the reaction [Oleic Acid results in decreased expression of SOD1 mRNA]
CTD PMID:26634892 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:26634892 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO gastrodin results in increased phosphorylation of STK11 protein CTD PMID:26634892 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein] CTD PMID:30790395 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
gastrodin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of TNF protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TNF protein]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]
CTD PMID:26634892 PMID:30790395 PMID:31468582 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          oxygen atom 19423
            oxygen molecular entity 19423
              organooxygen compound 18998
                carbohydrates and carbohydrate derivatives 12342
                  carbohydrate derivative 11946
                    glycosyl compound 10983
                      glycoside 9266
                        Gastrodin 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organochalcogen compound 19052
                                organooxygen compound 18998
                                  carbohydrates and carbohydrate derivatives 12342
                                    carbohydrate 12342
                                      carbohydrate derivative 11946
                                        glycosyl compound 10983
                                          glycoside 9266
                                            Gastrodin 31
paths to the root