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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Gastrodin
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Accession:CHEBI:80828 term browser browse the term
Definition:A glycoside that has formula C13H18O7.
Synonyms:related_synonym: 4-(Hydroxymethyl)phenyl-beta-D-glucopyranoside;   Formula=C13H18O7;   InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1;   InChIKey=PUQSUZTXKPLAPR-UJPOAAIJSA-N;   SMILES=OC[C@H]1O[C@@H](Oc2ccc(CO)cc2)[C@H](O)[C@@H](O)[C@@H]1O
 xref: CAS:62499-27-8;   KEGG:C16964
 xref_mesh: MESH:C045345


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Gastrodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] CTD PMID:26634892 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:26634892 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in increased expression of ACSL4 protein] CTD PMID:31698019 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO gastrodin promotes the reaction [RELA protein binds to BCL2 promoter]
gastrodin results in increased expression of BCL2 mRNA
CTD PMID:23578476 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO gastrodin results in increased expression of BCL2L1 mRNA CTD PMID:23578476 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 affects activity ISO gastrodin affects the activity of CASP3 protein CTD PMID:23578476 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 affects activity ISO gastrodin affects the activity of CASP9 protein CTD PMID:23578476 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:26634892 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:26634892 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP gastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 mRNA]; gastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 protein]; gastrodin inhibits the reaction [Rotenone results in increased phosphorylation of GJA1 protein] CTD PMID:23783886 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 protein] CTD PMID:31698019 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of HMGB1 protein] CTD PMID:31468582 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
gastrodin results in increased expression of HMOX1 protein
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in decreased expression of HMOX1 protein]
[gastrodin co-treated with Oleic Acid] results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[gastrodin co-treated with Oleic Acid] results in increased expression of HMOX1 protein]
[gastrodin co-treated with Dietary Fats] results in increased expression of HMOX1 protein; gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of HMOX1 protein]
CTD PMID:26634892 PMID:31468582 PMID:31698019 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma affects expression ISO gastrodin affects the expression of IFNG protein CTD PMID:23578476 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of IL1B protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein] CTD PMID:30790395 PMID:31468582 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 affects expression
multiple interactions
increases expression
ISO gastrodin affects the expression of IL2 protein
gastrodin promotes the reaction [RELA protein binds to IL2 promoter]
gastrodin results in increased expression of IL2 mRNA
CTD PMID:23578476 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 affects expression ISO gastrodin affects the expression of IL4 protein CTD PMID:23578476 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
gastrodin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of IL6 protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]
CTD PMID:26634892 PMID:30790395 PMID:31468582 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein] CTD PMID:30790395 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of MYD88 protein] CTD PMID:30790395 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO
EXP
[gastrodin co-treated with Dietary Fats] results in increased phosphorylation of NFE2L2 protein; gastrodin affects the reaction [Glutamic Acid affects the localization of NFE2L2 protein]
gastrodin results in increased expression of NFE2L2 protein
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in decreased expression of NFE2L2 protein]
[gastrodin co-treated with Oleic Acid] results in increased phosphorylation of and affects the localization of NFE2L2 protein; dorsomorphin inhibits the reaction [[gastrodin co-treated with Oleic Acid] results in increased phosphorylation of and affects the localization of NFE2L2 protein]; gastrodin results in increased phosphorylation of and affects the localization of NFE2L2 protein
CTD PMID:26634892 PMID:31468582 PMID:31698019 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased phosphorylation of NFKBIA protein] CTD PMID:31468582 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 protein]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of PTGS2 mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of PTGS2 mRNA]
CTD PMID:26634892 PMID:31698019 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
gastrodin promotes the reaction [RELA protein binds to BCL2 promoter]; gastrodin promotes the reaction [RELA protein binds to IL2 promoter]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased phosphorylation of RELA protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]
CTD PMID:23578476 PMID:30790395 PMID:31468582 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of SLC40A1 protein] CTD PMID:31698019 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of SOD1 mRNA]
gastrodin inhibits the reaction [Oleic Acid results in decreased expression of SOD1 mRNA]
CTD PMID:26634892 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:26634892 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO gastrodin results in increased phosphorylation of STK11 protein CTD PMID:26634892 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein] CTD PMID:30790395 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
gastrodin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of TNF protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TNF protein]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]
CTD PMID:26634892 PMID:30790395 PMID:31468582 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      atom 19771
        nonmetal atom 19654
          oxygen atom 19357
            oxygen molecular entity 19357
              organooxygen compound 18879
                carbohydrates and carbohydrate derivatives 12262
                  carbohydrate derivative 11892
                    glycosyl compound 10963
                      glycoside 9256
                        Gastrodin 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            heteroorganic entity 19208
                              organochalcogen compound 18953
                                organooxygen compound 18879
                                  carbohydrates and carbohydrate derivatives 12262
                                    carbohydrate 12262
                                      carbohydrate derivative 11892
                                        glycosyl compound 10963
                                          glycoside 9256
                                            Gastrodin 30
paths to the root