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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Deoxyschizandrin
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Accession:CHEBI:80818 term browser browse the term
Definition:A tannin that has formula C24H32O6.
Synonyms:related_synonym: Formula=C24H32O6;   InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3;   InChIKey=JEJFTTRHGBKKEI-UHFFFAOYSA-N;   SMILES=COc1cc2CC(C)C(C)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC)c1OC
 xref: CAS:61281-38-7;   KEGG:C16951
 xref_mesh: MESH:C034734


show annotations for term's descendants           Sort by:
Deoxyschizandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor2 adiponectin receptor 2 multiple interactions ISO schizandrin A binds to and results in increased activity of ADIPOR2 protein CTD PMID:23691032 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of AKT1 protein] CTD PMID:32057180 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO MEG3 protein affects the reaction [schizandrin A results in increased expression of BAX protein] CTD PMID:32057180 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO schizandrin A results in decreased expression of BCL2 protein
MEG3 protein affects the reaction [schizandrin A results in decreased expression of BCL2 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of BCL2 protein]		 CTD PMID:32057180 PMID:35321622 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO MEG3 protein affects the reaction [schizandrin A results in increased cleavage of CASP3 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased cleavage of CASP3 protein] CTD PMID:32057180 PMID:35321622 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO MEG3 protein affects the reaction [schizandrin A results in decreased expression of CCND1 protein] CTD PMID:32057180 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO schizandrin A results in decreased activity of CYP1A2 protein CTD PMID:25753323 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO schizandrin A results in increased expression of CYP3A4 mRNA CTD PMID:16267138 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:35321622 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:35321622 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:35321622 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Meg3 maternally expressed 3 multiple interactions
increases expression		 ISO MEG3 protein affects the reaction [schizandrin A results in decreased expression of BCL2 protein]; MEG3 protein affects the reaction [schizandrin A results in decreased expression of CCND1 protein]; MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of AKT1 protein]; MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of NFKBIA protein]; MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of PIK3C3 protein]; MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of RELA protein]; MEG3 protein affects the reaction [schizandrin A results in increased cleavage of CASP3 protein]; MEG3 protein affects the reaction [schizandrin A results in increased expression of BAX protein]; MEG3 protein affects the reaction [schizandrin A results in increased expression of TP53 protein]
schizandrin A results in increased expression of MEG3 mRNA		 CTD PMID:32057180 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO schizandrin A results in decreased expression of MMP9 protein CTD PMID:32057180 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 ISO schizandrin A results in decreased phosphorylation of NFKBIA protein
MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of NFKBIA protein]		 CTD PMID:32057180 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO schizandrin A results in increased activity of NR1I2 protein
schizandrin A binds to and results in increased activity of NR1I2 protein		 CTD PMID:16267138 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ocln occludin multiple interactions ISO schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of OCLN protein] CTD PMID:35321622 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases phosphorylation
multiple interactions		 ISO schizandrin A results in decreased phosphorylation of PIK3C3 protein
MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of PIK3C3 protein]		 CTD PMID:32057180 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases phosphorylation ISO schizandrin A results in increased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases phosphorylation ISO schizandrin A results in decreased phosphorylation of PRKAA1 protein CTD PMID:23691032 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 decreases phosphorylation ISO schizandrin A results in decreased phosphorylation of PRKAA2 protein CTD PMID:23691032 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation		 ISO MEG3 protein affects the reaction [schizandrin A results in decreased phosphorylation of RELA protein] CTD PMID:32057180 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of TJP1 protein] CTD PMID:35321622 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO MEG3 protein affects the reaction [schizandrin A results in increased expression of TP53 protein] CTD PMID:32057180 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin decreases expression ISO schizandrin A results in decreased expression of VIM protein CTD PMID:32057180 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        pharmaceutical 19491
          drug 19491
            astringent 11029
              tannin 303
                Deoxyschizandrin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic aromatic compound 19359
                                  phenols 18634
                                    polyphenol 9423
                                      tannin 303
                                        Deoxyschizandrin 24
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